LOCUS       NM_008547               3385 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus male germ cell-associated kinase (Mak), transcript
            variant 2, mRNA.
ACCESSION   NM_008547
VERSION     NM_008547.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3385)
  AUTHORS   Varner,L.R., Chaya,T., Maeda,Y., Tsutsumi,R., Zhou,S., Tsujii,T.,
            Okuzaki,D. and Furukawa,T.
  TITLE     The deubiquitinase Otud7b suppresses cone photoreceptor
            degeneration in mouse models of retinal degenerative diseases
  JOURNAL   iScience 27 (4), 109380 (2024)
   PUBMED   38510130
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3385)
  AUTHORS   Meade,R.K., Long,J.E., Jinich,A., Rhee,K.Y., Ashbrook,D.G.,
            Williams,R.W., Sassetti,C.M. and Smith,C.M.
  TITLE     Genome-wide screen identifies host loci that modulate Mycobacterium
            tuberculosis fitness in immunodivergent mice
  JOURNAL   G3 (Bethesda) 13 (9) (2023)
   PUBMED   37405387
REFERENCE   3  (bases 1 to 3385)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3385)
  AUTHORS   Chaya,T., Omori,Y., Kuwahara,R. and Furukawa,T.
  TITLE     ICK is essential for cell type-specific ciliogenesis and the
            regulation of ciliary transport
  JOURNAL   EMBO J 33 (11), 1227-1242 (2014)
   PUBMED   24797473
REFERENCE   5  (bases 1 to 3385)
  AUTHORS   Chen,T., Wu,D., Moskaluk,C.A. and Fu,Z.
  TITLE     Distinct expression patterns of ICK/MAK/MOK protein kinases in the
            intestine implicate functional diversity
  JOURNAL   PLoS One 8 (11), e79359 (2013)
   PUBMED   24244486
  REMARK    GeneRIF: the expressions of ICK/MAK/MOK proteins in the intestinal
            tract can be differentially and dynamically regulated, implicating
            a significant functional diversity within this group of protein
            kinases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3385)
  AUTHORS   Shinkai,Y., Satoh,H., Takeda,N., Fukuda,M., Chiba,E., Kato,T.,
            Kuramochi,T. and Araki,Y.
  TITLE     A testicular germ cell-associated serine-threonine kinase, MAK, is
            dispensable for sperm formation
  JOURNAL   Mol Cell Biol 22 (10), 3276-3280 (2002)
   PUBMED   11971961
  REMARK    GeneRIF: data show that function of MAK is not essential for
            spermatogenesis and male fertility.
REFERENCE   7  (bases 1 to 3385)
  AUTHORS   Taketo,M., Jinno,A., Yamaguchi,S., Matushime,H., Shibuya,M. and
            Seldin,M.F.
  TITLE     Mouse Mak gene for male germ cell-associated kinase maps to
            chromosome 13
  JOURNAL   Genomics 19 (2), 397-398 (1994)
   PUBMED   8188277
REFERENCE   8  (bases 1 to 3385)
  AUTHORS   Bladt,F. and Birchmeier,C.
  TITLE     Characterization and expression analysis of the murine rck gene: a
            protein kinase with a potential function in sensory cells
  JOURNAL   Differentiation 53 (2), 115-122 (1993)
   PUBMED   8359591
REFERENCE   9  (bases 1 to 3385)
  AUTHORS   Koji,T., Jinno,A., Matsushime,H., Shibuya,M. and Nakane,P.K.
  TITLE     In situ localization of male germ cell-associated kinase (mak) mRNA
            in adult mouse testis: specific expression in germ cells at stages
            around meiotic cell division
  JOURNAL   Cell Biochem Funct 10 (4), 273-279 (1992)
   PUBMED   1473268
REFERENCE   10 (bases 1 to 3385)
  AUTHORS   Matsushime,H., Jinno,A., Takagi,N. and Shibuya,M.
  TITLE     A novel mammalian protein kinase gene (mak) is highly expressed in
            testicular germ cells at and after meiosis
  JOURNAL   Mol Cell Biol 10 (5), 2261-2268 (1990)
   PUBMED   2183027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133496.3, X66983.1 and AK044399.1.
            
            On Mar 11, 2009 this sequence version replaced NM_008547.1.
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR
            and has multiple differences in the CDS, compared to variant 1. The
            resulting protein (isoform 2) is shorter and lacks internal
            sequence segments when it is compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66983.1, SRR9219380.61249.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC133496.3         19425-19430
            7-1371              X66983.1           1-1365
            1372-1819           AK044399.1         1390-1837
            1820-2163           X66983.1           1814-2157
            2164-3385           AK044399.1         2254-3475
FEATURES             Location/Qualifiers
     source          1..3385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.25 cM"
     gene            1..3385
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /note="male germ cell-associated kinase"
                     /db_xref="GeneID:17152"
                     /db_xref="MGI:MGI:96913"
     exon            1..329
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            330..384
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            385..506
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            507..586
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            587..719
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..891
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1059
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1371
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1538
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1687
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1819
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1942
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..3385
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2364
                     /gene="Mak"
                     /gene_synonym="A930010O05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtccata agaatggaag aagtgtctct ttgccagctt ccttgttgct gtgtctcagg
       61 agcctgcctg atcttgagga ggagccgtgt ttaatgatga caagcctgtc tccagtgtag
      121 caacaacaac aaaaaaagga ggaccacaca ttaaagaagt atttagagtt ctactggaca
      181 aggaagagac ctccgtcaac aaactctcct ggaatacctc ttcccaagat gaaccgatac
      241 acaaccatga agcagctggg agacggcacg tatgggagtg tactgatggg caagagcaat
      301 gagtctgggg agctggtggc aatcaagagg atgaagagaa agttctattc ttgggatgag
      361 tgtatgaact tgcgagaagt taagtccctg aaaaaactca atcacgccaa tgtgattaaa
      421 ctaaaagaag ttatcagaga gaatgaccat ctttattttg tatttgaata tatgaaagaa
      481 aacctctatc agctaatgaa agacagaaac aaactgttcc ctgagtcagt catcagaaat
      541 attatgtatc agatactaca ggggctggca tttatccata aacacggctt ttttcacagg
      601 gacatgaaac ctgagaactt gctctgcatg ggcccagagc tggtgaagat tgctgatttt
      661 ggacttgcaa gagaattaag atcacagcca ccatatactg actatgtgtc taccagatgg
      721 taccgggctc ctgaagtctt actaaggtct tcggtgtaca gctctcccat tgacgtgtgg
      781 gccgtgggaa gtataatggc cgagttatat acatttaggc cgcttttccc agggacaagt
      841 gaagttgatg agatctttaa aatctgccaa gtgttaggga ctcccaagaa gagtgactgg
      901 ccggaaggat accagcttgc atcctccatg aacttccgct ttccccagtg cattcccatc
      961 aacctaaaaa ctctcattcc caatgccagt agcgaggcca tccagctcat gacagagatg
     1021 ctgaactggg atccaaagaa gcgaccaaca gcaagccagg cactgaaaca cccatatttc
     1081 caagtcggtc aggtactggg ctcttctgca caccatctgg atacaaaaca gactttacac
     1141 aagcagctgc agcctctgga gccaaagcca tcttcctctg aacgggatcc taagcctttg
     1201 ccaaacatac ttgatcagcc tgccgggcag ccccagccaa aacagggcca ccaaccactg
     1261 cagaccattc agccaccaca gaacacagtg actcacccac ccccaaagca gcagggtcac
     1321 cagaaaccac cacaaaccat gtttccaagt atcatcaaaa ccatcccagt gaattcagtc
     1381 agcaccctgg gccataaggg agcccggaga cggtggggtc agacagtctt caagtctgga
     1441 gacagctgtg acgacattga ggacgactta ggagcctccc actccaagaa gccaagcatg
     1501 gaagcctgca aggagaagaa gaaggagtct ccatttcggt ttccagattc aggactccca
     1561 gtctccaatc actttaaggg ggaaaatagg aatttacatg catctgtttc cttaaaatct
     1621 gatccaaact tgtcaactgc ttcaacggct aagcagtact atttgaaaca atcaagatac
     1681 cttccaggtg tgaaccccaa gaatgtgtct ttggtagctg gaggcaagga tataaattca
     1741 cactcttgga ataatcagct atttcctaag tcgctgggat ccatgggggc ggacctttcc
     1801 ttcaagagga gtaacgcagc aggaaacctt gggagctaca ccacttacaa ccagacggga
     1861 tacatgcctt cctttctcaa gaaagaagtg ggatcagctg gccagaggat ccaattggca
     1921 cctttaggtg cgtcggcttc ggactatacc tggagcacaa aaactggacg aggccagttt
     1981 tcgggacgaa cttacaaccc cacagccaaa aatctcaata ttgtgaaccg cacacagcca
     2041 gtcccctcgg tacacgggag gacagactgg gtggctaagt atggaggcca ccggtaggag
     2101 aggtggaagc cctgactcat tgctccgtag aggacgatca agccccttga tcccgggagc
     2161 cctacagagt ctatttctac cgagttccac aagacgcaca caactgcggg cgcctcaaag
     2221 agcggagggc agctcccgat cgcttccttt tccagaaatg caatgcattt tcttaacttg
     2281 tggccagcag tgctgacgca gcaccgtgct gagacttttt gagagggact ttaaagagta
     2341 ttgaataaat tatttgccaa agtatcaagt atttgaccta ccaattccta gataagtaca
     2401 caggctttta gagaacgact ctgggaagtt gcatagtagc ctaagctgtt gaggttctgg
     2461 tcccccgcag gggccggacc tatttgcctc tgctcccttt tcatagtggg gaggcagggg
     2521 ctgagttact gggctgagtt ggcagagcgt ctgctctccc accttggcaa tgtcagaaag
     2581 atggtaacta cctttcggtt ttctgcattt gaaactgtga gatctgtgag cgggtgcatc
     2641 taagccgggt atctttctta gaagcaaacc tctctccagt ctctatcaga gtctgcccgt
     2701 ctcgttttag tcctgttgtt ggaccttgac caaactggga actcacgatg actgtctgac
     2761 tctagctcgg tgagttccac cttcatcacc agggttctct tgtcggctca gctttaagga
     2821 cacggtttgc ttgaaaccgt atctgatgct tggccatctg actctcctaa ctcctgttcc
     2881 cgtgtgtaac tacctgacac aaaggtgaaa cgtgccagct gctcctcagg caaacccttg
     2941 ctgctgccgg tcactgacta gcctctgacc ctcacattag agccgcaggg caaatgcact
     3001 cagttgccac agcagagttt catgcagctc gttgttccta cttttatacc aaaaaaaaaa
     3061 aaaagttttt aaataaatat tttaaagtta ggactacttt aacctgccac ttgatgggct
     3121 gggcatgatt agtactgtat gtatattttt tgaaagaata atgttatcgc ctgctgatat
     3181 ttttatgtat ttatggctat gtaacagatg ccgatggaac ctgcatcgtc ttgtgggcac
     3241 tgccccaaaa gcacattatc aaatcctata tttttgtata gaagatatag ctgttcatat
     3301 tttacatgtt taaaatgtta aaacttgaaa tagtaattta tcccagtcct ggtggttatt
     3361 tgtatgtgta caagtttatt gtctc
//
