LOCUS       NM_001310455            6750 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MAM and LDL receptor class A domain containing 1
            (Malrd1), mRNA.
ACCESSION   NM_001310455 XM_006497576 XM_006543620
VERSION     NM_001310455.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6750)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6750)
  AUTHORS   Lee,J.M., Ong,J.R., Vergnes,L., de Aguiar Vallim,T.Q., Nolan,J.,
            Cantor,R.M., Walters,J.R.F. and Reue,K.
  TITLE     Diet1, bile acid diarrhea, and FGF15/19: mouse model and human
            genetic variants
  JOURNAL   J Lipid Res 59 (3), 429-438 (2018)
   PUBMED   29295820
  REMARK    GeneRIF: genetic variation in DIET1 may be a determinant of FGF19
            secretion levels, and may affect bile acid metabolism in both
            physiological and pathological conditions
REFERENCE   3  (bases 1 to 6750)
  AUTHORS   Reue,K., Lee,J.M. and Vergnes,L.
  TITLE     Diet1 is a regulator of fibroblast growth factor 15/19-dependent
            bile acid synthesis
  JOURNAL   Dig Dis 33 (3), 307-313 (2015)
   PUBMED   26045262
  REMARK    GeneRIF: Diet1 appears to be a control point for the production of
            fibroblast growth factor 15/19 in enterocytes, and thus a regulator
            of bile acid and lipid homeostasis.
REFERENCE   4  (bases 1 to 6750)
  AUTHORS   Vergnes,L., Lee,J.M., Chin,R.G., Auwerx,J. and Reue,K.
  TITLE     Diet1 functions in the FGF15/19 enterohepatic signaling axis to
            modulate bile acid and lipid levels
  JOURNAL   Cell Metab 17 (6), 916-928 (2013)
   PUBMED   23747249
  REMARK    GeneRIF: Diet1-deficient mice exhibited an elevated bile acid pool
            size and impaired feedback regulation of hepatic Cyp7a1, which
            encodes the rate-limiting enzyme in bile acid synthesis.
REFERENCE   5  (bases 1 to 6750)
  AUTHORS   Phan,J., Pesaran,T., Davis,R.C. and Reue,K.
  TITLE     The Diet1 locus confers protection against hypercholesterolemia
            through enhanced bile acid metabolism
  JOURNAL   J Biol Chem 277 (1), 469-477 (2002)
   PUBMED   11682476
REFERENCE   6  (bases 1 to 6750)
  AUTHORS   Mouzeyan,A., Choi,J., Allayee,H., Wang,X., Sinsheimer,J., Phan,J.,
            Castellani,L.W., Reue,K., Lusis,A.J. and Davis,R.C.
  TITLE     A locus conferring resistance to diet-induced hypercholesterolemia
            and atherosclerosis on mouse chromosome 2
  JOURNAL   J Lipid Res 41 (4), 573-582 (2000)
   PUBMED   10744778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KC836882.1 and AL772224.2.
            
            On or before Jul 13, 2015 this sequence version replaced
            XM_006497576.2, XM_006543620.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KC836882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                KC836882.1         1-10
            11-6005             KC836882.1         12-6006
            6006-6006           AL772224.2         131222-131222
            6007-6750           KC836882.1         6008-6751
FEATURES             Location/Qualifiers
     source          1..6750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 5.8 cM"
     gene            1..6750
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /note="MAM and LDL receptor class A domain containing 1"
                     /db_xref="GeneID:102635496"
                     /db_xref="MGI:MGI:1928271"
     exon            1..352
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..6525
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /note="MAM and LDL-receptor class A domain-containing
                     protein 1"
                     /codon_start=1
                     /product="MAM and LDL-receptor class A domain-containing
                     protein 1 precursor"
                     /protein_id="NP_001297384.1"
                     /db_xref="CCDS:CCDS79736.1"
                     /db_xref="GeneID:102635496"
                     /db_xref="MGI:MGI:1928271"
                     /translation="MFLPKAAVSAFSMHGSLCFLWTVCLSISPLSQQGVQAFQCSNGV
                     SLPSDYVCDFTDHCGDNSEEQQCWSYGRCNFEDRLCSMTEDQTLQPGWTRRSGIISNS
                     PPFWDHNGNISAHFLALVSRVDSISSNLRSRIFLPTNDQQVCQITFYNFSSNQNGKLI
                     AGLQTLCGDPIEHLWQKTEILQSRWERNVITVQSSQQFQVIFQAQMLATHGQEEVIAI
                     DDISFSSGCLPADVCQTCGFDLDTCGLATEASAGRTSWMCTKVREIPSLDSVPWQDQR
                     GHDEGSFVWMRAGHASVSRLVESSAYLNSSVCHCMDGNCRLQFNYTMENSILRVRLYN
                     DKEEKKTWTFNTSTYSTWMKADVLIPEDLKAFKVVLEGTVLSQKSFIGIDQLLVYNFG
                     QTHSQKLCSVNEYTPASRQCLTHSSVCDSGMDHSNGIDEDSEACASLLTWDFESGFCG
                     WEPFPTEDSHWEVVRGLSNGEHLFLEAGHTVSRNQGSFIYFGPQKSTAVARLGSPILT
                     KSLTTFTPCQVRFWYHLSEHSSLSVFTRTSVDGSLLKQSEVTQFSDSQWSQAKVDLHA
                     KAEESTLPFQLVLEATILSSNATVAVDDISISHECEISYKSLRSTSIQNKVADCDFEA
                     NSCGWFEASGGDHFDWVWSSQSNLSADLEQQAPPRDHTHGTAQGHFMFILKTSNSLFQ
                     TAKLQSPTFSQTGPGCTMSFWFYNYGLSVGAAELQLHLENSRDTTALWRVLYNQGNQW
                     SEATVQLGRLTQPFYLSLEKVSLAVYSGVSAVDDIHFENCALPPPVESCDEPDHFWCR
                     QTKACIGRHQLCDLVDDCGDYTDETGCAPGLQCNFENGICNWEQSTKDDFNWTRYQGP
                     TSTMNTGPMKDHTLGTAKGHYLYIETSGPQGFQDKAVLLSPILNATEAKVCTFRLYYH
                     MFGKHIYRLAIYQRIWSNTKGQLLWQIFGDQGNRWIRKDLSITSRKPFQILIMASVGD
                     GFTGDIAIDDLSFMDCTLYPDNLPMDIPSPPETSVPVTLPPNNCTDDQFVCRSNGHCV
                     GNIQKCDFRYDCIDKSDESSCVLEVCTFEERKLCKWYQPIPANSLHDSNTFRWGLGNG
                     ISIHHGEENHRPSVDHTKNTTDGWYLYADSSNGKFGDLADIVTPVISLMGPRCTLVFW
                     TYMNGATVGSLQVLIKMGNTISKVWAQSGQQGPQWKKAEVFLGIHSHVEIVFRAKRGV
                     SYIGDVAVDDVSFQNCSPLLSTNRKCTTDEFMCANKHCIEKDKLCDFVNDCADNSDET
                     TFICGTSSGRCDFEFDLCTWEQDQDEDIDWNLKASNIPATSTEPAVDHTLGNSSGHYI
                     ILKSFFPQQPVKTGRISSPVISKRSKDCKIIFNYHMYGSGIAALLLLQVTVTNHTRVL
                     LNLTKEQGNFWQRKELSLSSDEDFRVKFEGRVGEGIRGNIALDDIVLTKSCLPSHHST
                     REEPAFPLPTGFCPRGYEECQNGRCYSPEQRCNFVDDCGDNSDENECGGSCTFEKGWC
                     GWKNSLAENSDWVLGIGSYKSQRPPKDHTLGNEHGHFMYLEATPVGLHGDKAHFKSAT
                     WQESSAACTMSFWYFISAKATGSIQILIKTDKGLWEVWQQSKPDPGNHWRRATILLGK
                     LRNFEVIFQGIRTRDLGGGAAIDDIEFNNCTTVGETTDICSEETDFLCQDKKCIASHL
                     VCDYKPDCSDTSDEAHCGYYTSTAGSCNFETTSGDWTVECGLTQDPEDDLDWSIGSII
                     PTEGLSRDSDHTPGSGRHFLYVNTSLAEEGSTARIITSHFFPASLGICTVRFWFYMVD
                     PHIVGILKVYLIEKSGLNILMWSMMRNKNTGWTYAHVPLSSNSPFKVAFEADLGGKED
                     IFIALDDITFTPTCASGGPALPQPPLCEEGQFACIYALQCVSASEKCDGQEDCIDGSD
                     EMNCSLGPSPQPCSDTEFQCFESQCIPSLLLCDGVADCQFNEDESSCVNQSCPSGALA
                     CNSSGLCIPAHQRCDGTAHCKDIQVDESSCSECPIHYCRNGGTCVIENIGPTCRCVQG
                     WTGNRCHIRSNLSTEGSVHTQNYIWTLLGIGLGFLLTHIAVAILCSLGIRRRPMRKSE
                     GVGNHSFINPVYRNCINQEKTQSSIYSFPNPFYGAASGSLETVSHHLKS"
     exon            353..493
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            494..588
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            589..750
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            751..847
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            848..994
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1161
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1254
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1462
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1609
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1707
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1881
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2002
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2155
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2261
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2629
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..3042
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3130
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3307
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3470
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3627
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3738
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3952
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4200
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4492
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            4493..4738
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4896
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..5080
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5209
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            5210..5371
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            5372..5529
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            5530..5731
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            5732..5995
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            5996..6121
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            6122..6188
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            6189..6268
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            6269..6365
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            6366..6441
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     exon            6442..6740
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6722..6727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /note="hexamer: AATAAA"
     polyA_site      6740
                     /gene="Malrd1"
                     /gene_synonym="Diet1; Gm13318; Gm13364"
                     /note="major polyA site"
ORIGIN      
        1 tacagcctgg agagtcatct gtaaagcagt ttcacaggaa ctggggtgca cactcacagg
       61 agaaaaatct ggaaaacaag agagaaaata acaacttgaa gttatgatca ctgattttat
      121 aagtgactga ctttgcactc ccaacaccaa ggaatgtttc tccccaaggc tgctgtgtca
      181 gccttctcaa tgcatggatc tctttgtttc ctttggactg tctgtctttc tatttctcca
      241 ttgagtcagc aaggagtcca agcctttcag tgcagtaatg gagtctcttt gccttctgac
      301 tatgtgtgtg actttacaga ccactgtggg gacaacagtg aagagcagca atgctggagt
      361 tatgggagat gcaactttga ggacaggctc tgtagcatga cagaggacca gaccctgcaa
      421 cctggttgga caagaagaag tgggataatt agtaattcac ctccattttg ggaccacaat
      481 ggaaacatat ctgcccattt tcttgcactg gtctccaggg tcgattccat ctcctcaaac
      541 ttaagaagca gaattttcct accaactaat gatcagcaag tttgtcagat taccttttat
      601 aacttctcca gtaaccagaa tggcaaattg atagcaggcc ttcaaaccct gtgtggggat
      661 cctattgagc atttatggca gaaaacagag atactccaga gtcggtggga aagaaatgtc
      721 attacagtcc aaagctcaca gcagtttcag gtcatttttc aagctcaaat gcttgcaact
      781 catggacagg aggaagttat agctatcgat gatatttctt tcagttctgg ttgcttgcct
      841 gcagatgtgt gccagacttg tggatttgac cttgacacct gtggattggc aactgaggca
      901 tctgctggga gaacttcttg gatgtgtaca aaagtaagag agatcccttc actggactct
      961 gtaccttggc aggatcaacg tggccatgat gaaggttcct ttgtatggat gagggccggt
     1021 cacgcatctg tttctagact cgttgagagc agtgcatatt taaacagctc tgtatgtcac
     1081 tgcatggatg ggaactgccg tcttcagttc aattacacga tggaaaatag catcctgaga
     1141 gtaagactgt acaatgacaa ggaagaaaaa aagacttgga cattcaatac atcaacttac
     1201 agcacatgga tgaaagcaga tgtgttaata ccagaagatc tgaaggcatt taaggttgtt
     1261 ttggaaggca cagttttgag tcagaaaagt tttattggga ttgatcagct gttagtctac
     1321 aactttggac agactcactc ccagaagctt tgttctgtaa atgaatacac tcctgccagt
     1381 aggcagtgcc ttactcactc ttctgtctgc gactctggaa tggaccactc caatgggatt
     1441 gatgaagact cagaggcttg tgcaagtctc cttacctggg acttcgagtc tggtttctgt
     1501 ggctgggaac catttcccac cgaagactcc cactgggagg tagtgagagg actgagcaat
     1561 ggagaacatc tgtttcttga ggctggtcac acagtgagca gaaaccaagg atcatttatt
     1621 tattttggac cacagaagtc cactgcagtg gccaggcttg gcagtcctat ccttaccaaa
     1681 tcactcacta cctttactcc ttgccaggtg cggttttggt atcatttatc agagcattcc
     1741 agtctctctg ttttcacaag aacatcagta gatggcagtt tgctaaagca gagtgaagtg
     1801 acccaattct ctgactctca gtggagccaa gcaaaagttg atctccacgc aaaagctgaa
     1861 gagtctactc ttcctttcca gttagtttta gaagctacca ttttgtcatc aaatgctacg
     1921 gttgctgtag atgacatcag tatatcccat gaatgtgaaa tttcctataa gtcacttcga
     1981 agtaccagca tacaaaataa agttgctgat tgtgactttg aagcaaacag ctgtgggtgg
     2041 tttgaagcca gtggtggtga ccattttgac tgggtgtgga gctcccaaag taatctttct
     2101 gctgatttag aacaacaagc tccacctaga gatcacactc atggtacagc tcaagggcat
     2161 ttcatgttca ttttgaagac gagcaacagc ttgtttcaaa ctgctaaact tcagagccca
     2221 actttcagcc agactgggcc tgggtgcaca atgtcattct ggttttataa ctatggactg
     2281 tcagtggggg cagctgagtt gcagctacat ctagaaaatt ccagggacac cactgccctc
     2341 tggagagtgc tatataacca aggcaaccag tggtcagagg caactgtcca gcttggacgc
     2401 ctcactcaac ccttctatct gtcactagag aaagtcagtc tggcagttta tagtggggtc
     2461 tctgcggttg atgacatcca ttttgaaaac tgtgctcttc ctcctcctgt ggagagctgt
     2521 gatgaaccag accacttctg gtgtagacag acgaaggctt gcatcggaag gcatcagctc
     2581 tgtgatctgg ttgatgattg tggagattat acagatgaga ctggctgtgc accaggacta
     2641 cagtgtaact ttgaaaatgg aatttgtaac tgggagcaaa gtacaaagga tgacttcaac
     2701 tggaccagat accagggtcc tacttcaacg atgaacacag gcccaatgaa ggaccataca
     2761 ctgggcacag ccaaaggaca ctacctttac attgaaacct cagggccaca gggatttcaa
     2821 gacaaagctg ttttacttag ccccattctt aatgccactg aagcaaaagt ctgcaccttc
     2881 cgcctgtact atcacatgtt tggaaagcat atttatcggc tggctatcta ccagagaatt
     2941 tggagcaata ccaagggaca gctgctgtgg cagatatttg gggatcaagg caacagatgg
     3001 ataagaaaag acctcagtat taccagcagg aagccctttc agatcttgat aatggcctca
     3061 gtgggagatg gatttactgg agatattgca attgatgatc tgtcattcat ggattgtacc
     3121 ctctacccag ataatttgcc aatggacatt ccaagtccac cagaaacttc agttccagtg
     3181 accttgcctc caaacaactg caccgatgat caatttgtct gcaggtctaa tggtcactgt
     3241 gttggaaaca ttcagaaatg tgacttcaga tatgactgca ttgacaaatc ggatgagtca
     3301 tcttgtgtac tggaggtttg tacatttgaa gagagaaaac tatgtaaatg gtaccaacca
     3361 atcccagcaa attcactcca tgattcaaat acattcaggt ggggactcgg taatgggatc
     3421 agtattcatc atggggaaga aaaccacaga ccatcagtag atcacacaaa aaatactaca
     3481 gatggttggt acctgtatgc tgacagttca aatgggaagt ttggagacct tgccgatatt
     3541 gttactcctg tcatctcact catgggaccg aggtgtacat tggtgttctg gacttatatg
     3601 aacggtgcta cagtgggctc tctccaggta ctcataaaga tgggcaatac gatttccaaa
     3661 gtgtgggctc agagtggaca gcaagggcca cagtggaaga aagccgaagt gtttttaggc
     3721 attcattcgc acgtggagat cgtctttagg gcaaaacgtg gtgtgagtta cataggagat
     3781 gtggcagtag atgatgtttc ctttcaaaac tgctctccgt tgcttagcac aaacagaaag
     3841 tgcaccactg atgaattcat gtgtgctaac aagcattgca ttgaaaagga caaactatgt
     3901 gactttgtga atgactgtgc agataattca gatgagacca cgttcatctg tggtacctct
     3961 agtgggcgct gtgacttcga gtttgacctt tgtacctggg agcaagatca ggatgaggac
     4021 attgactgga acctgaaagc tagcaacatc ccagctacaa gcactgagcc agcagtcgac
     4081 cacaccctgg gaaactcctc tggtcattac atcattctca aaagcttttt cccacagcag
     4141 cccgtgaaaa caggcagaat atcaagccca gttataagca agagaagcaa agactgcaag
     4201 attattttta attatcacat gtatggaagt ggcattgcgg ccctcctctt gctccaggtg
     4261 acagtcacaa atcacacaag ggtgctcctg aatctcacta aagaacaagg caatttctgg
     4321 cagaggaaag aattgtcatt gtctagtgat gaagactttc gagtcaaatt tgaaggcaga
     4381 gttggggaag gcatccgtgg taacattgca cttgatgaca ttgtacttac aaagagctgt
     4441 ctgccatctc accactccac aagggaagag ccagcctttc cccttccaac aggcttttgc
     4501 ccacggggct atgaggagtg tcagaatggc agatgctaca gtccagagca gaggtgtaat
     4561 tttgtagatg actgtggaga taacagtgat gagaatgagt gtggtggctc ctgcactttt
     4621 gagaaaggtt ggtgtggctg gaagaactcc ctagctgaaa actccgattg ggttttagga
     4681 attgggtctt ataaaagcca acgacctccc aaagaccaca cacttggaaa tgaacatggt
     4741 cacttcatgt atctggaggc taccccagtg ggtcttcatg gtgacaaagc ccacttcaag
     4801 agtgccacat ggcaagaatc cagcgctgcc tgcactatga gcttctggta tttcatatct
     4861 gcaaaagcca caggatccat tcagattctc attaagacag acaaaggact ctgggaagta
     4921 tggcaacaaa gcaagccaga tcctggtaat cactggcgaa gggccaccat cctgttggga
     4981 aaattgagga attttgaggt catatttcaa ggaatcagaa caagggacct agggggcgga
     5041 gctgcgattg atgatattga attcaataat tgcacaactg ttggagaaac cactgatatt
     5101 tgttcagaag aaacagattt tttgtgccaa gacaagaagt gcatcgcatc ccaccttgtt
     5161 tgtgactaca agccagactg ctctgacact tctgatgaag ctcattgtgg gtattacaca
     5221 agcaccgcag gaagctgcaa ttttgaaaca acttcaggag actggactgt ggagtgtgga
     5281 ctcacccaag atcctgaaga tgacttggat tggagcatcg gtagcataat tcctactgaa
     5341 ggcttgagca gagattcgga ccacacacca ggtagtggac ggcatttctt gtatgtcaac
     5401 acttctctag ctgaagaagg atctactgca agaatcatta cctctcactt ttttccagca
     5461 agccttggaa tatgtactgt tcggttctgg ttctacatgg tagatcccca tattgtgggg
     5521 atattaaagg tatatctcat cgagaaatca ggactaaaca tcctgatgtg gtccatgatg
     5581 cgaaacaaaa acactggttg gacctatgcg catgtacctc tttctagtaa cagtcccttc
     5641 aaggttgcat tcgaggctga cttgggtgga aaggaggaca tctttattgc tcttgatgac
     5701 atcactttca caccaacgtg tgcatctgga ggaccagcct taccacagcc accactttgt
     5761 gaagaaggcc agtttgcttg tatctacgca ctccagtgtg tctctgcttc agagaagtgt
     5821 gatgggcaag aagattgtat agatggatct gatgaaatga attgctctct cggaccctct
     5881 cctcaaccat gcagtgatac agaattccag tgctttgaaa gccagtgtat cccatctctc
     5941 ctgctatgtg atggagtggc tgattgccaa tttaatgaag atgaatccag ctgtgtcaat
     6001 cagagctgcc ccagtggagc tttggcatgc aactcatcgg gcctctgtat cccagctcac
     6061 cagcgctgtg atggtactgc ccactgcaag gacattcaag tagatgaatc cagctgctca
     6121 gagtgtccaa tacattattg cagaaatggt ggcacttgtg tgatagagaa tattggtccc
     6181 acgtgtaggt gtgtacaagg atggacagga aatcgatgcc acatcaggtc taacctttct
     6241 actgagggtt ctgtgcatac tcaaaattac atatggactc tgctgggtat cggacttggg
     6301 ttccttctga ctcatattgc agtggccatc ttgtgttccc ttggcatcag aagaagacca
     6361 atgaggaaat ctgagggggt tggcaaccat tcctttatca atccagttta taggaactgc
     6421 atcaaccaag agaaaactca gagttccatc tattctttcc caaatccatt ttatggcgca
     6481 gcatctggaa gcctggagac agtgtcgcat catctcaaat cttaacacaa aaactaggct
     6541 tccatcaata tgtgttaata gaaaatctca ttcactaaac tgatcctgtg tgaagtaaaa
     6601 gagaaaatat tcaaatgtta gttcgattac aatgtattgg aaacatactc cttacagatt
     6661 ctttgaatat ttccatggaa tcactgacag atccttaact tcattgtata tctgagactt
     6721 caataaaacg ttctgcctaa aaaaaaaaaa
//
