LOCUS       NM_001081199            3990 bp    mRNA    linear   ROD 14-SEP-2024
DEFINITION  Mus musculus MAM domain containing 4 (Mamdc4), mRNA.
ACCESSION   NM_001081199 XM_355317
VERSION     NM_001081199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3990)
  AUTHORS   Cox,C.M., Wu,M.H., Padilla-Rodriguez,M., Blum,I., Momtaz,S.,
            Mitchell,S.A.T. and Wilson,J.M.
  TITLE     Regulation of YAP and Wnt signaling by the endosomal protein MAMDC4
  JOURNAL   PLoS One 19 (5), e0296003 (2024)
   PUBMED   38787854
  REMARK    GeneRIF: Regulation of YAP and Wnt signaling by the endosomal
            protein MAMDC4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3990)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3990)
  AUTHORS   Wu,M.H., Padilla-Rodriguez,M., Blum,I., Camenisch,A., Figliuolo da
            Paz,V., Ollerton,M., Muller,J., Momtaz,S., Mitchell,S.A.T.,
            Kiela,P., Thorne,C., Wilson,J.M. and Cox,C.M.
  TITLE     Proliferation in the developing intestine is regulated by the
            endosomal protein Endotubin
  JOURNAL   Dev Biol 480, 50-61 (2021)
   PUBMED   34411593
  REMARK    GeneRIF: Proliferation in the developing intestine is regulated by
            the endosomal protein Endotubin.
REFERENCE   4  (bases 1 to 3990)
  AUTHORS   Cox,C.M., Lu,R., Salcin,K. and Wilson,J.M.
  TITLE     The Endosomal Protein Endotubin Is Required for Enterocyte
            Differentiation
  JOURNAL   Cell Mol Gastroenterol Hepatol 5 (2), 145-156 (2017)
   PUBMED   29322087
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL732590.7.
            
            On Feb 6, 2007 this sequence version replaced XM_355317.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on orthologous alignments from rat and human.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL732590.7         65809-65953         c
            146-268             AL732590.7         64794-64916         c
            269-442             AL732590.7         64544-64717         c
            443-568             AL732590.7         64331-64456         c
            569-699             AL732590.7         64023-64153         c
            700-784             AL732590.7         63866-63950         c
            785-910             AL732590.7         63596-63721         c
            911-1048            AL732590.7         63267-63404         c
            1049-1137           AL732590.7         63095-63183         c
            1138-1311           AL732590.7         62822-62995         c
            1312-1396           AL732590.7         62496-62580         c
            1397-1585           AL732590.7         62223-62411         c
            1586-1714           AL732590.7         61990-62118         c
            1715-1846           AL732590.7         61764-61895         c
            1847-1971           AL732590.7         61541-61665         c
            1972-2083           AL732590.7         61349-61460         c
            2084-2200           AL732590.7         61089-61205         c
            2201-2335           AL732590.7         60883-61017         c
            2336-2472           AL732590.7         60657-60793         c
            2473-2692           AL732590.7         60348-60567         c
            2693-2830           AL732590.7         60121-60258         c
            2831-2949           AL732590.7         59917-60035         c
            2950-3040           AL732590.7         59733-59823         c
            3041-3187           AL732590.7         59462-59608         c
            3188-3322           AL732590.7         59213-59347         c
            3323-3450           AL732590.7         58989-59116         c
            3451-3559           AL732590.7         58803-58911         c
            3560-3735           AL732590.7         58169-58344         c
            3736-3990           AL732590.7         57752-58006         c
FEATURES             Location/Qualifiers
     source          1..3990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.41 cM"
     gene            1..3990
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /note="MAM domain containing 4"
                     /db_xref="GeneID:381352"
                     /db_xref="MGI:MGI:2685841"
     exon            1..145
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..3798
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /note="apical endosomal glycoprotein; probable ortholog of
                     human apical early endosomal glycoprotein precursor
                     (AEGP); MAM domain-containing protein 4"
                     /codon_start=1
                     /product="apical endosomal glycoprotein precursor"
                     /protein_id="NP_001074668.2"
                     /db_xref="CCDS:CCDS50531.1"
                     /db_xref="GeneID:381352"
                     /db_xref="MGI:MGI:2685841"
                     /translation="MCLPSHLLSTWVLFMVTLPAAQSLGKTWLPNHCRSPIKAVCNFV
                     CDCGDCSDETQCGFHGASTIPSTSFTCNFEQDSCGWQDISTSGYRWLRDRAGAVLHGP
                     GPHSDHTHGTDLGWYMAVGTHSGKEPSTATLRSPVMREAAPTCELRLWYHIASRDVAE
                     LRLDLTHGVETLTLWQTSGPWGPGWQELAVNTGRIQGDFKVTFSATRNATHRGAVALD
                     DVEFRDCGLPIPQARCPLGHHHCQNKACVEPHQLCDGEDNCGDRSDEDPLICSHHMAT
                     DFETGLGPWNQLEGWTRNHSAGSMVSPAWPHRDHSRNSAYGFFLISVAKPGTTAVLYS
                     PEFQGSVSNNCSFTFYYYLHGSEASHFQLFLQAQGLNTPQVPVLLRSRHGELGTAWVR
                     DRVDIQSAHPFRILLAGETGPGGVVGLDDLIMSSHCMLVPAMSTLQSSLSGPVPLALY
                     PQTSIKLPQQTCEPGHLSCGDLCVPPEQLCDFQKHCAEGEDEHKCGTTDFESASAGGW
                     EDISVGKLQWQWVEAQEKSKPAGDANRDAPGHFLSLQKAWGQLRSEARALTPALGPSG
                     PHCELHMAYYFQSHPQGFLALVVVENGFRELLWQAPGGGSGSWTEEKIILGARRRPFQ
                     LEFVSLVDLDGPGQQGAGVDNVTLRDCNPMVTTESDQELSCNFERDSCSWHTGHLTDA
                     HWHRIKSHGSQLDHTTGQGFFMFLDPTDPPARGQGALLLTRPQVPVVPKECLSFWYRL
                     YGPQIGTLCLAMRREREEDILLWSRSGTHGNRWHQAWVTLHHQPEASTKYQLLFEGLR
                     NGYHGTMALDDIAVRPGPCWAPKSCSFEDSDCGFSPGGWGLWTHQSNASGLASWGPWI
                     DHTTGTAQGHYMVVDTSPNVLPKGHVAALTSEEHQPLSQPACLTFWYHMSVPNPGTLR
                     VHVEESTRRQELSISAHGRSAWRLGSVNVQAEQAWKVVFEAVAAGVEYSYMALDDISL
                     QDGPCPQPGSCDFETGLCGWSHLPWPSLGGYSWDWSSGATPSRYPQPSVDHTLGTEAG
                     HFAFFETSVLGPGGQAAWLRSEPLPATTVSCLRFWYYMGFPEHFYKGELRVLLSSARG
                     QLAVWYQGGHLRDQWLQVQIELSNSEEFQIVFEATLGGQPALGPIAIDDVQYLAGQQC
                     KQPSPSQGEVAAPVSVPVAVGGALLFFMFLVLMGLGGWHWLQKQHCPGQRSTDAAASG
                     FANILFNADHVTLPESITSNPQSPPDLA"
     exon            146..268
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            269..442
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            443..568
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            569..699
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            700..784
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            785..910
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1048
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1137
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1311
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1396
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1585
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1714
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1846
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1971
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2083
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2200
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2335
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2472
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2692
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2830
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2949
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3040
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3187
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3322
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3450
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3559
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3735
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3990
                     /gene="Mamdc4"
                     /gene_synonym="Gm995"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctaagtc agcctgtgag gccacggtgg actgataact gagaagtctc ctctagactg
       61 cacagcctca cttgaactgg gacctcctct agcctggcca tgtgcctgcc tagccacctt
      121 ctttcaacct gggtcctgtt tatggttacc ctgccagctg cacagtcgct aggcaagacc
      181 tggctcccca accactgcag aagccccatc aaagctgtat gcaactttgt gtgtgactgt
      241 ggagactgtt cagacgaaac tcagtgtggt ttccatggag cctcaactat cccaagcacc
      301 tccttcacct gcaactttga gcaggactcc tgtggctggc aggacatcag cacctcaggc
      361 tatcgatggc ttcgagaccg ggcaggggca gtgctgcatg gtcctgggcc tcattctgac
      421 catacacatg gcactgactt gggctggtat atggctgtgg gaacccacag tgggaaggag
      481 ccatctactg cgactctgcg ttctcctgtc atgcgtgagg cagcccctac ctgtgaactg
      541 aggctctggt accacattgc ctctagagat gtcgctgagc tgcggctgga cctgacccat
      601 ggtgtggaga cactgactct atggcagacc tcaggaccct ggggccctgg ctggcaggag
      661 ctggcagtga acactggccg catccagggt gacttcaaag tgacattttc tgccacccga
      721 aatgccacac acaggggcgc tgtggccttg gatgatgtgg agttccggga ctgtgggcta
      781 cccatccctc aggccaggtg ccccctgggg catcaccact gccagaacaa ggcttgtgtg
      841 gagccccacc agctctgtga tggtgaagac aactgtggag acagatctga tgaagaccca
      901 ctcatctgca gccaccacat ggccactgac tttgagacag gcctgggacc gtggaaccag
      961 ttagagggct ggacccggaa ccacagtgct ggcagcatgg tgagccctgc ctggccccac
     1021 cgagatcaca gccgcaacag tgcatacggc ttcttcctca tctctgtggc caagcctggc
     1081 accactgctg tcctctacag ccctgagttc caaggctcag tctccaacaa ctgctcgttc
     1141 accttctatt actacctgca cgggtctgag gccagccact tccagctgtt cctgcaggca
     1201 caggggctca acacccccca ggtccctgtt ctacttcgaa gccgccatgg agaactgggg
     1261 acagcctggg tcagagaccg ggttgacatt caaagtgccc atccatttcg gatccttcta
     1321 gctggggaga cgggtccagg aggcgtcgtg ggcctagacg accttatcat gtctagccac
     1381 tgcatgcttg ttccagctat gtccaccctg cagtcatcac tttctggacc tgtgccatta
     1441 gccctctatc cccagacatc catcaagctg ccccagcaga cctgtgagcc aggacatctc
     1501 tcctgtggtg acctgtgtgt gccccctgag cagctgtgtg atttccagaa gcactgtgca
     1561 gagggcgagg atgaacacaa gtgtggcacc acagactttg agtccgcctc tgctgggggc
     1621 tgggaggaca tcagtgtagg gaagctgcag tggcaatggg ttgaagccca ggagaagagc
     1681 aagcctgccg gggatgccaa tcgggatgct cctgggcact tcctatctct gcagaaggcc
     1741 tgggggcagc taagatctga ggcccgggct ctcacacctg ctctgggccc ctctggccct
     1801 cactgtgaac tccacatggc ttactatttt caaagtcacc cccaaggctt cttggcactg
     1861 gttgtggtgg agaatggctt ccgggagctg ctgtggcaag ccccaggcgg cggcagcggg
     1921 agctggacag aggagaagat tattctcggg gcacggcgcc ggccgttcca gctggagttt
     1981 gtcagtctgg tggacttgga tggccctggc cagcaggggg ctggggtgga caatgtgact
     2041 ctgagagact gcaaccccat ggtgaccact gaaagtgacc aagagctctc ctgtaacttt
     2101 gaacgggact cctgcagctg gcatacaggc cacctcacag atgcccactg gcaccgtata
     2161 aaaagccacg gctctcagct tgaccacaca actggccaag gctttttcat gttcttggat
     2221 cccacggacc cacctgctcg aggccaaggt gccctgttgc tcacaagacc tcaggtgcca
     2281 gttgtcccca aggaatgtct cagcttctgg taccgcctgt atgggcccca gattgggaca
     2341 ctgtgcctgg ccatgaggag ggagcgggag gaagacatac tactgtggtc ccggtcgggc
     2401 acccatggca accgctggca ccaggcttgg gtcactcttc atcaccagcc agaggccagc
     2461 accaagtacc agttgctgtt tgaaggcctc cggaatgggt accatggcac aatggccctg
     2521 gatgacatag ctgtgcggcc tggcccctgc tgggccccca agagctgttc ctttgaagac
     2581 tctgactgtg gcttctcccc agggggctgg ggtctgtgga cgcaccagag taatgcctca
     2641 ggccttgctt cttggggtcc ttggatagac cataccacag ggacagccca agggcactac
     2701 atggtggtgg acaccagccc aaatgtactg cccaagggtc atgtggccgc tctgacttca
     2761 gaggaacacc agcccctgtc ccagcctgcc tgtctgacct tctggtacca catgagcgtc
     2821 cccaatccag gcaccttgag ggtccacgtg gaagagagca caaggcgtca agagctcagc
     2881 atcagtgccc atggtagatc tgcctggcgc ctgggcagcg tcaatgtgca ggctgagcaa
     2941 gcctggaagg tggtgtttga ggctgtggct gctggtgtag aatattccta catggctcta
     3001 gatgacattt ccctccaaga tgggccctgt cctcagccag gttcctgtga ctttgaaact
     3061 ggcctgtgtg ggtggagcca cctgccctgg cccagcctgg gcgggtacag ctgggactgg
     3121 agtagtggag ccaccccatc ccgctacccc cagccttcag tggaccatac cctgggcaca
     3181 gaagcaggcc attttgcttt ctttgaaacc agcgtgctag gtcctggggg ccaggcagcc
     3241 tggctgcgca gtgagccact gccagcaaca acagtctcat gcctccgctt ctggtactac
     3301 atgggctttc ctgagcattt ctacaagggt gagttgagag tgctcctgag cagtgcccga
     3361 ggccagctag ctgtgtggta ccagggtggg cacttgcggg accagtggct acaagtccag
     3421 attgaactgt ccaactctga ggagttccag attgtttttg aagccactct gggtggccag
     3481 ccagctctgg ggcccattgc cattgatgat gtgcagtacc tggctggaca acagtgcaag
     3541 cagccttcac ctagccaggg tgaagtggca gcacccgtgt ctgtgccagt tgccgttgga
     3601 ggagccctcc tctttttcat gttcctggtg ctcatgggcc ttgggggctg gcattggctg
     3661 cagaagcagc actgccccgg ccagaggagt acagatgcag cagcctctgg ctttgccaat
     3721 atcctcttca atgcggatca tgttaccctc ccagaatcaa tcaccagcaa cccacagagc
     3781 cctccagacc tggcctgaca tggcatctct tgcagcatct aaacctcaca agcacctgac
     3841 tgtctacatg tgggcctgga tgtagggact gagtcatatt taccttcgcc agctctttct
     3901 ctatctggtg tctttgccct ctggtgtgat ggagaagggt agaggggtcc ttgtaccaag
     3961 aataaatgct ctacacagtg agggcaaccc
//
