LOCUS       NM_175334               5573 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mastermind like transcriptional coactivator 1 (Maml1),
            transcript variant 2, mRNA.
ACCESSION   NM_175334
VERSION     NM_175334.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5573)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5573)
  AUTHORS   Portal,C., Rompolas,P., Lwigale,P. and Iomini,C.
  TITLE     Primary cilia deficiency in neural crest cells models anterior
            segment dysgenesis in mouse
  JOURNAL   Elife 8, e52423 (2019)
   PUBMED   31845891
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5573)
  AUTHORS   Ge,X., Xiao,G., Huang,H., Du,J., Tao,Y., Yang,A., Wu,H., Zhang,Z.
            and Qiu,M.
  TITLE     Stage-dependent regulation of oligodendrocyte development and
            enhancement of myelin repair by dominant negative Master-mind 1
            protein
  JOURNAL   Glia 67 (9), 1654-1666 (2019)
   PUBMED   31038233
  REMARK    GeneRIF: dnMAML1 expression leads to robust precocious
            oligodendrocytes differentiation and premature axonal myelination
            in the spinal cord, possibly by upregulating Nkx2.2 and
            downregulating Pdgfra expression. Unexpectedly, at late embryonic
            stages, dnMAML1 expression dramatically increased the number of
            oligodendrocyte precursor cells (OPCs), indicating a
            stage-dependent effect of Notch signaling on OPC proliferation.
REFERENCE   4  (bases 1 to 5573)
  AUTHORS   Zhang,J., Niu,J., Tian,B. and Zhao,M.
  TITLE     microRNA-193b protects against myocardial ischemia-reperfusion
            injury in mouse by targeting mastermind-like 1
  JOURNAL   J Cell Biochem 120 (8), 14088-14094 (2019)
   PUBMED   30993760
  REMARK    GeneRIF: microRNA-193b protects against myocardial
            ischemia-reperfusion injury in mouse by targeting mastermind-like
            1.
REFERENCE   5  (bases 1 to 5573)
  AUTHORS   Ayoub,A.E., Dominguez,M.H., Benoit,J., Ortega,J.A., Radonjic,N.,
            Zecevic,N. and Rakic,P.
  TITLE     Coordination of Neuron Production in Mouse and Human Cerebral
            Cortex by the Homolog of Drosophila Mastermind Protein
  JOURNAL   Brain Behav Evol 93 (2-3), 152-165 (2019)
   PUBMED   31416089
  REMARK    GeneRIF: Neuron production in mouse cerebral cortex is coordinated
            by the MAML1.
REFERENCE   6  (bases 1 to 5573)
  AUTHORS   Maillard,I., Weng,A.P., Carpenter,A.C., Rodriguez,C.G., Sai,H.,
            Xu,L., Allman,D., Aster,J.C. and Pear,W.S.
  TITLE     Mastermind critically regulates Notch-mediated lymphoid cell fate
            decisions
  JOURNAL   Blood 104 (6), 1696-1702 (2004)
   PUBMED   15187027
  REMARK    GeneRIF: a dominant negative mutant of MAML1 resulted in early
            inhibition of T-cell development and the appearance of intrathymic
            B cells, phenotypes consistent with Notch1 inhibition
REFERENCE   7  (bases 1 to 5573)
  AUTHORS   Wu,L., Kobayashi,K., Sun,T., Gao,P., Liu,J., Nakamura,M.,
            Weisberg,E., Mukhopadhyay,N.K. and Griffin,J.D.
  TITLE     Cloning and functional characterization of the murine
            mastermind-like 1 (Maml1) gene
  JOURNAL   Gene 328, 153-165 (2004)
   PUBMED   15019995
  REMARK    GeneRIF: There seems to be close correlation of the spatial and
            temporal expression of Maml1, in the central nervous system (CNS)
            during early development, implicating a role for the Maml1 gene in
            neurogenesis.
REFERENCE   8  (bases 1 to 5573)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5573)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5573)
  AUTHORS   Wu,L., Sun,T., Kobayashi,K., Gao,P. and Griffin,J.D.
  TITLE     Identification of a family of mastermind-like transcriptional
            coactivators for mammalian notch receptors
  JOURNAL   Mol Cell Biol 22 (21), 7688-7700 (2002)
   PUBMED   12370315
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI509152.1, AK129088.1, BC058658.1 and BC094599.1.
            
            On Oct 3, 2007 this sequence version replaced NM_175334.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129088.1, AY442299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AI509152.1         1-20
            21-2202             AK129088.1         1-2182
            2203-5005           BC058658.1         1543-4345
            5006-5573           BC094599.1         4203-4770
FEATURES             Location/Qualifiers
     source          1..5573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.42 cM"
     gene            1..5573
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /note="mastermind like transcriptional coactivator 1"
                     /db_xref="GeneID:103806"
                     /db_xref="MGI:MGI:1890504"
     exon            1..611
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..3338
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mastermind-like protein 1; mastermind like 1"
                     /codon_start=1
                     /product="mastermind-like protein 1 isoform 2"
                     /protein_id="NP_780543.2"
                     /db_xref="CCDS:CCDS24632.2"
                     /db_xref="GeneID:103806"
                     /db_xref="MGI:MGI:1890504"
                     /translation="MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAV
                     SPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAAATAPVAAPAPASAPAAARLDAA
                     DGPEHGRPVAHLHDTVKRSLDSAASPQNGDQPNGYGDLFPGHKKTRREAPLGVSVSAN
                     GLPPASPLGQPDKPSGGDTLQTAGKHSLGLDPINKKCLADSGIHLNGGSNSSEPFPLS
                     LSKELKQEPVDDLPCMIAGAGGSVAQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKD
                     LFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFL
                     GASSAPVGTDSPSLGSSQTLFHTTSQPGVDNSSPNLMPASAQAQSAQRALTSVVLPSQ
                     GPGGASELSSAHQLQQIAAKQKREQMLQNPQQAAPAPGPGQLATWQQAGPSHSPLDVP
                     YPMEKPASPSGYKQDFTNSKLLMMPGVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNQN
                     PVNNQGSVLDYGNTKPLSHYKADCGQGGPGSGQNKPALMAYLPQQLPHLSNEQNSLFL
                     MKPKSGNMPFRSLVPPGQEQNPSSVPVAAPAASVGTQPTVSVASTHNSSPYLSSQQQA
                     AVMKQHQLLLDQQKQREQQQQQLQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPT
                     QSTFPQQVGQFTGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPSSS
                     GQQDRGVAQFTGSQSLPQNSLYGMASGLAQIVAQPPPQATSTHAHIPRQTNVGQNAST
                     SAAYGQNSLGSASLSQQHSKGTLPPGLTKPQVPRVSAAMGSQNASWQHQGMPNLSSQT
                     SGNSSVNPFTAAPSFHIQQAHLKLAGQQFSQAMPSRPMAPLSSAGAAGPMLPPVSAQQ
                     RNSAPASAPPQAAPQQGLPGLSPSGPELGAFGQSPTSQMSGRPGLHCAQAYPVRTMGQ
                     ELPFAYSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ"
     exon            612..2027
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2261
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2358
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..5553
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5527..5532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /note="hexamer: AATAAA"
     polyA_site      5553
                     /gene="Maml1"
                     /gene_synonym="D930008C07Rik; Mam-1; Mam1; mKIAA0200"
                     /note="major polyA site"
ORIGIN      
        1 ccgaaaacaa ttttaagatg gcggcggcag cggcgcggaa aacaatgggg caggggtata
       61 gcggacaggc cgaagcctga ggcgggcggt gttccccggc ctggaatcgg gccgagcggg
      121 gccggaggaa gacccgccgc cgcgcccgag cccgctccac agcccggccg gacatggcgc
      181 gggcgtgagg cggatccggg ccgtcagaag cggaggaacc cgaagtggca gccggcgccg
      241 ggaggcccgg gcccggccag tgccgcccgc ggcccatggt gctacccacc tgccccatgg
      301 cggagttcgc gctgccgcgg cacagcgcgg tcatggagcg cctccgccgg cgcatcgaac
      361 tgtgccggcg ccaccacagc acctgtgagg cccgctacga ggctgtgtct cccgagcgcc
      421 tggagctcga gcgccagcac acctttgccc tgcaccagcg ctgcatccag gccaaggcca
      481 agcgcgccgg caagcaccgg cagccgccgg ccgccgccac ggccccggtt gccgctccgg
      541 cccccgcctc ggccccggcg gccgcgcgcc tggacgcagc ggacggcccg gagcacggcc
      601 gcccggtcgc gcatcttcat gatacagtga agaggagtct tgacagtgct gcctcccctc
      661 agaatggcga tcaaccaaat ggctacggag acttgtttcc tgggcataag aagacacgcc
      721 gggaggcccc tctgggggtc agtgtgtctg ccaatgggct tcctcctgcc tcgcccctgg
      781 gccagcccga caagccttca gggggagaca ccctgcagac cgctgggaag cactctctgg
      841 ggctcgatcc catcaacaag aagtgtctgg cagactcagg catccacctg aatggaggca
      901 gcaactccag tgagcccttt cctctaagcc tgagtaaaga actcaagcag gagccagtgg
      961 acgacctgcc gtgcatgatc gcgggcgctg gaggctccgt agctcagagc aacctcatgc
     1021 cggacctcaa ccttaatgag caggagtgga aggagctcat cgaggagctc aacaggtcag
     1081 tgcccgacga agacatgaag gacctgttta cggaggactt tgaggagaag aaggatccag
     1141 agcctcctgg ctctgccaca caaacccccc tggcccagga cattaatatt aagactgagt
     1201 tctctccagc agcttttgag caggagcagt taggttctcc acaagtaagg gctgggtctg
     1261 caggccagac cttcctagga gcctcatctg cccctgtggg cacagattct ccaagccttg
     1321 ggagctctca gactctgttt cacacaacta gtcaacctgg ggtggataat tccagtccaa
     1381 acctgatgcc ggcatcagcc caggctcaaa gtgcacaaag agccctcacg agtgtggtat
     1441 tacctagcca gggcccaggc ggggcctcgg agctgtcctc tgctcaccag ctccagcaga
     1501 tagctgccaa gcagaagcgc gagcagatgt tgcagaatcc ccagcaagct gccccagcac
     1561 ccggcccagg ccagctggcc acgtggcagc aggcagggcc ctcccacagt cccttagatg
     1621 ttccttatcc catggagaag cctgccagcc cttctggcta caagcaagac tttaccaact
     1681 caaaactgct catgatgccc ggtgtgaaca agagttctcc tcggccagga ggcccctacc
     1741 tccaacctag ccactccaac ctgctgagtc accagtcacc aagtaacttg aatcagaacc
     1801 ccgtgaataa ccaagggtct gtgctagact atggcaatac aaagcccctt tctcattaca
     1861 aagcagactg tggccaaggt ggtcctgggt ctggccagaa caaaccagct ttgatggcat
     1921 atcttcccca gcagctgccc catctgagta acgagcagaa ctccttgttt ctgatgaaac
     1981 caaagtcagg aaacatgccc ttccggtcat tggttccacc tggccaggag cagaaccctt
     2041 ccagtgtccc tgtagctgcc ccagctgcca gtgtgggaac ccagcctact gtgtctgtgg
     2101 ccagcactca caacagctcg ccatacctca gcagccagca gcaggcagct gtgatgaagc
     2161 agcaccagct gctcctggac cagcagaagc agagggagca gcagcagcag cagctgcagc
     2221 agcagcagtt cctgcagagg cagcacctcc tggctgagca ggagaaacaa cagtttcagc
     2281 gtcatctgac ccgcccaccc ccccagtacc aagacccaac acaaagcacc ttcccacaac
     2341 aggttggaca gttcacagga ccttctgctg ctgtgcctgg gatgaacaac ttgggtccgt
     2401 ccaactccag ctgtcctcga gtgttccctc agcctgggac tctgatgtcc atgggccctg
     2461 gacatgcccc tgtctcctct ctcccctcca gctcaggcca gcaggaccgt ggagtggccc
     2521 agtttactgg gtcccagagt ttgcctcaga acagccttta tggcatggca tctggcctag
     2581 cccagatagt tgcccagccc ccaccacagg ctaccagcac acatgcccac attccacggc
     2641 agaccaacgt gggccagaac gcctccacct cggctgcata tggacagaac tctctgggga
     2701 gtgccagtct ttcccagcag cacagtaagg gaaccctgcc tcctggttta acaaagccac
     2761 aagtcccaag ggtgtcagca gccatgggaa gccagaatgc ctcgtggcag catcagggaa
     2821 tgccaaacct gagcagccag acgtctggga acagcagtgt gaaccccttc actgcagctc
     2881 ccagtttcca catacagcaa gcccacctga aactagctgg ccagcagttc tcccaagcca
     2941 tgcccagcag gcccatggcg cctctgagtt cagcaggtgc agcagggccc atgctgcccc
     3001 cagtgagtgc acagcagagg aacagtgccc ctgcatctgc acctccccaa gcagccccgc
     3061 agcagggctt gcctggctta agtccttcgg ggcccgagct gggggccttc ggccagagcc
     3121 ccacctccca gatgagcggc cggccagggc tacactgtgc gcaggcttac cctgtgagga
     3181 ccatgggcca agagctgccc tttgcctaca gcgggcagcc aggtagcagt ggtctgtcca
     3241 gtgtggctgg acacactgac ctgatcgact cgctgctgaa gaacaggact tctgaggagt
     3301 ggatcaatga attggatgat cttttagggt cacagtaaca gagacgactg tggtgttttc
     3361 agtgtttagt catcttatat ttttgttctc agattcaaga aagcaactac tttggaccaa
     3421 aagccatggc ccagagaatt gggccagtag aacctaagcc acacctgagg ccagctctgg
     3481 tcagtctctg atggtccatt gggctggctc agcacattga catcactaac tagggttggg
     3541 atagcttcct acccagatga ccaaaaagcc agtggaaaca gttaagcccc tccatatcag
     3601 gcttaccaag aatatgtgcc ctgtttttac ccgagatttc tccacttgcc tcaaggctgg
     3661 gaacaaactt ctgttggaat tttaaatagg attatttgca ttttatagca taggcataat
     3721 ttttttaatt taagattttt aagcagatta ggacaggtgg tggttgtatt gtaagtggca
     3781 ctgggaaccc agggtttcct tgggagttga ggccttcttt attcctgctc tgtcagcttt
     3841 catggtcact ggaaatcact gccacagtac aggctgtgac tgcagatgcc aaaatgatta
     3901 ggatgccaca gatggtacat ctagtggtcc agataggatc cctcctgaaa tctcctactt
     3961 cttgtctgcc actcactctt gaggacactg ggcccccatg gaatccctcc atgccctagc
     4021 atggctaaat gctgaaggtg gaggttcagc atgtctgaca acccggatgt acaccgtaga
     4081 agtgccattc agttgtacac acatctttcc tcctccacat catccccacg acccttctaa
     4141 ctcctggcct cttccagcca aaacgggaaa agtggctgac ttcactgcat tagaagagga
     4201 aaagtccaac tccttaggga gtctgagcct ggcacgggct tggggaaaga aggctgcagg
     4261 cagcctgccg tctaggcatc actttatttt ttatcctcca gacttctgct cctcccacag
     4321 ctgatgactt gcacttttaa agtggtttta taacactaac ccgtccttgc taaagattga
     4381 agtaggttct cttaaaaggt ctattgatgg acatgtctga gcagagaaac cgtggaatag
     4441 aatatggtgc gtgggctgct aacagcaaga gggagcactt gtcttcatca caagcaagat
     4501 gatgagcaca gagtgagacc tttaacagga tggcggaggg aaaggtgttt gctggagtga
     4561 cttccgtgca gagtggtcta tagagaaact acagctctgc ccattgtcct ggggtcctgg
     4621 aacttcgtcc agtgttaaga actgagccaa ggagaagcac gagcagcctt cgcacctgga
     4681 gggtcagaac gtgcacacac tgctaactag tttgcaccgg cagtgccttt ttcactgagg
     4741 gcacctgtgc tctcaggtcc ttgtccctca tagccatttc tcctgccatg tccccccctc
     4801 ccccagcccc cagaaactca gttcagctct cagagaagca ggtgaatcat aaagtcagtg
     4861 aagacgccgc cctctgattc tccccactgt agggggaagg aagggagtga cttcagtggg
     4921 ttctctacca aaaacagggc taagggctgg agatggatcc ccgttccttg tccagcctcc
     4981 tgctaccgct gcccacctcc tgcctccatt gcccaggcca cactagttgg ccccagcact
     5041 ctaccttagg cccaggctgg ccacaggcag tgggcagctc acttgctgca gtgtcatagc
     5101 aataaaatgt gattcttggg gtctgcccag agctgcccat ggctttattt atgagtgtgg
     5161 ctttgaggag ttgggaagag gtaacccact tctctcccat cttctccgag ccatgactca
     5221 agaagaaaag ggtgctcgga ctctcttata cacatgtgct ttgtgtaaat aaatgtttac
     5281 aattttatat tgaagatgga ataagtgtta gagcgtccaa ctgtatattt tttactttta
     5341 tagattttaa aactgatcct ttatatgtgt ttggagctat gataagtttt atggcaagca
     5401 gttggtattg ttaacttttt atgatcatca aaagtacata aaagtcctat taatcccctt
     5461 actctgcttc ccttagctct ggtatacacc aaaaagaaat ctttactttc cttgtgttat
     5521 aaaaataata aaaatatttt actagtatgg aaaaaaaaaa aaaaaaaaaa aaa
//
