LOCUS       NM_010762               2792 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus myelin and lymphocyte protein, T cell differentiation
            protein (Mal), transcript variant 1, mRNA.
ACCESSION   NM_010762
VERSION     NM_010762.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2792)
  AUTHORS   Kim,H., Gao,E.B., Draper,A., Berens,N.C., Vihma,H., Zhang,X.,
            Higashi-Howard,A., Ritola,K.D., Simon,J.M., Kennedy,A.J. and
            Philpot,B.D.
  TITLE     Rescue of behavioral and electrophysiological phenotypes in a
            Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4
            expression
  JOURNAL   Elife 11, e72290 (2022)
   PUBMED   35535852
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2792)
  AUTHORS   Leszczynska,E., Makuch,E., Mitkiewicz,M., Jasyk,I., Narita,M.,
            Gorska,S., Lipinski,T. and Siednienko,J.
  TITLE     Absence of Mal/TIRAP Results in Abrogated
            Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed
            IFNbeta and IFN-I Activated Gene Production
  JOURNAL   Int J Mol Sci 21 (23), 8925 (2020)
   PUBMED   33255528
  REMARK    GeneRIF: Absence of Mal/TIRAP Results in Abrogated
            Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed
            IFNbeta and IFN-I Activated Gene Production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2792)
  AUTHORS   Linden,J.R., Flores,C., Schmidt,E.F., Uzal,F.A., Michel,A.O.,
            Valenzuela,M., Dobrow,S. and Vartanian,T.
  TITLE     Clostridium perfringens epsilon toxin induces blood brain barrier
            permeability via caveolae-dependent transcytosis and requires
            expression of MAL
  JOURNAL   PLoS Pathog 15 (11), e1008014 (2019)
   PUBMED   31703116
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2792)
  AUTHORS   Tuna,K.M., Liu,B.C., Yue,Q., Ghazi,Z.M., Ma,H.P., Eaton,D.C. and
            Alli,A.A.
  TITLE     Mal protein stabilizes luminal membrane PLC-beta3 and negatively
            regulates ENaC in mouse cortical collecting duct cells
  JOURNAL   Am J Physiol Renal Physiol 317 (4), F986-F995 (2019)
   PUBMED   31364376
  REMARK    GeneRIF: siRNA-mediated knockdown of MAL in cells resulted in a
            decrease in PLC-beta3 protein expression and an increase in PIP2
REFERENCE   5  (bases 1 to 2792)
  AUTHORS   Kennedy,A.J., Rahn,E.J., Paulukaitis,B.S., Savell,K.E.,
            Kordasiewicz,H.B., Wang,J., Lewis,J.W., Posey,J., Strange,S.K.,
            Guzman-Karlsson,M.C., Phillips,S.E., Decker,K., Motley,S.T.,
            Swayze,E.E., Ecker,D.J., Michael,T.P., Day,J.J. and Sweatt,J.D.
  TITLE     Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory
            Function
  JOURNAL   Cell Rep 16 (10), 2666-2685 (2016)
   PUBMED   27568567
REFERENCE   6  (bases 1 to 2792)
  AUTHORS   Saravanan,K., Schaeren-Wiemers,N., Klein,D., Sandhoff,R.,
            Schwarz,A., Yaghootfam,A., Gieselmann,V. and Franken,S.
  TITLE     Specific downregulation and mistargeting of the lipid
            raft-associated protein MAL in a glycolipid storage disorder
  JOURNAL   Neurobiol Dis 16 (2), 396-406 (2004)
   PUBMED   15193296
  REMARK    GeneRIF: The specific reduction and mistargeting of MAL protein as
            a reaction to sulfatide overload may contribute to the pathogenic
            mechanisms in metachromatic leukodystrophy.
REFERENCE   7  (bases 1 to 2792)
  AUTHORS   Gieselmann,V.
  TITLE     Metachromatic leukodystrophy: recent research developments
  JOURNAL   J Child Neurol 18 (9), 591-594 (2003)
   PUBMED   14572136
  REMARK    Review article
REFERENCE   8  (bases 1 to 2792)
  AUTHORS   Frank,M., Atanasoski,S., Sancho,S., Magyar,J.P., Rulicke,T.,
            Schwab,M.E. and Suter,U.
  TITLE     Progressive segregation of unmyelinated axons in peripheral nerves,
            myelin alterations in the CNS, and cyst formation in the kidneys of
            myelin and lymphocyte protein-overexpressing mice
  JOURNAL   J Neurochem 75 (5), 1927-1939 (2000)
   PUBMED   11032882
REFERENCE   9  (bases 1 to 2792)
  AUTHORS   Magyar,J.P., Ebensperger,C., Schaeren-Wiemers,N. and Suter,U.
  TITLE     Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are
            members of an extended gene family
  JOURNAL   Gene 189 (2), 269-275 (1997)
   PUBMED   9168137
REFERENCE   10 (bases 1 to 2792)
  AUTHORS   Perez,P., Puertollano,R. and Alonso,M.A.
  TITLE     Structural and biochemical similarities reveal a family of proteins
            related to the MAL proteolipid, a component of detergent-insoluble
            membrane microdomains
  JOURNAL   Biochem Biophys Res Commun 232 (3), 618-621 (1997)
   PUBMED   9126323
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK158653.1 and BY626921.1.
            
            On Jan 15, 2010 this sequence version replaced NM_010762.4.
            
            Summary: This gene encodes a highly hydrophobic integral membrane
            protein belonging to the MAL family of proteolipids. The encoded
            protein has been localized to the endoplasmic reticulum of T-cells
            and is a candidate linker protein in T-cell signal transduction. In
            addition, this proteolipid is localized in compact myelin of cells
            in the nervous system and has been implicated in myelin biogenesis
            and/or function. The protein plays a role in the formation,
            stabilization and maintenance of glycosphingolipid-enriched
            membrane microdomains. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006826.1, AK158653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2774              AK158653.1         2-2775
            2775-2792           BY626921.1         372-389
FEATURES             Location/Qualifiers
     source          1..2792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.06 cM"
     gene            1..2792
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /note="myelin and lymphocyte protein, T cell
                     differentiation protein"
                     /db_xref="GeneID:17153"
                     /db_xref="MGI:MGI:892970"
     exon            1..655
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /inference="alignment:Splign:2.1.0"
     exon            656..823
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /inference="alignment:Splign:2.1.0"
     exon            824..949
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /inference="alignment:Splign:2.1.0"
     exon            950..2778
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2672
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
     regulatory      2762..2767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /note="hexamer: AAGAAA"
     polyA_site      2778
                     /gene="Mal"
                     /gene_synonym="Mpv17; Vip17"
                     /note="major polyA site"
ORIGIN      
        1 atatagtttc cctgacgagc cttgctgttg cccctagaac ccccagcctg ccggtgagat
       61 cgaaatgtgc cctccgggag cttggatgtg aaggctgcac attaacacac ccagcggaag
      121 actggagaca cgactagagt taaagggaat ggatgtcaaa gtggggaagt ctccgatagg
      181 ttattgatga atagtgatca cctgcgtggc gcgcaacaca gggaagtgca gcgcgcgagc
      241 cgctccatcc actgccctca ggcaggtggc aactagggtt aggtcaggag cgtacagatt
      301 cccaacccag tcctgcagat cttcagagag cactccgtcg ggtttcaggg cggcgccaga
      361 ggcgattcag ccttgtcctc tagggcagta gacccgggcg gggcgggtgg ccggagctcc
      421 gccctcctct gaccctggct tttcagcttt taacccgcgc gggagggcgc cgcggccact
      481 gggctctccg gagggagcga gtggtcagtg cggagccgga ggcgagcgtg tccagtccca
      541 aggccgacgc cagctcgcag gcatggctcc ggcagcggct tcgggtggca gcaccctgcc
      601 cagtggcttc tcggtcttca ccaccttccc tgacttgctc ttcgtttgtg agtttgtctt
      661 tggaggcctg gtgtggatcc tgattgcctc ctccctggta cccttgcccc tggcccaggg
      721 ctgggtgatg tttgtgtctg tgttctgctt tgtggccacc acttccctga tgatcttgta
      781 cataattggt actcatggcg gtgagacttc ctggatcaca ctggatgcag cctaccactg
      841 tgtggctgcc ctattttacc tcagtgcctc agttctggaa gccctggcca ccatctcaat
      901 gtttgatggc tttacttaca agcattacca tgaaaacatc gccgcagtgg tgtttgccta
      961 cgtggtcact ctgatctacg tggtccatgc tgtgttttcc ttaatcagat ggaagtcttc
     1021 ataggacagc agatcgggag ctgagaccca gatgcaatta actggtcagc ccatcttccc
     1081 cattaacttc ctagaacaca gactggatgg tggagaaaag aaaacaagcc aaaaagaaaa
     1141 caaaacaaac acaaaaacaa aaggaagcca tattcaagcc atattcgcgt ctcttgggtg
     1201 ttatgtttac cttctgtcaa ggtttagggc ttgctatatt taacttctag ctaagggagg
     1261 aaggagttgt cttggaaggg gacctttttg cccttgaccg ggacagttgg tgggaactgg
     1321 gaaccttgat ctgaagaaat gacgatttac acttgaccct tgaagtatgt cctaagaatt
     1381 tgcctcttgg aattttttaa gggctctttt gagcactcat cccctggcat gtcttagtct
     1441 ttgtgaatag tctgggtgtc acaggcactg aaattcaccc aacagaggtc tccggacgtt
     1501 cacagtggaa gatgagctcc tttgaaatgc ttcattaaat acttttgtgt ctcatgcttc
     1561 aggtggggaa ctggagggat gtctttcatt cttgaggacc agggacacct tcctgttcaa
     1621 ctttcttcct gcagagtcct ttgattaacc tgattctcaa gggacagttc agatgtgtgt
     1681 gctgggccag tctttcccaa agtgactcac tgaggacgcc accctcacaa cagtgtccac
     1741 caggatagcg tctcccttgt agacacatcc cgtagagctc tgcctttgtc tttcaaggca
     1801 caacagtctg ctgaattaga gtcttctcaa gctctgagga aactaggtgt gggcattctt
     1861 tctattctta aggctgatct aaaatgtccg ggtgtctgca gtctcttgat gtgtttggac
     1921 atgttctcag accactcctt gtgggagaaa gggacctgac tctagagcaa agtgagaggc
     1981 aatggctatc tctggctgcc acactccagg tgagggatgt ctgacctgaa agaagaaagt
     2041 ataattagga aggacatgga gaatctgcaa agtcagacgt tctgctagga gatctcactt
     2101 tgtccccaca ctttaaagaa ctgagtgaca tcctagagat ggagtcccag atgcagggat
     2161 gtcctgccag ccaccaggag attcaggatt ctagcctcag tcagctttca ctagctgatg
     2221 ttttattctc caacaaagta ggagattgag acctacaact aaattagatt tggggatttt
     2281 tctatgttgg ttctcaggat ggaacccagg gggtttgcat gctgggtaag cactcttcta
     2341 ccagatccca tcatcagccc caaattggat ctcactggca cattcagaag gactttggtt
     2401 atcccagcca tactggtatc tgaattcacc atttgcccac ttaacacagc caaaatttca
     2461 tactaaaaca caagcaaaag attaggggga gttattttta aaaattaaaa tataaactaa
     2521 gagattatac aaagtttatt ataatgttta acaaaatctg taactgagtg ctgactgggg
     2581 tagtcttata ctttcaacaa agctgaaccc taacattaca ctaaccagca gctcaacacg
     2641 agtgagcatc acttttagac aagaagaaga aagagatgaa ggaaggaaga aaagaggcaa
     2701 ggaagggtga ctaagaggaa ttgcccaagg tttctcaatg tttcagattt ttaatcatta
     2761 aaagaaactt tcatacaaaa aaaaaaaaaa aa
//
