LOCUS       NM_001377075            1293 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus membrane anchored junction protein (Majin), transcript
            variant 3, mRNA.
ACCESSION   NM_001377075 XM_006531820
VERSION     NM_001377075.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Rezaei,M., Liang,M., Yalcin,Z., Martin,J.H., Kazemi,P., Bareke,E.,
            Ge,Z.J., Fardaei,M., Benadiva,C., Hemida,R., Hassan,A., Maher,G.J.,
            Abdalla,E., Buckett,W., Bolze,P.A., Sandhu,I., Duman,O.,
            Agrawal,S., Qian,J., Vallian Broojeni,J., Bhati,L., Miron,P.,
            Allias,F., Selim,A., Fisher,R.A., Seckl,M.J., Sauthier,P.,
            Touitou,I., Tan,S.L., Majewski,J., Taketo,T. and Slim,R.
  TITLE     Defects in meiosis I contribute to the genesis of androgenetic
            hydatidiform moles
  JOURNAL   J Clin Invest 134 (22), e170669 (2024)
   PUBMED   39545410
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Akter,M.S., Hada,M., Shikata,D., Watanabe,G., Ogura,A. and
            Matoba,S.
  TITLE     CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant
            genes identifies critical genes for male germ cell development in
            mice
  JOURNAL   Sci Rep 11 (1), 15438 (2021)
   PUBMED   34326397
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   da Cruz,I., Brochier-Armanet,C. and Benavente,R.
  TITLE     The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back
            to the common ancestor of metazoans
  JOURNAL   BMC Evol Biol 20 (1), 55 (2020)
   PUBMED   32408858
  REMARK    GeneRIF: The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres
            dates back to the common ancestor of metazoans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    GeneRIF: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to
            the nuclear envelope
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Zhang,J., Tu,Z., Watanabe,Y. and Shibuya,H.
  TITLE     Distinct TERB1 Domains Regulate Different Protein Interactions in
            Meiotic Telomere Movement
  JOURNAL   Cell Rep 21 (7), 1715-1726 (2017)
   PUBMED   29141207
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Tu,Z., Bayazit,M.B., Liu,H., Zhang,J., Busayavalasa,K., Risal,S.,
            Shao,J., Satyanarayana,A., Coppola,V., Tessarollo,L., Singh,M.,
            Zheng,C., Han,C., Chen,Z., Kaldis,P., Gustafsson,J.A. and Liu,K.
  TITLE     Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope
            attachment during meiotic prophase I independent of Cdk2 activation
  JOURNAL   Proc Natl Acad Sci U S A 114 (3), 592-597 (2017)
   PUBMED   28031483
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Shibuya,H., Hernandez-Hernandez,A., Morimoto,A., Negishi,L.,
            Hoog,C. and Watanabe,Y.
  TITLE     MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging
            Telomere Cap
  JOURNAL   Cell 163 (5), 1252-1266 (2015)
   PUBMED   26548954
  REMARK    GeneRIF: Study identified meiosis-specific telomere and inner
            nuclear membrane-binding proteins, telomere repeat-binding bouquet
            formation protein 2 (TERB2) and membrane-anchored junction protein
            (MAJIN), which form a complex with TERB1.
            Erratum:[Cell. 2018 May 3;173(4):1058. doi:
            10.1016/j.cell.2018.04.025.. PMID: 29727665]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127556.4.
            
            On Dec 12, 2019 this sequence version replaced XM_006531820.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC127556.4         26733-26970
            239-355             AC127556.4         38052-38168
            356-401             AC127556.4         48606-48651
            402-474             AC127556.4         64061-64133
            475-583             AC127556.4         65036-65144
            584-1293            AC127556.4         65909-66618
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1293
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="membrane anchored junction protein"
                     /db_xref="GeneID:622554"
                     /db_xref="MGI:MGI:1923913"
     exon            1..238
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            239..355
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..629
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="membrane-anchored junction protein isoform 3"
                     /protein_id="NP_001364004.1"
                     /db_xref="GeneID:622554"
                     /db_xref="MGI:MGI:1923913"
                     /translation="MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVI
                     VQELESTDEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVVPPLQHSSPPPPKEPGA
                     RGFLGFLSALFPFRYFFKKSGQ"
     exon            356..401
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            402..474
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            475..583
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1293
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1270..1275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1293
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaagttcc aaggcttcgc ttgtgcacat caagctaaag gccgagttca gaggagaccg
       61 acgagaacct gagtccctgg cccgcagtct tttgacttcg acgtcctctc ttggaaaaaa
      121 aaaaaagatt tctgagcaga aagtcaagcg tggccacctt tctgaggtgc tggaggaacc
      181 ctagtcagtg tgcgagcgac aagtgtggct gtcagcgcct gagcgcttcg aggctgaggc
      241 tgccgtcaaa aacaatgagt ttaaaaccat tcacctaccc atttccagag acaaggttcc
      301 ttcatgcagg acccaatgtg tataagttca aaatcagata tggcaacagt atcagaggag
      361 aagaaataga ggataaggaa gtcatcgtcc aggagctgga gagcacggac gaagaagccc
      421 agcaggaata tcaggacacc ccagcttcta atgccattgc tgtcaaggaa caggatgctg
      481 cgttggggca tggcctgcaa gggttggttg tccctccact gcaacatagc agtccaccac
      541 ccccgaaaga gccaggagcc agaggcttct tggggtttct aagtgctctc ttcccgttcc
      601 ggtacttctt caagaagagc ggtcagtgag ccttccagga ccacagcacg cgtggggcag
      661 gggtcagcat agaagagatg tcctcctgca gtaactcccc ggagctacca cacctctctt
      721 gcttttgttt tcttttgtct tgcatttatt ttgagacaag tgttattgta tacagcccag
      781 gctggcttca gtctgtgcct ctgctcccgg tgcactccca cgtgccatcc ttttctcctg
      841 accccggtca cggggacaag ggcaccaggc cgggtcctca catgagttta tcctcttgtt
      901 tgcctttggt gtttcctatc caaaccagta agaacgaggc tagagagatg gtagttgagt
      961 gcacactgat agtgcagagg gcctgagttt ggttctcagt acccatggca agcaacctgc
     1021 aactccagct ctatcaggat ggcctggcgc tttctggcct ctgcagaaac ttacgccccg
     1081 cacgccctgc accctcgtaa tcggaagagc aagacaaaac aatactaaga agggccagaa
     1141 aggcggcttg ataaagcatc tgcagccaga cctgacagcc tgagttcagc ctccatgtat
     1201 gtgcaccatg gcatgtgccc cacacagaat aaaatgtact tttattaaaa acttcaaaat
     1261 aaataagtaa ataaaacgct ataaagaatt cta
//
