LOCUS       NM_001029983            3748 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mannosidase, alpha, class 1B, member 1 (Man1b1), mRNA.
ACCESSION   NM_001029983 XM_130073
VERSION     NM_001029983.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Sevilla,L.M., Comstock,S.S., Swier,K. and Miller,J.
  TITLE     Endoplasmic reticulum-associated degradation-induced dissociation
            of class II invariant chain complexes containing a
            glycosylation-deficient form of p41
  JOURNAL   J Immunol 173 (4), 2586-2593 (2004)
   PUBMED   15294975
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247979.1, BY732333.1, BC138551.1, AL732557.4 and BQ129775.1.
            
            On Apr 22, 2010 this sequence version replaced NM_001029983.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138550.1, SRR7974084.2010.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY247979.1         2-6
            6-699               BY732333.1         2-695
            700-2491            BC138551.1         656-2447
            2492-3732           AL732557.4         23736-24976
            3733-3748           BQ129775.1         125-140
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.17 cM"
     gene            1..3748
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /note="mannosidase, alpha, class 1B, member 1"
                     /db_xref="GeneID:227619"
                     /db_xref="MGI:MGI:2684954"
     exon            1..234
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2094
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /EC_number="3.2.1.113"
                     /note="ER mannosidase 1; ER alpha-1,2-mannosidase;
                     man9GlcNAc2-specific-processing alpha-mannosidase"
                     /codon_start=1
                     /product="endoplasmic reticulum mannosyl-oligosaccharide
                     1,2-alpha-mannosidase"
                     /protein_id="NP_001025154.1"
                     /db_xref="CCDS:CCDS15765.1"
                     /db_xref="GeneID:227619"
                     /db_xref="MGI:MGI:2684954"
                     /translation="MYPPPAPPPAPHRDFISVTLSLGESYDNSKSRRRRSCWRKWKQL
                     SRLQRNVILFVLGFLILCGFLYSLHTADQWKALSGRPAEVEKMKQEVLPVLPAPQKES
                     AEQEGFADILSQKRQRHFRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENT
                     QRTVISWRGAVIEPEQATELPYKRAEASIKPLVLASKIWKEPAPPNERQKGVIEAFLH
                     AWKGYQKFAWGHDELKPVSKTFSEWFGLGLTLIDALDTMWILGLKQEFKQARKWVSEN
                     LDFQKNVDVNLFESTIRILGGLLSTYHLSGDSLFLTKAEDFGKRLMPAFTTPSKIPYS
                     DVNIGTGFAHSPQWTSDSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSLSG
                     KKDGLVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVKAI
                     EGIKAHLLRQSQPRKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVHHGLPADHMDLA
                     RALMETCYQMNQQMETGLSPEIAHFNMYPRADHKDVEVKPADRHNLLRPETVESLFYL
                     YRVTRDRKYQDWGWEILQSFNKYTRVPSGGYSSINNVQNSHKPEPRDKMESFFVGETL
                     KYLYLLFSDDLELLSLDSCVFNTEAHPLPIWAPA"
     exon            235..343
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            344..459
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            460..614
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            615..724
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            725..910
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1059
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1248
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1439
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1560
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1758
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1890
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..3742
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3716..3721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /note="hexamer: ATTAAA"
     polyA_site      3741
                     /gene="Man1b1"
                     /gene_synonym="E430019H13Rik; ERMan1; Gm108; MANA-ER"
                     /note="major polyA site"
ORIGIN      
        1 tgtttagggc gatgggcggg gtgtggatgc cttcgttatg gcagcccgcg gtctttctca
       61 gtcttgggct tcctgacgcc tccagcaagc gaggtctttt gggccggctt cgcagttatg
      121 tacccaccgc cggcgccgcc gccggcgcct caccgggact tcatctcggt gacgctgagc
      181 ctgggcgaga gctacgacaa cagcaagagc cggcggcggc gctcatgctg gaggaaatgg
      241 aagcagcttt cgaggctaca gcggaatgtg attctcttcg tcttgggctt tctgattctc
      301 tgtggattcc tgtactctct tcatacggct gaccagtgga aagctctgag tggcagacct
      361 gcagaagtag agaagatgaa gcaagaagtc ctgcctgtct taccagcgcc tcagaaggaa
      421 agtgctgaac aagaagggtt tgcagacata ctctctcaga agcggcaaag gcattttcgg
      481 cggggccctc cccatctgca gattagaccc cccaacacag tctccaagga tgggatgcag
      541 gatgatgcta aggagagaga agcagccctg gggaaggctc agcaggaaga aaacacacag
      601 agaaccgtca tcagctggcg gggagccgtg attgagcctg aacaggccac tgaacttcct
      661 tacaaaagag ctgaagcctc catcaaacct ctggttttgg catccaagat atggaaagag
      721 ccagcccccc cgaatgagcg ccagaaggga gtgattgagg cctttctcca tgcttggaag
      781 ggttaccaaa agtttgcttg gggccatgat gaactaaaac ctgtgtccaa aaccttcagt
      841 gagtggtttg gcctgggcct caccctgatc gatgccttgg ataccatgtg gattttgggt
      901 ctgaagcaag aatttaagca agccaggaaa tgggtatcag agaacttaga ctttcagaag
      961 aatgttgatg tcaacctgtt tgagagcacc attcgcatct tagggggcct gctgagtacc
     1021 taccacctgt cgggggacag cctcttcctg accaaagctg aagattttgg aaaacggctg
     1081 atgcctgcct tcactacgcc ctccaagatc ccatactctg atgtgaacat tggcactgga
     1141 tttgcccact caccccagtg gacttcagac agcacggtgg cagaagtgac gagcattcag
     1201 ttggagttcc gggagctctc tcgtcttact ggaataaaga aattccagga ggccgtggag
     1261 gaagtgacaa agcacatcca ctccctgtct gggaagaaag acgggctggt gcctatgttc
     1321 atcaacacga acagcggcct cttcacccac ccaggagtgt tcaccttggg ggccagggct
     1381 gacagctact acgaatacct gctgaaacag tggatccagg gtggcaagaa ggagacacag
     1441 ttgctggaag actatgttaa agccattgag gggataaaag cccatctgct ccggcagtct
     1501 cagcccagaa agctcacctt cgtgggagaa cttgcccacg gccgcttcag tgccaagatg
     1561 gaccacttag tgtgcttcct gccggggacg ctggctttgg gtgtccacca tggcctgcca
     1621 gctgaccaca tggatctagc tcgggccctc atggagacct gctaccagat gaaccaacag
     1681 atggagacag gtctgagccc tgagattgca catttcaaca tgtaccctcg ggcagatcat
     1741 aaagatgtgg aggtcaagcc agctgacagg cacaacctgc tgcggccaga gacggtggaa
     1801 agcctattct atctgtaccg tgtcacaagg gaccgcaagt accaggactg gggctgggaa
     1861 atcctgcaga gcttcaataa gtacacacgg gtcccctcag gtggctattc ttctatcaac
     1921 aacgtccaga attcccacaa gcctgagccc agggacaaga tggagagctt ctttgtgggg
     1981 gaaaccctga agtacttgta cctgctcttt tctgatgacc tggagctgct cagtctggac
     2041 agctgtgtgt tcaacacaga agcccatccc ctccccatct gggctcctgc gtaggaggag
     2101 agcacctggt ctgggcactg atggagactg aggtgggcct gttgggtccc tgaccttcac
     2161 aaggcccaca tagttttggg cagctgtcaa gtgtgatgta cctgcccagt tgtaggtccc
     2221 tccagtttca acttttcatg aaggtggtgg gaggggcagg agtcagacta gcaggtatgg
     2281 gttctggggt ttaggctgga aagtctacca agcctttgac ttcctcgaaa cctcatatca
     2341 tggctcctga ttcccatacc tgaatgaccc tgttggctgg ctaccggcag ccccatggta
     2401 gtcccaagac ttcttatcac ctcctgggac cacccaggac cccagtgcct gtattgagtt
     2461 cagagtgata gcccaaacca gtgaggtgct gggcatggcc caatggcctg tgatagccct
     2521 gactcctgat tgacccatgg gtccactggg ccagtgtgac cttgagggtc tttgtggctc
     2581 tagtgtttac gggttggact cagggatcct cctggctacc ctactgggct ggcgggggtt
     2641 agaacagtaa atttgtctta ttcccaggat accctggtat aatgtgatct ctcagctgag
     2701 aagaaagtgg acttggtccc actgtaatgg ttcttgtgga gaggagggaa ggggtggtgt
     2761 ctatctagac tgaccttaag gggacagcag gttctctgga taacatctca gcaactaccc
     2821 tctaaagtca gagctcctgt ccacttcagg taggaaggct ttggggccat tatacaaaca
     2881 ggctaggatg cttggttgtg ccgtctcaca agggcctgtg aagatcacat gctgctgccg
     2941 gctgataggt ttgtggtagt tgtgccttgg tgtctgagcc catggagtag gccctgtctt
     3001 tgatgagttg ttactagact atccctgggc cttggctagg attctcctat ccaattccat
     3061 gcagtacagc atagggcaaa ctggacagaa tagaaaggac ctcaaggctc tgggcctgtg
     3121 ttccctgtat atcccaagat ctggagattt gacatgctaa ctaactcatc tgcagctcag
     3181 tggcagccac cttgtgcctc tgaggtatag tagctacgct ggggacttcc tgttaaacac
     3241 gtggacccca agccagttct aacaccaaag gtgtttacaa agaaggactt ggctggtcac
     3301 atatccttag gccttgagtt tatgggtaga agctgccgcc ctccaccccc cccccccccc
     3361 atcagttata accctttggt tgatgttagc ttctccctat gctgtcctcc tctaccggag
     3421 ccccataggc ttgtgaatgg acaggttcag gcggcgccca gggcctaagc attgagaagt
     3481 gtattctcca tctcctgcca aactatggct ggtgtcaagg gatgacagta actgccctgt
     3541 ggccctctga agaggtactg tggatcagag aaactgggta gatgtccaca aagctgggag
     3601 cctcattaaa gcatacaaga tgggaatggg cctggaaggg gaggctggtg cccagtagag
     3661 gcaggtttcc ctcctcctcc aaagcaggaa acctgagagc tagagtccct gcttaattaa
     3721 atgtctaaat ggtctcagca agaaaaaa
//
