LOCUS       NM_025564                766 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mago homolog B, exon junction complex core component
            (Magohb), transcript variant 1, mRNA.
ACCESSION   NM_025564
VERSION     NM_025564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 766)
  AUTHORS   Li,L., Ruan,X., Wen,C., Chen,P., Liu,W., Zhu,L., Xiang,P.,
            Zhang,X., Wei,Q., Hou,L., Yin,B., Yuan,J., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     The COMPASS Family Protein ASH2L Mediates Corticogenesis via
            Transcriptional Regulation of Wnt Signaling
  JOURNAL   Cell Rep 28 (3), 698-711 (2019)
   PUBMED   31315048
REFERENCE   2  (bases 1 to 766)
  AUTHORS   Gong,P., Zhao,M. and He,C.
  TITLE     Slow co-evolution of the MAGO and Y14 protein families is required
            for the maintenance of their obligate heterodimerization mode
  JOURNAL   PLoS One 9 (1), e84842 (2014)
   PUBMED   24416299
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 766)
  AUTHORS   Singh,K.K., Wachsmuth,L., Kulozik,A.E. and Gehring,N.H.
  TITLE     Two mammalian MAGOH genes contribute to exon junction complex
            composition and nonsense-mediated decay
  JOURNAL   RNA Biol 10 (8), 1291-1298 (2013)
   PUBMED   23917022
  REMARK    GeneRIF: findings show 2 genes MAGOH and MAGOHB are expressed in
            mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA
            increases after LPS stimulation; both MAGOH proteins interact with
            other exon junction complex (EJC) components, incorporate into
            mRNA-bound EJCs and activate nonsense-mediated decay
REFERENCE   4  (bases 1 to 766)
  AUTHORS   Ladopoulos,V., Hofemeister,H., Hoogenkamp,M., Riggs,A.D.,
            Stewart,A.F. and Bonifer,C.
  TITLE     The histone methyltransferase KMT2B is required for RNA polymerase
            II association and protection from DNA methylation at the MagohB
            CpG island promoter
  JOURNAL   Mol Cell Biol 33 (7), 1383-1393 (2013)
   PUBMED   23358417
  REMARK    GeneRIF: Reexpression of KMT2B was sufficient to reinstate an
            active MagohB promoter.
REFERENCE   5  (bases 1 to 766)
  AUTHORS   Bono,F. and Gehring,N.H.
  TITLE     Assembly, disassembly and recycling: the dynamics of exon junction
            complexes
  JOURNAL   RNA Biol 8 (1), 24-29 (2011)
   PUBMED   21289489
  REMARK    Review article
REFERENCE   6  (bases 1 to 766)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
REFERENCE   7  (bases 1 to 766)
  AUTHORS   Depatie,C., Lee,S.H., Stafford,A., Avner,P., Belouchi,A., Gros,P.
            and Vidal,S.M.
  TITLE     Sequence-ready BAC contig, physical, and transcriptional map of a
            2-Mb region overlapping the mouse chromosome 6 host-resistance
            locus Cmv1
  JOURNAL   Genomics 66 (2), 161-174 (2000)
   PUBMED   10860661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008200.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025564.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is also supported by available conservation
            data. The use of an alternative upstream start codon would result
            in a protein that is 2 aa longer.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008200.1, BY708153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               AK008200.1         3-768
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..766
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /note="mago homolog B, exon junction complex core
                     component"
                     /db_xref="GeneID:66441"
                     /db_xref="MGI:MGI:1913691"
     exon            1..173
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..526
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein mago nashi homolog 1-related; protein mago nashi
                     homolog 2; mago nashi protein; mago-nashi homolog B;
                     mago-nashi homolog, proliferation-associated, related
                     sequence 1"
                     /codon_start=1
                     /product="protein mago nashi homolog 2 isoform 1"
                     /protein_id="NP_079840.2"
                     /db_xref="CCDS:CCDS39670.2"
                     /db_xref="GeneID:66441"
                     /db_xref="MGI:MGI:1913691"
                     /translation="MSMGSDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKN
                     DVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFT
                     TSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI"
     exon            174..232
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..343
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..426
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..766
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      628..633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /note="hexamer: AATATA"
     polyA_site      642
                     /gene="Magohb"
                     /gene_synonym="2010012C16Rik; Mago; Magoh; Magoh-rs1"
                     /note="major polyA site"
ORIGIN      
        1 tgcctgcgcc cgtgacgtca ctacctcgcg ccggcggcac gttggccccg cggtatagcg
       61 ggctttaccg agggtaaaaa tgtctatggg tagtgatttc taccttcgct actacgtcgg
      121 gcataagggc aagtttgggc acgagttttt ggagttcgag tttcggccgg acgggaagct
      181 tagatatgcc aacaacagta attataaaaa tgacgtgatg atcagaaaag aggcctatgt
      241 ccacaagagt gtaatggaag aactgaagag aattattgac gacagtgaaa ttacaaaaga
      301 ggacgacgct ctgtggccac cccctgacag ggttgggcgg caggaacttg aaatcgtaat
      361 tggggatgaa cacatttctt ttaccacgtc aaaaataggt tctcttattg atgtaaatca
      421 gtcaaaggat cctgaaggcc ttcgtgtatt ttactatttg gtacaagact tgaaatgctt
      481 agtgttcagc ctcattggtc tacacttcaa gattaagcca atttgaatgg gatgtttttg
      541 agattattta tatatttaat taaaggaagg gttttctatt ggcaattttg ggatttttat
      601 gaatgtgaaa cttttatata taaactcaat atatgaaaaa aacccaggtt acatggtttt
      661 tatttcttgg ctccacatgg aatagacagt ttctatatat aattgattct gtaaataaaa
      721 gccatttttt gttgaaattt tgctctaata aaatgtacca aagcct
//
