LOCUS       NM_001081181            3602 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus matrix AAA peptidase interacting protein 1 (Maip1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001081181 XM_283579
VERSION     NM_001081181.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161493.6 and AK079116.1.
            
            On Feb 5, 2019 this sequence version replaced NM_001081181.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071241.1, SRR7345562.1199353.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AC161493.6         147549-147830
            283-1607            AK079116.1         3-1327
            1608-3602           AC161493.6         157242-159236
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.79 cM"
     gene            1..3602
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /note="matrix AAA peptidase interacting protein 1"
                     /db_xref="GeneID:68115"
                     /db_xref="MGI:MGI:1915365"
     exon            1..957
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..1383
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /note="m-AAA protease-interacting protein 1,
                     mitochondrial"
                     /codon_start=1
                     /product="m-AAA protease-interacting protein 1,
                     mitochondrial precursor"
                     /protein_id="NP_001074650.1"
                     /db_xref="CCDS:CCDS48266.1"
                     /db_xref="GeneID:68115"
                     /db_xref="MGI:MGI:1915365"
                     /translation="MALAARLLPLPLLSRPLPGPVTRLRTLGSTEVRLTLTEICCLCR
                     RRLGSSAAPIPRYTRAWTSPALRSWSSRRSLLGRVEHPPALASLPASPSRSYSTEEQP
                     QQRQRTRMIILGFSNPINWVRTRIYAFLIWAYFDKEFSIAEFSEGAKQAFAYVSKLLS
                     QCKFDLLEELVAKEVLQILKEKVTSLSDNHKNALAADIDDIVYTSTGDISIYYDEKGR
                     KFVNILMCFWYLTSANIPSESLSGANVFQVKLGDQSVETKQLLSASYEFQREFTQGVK
                     PDWTIARIEHSKLLE"
     exon            958..1029
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1156
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1304
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..3602
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1554
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /note="major polyA site"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3602
                     /gene="Maip1"
                     /gene_synonym="9430016H08Rik"
ORIGIN      
        1 cccttgacag cagagcgcct tctcttcccc cgaacaatct ctgggttgca ggagagcaga
       61 tgggccgcca gaaggtaccg gggtgtctcc cctgcctttc cgcggcgggc ctcctcacct
      121 gtggataaag atgctccatg aactgctccc gggagacgcc ccgcagccgg ggtaccggaa
      181 gacgctgctc agccatggtg aaattcacag gcctgggaat ttggacgagt tcttccacgc
      241 gtgatttccc ctggaaacac tactccggaa gaaatggtcc gcgtaggtga ctgaccccag
      301 agggcggcgg ctggttcgaa gtgcgcacgg cggggagccc gagggcttcg gcctgggctg
      361 agggctaaca cagccgaaat gagaggactc acccgaggcg gcggcagcga ggcggccttg
      421 gctccacttc tccaaccccg gcgagctggt ttccctccgg cctgctttca gtactgcaca
      481 ggcatgcaga ggtgaaaggt cacaaacatg gcgctggccg cccgtctcct acctctgccc
      541 ctgctttccc ggccgctgcc cggcccggtc acccgactcc ggactctcgg tagcaccgag
      601 gtgaggctga cgctgactga aatttgctgc ctgtgccgcc gtcgcctggg ctcaagcgcg
      661 gctccgatcc ctcgctacac tcgggcctgg acaagccctg cgttgcgttc ctggagctcc
      721 cgaagatccc ttctcggccg ggtagaacat cctccagccc tcgcttcttt acccgctagt
      781 cccagccgca gctacagcac cgaggagcag ccccagcaac gccagagaac cagaatgatc
      841 attctgggat tttccaatcc catcaactgg gtccggactc gaatttacgc cttccttatt
      901 tgggcctatt tcgacaaaga gttcagtatc gctgagttct ctgaaggggc gaagcaggct
      961 tttgcttatg tatccaagtt gctgtcacag tgtaaatttg atctattgga agaacttgta
     1021 gccaaagagg tgctacagat attaaaagaa aaagttactt cattgtctga taaccataag
     1081 aatgcacttg ctgcagacat agatgacatt gtctacacat caacaggcga tatctccatt
     1141 tactatgatg agaaaggaag gaagtttgtg aacatcctga tgtgcttttg gtatctgact
     1201 agtgccaaca tccccagtga gtctttaagt ggagccaatg tgttccaggt gaagctgggg
     1261 gatcagagtg tggaaactaa acagctgctc agtgcaagct atgaatttca gagggaattc
     1321 acacaaggag taaagcctga ttggacgatt gcgcggattg aacactccaa gttactagaa
     1381 taatctttct tggaaaaaaa aatcagggcg tgaactctta ataattgctg tgaaaaacta
     1441 aggaagacaa gtttctggat gatttgattt taacttaatt aagtctgtgg attacttttg
     1501 tattatttgg aaatactcag tatattgacc taatacaata aaacattttc cacagattgc
     1561 tagtgttctt taaaggaggt caaagtaaaa cacaaaacta cagcaccaca ttggtgtcct
     1621 gtttaatatc attctaaact acacatgtat atatgtaaaa cacagaacga cagcaccaca
     1681 ttggtgtcct gctgagtgtc attcaaatgt tttatatgaa catgtgtcac agactagttt
     1741 tatacatgtg aattattgaa actactgtat atctctaatg atccaagttt ctgcaagatt
     1801 tctacaagcc actgagccta gtatgtttga ttatctggat agtgatccag ataaggactg
     1861 ggtagaacca tagcagcttg acctctgtag gacatccatg tttgtttact gttcacagta
     1921 gtgatgaaat ggagccagcc tagatgtcca tcagcaagca ctagaataca tgaagaaaat
     1981 gtggcacata aacacagtgg gcatttattt agctgtaagg aagagtgaaa tcatgtgaag
     2041 aaagtgaatg agctggagat aaatctgtta agtgaaatga gtcagacgta gacagtgatt
     2101 gcatagctta tattgtggag tctaaacttt aattcttgtg cgtcagggaa ggccatgaga
     2161 gtagaacgga acgggtacta aacgaggagc ggaggagatg ttggggggag gaggataata
     2221 gagtacttac taccttttta gaaaaatgaa tgtgacagaa ggcttttaga aactataaac
     2281 agatttgtta ttaatagata tgtttcagaa ttgctaagga cctctggaca aaatgaactt
     2341 cagaaataga accatatata tatgggacaa gtaatcttta ccaaggtatc agagtaattc
     2401 aataaggaaa gaatgttaaa caaatgcaac aactgatact catacaggat aagggcttta
     2461 caaaatggac aatggactta aaagccaaaa gtagagattc tagaaagaag cgagagaaat
     2521 gtttgctgcc ttggataggc agagttcttt gggggagaag gaggggaggg gtgcagacag
     2581 taatcataag caggaaagtc tcaatcaagg tgaaattgct ctctgaaaga caggttgtga
     2641 ggaaatgtgt gtatcttgca aaggcataac cagaatgcat aagtaaccct tacagctgaa
     2701 tagtgacatg ctaaacagtg tggccgatgc taggcagaca atttgaagtc aattgcttca
     2761 taacactaat taatatagct gtaccccagt catctggaat tatattctag tgacacgaac
     2821 ttactaagac agctaatgac aactgctgct ttagtcttta tgtcaattgc ataaccacac
     2881 tgggtgtgtg tgtcctctgg ctttattttt gggtcagttc ttcaggtaca agtggctgca
     2941 tctggtgatg gccttcttag aggactttac ctggagcacc tgggaatacc tctctgatcc
     3001 tttacaagct accaggaagt catggtccca ccctaatgac ctcattcaaa gacctgcctc
     3061 caaatactat tgcttaaatt tcactttctt cataaactac aatagggatc aggttaccat
     3121 gcataaagct cttgagagca ttcagaccac gtgccaacca acaaaactga taccaactgg
     3181 tgaagactta gagtaactgg agtttgtgta tattgctcat atgatggcaa aaaatagtgc
     3241 aggcactttg gaaaagagtt tggtagcttc ttcttaaata aagacttacc ataggatctc
     3301 tggtagtttg aatgacaaat atcctgtata ggttcatgta ctaaacactt atccccagtc
     3361 aatgacattt ggaaaggtat gaacaaaggg agatgccgaa ccttagagga aggccatcac
     3421 ctggaccggc tctgagagtt tctaacatca ttccacttct ggctctctct ctttcatgtt
     3481 tgaaaatgat ctctcagctt tctgctctgg ctgccttctg tccttccctc tcccaacaca
     3541 cataccatta tggactccct ctgaaactgt aagccaaaat aaactcttgt agccaaaaga
     3601 aa
//
