LOCUS       NM_001282737             692 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus mago homolog, exon junction complex core component
            (Magoh), mRNA.
ACCESSION   NM_001282737 NM_010760
VERSION     NM_001282737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 692)
  AUTHORS   Sheehan,C.J., McMahon,J.J., Serdar,L.D. and Silver,D.L.
  TITLE     Dosage-dependent requirements of Magoh for cortical interneuron
            generation and survival
  JOURNAL   Development 147 (1) (2020)
   PUBMED   31857347
  REMARK    GeneRIF: findings implicate Magoh as a crucial regulator of
            interneuron development
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 692)
  AUTHORS   Blazquez,L., Emmett,W., Faraway,R., Pineda,J.M.B., Bajew,S.,
            Gohr,A., Haberman,N., Sibley,C.R., Bradley,R.K., Irimia,M. and
            Ule,J.
  TITLE     Exon Junction Complex Shapes the Transcriptome by Repressing
            Recursive Splicing
  JOURNAL   Mol Cell 72 (3), 496-509 (2018)
   PUBMED   30388411
REFERENCE   3  (bases 1 to 692)
  AUTHORS   Mao,H., Brown,H.E. and Silver,D.L.
  TITLE     Mouse models of Casc3 reveal developmental functions distinct from
            other components of the exon junction complex
  JOURNAL   RNA 23 (1), 23-31 (2017)
   PUBMED   27780844
REFERENCE   4  (bases 1 to 692)
  AUTHORS   Mao,H., McMahon,J.J., Tsai,Y.H., Wang,Z. and Silver,D.L.
  TITLE     Haploinsufficiency for Core Exon Junction Complex Components
            Disrupts Embryonic Neurogenesis and Causes p53-Mediated
            Microcephaly
  JOURNAL   PLoS Genet 12 (9), e1006282 (2016)
   PUBMED   27618312
  REMARK    GeneRIF: we first show that Eif4a3 haploinsufficiency phenocopies
            aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant
            mice.we show that genetic ablation of one downstream pathway, p53,
            significantly rescues microcephaly of all 3 EJC mutant
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 692)
  AUTHORS   Pilaz,L.J., McMahon,J.J., Miller,E.E., Lennox,A.L., Suzuki,A.,
            Salmon,E. and Silver,D.L.
  TITLE     Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the
            Developing Brain
  JOURNAL   Neuron 89 (1), 83-99 (2016)
   PUBMED   26748089
REFERENCE   6  (bases 1 to 692)
  AUTHORS   Silver,D.L., Watkins-Chow,D.E., Schreck,K.C., Pierfelice,T.J.,
            Larson,D.M., Burnetti,A.J., Liaw,H.J., Myung,K., Walsh,C.A.,
            Gaiano,N. and Pavan,W.J.
  TITLE     The exon junction complex component Magoh controls brain size by
            regulating neural stem cell division
  JOURNAL   Nat Neurosci 13 (5), 551-558 (2010)
   PUBMED   20364144
  REMARK    GeneRIF: Magoh haploinsufficiency causes microcephaly because of
            intermediate neural progenitors depletion and neuronal apoptosis.
REFERENCE   7  (bases 1 to 692)
  AUTHORS   Matera,I., Watkins-Chow,D.E., Loftus,S.K., Hou,L., Incao,A.,
            Silver,D.L., Rivas,C., Elliott,E.C., Baxter,L.L. and Pavan,W.J.
  TITLE     A sensitized mutagenesis screen identifies Gli3 as a modifier of
            Sox10 neurocristopathy
  JOURNAL   Hum Mol Genet 17 (14), 2118-2131 (2008)
   PUBMED   18397875
REFERENCE   8  (bases 1 to 692)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
REFERENCE   9  (bases 1 to 692)
  AUTHORS   Zhao,X.F., Colaizzo-Anas,T., Nowak,N.J., Shows,T.B., Elliott,R.W.
            and Aplan,P.D.
  TITLE     The mammalian homologue of mago nashi encodes a serum-inducible
            protein
  JOURNAL   Genomics 47 (2), 319-322 (1998)
   PUBMED   9479507
REFERENCE   10 (bases 1 to 692)
  AUTHORS   Newmark,P.A., Mohr,S.E., Gong,L. and Boswell,R.E.
  TITLE     mago nashi mediates the posterior follicle cell-to-oocyte signal to
            organize axis formation in Drosophila
  JOURNAL   Development 124 (16), 3197-3207 (1997)
   PUBMED   9272960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134232.1 and AK011512.1.
            
            On Apr 19, 2014 this sequence version replaced NM_010760.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU847701.1, BI154777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               BY134232.1         2-383
            383-692             AK011512.1         322-631
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..692
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /note="mago homolog, exon junction complex core component"
                     /db_xref="GeneID:17149"
                     /db_xref="MGI:MGI:1330312"
     exon            1..191
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..250
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..361
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..444
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..692
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      653..658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /note="hexamer: AATAAA"
     polyA_site      663
                     /gene="Magoh"
                     /gene_synonym="Mago-m; Mos2"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttccg cgcgccacca ttacgccagt ataagacgta gaccgcaggc cgtggtagtg
       61 tcatccgttc ctaaagttcc gtcctccttg tcccttgcga ggcatggaga gtgactttta
      121 cctgcgttac tacgtgggcc acaaaggcaa gttcggtcat gagttcctgg agtttgaatt
      181 ccgacctgac ggtaaattgc gatacgccaa caacagcaat tacaaaaatg acgtcatgat
      241 caggaaagag gcttatgtgc ataaaagtgt gatggaagag ttaaagagaa ttattgatga
      301 cagtgaaatc accaaagaag atgatgctct gtggccccct cctgatcgcg tgggccggca
      361 ggagcttgaa attgtcattg gagatgaaca catttctttc acaacatcaa aaattggttc
      421 ccttattgat gtcaaccagt ccaaggatcc ggaaggcttg cgagtatttt attatcttgt
      481 ccaggacctg aagtgtttag tcttcagtct gattggatta cacttcaaga ttaaaccaat
      541 ctagatattg gatattgtgg acacaaggcg ggtgggagtt tttagttacc ataattagga
      601 ttttttttct gtatattggg gcaattttta taaacaataa atgatgatct ttaataaatg
      661 cgataacatc tttttttgtt atttttctaa ac
//
