LOCUS       NM_001365019            5081 bp    mRNA    linear   ROD 14-FEB-2023
DEFINITION  Mus musculus MALT1 paracaspase (Malt1), transcript variant 2, mRNA.
ACCESSION   NM_001365019 XM_006525937
VERSION     NM_001365019.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5081)
  AUTHORS   O'Neill TJ, Gewies A, Seeholzer T and Krappmann D.
  TITLE     TRAF6 controls T cell homeostasis by maintaining the equilibrium of
            MALT1 scaffolding and protease functions
  JOURNAL   Front Immunol 14, 1111398 (2023)
   PUBMED   36761777
  REMARK    GeneRIF: TRAF6 controls T cell homeostasis by maintaining the
            equilibrium of MALT1 scaffolding and protease functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5081)
  AUTHORS   Xu Z, Qiao S, Qian W, Zhu Y, Yan W, Shen S and Wang T.
  TITLE     Card9 protects fungal peritonitis through regulating Malt1-mediated
            activation of autophagy in macrophage
  JOURNAL   Int Immunopharmacol 110, 108941 (2022)
   PUBMED   35850054
  REMARK    GeneRIF: Card9 protects fungal peritonitis through regulating
            Malt1-mediated activation of autophagy in macrophage.
REFERENCE   3  (bases 1 to 5081)
  AUTHORS   Rosenbaum M, Schnalzger T, Engleitner T, Weiss C, Mishra R, Mibus
            C, Mitterer T, Rad R and Ruland J.
  TITLE     MALT1 protease function in regulatory T cells induces MYC activity
            to promote mitochondrial function and cellular expansion
  JOURNAL   Eur J Immunol 52 (1), 85-95 (2022)
   PUBMED   34668583
  REMARK    GeneRIF: MALT1 protease function in regulatory T cells induces MYC
            activity to promote mitochondrial function and cellular expansion.
REFERENCE   4  (bases 1 to 5081)
  AUTHORS   Kurgyis Z, Vornholz L, Pechloff K, Kemeny LV, Wartewig T,
            Muschaweckh A, Joshi A, Kranen K, Hartjes L, Mockel S, Steiger K,
            Hameister E, Volz T, Mellett M, French LE, Biedermann T, Korn T and
            Ruland J.
  TITLE     Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies
            psoriasiform skin inflammation
  JOURNAL   Sci Immunol 6 (65), eabi4425 (2021)
   PUBMED   34826258
  REMARK    GeneRIF: Keratinocyte-intrinsic BCL10/MALT1 activity initiates and
            amplifies psoriasiform skin inflammation.
REFERENCE   5  (bases 1 to 5081)
  AUTHORS   O'Neill TJ, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I,
            Grass C, Schmidt H, Kriegsmann K, Tofaute MJ, Demski K, Poth T,
            Rosenbaum M, Schnalzger T, Ruland J, Gottlicher M, Kriegsmann M,
            Naumann R, Heissmeyer V, Plettenburg O, Wurst W and Krappmann D.
  TITLE     TRAF6 prevents fatal inflammation by homeostatic suppression of
            MALT1 protease
  JOURNAL   Sci Immunol 6 (65), eabh2095 (2021)
   PUBMED   34767456
  REMARK    GeneRIF: TRAF6 prevents fatal inflammation by homeostatic
            suppression of MALT1 protease.
REFERENCE   6  (bases 1 to 5081)
  AUTHORS   Hulpiau P, Driege Y, Staal J and Beyaert R.
  TITLE     MALT1 is not alone after all: identification of novel paracaspases
  JOURNAL   Cell Mol Life Sci 73 (5), 1103-1116 (2016)
   PUBMED   26377317
REFERENCE   7  (bases 1 to 5081)
  AUTHORS   Ruefli-Brasse AA, French DM and Dixit VM.
  TITLE     Regulation of NF-kappaB-dependent lymphocyte activation and
            development by paracaspase
  JOURNAL   Science 302 (5650), 1581-1584 (2003)
   PUBMED   14576442
  REMARK    GeneRIF: findings demonstrate that primary T and B lymphocytes from
            paracaspase (MALT1)-deficient mice are defective in
            antigen-receptor-induced NF-kappaB activation, cytokine production,
            and proliferation
REFERENCE   8  (bases 1 to 5081)
  AUTHORS   Ruland J, Duncan GS, Wakeham A and Mak TW.
  TITLE     Differential requirement for Malt1 in T and B cell antigen receptor
            signaling
  JOURNAL   Immunity 19 (5), 749-758 (2003)
   PUBMED   14614861
REFERENCE   9  (bases 1 to 5081)
  AUTHORS   Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L,
            Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H,
            Xu F, Salvesen G and Godzik A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   10 (bases 1 to 5081)
  AUTHORS   McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q,
            Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW and Nunez G.
  TITLE     Bimp1, a MAGUK family member linking protein kinase C activation to
            Bcl10-mediated NF-kappaB induction
  JOURNAL   J Biol Chem 276 (33), 30589-30597 (2001)
   PUBMED   11387339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102240.12.
            
            [WARNING] On Apr 18, 2023 this sequence was replaced by
            NM_001365019.2.
            
            On Jul 20, 2018 this sequence version replaced XM_006525937.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110487.1, SRR13948564.1885324.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC102240.12        58475-58883         c
            410-576             AC102240.12        51885-52051         c
            577-698             AC102240.12        44920-45041         c
            699-858             AC102240.12        42161-42320         c
            859-1037            AC102240.12        41516-41694         c
            1038-1134           AC102240.12        40855-40951         c
            1135-1167           AC102240.12        40266-40298         c
            1168-1194           AC102240.12        38300-38326         c
            1195-1224           AC102240.12        36169-36198         c
            1225-1428           AC102240.12        31501-31704         c
            1429-1606           AC102240.12        26960-27137         c
            1607-1681           AC102240.12        25758-25832         c
            1682-1809           AC102240.12        25032-25159         c
            1810-1959           AC102240.12        19335-19484         c
            1960-2117           AC102240.12        16716-16873         c
            2118-2243           AC102240.12        14615-14740         c
            2244-5081           AC102240.12        11048-13885         c
FEATURES             Location/Qualifiers
     source          1..5081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18"
     gene            1..5081
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /note="MALT1 paracaspase"
                     /db_xref="GeneID:240354"
                     /db_xref="MGI:MGI:2445027"
     exon            1..409
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2681
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mucosa-associated lymphoid tissue lymphoma translocation
                     protein 1 homolog; mucosa associated lymphoid tissue
                     lymphoma translocation gene 1; paracaspase-1"
                     /codon_start=1
                     /product="mucosa-associated lymphoid tissue lymphoma
                     translocation protein 1 homolog isoform 2"
                     /protein_id="NP_001351948.1"
                     /db_xref="CCDS:CCDS89264.1"
                     /db_xref="GeneID:240354"
                     /db_xref="MGI:MGI:2445027"
                     /translation="MSLWGQPLQASPPLAVRQPPTASSGPSTSPPAGATLNRLPEPLL
                     RRLSESLDRAPEGRGWRQLAELAGSRGRLRLSGLDLEQCSLKVLEPEGSPSLCLLKLM
                     GEKGCTVTELSDFLQALEHTEVLPLLNPPGLKITVNPESKAVLAGQFVKLCCRATGHP
                     FVQYQWFKMNKEIPYGNSSELVFNTVHVKDAGFYVCRVNNSSTFEFSQWSQLDVCDVA
                     EVTDSFQGSMDGISESRLQICVEPRSQRLVPGSMLLLQCVAIGSPMPHYQWFKDESPL
                     THETKKHYTVPYVDIEHEGTYWCHVYNDRDSQDSKKAEVTIGRTDEAVECTEDELNNL
                     GHPDNKEQTGQPLAKDKVALLIGNMSYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLL
                     DLTEYEMCNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCV
                     QNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFE
                     IQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGRQALEIRSSLSEKR
                     ALTDPVQGAPCSAEALVRNLQWAKAHELPESMCLKFQCGVHIQLGFAAEFSNVMIIYT
                     SIVHKPPEIIMCDAYVTDFPLDLDIDPKHANKGTPEETGSYLVSKDLPKHCLYTRLSS
                     LQKLKEHLIFTVCLSYQYSGLEDTVEEKQEVNVGKPLIAKLDMHRGLGRKTCFQACRM
                     PDEPYHSSTSTSAGAGHFHSSQDSFHDVYHSHLGNADSGMPPDRCHCSRTPHTFISNY
                     PPHHYCQFGRSNVPVETTDEMPFSFSDRLMISEN"
     exon            410..576
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..698
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..858
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1037
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1134
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1167
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1194
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1224
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1428
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1606
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1681
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1809
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1959
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2117
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2243
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..5081
                     /gene="Malt1"
                     /gene_synonym="A630046N12; D430033E09Rik; Pcasp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagggggaa cctgtttcgc agcccgggag cagtgcttct tcctgtgagg gcctcgccgt
       61 gcagccactt ctccttccgc tcctgcggct cccgggacgg cgagaggcaa gcggaaggtg
      121 cgcgaacgcc gaggcctgag gtgaccggcg ggagctgggc agtcgaggcc accggcgtag
      181 ccatgtcgct gtgggggcag ccgctgcagg cctcacctcc cctggccgtg cggcagcccc
      241 ctaccgcgtc ctcgggacct tcgacctccc ctccagccgg cgcaaccctc aaccgcctgc
      301 ccgagccgct gctgcggagg ctcagcgaga gcttggaccg cgctccggag ggccggggct
      361 ggcggcagct ggccgagctg gcgggcagtc ggggacgcct ccggctcagt ggcctggacc
      421 tggaacagtg ttctcttaaa gtattggagc cagagggaag cccaagtttg tgtttattga
      481 aactaatggg tgaaaaagga tgtacagtca cagaactgag cgacttccta caggctttgg
      541 agcacactga ggttcttccg cttctcaacc ccccaggatt aaagatcact gtaaacccag
      601 aatccaaggc agtgttggct ggacagtttg taaaactgtg ctgccgggca actggacatc
      661 cttttgtaca atatcaatgg ttcaaaatga ataaagagat cccatatgga aattcatcag
      721 aacttgtttt taacacagtg catgtaaaag atgcaggctt ttatgtctgc cgggttaaca
      781 acagttccac ttttgaattt agccagtggt cacagctgga tgtgtgtgat gtggcagaag
      841 taacagacag cttccaggga agtatggatg gcatctcaga atccaggttg caaatctgtg
      901 ttgaaccaag gtcccaaagg ctggtgccag gcagcatgtt gttgttacag tgtgttgcta
      961 ttggaagtcc tatgcctcac taccagtggt ttaaagatga atcaccatta acacatgaga
     1021 caaaaaagca ctacacggtt ccatatgtgg atatagaaca tgaaggaacc tactggtgtc
     1081 atgtatataa tgaccgagac agtcaagata gcaagaaggc agaagtcacc ataggaagaa
     1141 cagatgaggc agtggagtgc actgaagatg aattaaacaa tttggggcat cctgataata
     1201 aagaacaaac tggccagcct ttggcaaagg acaaagtcgc ccttttgata gggaatatga
     1261 gttactggga gcatcccaag cttaaagcgc ctttggtgga tgtgtatgaa ttgaccaact
     1321 tactaagaca actagatttc aaagttgtct cactgttgga ccttactgaa tatgagatgt
     1381 gtaacgctgt ggatgaattt ttactacttt tagacaaagg agtatatgga ttgttatatt
     1441 atgcagggca cggttatgaa aactttggaa acagtttcat ggtccctgtt gatgctccaa
     1501 atccatatag gtctgaaaat tgcctatgcg tacaaaacat actgaaatta atgcaagaaa
     1561 aggagactgg cctgaatgtg ttcctgttgg atatgtgtcg gaaaagaaat gactacgatg
     1621 ataccattcc aatcttggac gcactgaaag tcactgccaa cattgtgttt ggatatgcca
     1681 cgtgccaagg agcagaagcc tttgaaatcc agcattctgg gttggcaaat gggattttta
     1741 tgaaattttt aaaagataga ttattagaag acaagaaaat tactgtgtta ctggatgaag
     1801 ttgcagaaga tatgggtaaa tgtcacctta ccaaaggcag acaagctcta gagattcgca
     1861 gcagcttgtc tgaaaagaga gcacttactg atccagtcca gggagcacct tgctctgcag
     1921 aggctctggt gcgcaatcta cagtgggcca aggctcatga acttccagaa agtatgtgcc
     1981 ttaaatttca gtgtggcgtt cacattcaat taggatttgc cgcagagttc tccaatgtca
     2041 tgataatcta cacaagtata gtccacaaac cacctgagat aataatgtgt gacgcctatg
     2101 ttactgattt ccctcttgac ctagatattg atccaaaaca tgcaaacaag gggactcctg
     2161 aagaaactgg cagctactta gtatcaaaag accttcccaa gcactgcctc tacactagac
     2221 tcagctcact acaaaaatta aaggaacatc tgatcttcac agtctgtctg tcctatcagt
     2281 attcaggact agaagacact gtggaggaga agcaggaggt gaacgtgggg aagcctctta
     2341 ttgccaagct agacatgcac cgaggactgg gcaggaagac ttgcttccaa gcttgtcgta
     2401 tgcctgacga gccgtaccac agctccacat ctacctcagc gggagcgggg catttccatt
     2461 cctctcagga ctcattccat gatgtgtacc attcacatct tggcaatgca gacagtggta
     2521 tgccaccaga caggtgtcat tgcagccgga ctccacacac attcatttca aattatcccc
     2581 cccaccacta ctgccagttt ggtagaagta atgtgcccgt agagacaact gatgaaatgc
     2641 cattcagttt ttctgacagg cttatgattt ctgaaaactg accttcatgg ttttgaaaat
     2701 tagaatagtt acagtaatct cacataaatt aacacataaa gtgaggtgtg gtgaaaaggc
     2761 aaacatgtat gtatggagag aaaactagca acaactcttt ttataggaat atgagatgtt
     2821 ggaattacgt tatttaagct gggcagtgat gacacacact tttaatctca gcactcagaa
     2881 ggcagaggaa ggggcagatc tctgagtttg agaccagctt ggtgtacata gtgagttcca
     2941 ggacagccag aaatacagag agaaatcctg tctaacaaca acaacaaaaa ttacattatt
     3001 tatctaaact gtcttttgct tttgtcctgt tgtaagactt tgtgaattaa tttgttctgt
     3061 aagaatgatg tgtggggcct gtaaatattg ctcagtggta cagtgctcag ctaatatgtg
     3121 gaaggttctg gacttgctca tcattactag aggggaaaat gagttattag agtaaatatg
     3181 tatgtgtatc agatattttc attttgacca ctcataagag caatgaaaat ggcattatta
     3241 tagattgagt tatgtcatta gcacggaaaa agaacccttt ctctttttca gagttatttt
     3301 atttatgtgt atatgtggag acctgagtgt atatgtgtgc taatggagac cagaagaggg
     3361 catcagatac tggaactgga attacaggca ggtgtgagca ctcagtgtga atgctaaaag
     3421 ctgagcccac ttcctctgca agtgttctta acatctctca accccgaaag aacctttcag
     3481 tcatcgggct taataacttc attttatcaa tgggaaaaac agaggcaatc tgtcttacac
     3541 tggagcacag ctgaagtctc agctctggtc tcaaatttct cttccactgc tttctactct
     3601 tcaagtggtt tagacatcta aaaaagtctt aagagtgtgg tggtgcatgc ctttaatccc
     3661 agcactcggg aggccgaggc aaataggtct ctgtgagttt aagaccatcc ttgtctacaa
     3721 agaaagttca gaagagccag ggctacactg agaaacctgt caaaaaaaat tcttagagct
     3781 aaggtaatgg ctcacttaat agattgcctg ctgcaaagtg tgaagaccag agattggatc
     3841 ccagaactga cctaaaggat ggggtcatag acagccgaat caatgacctc tagggtcagt
     3901 gaaagactgt ctaatgtaga aagcaactga ggaagacagc cagtgtcaac cttcagtgtc
     3961 ctgttgtgtg tgtgcacatg tactcacata aaaacataca tacagagaga ggtcttgggg
     4021 gaatgctaac acagagaata ggcatttgga ctggggagga agaagctgat gtcagcttac
     4081 agctcaggtc atactccatc accaagggaa gtcaccagcg cagaggccat ggatgagtgc
     4141 tgcttactgg cttgctctcc agggcttgct cagtctgctt ccttatagca cttaggacca
     4201 gcatcccaca gtgtgctggg tcctcccata ttactcacca atcaagaaaa tgccccacag
     4261 accctgcagg ccaatctgat gaaagcattt tctcagttga ggttcctcat ccaaaatgac
     4321 tagtttgtgt caagctaaca gaaaaacggc cagtgtatgg acgtttccct taacatcttt
     4381 aaagtgtgtg acttttcaag tctctggctt gagcacaaag gtaaccttgt caatacatcc
     4441 caaattcttg tcaaatccca tagccggagc ttaggtaact gctgtgcaca tggacacaag
     4501 tctaacatgc ctattttact tctgtgggcg ttcttaacaa gcagcctagt gtattgtaca
     4561 ttgtttcctg ttgtttaaaa catctgtagg ggggggagct aaataaaatt aattttaaaa
     4621 gatatgttac aggggctgga aagatggctc agaggttaag agcactggct gctcttccag
     4681 aggtcttgag ttcaattccc agcaaccaca tggtggctca caaccatctg taatgggatc
     4741 tgatgccctt ttctggcctg cagacatata tgcagtcagg acactgtgta aataataaat
     4801 cttattttaa aaaaggttta aaaaaaacag ataagttaca gttgaattgt attcactcca
     4861 gaattacttt gtaaaaacaa aaatgcatat ttaatatgac cagttgttaa tgtataaaat
     4921 attctgtgta gcaacccaga gcagcagaac actttctttt cattgggatt atagttttct
     4981 ttgcttagct gtgttttcct aattgtatat actgaacaac tgttgtgtaa cttaaaatac
     5041 agatgaatac aattattata aagatgccca gtttttgata a
//
