LOCUS       NP_777282                686 aa            linear   ROD 02-MAY-2024
DEFINITION  MAM domain-containing protein 2 precursor [Mus musculus].
ACCESSION   NP_777282
VERSION     NP_777282.1
DBSOURCE    REFSEQ: accession NM_174857.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 686)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   3  (residues 1 to 686)
  AUTHORS   Klein,A.D., Ferreira,N.S., Ben-Dor,S., Duan,J., Hardy,J., Cox,T.M.,
            Merrill,A.H. Jr. and Futerman,A.H.
  TITLE     Identification of Modifier Genes in a Mouse Model of Gaucher
            Disease
  JOURNAL   Cell Rep 16 (10), 2546-2553 (2016)
   PUBMED   27568557
REFERENCE   4  (residues 1 to 686)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124557.4,
            AC131118.4 and AC144941.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035566.1, AK154219.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 18.22 cM"
     Protein         1..686
                     /product="MAM domain-containing protein 2 precursor"
                     /note="MAM domain-containing protein 2; MAM
                     domain-containing proteoglycan"
                     /calculated_mol_wt=75474
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1895
     mat_peptide     19..686
                     /product="MAM domain-containing protein 2.
                     /id=PRO_0000014863"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CG85.1)"
                     /calculated_mol_wt=75474
     Region          26..167
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CG85.1)"
     Region          170..327
                     /region_name="MAM"
                     /note="MAM domain, meprin/A5/mu; pfam00629"
                     /db_xref="CDD:459878"
     Site            329
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CG85.1)"
     Region          342..497
                     /region_name="MAM"
                     /note="MAM domain, meprin/A5/mu; pfam00629"
                     /db_xref="CDD:459878"
     Region          509..664
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CG85.1)"
     Region          665..686
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CG85.1)"
     CDS             1..686
                     /gene="Mamdc2"
                     /gene_synonym="1200015L10Rik; mamcan"
                     /coded_by="NM_174857.3:265..2325"
                     /db_xref="CCDS:CCDS29707.1"
                     /db_xref="GeneID:71738"
                     /db_xref="MGI:MGI:1918988"
ORIGIN      
        1 mllegvllvv qalqlanald lpagscafee dtcgfdsvfa flpwilneeg hyvymdtsfa
       61 rqgekavlls sdlqaeewnc lrlvyqittp pgsvsdpsql nlyvrfedes fdrllwstke
      121 psdswliasl dlqnsskkfk iliegvlgqg ntasialfei kmtagyciec dfeenhlcgf
      181 vnrwnpnvnw fvgggtaknt hsilpqdhtf rsehghymyv dsvyvkhfqe vaqlispvtt
      241 asmsgclsfy yqlqqgndnv fsvytrdmag lyeeiwkvds pgnaawnlae vefsapypme
      301 vifevafngp kggyvalddi sfspvhcqnq tglpfsavet scdfeiglcn fyqdkegpgw
      361 trvrvkanmy ragdhttgtg hyllantkft sqpgyigrly gpslpgnmqy cvrfhyaifg
      421 flkmsdtlav yifeenhvvq ekiwsvlesp rgvwmqaeis fkkpmptkvv fmslcksfwd
      481 cglvalddit iqlgncrspa rlppppgect fdqdecaftq ekrnrsswhr grgetptsyt
      541 gpkgdhttgv gyymyieash mvygqkahll sqplrgvpgk hcltffyhmy gagtgllsvy
      601 lkreedsees llwrrrgeqs iswlralvey scrrrhqiif eatrgvsirs diaiddvklq
      661 agpcagmedt teqssgysed lneiey
//
