LOCUS       NM_001159354            6581 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus membrane associated guanylate kinase, WW and PDZ
            domain containing 3 (Magi3), transcript variant 1, mRNA.
ACCESSION   NM_001159354
VERSION     NM_001159354.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6581)
  AUTHORS   Wang,H., Yang,W., Qin,Q., Yang,X., Yang,Y., Liu,H., Lu,W., Gu,S.,
            Cao,X., Feng,D., Zhang,Z. and He,J.
  TITLE     E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor
            for chemotherapy response in colorectal cancer
  JOURNAL   Mol Cancer 21 (1), 151 (2022)
   PUBMED   35864508
  REMARK    GeneRIF: E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a
            predictor for chemotherapy response in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6581)
  AUTHORS   Matsuzawa,K., Ohga,H., Shigetomi,K., Shiiya,T., Hirashima,M. and
            Ikenouchi,J.
  TITLE     MAGIs regulate aPKC to enable balanced distribution of
            intercellular tension for epithelial sheet homeostasis
  JOURNAL   Commun Biol 4 (1), 337 (2021)
   PUBMED   33712709
  REMARK    GeneRIF: MAGIs regulate aPKC to enable balanced distribution of
            intercellular tension for epithelial sheet homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6581)
  AUTHORS   Adam,M.G., Berger,C., Feldner,A., Yang,W.J., Wustehube-Lausch,J.,
            Herberich,S.E., Pinder,M., Gesierich,S., Hammes,H.P., Augustin,H.G.
            and Fischer,A.
  TITLE     Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1
            and DLL4 and inhibits sprouting angiogenesis
  JOURNAL   Circ Res 113 (11), 1206-1218 (2013)
   PUBMED   24025447
REFERENCE   4  (bases 1 to 6581)
  AUTHORS   Franklin,J.L., Yoshiura,K., Dempsey,P.J., Bogatcheva,G.,
            Jeyakumar,L., Meise,K.S., Pearsall,R.S., Threadgill,D. and
            Coffey,R.J.
  TITLE     Identification of MAGI-3 as a transforming growth factor-alpha tail
            binding protein
  JOURNAL   Exp Cell Res 303 (2), 457-470 (2005)
   PUBMED   15652357
  REMARK    GeneRIF: MAGI-3 has a role in efficient trafficking of TGFalpha to
            the cell surface in polarized epithelial cells.
REFERENCE   5  (bases 1 to 6581)
  AUTHORS   Wright,G.J., Leslie,J.D., Ariza-McNaughton,L. and Lewis,J.
  TITLE     Delta proteins and MAGI proteins: an interaction of Notch ligands
            with intracellular scaffolding molecules and its significance for
            zebrafish development
  JOURNAL   Development 131 (22), 5659-5669 (2004)
   PUBMED   15509766
REFERENCE   6  (bases 1 to 6581)
  AUTHORS   Yao,R., Natsume,Y. and Noda,T.
  TITLE     MAGI-3 is involved in the regulation of the JNK signaling pathway
            as a scaffold protein for frizzled and Ltap
  JOURNAL   Oncogene 23 (36), 6023-6030 (2004)
   PUBMED   15195140
REFERENCE   7  (bases 1 to 6581)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 6581)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122324.4, AC129293.9 and AC162922.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.9500213.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-762               AC122324.4         117508-118269
            763-879             AC129293.9         155874-155990       c
            880-999             AC129293.9         145208-145327       c
            1000-1209           AC129293.9         139602-139811       c
            1210-1387           AC129293.9         135351-135528       c
            1388-1467           AC129293.9         130280-130359       c
            1468-1525           AC129293.9         111775-111832       c
            1526-1620           AC129293.9         106656-106750       c
            1621-1809           AC162922.4         244665-244853       c
            1810-2415           AC162922.4         241116-241721       c
            2416-2447           AC162922.4         239467-239498       c
            2448-2604           AC162922.4         237179-237335       c
            2605-2696           AC162922.4         233535-233626       c
            2697-2889           AC162922.4         228860-229052       c
            2890-3072           AC162922.4         224329-224511       c
            3073-3258           AC162922.4         218121-218306       c
            3259-3361           AC162922.4         212098-212200       c
            3362-3488           AC162922.4         211260-211386       c
            3489-3632           AC162922.4         210601-210744       c
            3633-3771           AC162922.4         207824-207962       c
            3772-6581           AC162922.4         203582-206391       c
FEATURES             Location/Qualifiers
     source          1..6581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     gene            1..6581
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 3"
                     /db_xref="GeneID:99470"
                     /db_xref="MGI:MGI:1923484"
     exon            1..762
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..4871
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-associated guanylate kinase-related (MAGI-3);
                     membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 3; membrane-associated guanylate
                     kinase inverted 3"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 3 isoform 1"
                     /protein_id="NP_001152826.1"
                     /db_xref="CCDS:CCDS51031.1"
                     /db_xref="GeneID:99470"
                     /db_xref="MGI:MGI:1923484"
                     /translation="MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPY
                     LGRLRDEAGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRL
                     KTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGV
                     DYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDT
                     ESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGSMETREMHSETSDCWMKTVPSY
                     NQTNSSMDFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAK
                     APEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQAEIHSAK
                     TDVERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ
                     DGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVV
                     DIVAATPVINGQSLTKGETCMNTQDFKLGAMVLDQNGKSGQILASDRLNGPSESSEQR
                     ASLASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKE
                     IYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKTKTDTKENSGSLET
                     INEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFG
                     FRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT
                     AARNGHVLLTVRRKIFYGEKQPEDESHQAFSQNGSPRLNRAELPTRSAPQEAYDVTLQ
                     RKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADRCGGLKVGDHISAVNGQSIVD
                     LSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQANHIPG
                     DRIALEGEIGRDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHNQSLGCYPVELERGPR
                     GFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIEL
                     IQAGGNKVLLLLRPGTGLIPDHGDWDTNSPSSSNVIYDEQPPPLPSSHSASTFEESHV
                     PATEDSLTRVQICEKAEELKDTVQEKKSTLNGSQPEMKYQSVHKTMSKKDPPRGSGHG
                     EKSRLKGENGVTRRGRSASPKKSVNRHSEEHLEKIPRPLKSDPKEKSRDRSLSPRKGE
                     SKGRLTIKAGSGQDPNRKDRGRSSSPKKQQKIGGNSLSNTEGKLSEAGSRRAAGHPRD
                     STEQLPDGREKSGVSRKDLKQSQPGKTRTKSPEKKSSKVDETSLPSKKTSSTAGRVVS
                     EKEKGKKPTAGETSRETVEHTQISAKQLKQEAQEKTALGNADDHKGRESEVTDRCRER
                     AGCTPQSSSLVKKAPITPGPWRVPRANKVTGTTGMADKQL"
     exon            763..879
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            880..999
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1209
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1387
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1467
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1525
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1620
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1809
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2415
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2447
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2604
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2696
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2889
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3072
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3258
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3361
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3488
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3632
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3771
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..6581
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5953..5958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /note="hexamer: AATAAA"
     polyA_site      5972
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /note="major polyA site"
     regulatory      6048..6053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /note="hexamer: AATACA"
     polyA_site      6072
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
     regulatory      6488..6493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
                     /note="hexamer: AATATA"
     polyA_site      6512
                     /gene="Magi3"
                     /gene_synonym="4732496O19Rik; 6530407C02Rik; mKIAA1634"
ORIGIN      
        1 gcggggagga ggttgcggcg ggtttgaaag cgccagtttc ctggcagctg gggcaggcgt
       61 tggtctcggc gctccggctc cgcagcagcc gcgctccagc gagcgactaa gctcggtgcg
      121 cgcgtaccga tacgagcctc ggttccagcc gctccctcag ctcccgcccc tttgcctcag
      181 cctttcccgc cgcgcgggcg ccgagtcccg gccgtcggcg ctgaccccgc ccggagaccc
      241 cgccggcgcc gcccgcgggg cgcgcgctcc ctccggctct cctcagcggc ccgcgagagg
      301 ggcggctcgc ggcggcgcgc ggccggcggg ctgaggcggg gggtcgacgg cggcgcccct
      361 ctggccgggc tgtgcgcggg gcccggagcg gcaccgcggc cgcccgcgcg ggggctcccc
      421 atggtgcagc ggaggtcggg atgtcgaaga cgttgaagaa gaagaagcac tggctcagca
      481 aggtgcagga gtgtgcggta tcctgggccg ggcccccggg cgacttgggc gccgagatcc
      541 gcggcggcgc cgagcgcggc gagttccctt acctggggcg gctccgcgac gaggctggcg
      601 gcggcggagg cacctgctgc gtggtctcgg gcaaggcgcc cagtccgggc gatgtgctgt
      661 tggaggtgaa cgggacgccg gtcagtgggc tcaccaaccg ggacactctg gctgtcatcc
      721 gccacttccg cgagcccatc cgtctgaaga cggtgaagcc aggcaaagtt ataaataaag
      781 atttgcgaca ctacctgagt cttcagtttc agaaaggatc aattgaccac aaactacagc
      841 aagtcatcag agataatctc tatttgagaa ccatcccatg cactacaagg gctcccaggg
      901 atggggaagt cccaggggtg gattataact tcatttctgt tgaacaattc aaggcactgg
      961 aagaaagcgg agcattgtta gaaagtggaa cgtatgatgg aaatttctat ggcacaccca
     1021 agcctccagc agagcctagt cctttccagc ccgatccagt tgatcaggtc ctctttgaca
     1081 atgagtttga cacagaatcc caaagaaaaa gaaccacatc tgtcagcaag atggaaagga
     1141 tggacagctc tctccctgaa gaagaagaag atgaggacaa agaagctgtt aatggcagcg
     1201 gaagcatgga aactagagag atgcattctg agacatctga ctgctggatg aagactgttc
     1261 caagttataa ccaaacaaat agctccatgg actttagaaa ttatatgatg agagatgaga
     1321 atctggaacc gctgcccaaa aactgggaaa tggcctacac tgacacagga atgatctact
     1381 tcattgatca taatacgaag acaaccacct ggttggatcc tcgtctctgc aagaaagcca
     1441 aagcccctga agactgtgaa gatggagagc ttccctatgg ctgggagaaa atagaggacc
     1501 ctcagtatgg aacatactac gttgatcacc tcaaccagaa aactcagttt gaaaatccag
     1561 tggaggaagc caagaggaaa aagcagttag gacaggctga aattcattct gcaaaaacag
     1621 atgtggaaag agcacacttt actcgggacc catcccaact taaaggtgta cttgttcgag
     1681 catcgctgaa aaaaagcacc atgggctttg gctttaccat tattggtgga gataggcctg
     1741 atgaatttct acaagtaaaa aacgtgctca aagatggtcc tgccgctcag gatgggaaaa
     1801 ttgcaccagg tgatgttatt gtagacatca atggcaactg tgtccttggt cacacccatg
     1861 cagatgttgt ccagatgttt caactggtac ctgtcaacca gtatgtcaac cttactttat
     1921 gccgtggtta tccacttcct gatgacagtg aagatcctgt tgtggacatt gttgctgcta
     1981 cccctgtcat caatggacaa tctttaacaa agggagagac atgcatgaat actcaggatt
     2041 ttaaactggg agcaatggtt ttggatcaga atggaaaatc aggacaaatc ttggccagtg
     2101 atcgtctcaa tggtccatct gagtcaagtg agcagagggc atctctggca tcatcaggca
     2161 gctcacagcc tgaactagtg actatccctc tgattaaggg ccccaaaggc tttgggtttg
     2221 caattgctga cagcccaact ggacagaagg tgaaaatgat attggatagc cagtggtgtc
     2281 aaggccttca aaaaggggat atcatcaaag aaatttacca tcagaatgtg cagaatttaa
     2341 cacatctcca agtcgtagaa gtcctaaagc agttcccagt aggtgcagat gttccattgc
     2401 ttatcttaag aggaggtcct tgttcaccaa ctaaaactgc caaaacgaaa acagatacaa
     2461 aggaaaattc aggaagtttg gagactataa atgagcctat tccccagcct atgccttttc
     2521 cgcccagcat aatcagatca ggatccccaa aattggatcc ttctgaggtc tacctgaaat
     2581 ctaagacttt atatgaagat aaaccaccaa acaccaaaga tctggatgtc tttcttcgga
     2641 aacaagaatc agggtttggc ttcagggtgc taggaggaga tggacctgac cagtctatat
     2701 atattggggc catcattccc ctgggagcag ctgaaaaaga tggtaggctc cgtgctgctg
     2761 atgaattgat gtgtattgat gggattcctg ttaaaggaaa atcacacaag caagtattag
     2821 acttaatgac tactgctgct cgaaatggac acgtgctact aactgtcagg aggaagatct
     2881 tctatggaga gaaacaaccc gaggacgaaa gccatcaagc cttctcacag aacggatctc
     2941 ctcgcctgaa tcgggcagag cttccaacca ggtctgcccc acaggaggcc tatgatgtca
     3001 ccttacagag gaaagaaaat gaagggtttg gttttgtcat cctcacctct aaaagcaagc
     3061 cgcccccagg agttattcct cataaaattg gccgggtcat agacggaagt ccagctgatc
     3121 gttgtggagg actgaaagtt ggagatcaca tctctgctgt gaatgggcag tccattgtcg
     3181 acctatccca tgataatatt gttcagctca tcaaagatgc tggagtcacc gtcacgctga
     3241 cagtggttgc tgaagaagag catcatggtc caccatcagg aacaaactca gccaggcaga
     3301 gcccagcact acagcacagg cccatgggac aagcacaagc caaccacata cctggggaca
     3361 gaattgccct agaaggtgaa attgggagag atgtctgcag ttcttacaga cattcctggt
     3421 ctgaccataa gcaccttgca cagcctgaca ctgcagtgat ttcagttgtg ggcagtcggc
     3481 acaatcagag ccttggctgt taccctgtgg agctggagag aggccctcga ggctttgggt
     3541 tcagcctccg cggagggaag gagtacaaca tggggctgtt catcctgcgc ctggccgagg
     3601 acgggcccgc catcaaagac ggcaggattc acgttggtga ccagatcgtt gaaatcaatg
     3661 gggaaccgac acaaggcatc acacacactc gagcaattga gctcattcag gctggtggga
     3721 ataaagtcct cctccttctg aggccaggaa ctggcttgat acctgaccac ggtgattggg
     3781 atactaatag tccttcatct tccaatgtca tttatgatga acagccgcca cctctcccat
     3841 cttcacattc tgcttccaca tttgaagagt ctcatgtgcc agcaactgaa gactctctga
     3901 ctagagttca gatatgtgaa aaggcagaag aattaaagga cactgtacaa gaaaagaaaa
     3961 gcactttaaa tggaagccag cctgagatga agtatcagtc tgtccacaaa actatgagta
     4021 agaaggatcc acccagaggt tccgggcatg gcgagaagag tcgactaaaa ggagaaaatg
     4081 gtgttacacg gagaggtaga tctgctagtc ccaaaaagtc agttaaccga cattcagagg
     4141 aacatttgga aaagattccc aggcccctaa aaagtgatcc caaagaaaaa tctagagacc
     4201 gctcactgag ccctaggaaa ggagaaagta aaggtcggct caccattaag gcgggctctg
     4261 gacaagatcc caatagaaaa gacagaggac ggtcttctag ccccaagaag cagcaaaaga
     4321 taggaggcaa cagcctgtca aacactgaag gcaaattatc agaggctggg agccgaagag
     4381 cagcaggcca ccctagagac agcactgaac agctcccaga tgggagagaa aagtcagggg
     4441 tcagcaggaa agatctgaag cagagtcagc caggaaaaac cagaaccaag tctccagaga
     4501 aaaagagcag taaagttgat gaaacatctc tcccatccaa aaagactagc agcactgctg
     4561 gtagggtagt atctgaaaag gaaaaaggaa agaagccaac agcaggagaa acaagtagag
     4621 aaacagtaga gcacacccag atctcagcaa agcagctcaa gcaggaagct caagagaaga
     4681 cggcattagg taacgcagac gatcacaaag gcagagaatc agaggtcacg gacagatgca
     4741 gggagcgtgc ggggtgcaca cctcaaagta gctctctagt caagaaagca cccatcactc
     4801 caggaccctg gagggtgcca cgtgcaaata aagtcacagg cactactggc atggctgaca
     4861 aacagctgtg acctttcata taaaacaaag aaaattaagt tgtaatcttg tgctaaaaac
     4921 gcaacatttt aagggggaga ggtgtggttt tcccccagaa attcttcaat agcaagtcgt
     4981 caggctgcat gaagggcttc tgggattgct gagagccacc tggcctggcc ggccctttcc
     5041 tcatgctcag gaaggagcta catccaaggg ctcccctgcc acacccgcca ccccctgctc
     5101 ggctgctccc tcagcctgac atgatcctag cagtgagctc acagctcact ttgtgtttgt
     5161 gccaagttat ctgctgtatc atgtctgttt aatccttccc gttctgatat ttccagtcat
     5221 caaacagttc cgtttggctt gaagatgttt tcaatagcat gttgcatgtt tacagagaga
     5281 aatattcgag tccttgcaga ggaagaaatt gttagctcat catcaaagtg ggcacttgcc
     5341 tcttctcaca gcttctgacc gtcctagttt aaaaaatgca attcacaaac atcacattac
     5401 aggaaaggtc aaatattata aatgcttttt tacagctaag taaggtgttt aaagtaactg
     5461 ctaaaaatat tccttacaat tgaatgctca aaatgagaac gtactctaag caacagaatt
     5521 aacagcctcc tgccatgtta gccatcctta tgtagtgaca gtgtctcaga tcacctgtag
     5581 tcttgaggga agtacaagaa gcatgtagaa gtaccgcttg tttctcttta aagaaaaact
     5641 actacatctg gatattttga ttattaacca ttagtcttta atatagttga agacctaaaa
     5701 tagtatgtag atttttgtga gggacttaat catgaagcca gttctacagt ccactgccag
     5761 acaaagcacc agctcctgtg acagaggagc tcatctaggg gcagacacac aagcattagg
     5821 gattagaaac agagcctgtc ttaggcttcc tcagcaagtt aggactaata tggtatagac
     5881 tgtgtgtgtt ggaactttaa tttttagcta attatttaaa aacaaagttc tcagagttct
     5941 tttttaaaat ctaataaaaa tgtttgctga aagttggaga caattcttaa actcataaaa
     6001 tagatcaaga cattagttcc ctgaagcagc attcagaaac atctataaat acagacattc
     6061 ctcagaccaa aactgtctat ttacggagta tttgaatact cattctgtta ccttgtgagt
     6121 ctgacaaatt ccactgtgac aactgtactg gcccgttatg acacatgctt ccatccagaa
     6181 ctgtatttaa cccatctcaa aactacttga atagcgacaa ttaggaagct tgataaatgc
     6241 taagaattta gtactgcaga gatgatttat tttccctgta gtccacatta gtgatacaaa
     6301 tcctattttt attgttaact gtgacataac tttgatgtca tgttgtcaat atgatgtggc
     6361 tcttcctaag taacatgtca ctgtactgat tatatactga cttagcaatg tggccttgga
     6421 atgctgagca aaatatggat gtactggttg taaatgttta tatatgtaca gtacctttat
     6481 atatataaat atatatatat atatacactt gaggttctga ttagagaaag atctgtaaat
     6541 cgctcgttat tttttatata gatattaaaa aagaaaaaaa a
//
