LOCUS       NM_001190409            4427 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus magnesium transporter 1 (Magt1), transcript variant 1,
            mRNA.
ACCESSION   NM_001190409
VERSION     NM_001190409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4427)
  AUTHORS   Gotru,S.K., Mammadova-Bach,E., Sogkas,G., Schuhmann,M.K.,
            Schmitt,K., Kraft,P., Herterich,S., Mamtimin,M., Pinarci,A.,
            Beck,S., Stritt,S., Han,C., Ren,P., Freund,J.N., Klemann,C.,
            Ringshausen,F.C., Heemskerk,J.W.M., Dietrich,A., Nieswandt,B.,
            Stoll,G., Gudermann,T. and Braun,A.
  TITLE     MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and
            Accelerates Arterial Thrombosis and Ischemic Stroke in Mice
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (8), 1494-1509 (2023)
   PUBMED   37381987
  REMARK    GeneRIF: MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis
            and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
REFERENCE   3  (bases 1 to 4427)
  AUTHORS   Zocchi,M., Locatelli,L., Zuccotti,G.V., Mazur,A., Bechet,D.,
            Maier,J.A. and Castiglioni,S.
  TITLE     Magnesium Homeostasis in Myogenic Differentiation-A Focus on the
            Regulation of TRPM7, MagT1 and SLC41A1 Transporters
  JOURNAL   Int J Mol Sci 23 (3), 1658 (2022)
   PUBMED   35163580
  REMARK    GeneRIF: Magnesium Homeostasis in Myogenic Differentiation-A Focus
            on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4427)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   5  (bases 1 to 4427)
  AUTHORS   Gotru,S.K., Gil-Pulido,J., Beyersdorf,N., Diefenbach,A.,
            Becker,I.C., Vogtle,T., Remer,K., Chubanov,V., Gudermann,T.,
            Hermanns,H.M., Nieswandt,B., Kerkau,T., Zernecke,A. and Braun,A.
  TITLE     Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B
            Cells Dysregulates B Cell Development and Signaling in Mice
  JOURNAL   J Immunol 200 (8), 2529-2534 (2018)
   PUBMED   29581357
REFERENCE   6  (bases 1 to 4427)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   7  (bases 1 to 4427)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 4427)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Identification and characterization of a novel mammalian Mg2+
            transporter with channel-like properties
  JOURNAL   BMC Genomics 6, 48 (2005)
   PUBMED   15804357
  REMARK    GeneRIF: identifed a novel gene that encodes a protein involved
            with Mg2+-evoked transport, MagT1; results suggest that MagT1 may
            provide a selective and regulated pathway for Mg2+ transport in
            epithelial cells[MagT1]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4427)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672288.5 and AL670660.8.
            
            On Dec 29, 2018 this sequence version replaced NM_001190409.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.177318.1,
                                           SRR13948564.1823284.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AL672288.5         21714-21854         c
            142-311             AL672288.5         6874-7043           c
            312-429             AL672288.5         2450-2567           c
            430-570             AL670660.8         179247-179387       c
            571-711             AL670660.8         178828-178968       c
            712-801             AL670660.8         174223-174312       c
            802-865             AL670660.8         173567-173630       c
            866-940             AL670660.8         169263-169337       c
            941-1031            AL670660.8         164042-164132       c
            1032-4427           AL670660.8         157941-161336       c
FEATURES             Location/Qualifiers
     source          1..4427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.36 cM"
     gene            1..4427
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /note="magnesium transporter 1"
                     /db_xref="GeneID:67075"
                     /db_xref="MGI:MGI:1914325"
     exon            1..141
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            142..311
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..429
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            430..570
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            571..711
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            712..801
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            802..865
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            866..940
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1031
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..4427
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /note="hexamer: AATAAA"
     polyA_site      4427
                     /gene="Magt1"
                     /gene_synonym="2410001C15Rik; 2610529C04Rik;
                     2810482I07Rik; IAG2; IAP"
                     /note="major polyA site"
ORIGIN      
        1 aagaaagttt cgccccgccg ccaagagaga agcgtgaaca tggcctcgcc aaggtggttc
       61 tggtctgtgt gtgcgatcgc agcggtggca ctgctgctcg tttccaaggt tccttcggcc
      121 tctgcccaaa gaaagaagga gatggtgtta tctgagaagg ttagtcagct gatggaatgg
      181 gccaataaga gacctgtaat aagaatgaat ggagacaagt tccgtcgtct tgttaaagct
      241 ccaccgagaa attactcagt tgtcgtcatg tttactgctc tccaacttca tagacaatgt
      301 gtcgtttgca agcaagctga tgaagaattc cagattttgg caaattcttg gcgatactcc
      361 aatgcattta ccaacaggat attttttgcc atggtggatt ttgatgaagg ctcagatgta
      421 tttcaaatgc taaacatgaa ttcagctcca actttcatca actttcctcc gaaaggaaaa
      481 cccaaaaggg ctgatacata tgagttgcag gtgcgagggt tttcagctga gcagattgcc
      541 cggtggattg cagacagaac tgatgtcaac attagagtaa ttagacctcc aaattatgct
      601 ggacccctaa tgttgggact gctgctggct gttattggtg gacttgtgta tctgcgaaga
      661 agcaatatgg agttcctctt taataaaact ggatgggctt ttgcagcttt gtgttttgta
      721 cttgctatga catctggcca aatgtggaac catataagag gaccaccata tgctcataaa
      781 aatccccaca caggacacgt gaattacatc cacgggagca gccaggccca gtttgtagct
      841 gaaacccaca tcgttcttct attcaatggt ggggttacct taggaatggt gcttttatgt
      901 gaagctgcta cctctgacat ggatattggg aagcgaagga tgatgtgtat tgctgggatt
      961 ggactcgttg tgttattctt cagttggatg ctctctatct ttcgatcaaa ataccatggc
     1021 tatccataca gctttctgat gagttaaaga ggattccaga gaaacattga cactggtaat
     1081 ggaaactgaa aaataaaaac tatttggtgt ttgaagaatg caactcacat attttatatt
     1141 acctcttttt gtcaagtgat ctaagtagtt aatcattaaa ccaaagatgt gtagtgcctt
     1201 aacaagcagt tgtaaagatc atgaagtgtt tggaattgtg ctcctcctaa ccttcccttc
     1261 ccaatgaact taggaaacat ttggggtttg tagtattaag tactttataa acatttaaaa
     1321 ctactacttc attttactta gagaaaaact caaaactact atagttaact tgattttatc
     1381 tcatctaagg ttggggatgg aaggttctga gcaggaatct ccacctctgc ctattgcaaa
     1441 caactgcatc tggaagccat tgttcctttt ccttctttgt gcagatgtgt gtgctttaca
     1501 gacctttcct cttgggccca ggtatcatat acactgtgtc atctgaaaat ggaccgtgtc
     1561 gcctttggaa agatacatgt cttcctgtgt ctttccacct gaaatcagct acatatatgc
     1621 ctccttttac acattcagaa gtacctctaa ctaaagacta tgatttgtgc atgagtgtgc
     1681 tataactacc ttgtacatgg aaagatttct cattctgttt ctagttttat ttaaagtagc
     1741 ccttctctaa caataatagt ttcttgctaa aaatcagtat aacttataaa tggtctcaaa
     1801 tgtttgtgta agttacgcat tgttattgat ttcattctta tgtaacagaa aaataagctg
     1861 agttgtgttc atggaaagga ctcccttaga agaatgagaa aacacaatca tgaaatactg
     1921 atttgttgcc taggtacaga aatgaaatgg tttgccaggc tgtggtagat gaaggctgag
     1981 ctctgtgagt ttgtggtcag cctgggctac atagtgagac cctgtatcca ggggaaaaga
     2041 aaaaaaaagg aaggaaggaa gaaaagtagc atgttttcaa gctgaggctg gggctcagag
     2101 gtatagtgct tgcctagcaa gagttacact ctgtgttcaa tcccaatgcc ttagaaagat
     2161 ttcttgaaac ctggtctgtg aatttttcct tgttttgata aggactgttc cttgaaacct
     2221 ggtcttttgt tttttaaaac acatgttcgt aaaacatggg gctatttttt taaaataagt
     2281 gtttcttgaa acctattatg gctcttgttt tcatttttgt ttttgtgtgc cggttttcta
     2341 aaagcaatgt tcttgaaacc tgtctttgag acagagctct cgctgctctt acctctctta
     2401 gggagagctg tcccgccttc agctcacatt catcctcctg tctcagcttc tcaagtgctg
     2461 gggttgcagg cttgtgccac cattgactgt aatctgcttt tgctatcagt ttagcttttt
     2521 atttaccccg tcaattagag atacaaagaa tggtagcagg cacctgcctc tgctcttagc
     2581 taccctgctg gctgaagtag aatccaagaa gaccaagaac ttgacacatt ctggcatcat
     2641 attaacacct catctcaaaa atatgtcaga aaagaaaact atgaagggat tttgtttgaa
     2701 ttttatcttt ttttcctggt agtgaaaata accatatatg ctaaccagtt ttctatgagg
     2761 aatatttaaa tcatggttat aatatggctg actctggctt tcaccatagt tattaagaat
     2821 aatccaggga gctggagaga tggctcagtg gttaagagca ctgactgctc ttcctaaggt
     2881 cctgagttca aatcccagca accacatggt ggctcatagc tatccataat gagatctgat
     2941 gccctcttct ggtgtgtctg aagacagcta cagtgtctta catataacaa taaataaatc
     3001 tttaaaaaaa aataggtttg ccagggctaa agagatggct cagtggttaa gagcactgac
     3061 tgctcttcca gagatcatga gttcaattcc cggcaaccac atggtggctc acaaccctct
     3121 gtaatggaat ctgatgcctt cttctggtgc acctgaagat agctacagtg tacttacata
     3181 ctgtacatta aataaataaa taaataaatg atccaaaatg ctactgttaa gaaagtgtac
     3241 tcttaggccg ggcagtggtg gcgcacacct ctaaccccag cacttgggag gcagaggcag
     3301 gcggatttct gagttccagg acagccaggg ctatagagag aaaccctgtc tcaaaaaaga
     3361 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     3421 aagaaagaaa gaaagagaga gagaaggcag gaggcttgga gtggagctca gtgctagagc
     3481 acttaaaagg ctgtgggttc aatcccaaat accacaaaaa tctaggaatg taactgaaaa
     3541 atggaaagac atattagaaa ctacatttaa aatatagaca tggatatgtg actgagttga
     3601 tacagtgctt gcctagccat gggttcaaac cacaacatca cataagccgg gtatgggtgt
     3661 aagcacatgt gtgttatccc agtgcactcg ggagacagat gggaaccaga agttcaccct
     3721 catccttgag catagcgtga gtataaggcc aacctgagct acataaagac tctatcccaa
     3781 agacaaaaca aaaaacaaga aaagatactg tgactattcc ctgctattga tcatgcaata
     3841 gccttcccat gtcttatata atggagttta tagaaagaga tggacataat tgacccagga
     3901 aaaaaatttg ggggtgattt gttgtggttg ctacaaattt gatgactaga aggatcattc
     3961 cttgtaaatt gagtgattct taatttctta tctgctattc atgtacttgt ctctgccaaa
     4021 tgaatttacg ctgtgattct taggaaacta gtgtgaagac ttgtcaagtt gaactgggca
     4081 acactcctac tgtgttatct ctagctgctg gtgcctcccg tggccagtgt tttgtgtgtt
     4141 ttctccttgt ttaagagcaa cattcttgta tggagaaagg cttgctctgg ctaaaatctg
     4201 tgaaaagcag attttctcat ttaaaatagt gttacttttg tggaaatttt aaatttagct
     4261 tttatctgaa gtgccttaag tagattctta atttactttt ctagtactgg tttgaatata
     4321 attcattatg tatttttaat atactgttca aaaatgatac atactatagc aaagataacc
     4381 aaatgtctgg cttactgctt tctgtcaata aacttttaca atctaaa
//
