LOCUS       NM_207237               4715 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus mannosidase, alpha, class 1C, member 1 (Man1c1), mRNA.
ACCESSION   NM_207237 XM_131797
VERSION     NM_207237.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4715)
  AUTHORS   Tremblay LO, Nagy Kovacs E, Daniels E, Wong NK, Sutton-Smith M,
            Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C and
            Herscovics A.
  TITLE     Respiratory distress and neonatal lethality in mice lacking Golgi
            alpha1,2-mannosidase IB involved in N-glycan maturation
  JOURNAL   J Biol Chem 282 (4), 2558-2566 (2007)
   PUBMED   17121831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627122.18 and AL669982.10.
            
            [WARNING] On Dec 5, 2023 this sequence was replaced by NM_207237.4.
            
            On Apr 7, 2010 this sequence version replaced NM_207237.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.9774113.1,
                                           SRR7974084.15184.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1346              AL627122.18        124124-125469       c
            1347-1443           AL627122.18        61466-61562         c
            1444-1559           AL627122.18        14429-14544         c
            1560-1640           AL627122.18        12535-12615         c
            1641-1735           AL627122.18        5479-5573           c
            1736-1802           AL627122.18        2001-2067           c
            1803-1853           AL669982.10        240075-240125       c
            1854-1947           AL669982.10        237590-237683       c
            1948-2063           AL669982.10        235244-235359       c
            2064-2283           AL669982.10        228200-228419       c
            2284-2456           AL669982.10        225132-225304       c
            2457-2572           AL669982.10        223809-223924       c
            2573-4715           AL669982.10        220994-223136       c
FEATURES             Location/Qualifiers
     source          1..4715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.88 cM"
     gene            1..4715
                     /gene="Man1c1"
                     /note="mannosidase, alpha, class 1C, member 1"
                     /db_xref="GeneID:230815"
                     /db_xref="MGI:MGI:2446214"
     exon            1..1346
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             822..2699
                     /gene="Man1c1"
                     /EC_number="3.2.1.113"
                     /codon_start=1
                     /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase
                     IC"
                     /protein_id="NP_997120.1"
                     /db_xref="CCDS:CCDS18776.1"
                     /db_xref="GeneID:230815"
                     /db_xref="MGI:MGI:2446214"
                     /translation="MLVRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLP
                     HSSRLKRLFSASRTQQPGLEVMAEIAGHHSVSEQEPPPNPAPAAPAPGEDDPSRLVGV
                     LRRKGWLRRTRPTGPREEGNRVAALRPQEESVRFTFDYNGFRSRLRHPVLGTRTDESK
                     ESQSLVRAQREKIKEMMRFSWQNYRRYAMGKNELRPLTKDGFEGSMFGGLSGATIIDS
                     LDTLYLMELKEEFQEAKAWVQDSFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFR
                     VKAIKLGEKLLPAFNTPTGIPKGVVNFKSGSWGWATAGSSSILAEFGSLHLEFLHLTE
                     LSGNPVFAEKVKHIRKVLREIDKPFGLYPNFLSPTSGNWVQHHVSVGGLGDSFYEYLI
                     KSWLMSAKTDMEAKNMYYEALEAIETYLVNVSPGGLTYIAEWRGGILDHKMGHLACFS
                     GGMIALGADDAKEDKRAYYRELAAQITRTCHESYARSDTKLGPEAFWFNSGREAVATQ
                     LSESYYILRPEVVESYMYLWRQTHDPIYREWGWEVVMALEKHCRTEAGFSGIQDVYSS
                     NPNHDNRQQSFFLAETLKYLYLLFSEDNVLSLEDWVFNTEAHPLPVNRSDSFSIAGHP
                     H"
     exon            1347..1443
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1559
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1640
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1735
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1853
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1947
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2063
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2283
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2456
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2572
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..4715
                     /gene="Man1c1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcggcg ctgtcgcagt gagagccgga gcagcggcgg cccgtctgga gctgcggcgg
       61 gtgagcctgc gcggctagcg gagccgcggg gccgggaaca ggtgatcgca gcaggagacc
      121 cgcgccctcc cgagttgcgg cgccggagcc aaggcttcct ggctcagcgg caggcccagg
      181 gctgacagag gccagctgca ggcttcgcac gcgcttcccg ggtatccctc tccccgcgcg
      241 agcatctgaa gcccctgggt cccgcgcagc ctcgggagcg gcaaccgcgc gcggcggagc
      301 aaagttgtgg acgtgtcccg accgccgggc cctgcgccgt caccaccggc tgggctcgcg
      361 ctctaggagc tgcgctcgcc ctgcaagccc cgggggttcc ctttgcaaac tgctccagag
      421 gctgaaactt cgggtgccgg cgggtcgggg cctgcgtcct gcgcaccctc cgcgagggcg
      481 tcgcggacgg catgtgacca ctccggcgcg ggaaggcgcg ggagggcgcg ggctccgtgg
      541 atcaggcgga gggcaggctg cggcgcacgg cgggcccggg ctccagccga gcagcccccc
      601 tcgcccgggc cccgccgagg ccgccgcgcc cccgcccccg cgcgggagga ctcgctccaa
      661 actccctgaa cttcgggcgg gtcccgaagc ggcggcctcg aggtgcgcag ccttgctcgg
      721 ggaccccagc cacttcactc ttgctcccca cccttgagga ctctgaggac tcccggggcc
      781 ccgggcggag ctgacagccc cctcctgctg gccgcgccgc gatgctggtg aggaaagtgc
      841 cgggtttcgt cccggcctcg ccgtgggggc tgcggctgcc gcagaagttc cttttcctgc
      901 tcttcctctc gggcctcgtc accctgtgct ttggcgccct gttccttctg ccccattcct
      961 ctcgcctcaa gcgcctcttc tcggcctcgc ggacccaaca gcccggcctg gaggtgatgg
     1021 ccgaaatcgc cggtcaccac tcggtgtcag agcaggagcc gcctcccaac cctgcccctg
     1081 cggctccggc cccgggtgag gacgatccca gccgcctggt cggtgttctc cgtaggaaag
     1141 ggtggctgcg gcgaacccgc cccaccgggc cccgggagga aggcaacagg gttgcagccc
     1201 tcaggccgca ggaagagagc gtccggttca ctttcgacta caatggtttc cgcagccgcc
     1261 ttcgacaccc ggtcttgggg acaaggactg atgagagtaa ggagtcccag agtctggtgc
     1321 gagctcagcg agagaaaatc aaagagatga tgcggttttc ctggcagaat taccgccgtt
     1381 atgcgatggg caagaatgag ctccggccac tcacaaagga cggcttcgag ggcagcatgt
     1441 ttggcggtct cagtggggct accatcatcg attctcttga caccctctac ctcatggagc
     1501 tgaaagagga gttccaggag gccaaggcct gggtgcaaga cagcttccac ctgaacgtga
     1561 gtggagaagc atctttgttt gaagtgaaca tccggtatat cggaggactg ctctcggcct
     1621 tctacctgac tggagaagag gtgttccgag tgaaggccat caagctgggt gagaaactgc
     1681 tgcctgcctt caacacaccc acgggcatcc ccaagggcgt ggtcaacttc aaaagcggta
     1741 gctggggctg ggccacggca ggcagcagca gcatcctggc cgagtttggg tccctgcact
     1801 tggaattcct gcatctcact gaactctctg gcaatccagt ctttgcagaa aaggtcaaac
     1861 atatccgcaa ggtcctcagg gagattgaca aacccttcgg tctctacccc aacttcctca
     1921 gccccacgag tggaaactgg gtgcagcatc atgtctcggt aggaggactt ggggacagtt
     1981 tttatgaata tttgatcaag tcctggttga tgtcagccaa aacagatatg gaggctaaaa
     2041 atatgtacta cgaagccttg gaggccatag agacctatct cgtgaatgtc tctcccgggg
     2101 gcctgaccta cattgctgag tggcgtggag gaattctgga ccacaagatg ggacaccttg
     2161 cctgcttctc agggggcatg atcgcccttg gtgcagatga tgccaaggaa gataaaagag
     2221 cctactaccg agagcttgca gcccagatca ccaggacgtg ccatgagtcc tatgcccgct
     2281 cagacaccaa gctggggcct gaggccttct ggttcaactc tggccgagag gcggtggcca
     2341 cacaactgag cgagagctac tacatcctgc gccccgaggt ggtagagagc tacatgtacc
     2401 tatggcggca gacgcatgac cccatctaca gggagtgggg ctgggaggtg gtcatggccc
     2461 tggagaaaca ctgtcggacg gaagccggct tctcggggat ccaggacgtg tacagcagta
     2521 accccaacca tgacaacagg caacagagct tcttcctggc tgagacgctg aaatacctct
     2581 atcttctgtt ctctgaagat aacgtgctgt cactggaaga ctgggtgttc aacaccgagg
     2641 ctcatccgct gcccgtcaac cgctcggaca gctttagcat agctggccac cctcactgac
     2701 cactgtcgcc acgcctgtgt ctcagggacg cctctacttt cttgggatcc gggaccgttc
     2761 tcagaggcac tggggacgga aggcccgctg tgggcagacc ctggacggat gtgtcggaca
     2821 ggcgacttct tttcctctgt gaggagacag gagctggtga tgtaccagcg tgggcccctg
     2881 ggctatggtc cctggcgcct acacgttcct ttctatgggg gaatttctgt gtccccacac
     2941 ttgctgtccc tgggccaaag gactggaagt ttgcgttccc atcttgtgta tttggttcgg
     3001 tttccttttt ggtttaggga gttcggtttt gcttgacctt ccttgttttt tttctttctc
     3061 cccacttgag ttttatgaca attataattt tcagaatcat gtaccttcta aagtggcgcc
     3121 acctaactca aggagacctt tagtgtttgt acacacacac acacacacac acacacacac
     3181 acacacacac cacacacacc acacacactc ttgacccgtc tgcttttaat gcctatcacc
     3241 cgacattgat tctgtcccac ttcttgtcat ctaccctgtc atcggaggag acagtcccct
     3301 ttgctttggt cccaaatgtt acaaatcact aataatgcta ttttcattac tgtaatggag
     3361 aaatatgtga agtagaataa aggatttcat tgaataagaa atcagattgg actcattggc
     3421 caccagaggc tcctgggaga aaaatcctcc aacagtgtca cccgaagccg tcaccagctg
     3481 gcagaggagc tgaggtgtga tatactaaag gcagtgggtg cagcttctct gtctctctcc
     3541 aggtggccct agtaagtgca ggaaatgaga ggccagccct ttgggtagag ttgggtatga
     3601 atactcacac tcggatggag gagtggaaga agcccaggga ggtgactctg tttgcctgaa
     3661 gtcaccttgc ctctgggatc tcctggtcac cctggtcctt tgttcatgtt gtcaatcagc
     3721 aatgcttagt gagcccctgc ccccaccagg gctagatggc ctccacctcg cagtcagggc
     3781 gctcagatca tatacgatgc ctctacatta gtggaatgac tataaaccat tgccaatact
     3841 aacaaggatg caggaggctc agccaacagt agctaggacc tgggtggggg ttagggacat
     3901 aaggacaggg gttattgtca taaagataat aagacccaaa gacaagtagg cgctgtgtat
     3961 agacaaggac atagtgtgat atcttctaac ccagatttcc ctgtcactct ctctgtgcca
     4021 tctccctgtg aacccagaag ccatctacat ggcgaggagt ccaggcccct acactgccgt
     4081 gccaggcttg cctttccaac agccctgctg gcagcctgga cacagctgag gtgctgggta
     4141 aagttggctc tctcccagcc ccttcattag actgggcttg tcaactggcc atcaaggtat
     4201 tggggctcca ggcctggtga cacccaccca cccactgtgt gagcccagac cagtcacctc
     4261 acctctctgg gctgttttcc atcagcagaa attgcacctg ctggggttgc tatgagaacc
     4321 agcaagatgc tcctgatgcc ctttggtcca ggatccactg cctccttgtt ctagaggctc
     4381 agacatccca gctcttcctg agcagagctg tgcattcaca gtcctgctat ccgtagcaca
     4441 catgtcaaag ggaaagggtc acttgctgca caaacactgt aggacaatta agaaaccaag
     4501 ataatcagaa aggaaatatg gtcaccaccc aactctccgg aatgaatact gttatatttt
     4561 cttctagacc tttttctata aatatataga aaatatattt tgcaaacatg ttgtcagcct
     4621 atgcatactg ttttttctta taacctgctt ttgcacttaa ctatatattg tgaacatctt
     4681 tccatgtcaa gaaatataca catctgtcag cactc
//
