LOCUS       NM_001165919            1689 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus membrane anchored junction protein (Majin), transcript
            variant 1, mRNA.
ACCESSION   NM_001165919 XM_886988 XM_906412
VERSION     NM_001165919.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Rezaei,M., Liang,M., Yalcin,Z., Martin,J.H., Kazemi,P., Bareke,E.,
            Ge,Z.J., Fardaei,M., Benadiva,C., Hemida,R., Hassan,A., Maher,G.J.,
            Abdalla,E., Buckett,W., Bolze,P.A., Sandhu,I., Duman,O.,
            Agrawal,S., Qian,J., Vallian Broojeni,J., Bhati,L., Miron,P.,
            Allias,F., Selim,A., Fisher,R.A., Seckl,M.J., Sauthier,P.,
            Touitou,I., Tan,S.L., Majewski,J., Taketo,T. and Slim,R.
  TITLE     Defects in meiosis I contribute to the genesis of androgenetic
            hydatidiform moles
  JOURNAL   J Clin Invest 134 (22), e170669 (2024)
   PUBMED   39545410
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Akter,M.S., Hada,M., Shikata,D., Watanabe,G., Ogura,A. and
            Matoba,S.
  TITLE     CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant
            genes identifies critical genes for male germ cell development in
            mice
  JOURNAL   Sci Rep 11 (1), 15438 (2021)
   PUBMED   34326397
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   da Cruz,I., Brochier-Armanet,C. and Benavente,R.
  TITLE     The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back
            to the common ancestor of metazoans
  JOURNAL   BMC Evol Biol 20 (1), 55 (2020)
   PUBMED   32408858
  REMARK    GeneRIF: The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres
            dates back to the common ancestor of metazoans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    GeneRIF: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to
            the nuclear envelope
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Zhang,J., Tu,Z., Watanabe,Y. and Shibuya,H.
  TITLE     Distinct TERB1 Domains Regulate Different Protein Interactions in
            Meiotic Telomere Movement
  JOURNAL   Cell Rep 21 (7), 1715-1726 (2017)
   PUBMED   29141207
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Tu,Z., Bayazit,M.B., Liu,H., Zhang,J., Busayavalasa,K., Risal,S.,
            Shao,J., Satyanarayana,A., Coppola,V., Tessarollo,L., Singh,M.,
            Zheng,C., Han,C., Chen,Z., Kaldis,P., Gustafsson,J.A. and Liu,K.
  TITLE     Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope
            attachment during meiotic prophase I independent of Cdk2 activation
  JOURNAL   Proc Natl Acad Sci U S A 114 (3), 592-597 (2017)
   PUBMED   28031483
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Shibuya,H., Hernandez-Hernandez,A., Morimoto,A., Negishi,L.,
            Hoog,C. and Watanabe,Y.
  TITLE     MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging
            Telomere Cap
  JOURNAL   Cell 163 (5), 1252-1266 (2015)
   PUBMED   26548954
  REMARK    GeneRIF: Study identified meiosis-specific telomere and inner
            nuclear membrane-binding proteins, telomere repeat-binding bouquet
            formation protein 2 (TERB2) and membrane-anchored junction protein
            (MAJIN), which form a complex with TERB1.
            Erratum:[Cell. 2018 May 3;173(4):1058. doi:
            10.1016/j.cell.2018.04.025.. PMID: 29727665]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127556.4.
            
            On Dec 12, 2019 this sequence version replaced NM_001165919.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC127556.4         26733-26970
            239-355             AC127556.4         38052-38168
            356-401             AC127556.4         48606-48651
            402-477             AC127556.4         53992-54067
            478-603             AC127556.4         54516-54641
            604-635             AC127556.4         55385-55416
            636-733             AC127556.4         55687-55784
            734-797             AC127556.4         57534-57597
            798-870             AC127556.4         64061-64133
            871-979             AC127556.4         65036-65144
            980-1689            AC127556.4         65909-66618
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1689
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="membrane anchored junction protein"
                     /db_xref="GeneID:622554"
                     /db_xref="MGI:MGI:1923913"
     exon            1..238
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            239..355
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1025
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="membrane-anchored junction protein isoform 1"
                     /protein_id="NP_001159391.1"
                     /db_xref="CCDS:CCDS50364.1"
                     /db_xref="GeneID:622554"
                     /db_xref="MGI:MGI:1923913"
                     /translation="MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVI
                     VQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWERVSHLKFKHGESILTPYPFVFT
                     LYIEMKWFAEDLPSGKPADDIPLELVLAETEAEEATMRKWKRKLMEEPSSPSRQGPHR
                     AKMETSSEASSNKKPLKESKRSTDEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVV
                     PPLQHSSPPPPKEPGARGFLGFLSALFPFRYFFKKSGQ"
     exon            356..401
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            402..477
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..603
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            604..635
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            636..733
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            734..797
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            798..870
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            871..979
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1689
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1689
                     /gene="Majin"
                     /gene_synonym="1700123I01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggaagttcc aaggcttcgc ttgtgcacat caagctaaag gccgagttca gaggagaccg
       61 acgagaacct gagtccctgg cccgcagtct tttgacttcg acgtcctctc ttggaaaaaa
      121 aaaaaagatt tctgagcaga aagtcaagcg tggccacctt tctgaggtgc tggaggaacc
      181 ctagtcagtg tgcgagcgac aagtgtggct gtcagcgcct gagcgcttcg aggctgaggc
      241 tgccgtcaaa aacaatgagt ttaaaaccat tcacctaccc atttccagag acaaggttcc
      301 ttcatgcagg acccaatgtg tataagttca aaatcagata tggcaacagt atcagaggag
      361 aagaaataga ggataaggaa gtcatcgtcc aggagctgga ggattctatc cgtgcagtct
      421 tggcaaacat ggacagcctg caaccctttg ttacagaaca cttcattgta tttccctata
      481 aaagcaagtg ggagagagtt tcccacctga agtttaaaca tggggaaagc atcctgacgc
      541 cctacccgtt tgtttttact ttgtatatag agatgaaatg gtttgctgaa gacttgcctt
      601 ccgggaaacc agcagatgat attcctcttg agttggtcct agctgagacg gaagcagaag
      661 aagccacaat gaggaaatgg aaacggaaac tcatggagga gcccagctcc cctagcaggc
      721 aggggccaca cagggccaag atggagactt ctagtgaagc ttccagcaac aagaagcctc
      781 tgaaggagag caagaggagc acggacgaag aagcccagca ggaatatcag gacaccccag
      841 cttctaatgc cattgctgtc aaggaacagg atgctgcgtt ggggcatggc ctgcaagggt
      901 tggttgtccc tccactgcaa catagcagtc caccaccccc gaaagagcca ggagccagag
      961 gcttcttggg gtttctaagt gctctcttcc cgttccggta cttcttcaag aagagcggtc
     1021 agtgagcctt ccaggaccac agcacgcgtg gggcaggggt cagcatagaa gagatgtcct
     1081 cctgcagtaa ctccccggag ctaccacacc tctcttgctt ttgttttctt ttgtcttgca
     1141 tttattttga gacaagtgtt attgtataca gcccaggctg gcttcagtct gtgcctctgc
     1201 tcccggtgca ctcccacgtg ccatcctttt ctcctgaccc cggtcacggg gacaagggca
     1261 ccaggccggg tcctcacatg agtttatcct cttgtttgcc tttggtgttt cctatccaaa
     1321 ccagtaagaa cgaggctaga gagatggtag ttgagtgcac actgatagtg cagagggcct
     1381 gagtttggtt ctcagtaccc atggcaagca acctgcaact ccagctctat caggatggcc
     1441 tggcgctttc tggcctctgc agaaacttac gccccgcacg ccctgcaccc tcgtaatcgg
     1501 aagagcaaga caaaacaata ctaagaaggg ccagaaaggc ggcttgataa agcatctgca
     1561 gccagacctg acagcctgag ttcagcctcc atgtatgtgc accatggcat gtgccccaca
     1621 cagaataaaa tgtactttta ttaaaaactt caaaataaat aagtaaataa aacgctataa
     1681 agaattcta
//
