LOCUS       NM_001170746            6736 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus membrane associated guanylate kinase, WW and PDZ
            domain containing 2 (Magi2), transcript variant 1, mRNA.
ACCESSION   NM_001170746
VERSION     NM_001170746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6736)
  AUTHORS   Wang,T., Li,C., Wang,X. and Liu,F.
  TITLE     MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease
            through communication with TGF-beta-Smad3/nephrin pathway
  JOURNAL   FASEB J 37 (12), e23305 (2023)
   PUBMED   37950637
  REMARK    GeneRIF: MAGI2 ameliorates podocyte apoptosis of diabetic kidney
            disease through communication with TGF-beta-Smad3/nephrin pathway.
REFERENCE   2  (bases 1 to 6736)
  AUTHORS   Kearney,G., Grau,D., Nieves Torres,D., Shin,S.M. and Lee,S.H.
  TITLE     S-SCAM inhibits Axin-dependent synaptic function of GSK3beta in a
            sex-dependent manner
  JOURNAL   Sci Rep 12 (1), 4090 (2022)
   PUBMED   35260764
  REMARK    GeneRIF: S-SCAM inhibits Axin-dependent synaptic function of
            GSK3beta in a sex-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6736)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6736)
  AUTHORS   Arimura,N., Okada,M., Taya,S., Dewa,K.I., Tsuzuki,A., Uetake,H.,
            Miyashita,S., Hashizume,K., Shimaoka,K., Egusa,S., Nishioka,T.,
            Yanagawa,Y., Yamakawa,K., Inoue,Y.U., Inoue,T., Kaibuchi,K. and
            Hoshino,M.
  TITLE     DSCAM regulates delamination of neurons in the developing midbrain
  JOURNAL   Sci Adv 6 (36) (2020)
   PUBMED   32917586
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6736)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6736)
  AUTHORS   Becamel,C., Gavarini,S., Chanrion,B., Alonso,G., Galeotti,N.,
            Dumuis,A., Bockaert,J. and Marin,P.
  TITLE     The serotonin 5-HT2A and 5-HT2C receptors interact with specific
            sets of PDZ proteins
  JOURNAL   J Biol Chem 279 (19), 20257-20266 (2004)
   PUBMED   14988405
REFERENCE   7  (bases 1 to 6736)
  AUTHORS   Yamada,A., Irie,K., Deguchi-Tawarada,M., Ohtsuka,T. and Takai,Y.
  TITLE     Nectin-dependent localization of synaptic scaffolding molecule
            (S-SCAM) at the puncta adherentia junctions formed between the
            mossy fibre terminals and the dendrites of pyramidal cells in the
            CA3 area of the mouse hippocampus
  JOURNAL   Genes Cells 8 (12), 985-994 (2003)
   PUBMED   14750953
  REMARK    GeneRIF: Localization of synaptic scaffolding molecule (S-SCAM) at
            the puncta adherentia junctions formed between the mossy fibre
            terminals and the dendrites of CA3 pyramidal cells.
REFERENCE   8  (bases 1 to 6736)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 6736)
  AUTHORS   Pfister,S., Przemeck,G.K., Gerber,J.K., Beckers,J., Adamski,J. and
            Hrabe de Angelis,M.
  TITLE     Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic
            domain of the Notch ligand Delta1
  JOURNAL   J Mol Biol 333 (2), 229-235 (2003)
   PUBMED   14529612
REFERENCE   10 (bases 1 to 6736)
  AUTHORS   Shoji,H., Tsuchida,K., Kishi,H., Yamakawa,N., Matsuzaki,T., Liu,Z.,
            Nakamura,T. and Sugino,H.
  TITLE     Identification and characterization of a PDZ protein that interacts
            with activin type II receptors
  JOURNAL   J Biol Chem 275 (8), 5485-5492 (2000)
   PUBMED   10681527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121774.3, AC161802.7, AC113596.8, AC161494.3, AC132570.3,
            AC125138.4, AC158141.8 and AC157608.10.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               AC121774.3         163157-163700
            545-661             AC161802.7         9925-10041          c
            662-781             AC113596.8         157869-157988
            782-994             AC161494.3         38563-38775         c
            995-1205            AC161494.3         18267-18477         c
            1206-1285           AC161494.3         5345-5424           c
            1286-1343           AC132570.3         26250-26307         c
            1344-1465           AC125138.4         67614-67735
            1466-1648           AC125138.4         69823-70005
            1649-2287           AC125138.4         144120-144758
            2288-2319           AC158141.8         141749-141780       c
            2320-2509           AC158141.8         135543-135732       c
            2510-2551           AC158141.8         126443-126484       c
            2552-2643           AC158141.8         119771-119862       c
            2644-2836           AC158141.8         108723-108915       c
            2837-3085           AC158141.8         100715-100963       c
            3086-3271           AC158141.8         69106-69291         c
            3272-3446           AC158141.8         67548-67722         c
            3447-3642           AC158141.8         60610-60805         c
            3643-3786           AC158141.8         58881-59024         c
            3787-3925           AC158141.8         18876-19014         c
            3926-4014           AC158141.8         8717-8805           c
            4015-6736           AC157608.10        35362-38083
FEATURES             Location/Qualifiers
     source          1..6736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 8.6 cM"
     gene            1..6736
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 2"
                     /db_xref="GeneID:50791"
                     /db_xref="MGI:MGI:1354953"
     exon            1..544
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..4071
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activin receptor interacting protein 1;
                     membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 2; atrophin-1-interacting
                     protein 1; membrane-associated guanylate kinase inverted
                     2"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_001164217.1"
                     /db_xref="CCDS:CCDS51424.1"
                     /db_xref="GeneID:50791"
                     /db_xref="MGI:MGI:1354953"
                     /translation="MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYL
                     GEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGG
                     IVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITV
                     EEFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLNVTDQILPGATPSAEGKRKRNK
                     SVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVY
                     SQPEELKDQMDDTKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRL
                     AKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMP
                     HTELGAKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQ
                     VKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRG
                     YPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPH
                     SLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTG
                     QRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGG
                     FFSPWKTPKPMMDRWENQGSPQTSLSAPAVPQNLPFPPALHRSSFPDSTEAFDPRKPD
                     PYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPG
                     QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLT
                     VRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYSNSNHAAPSSNASPPEGFASHS
                     LQTSDVVIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGD
                     RILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQH
                     SPLAQQSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPF
                     TDYRQPPLDYRQPPGGDYSQPPPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA
                     KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIE
                     LIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTP
                     GVLPLPPPQACRK"
     exon            545..661
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            662..781
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            782..994
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1205
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1285
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1343
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1465
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1648
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2287
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2319
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2509
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2551
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2643
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2836
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3085
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3271
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3446
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3642
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3786
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3925
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4014
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..6736
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6698..6703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /note="hexamer: AATAAA"
     polyA_site      6718
                     /gene="Magi2"
                     /gene_synonym="Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2;
                     mKIAA0705; S-SCAM"
                     /note="major polyA site"
ORIGIN      
        1 gtcattcaag ggacagcaca acctcaccca agctctccta cctctgccca gccgtccctc
       61 tcatcctccc ccttcctccg ccacactcca tccaaagaag agggaaagcg cggagcagag
      121 ggagagaaag gcaaagtctg ccaccctctt cccttggccc ccttgctcct ccatcccgat
      181 tttgactccc agaccctcct tcccaaagga ccctctggaa ctgaggcgac tcaccctact
      241 gccatgtcca aaagcttgaa aaagaaaagc cactggacta gcaaagtcca cgagagtgtc
      301 attggcagga acccggaggg ccagctgggc tttgaactga aggggggcgc ggaaaacgga
      361 cagttcccct acctggggga ggtgaagccg ggcaaggtgg cctatgaaag cggcagcaag
      421 ttggtgtccg aggagctgct gctggaggtg aacgagaccc ccgtggcggg gctcaccatc
      481 agggacgttc tggccgtgat caaacactgc aaggaccccc tccggctcaa gtgtgtcaag
      541 caaggaggaa ttgttgataa agaccttcgt cactacctca acctaagatt tcagaagggt
      601 tctgttgacc atgaactaca gcaaatcatc cgtgacaacc tctacctccg cacagtgcca
      661 tgcaccacaa ggccacataa ggagggtgag gtccctggag tggactacat tttcataacc
      721 gttgaggagt ttatggaatt ggagaaaagt ggtgctctcc tagaaagcgg gacctatgaa
      781 gacaactact acggtacccc gaagcctcca gctgaaccag caccattatt aaatgtaaca
      841 gaccagatac ttccgggagc tactccaagt gctgagggga agcggaaaag aaataagtca
      901 gtgaccaaca tggagaaagc aagtatagag cctccagagg aggaagaaga agaaaggcct
      961 gtagtcaatg gaaacggcgt ggtcataacc ccagaatcca gtgaacatga agacaaaagt
     1021 gcaggtgcct caggggagac accctcccag ccttaccctg cacccgtgta cagccagccc
     1081 gaagagctca aggaccagat ggacgataca aagccaacaa agcctgagga gaacgaggac
     1141 tctgatccat tgcctgataa ctgggaaatg gcctacacag agaaggggga agtctacttc
     1201 attgaccata acacaaagac aacatcatgg ctggatccgc gacttgcgaa aaaggctaaa
     1261 cctccagaag agtgcaaaga aaatgagctt ccatatggct gggaaaaaat cgatgatcct
     1321 atatatggca cttactatgt tgaccacata aatagaagaa cacagtttga aaaccctgtc
     1381 ctggaagcaa aaaggaagct acagcaacat aacatgcccc acacagaact tggagcaaag
     1441 cccctgcagg ccccaggttt ccgagaaaag ccactcttca cccgggatgc atcccagttg
     1501 aagggaacgt tcctcagcac caccctcaaa aagagcaaca tgggctttgg gtttaccatc
     1561 attggtggag acgagccgga tgagtttcta caggtgaaaa gtgtgatccc ggatgggcct
     1621 gccgcacagg atgggaaaat ggagacaggt gatgtcattg tctatattaa tgaagtttgt
     1681 gtccttggac acactcatgc agatgttgtc aaacttttcc agtctgttcc tattggtcag
     1741 agtgtcaact tggtgttgtg tcgtggctac cctttgccct ttgaccctga agatcctgct
     1801 aacagcatgg tgccacccct tgcaataatg gagaggccac ctccggtgat ggtcaatgga
     1861 agacataact atgaaacata cttggaatac atttctcgga cctcacagtc ggtcccagat
     1921 attacagacc ggccacctca ttctttgcac tccatgccag ctgacggcca gctagatggc
     1981 acgtatccac cacccgtcca tgacgacaat gtgtctatgg cttcgtctgg agccactcaa
     2041 gctgaactta tgaccttaac cattgtgaaa ggtgcccagg gatttggctt tactattgcc
     2101 gacagtccca cgggacagcg ggtgaaacaa atccttgaca ttcagggatg ccctgggctg
     2161 tgtgaaggag acctcattgt tgagatcaac caacagaatg tacagaacct gagccataca
     2221 gaagtagtgg atatacttaa ggactgcccc gttggaagtg agacttcttt aatcatccat
     2281 cgaggaggtt tcttttctcc atggaaaact ccaaagccta tgatggaccg atgggagaac
     2341 caaggcagtc cacaaacaag tttatctgct ccggccgtcc cacagaacct gcccttccca
     2401 cctgcccttc acaggagctc ctttcctgat tcaacagagg cctttgaccc acggaagcct
     2461 gacccatatg agctctacga gaaatcgaga gccatttatg aaagtaggca acaagtgcca
     2521 cccaggacca gttttcgaat ggattcctct ggtccagatt ataaggaact ggatgttcac
     2581 cttcggagga tggagtctgg atttggcttt agaatccttg ggggagatga acctggacag
     2641 cctattttga tcggagccgt cattgccatg ggctcagctg acagagacgg ccgtctacac
     2701 ccaggagatg agcttgtcta tgtcgatggg atcccagtgg ctggcaagac ccaccgctat
     2761 gtcatcgacc tcatgcacca cgcggcccgc aatgggcagg ttaacctcac tgtgagaaga
     2821 aaggtgctat gtggagggga gccctgccca gagaatggga ggagtccagg ctctgtatca
     2881 actcaccaca gctctccgcg cagtgactat gccacctact ccaacagcaa ccacgccgcc
     2941 cccagcagca atgcctcacc tcctgaaggc tttgcctcac acagcttgca gaccagtgat
     3001 gtggtcattc accgcaaaga aaacgaaggg tttggcttcg tcatcatcag ctctctgaac
     3061 aggcctgagt ctggagccac cataactgtg ccccataaaa ttggacgaat cattgatggg
     3121 agccctgcag atcgctgtgc caaactcaaa gtgggcgacc gtatcttagc agtcaacggc
     3181 cagtctatca tcaacatgcc tcacgctgac attgtgaagc tcatcaagga cgccggtctc
     3241 agtgtcaccc ttcgcatcat tcctcaggag gagctcaaca gcccaacatc agcacccagt
     3301 tcagagaaac agagccccat ggcccagcag cacagccctc tggcccagca gagtcctctg
     3361 gcccagccaa gccccgccac ccccaacagc ccagtcgcac agccagctcc tccccaacct
     3421 ctccagctgc aaggacacga aaatagttac aggtcagaag ttaaagcgag gcaagatgtg
     3481 aagccagaca tccggcagcc tcccttcaca gactacaggc agcccccgct ggactacagg
     3541 cagcccccgg gaggagacta ctcacagccc ccacccttgg actacaggca gcactctcca
     3601 gacaccaggc agtaccctct gtcagactac aggcagccac aggattttga ttatttcact
     3661 gtggacatgg agaaaggagc caaaggattt ggattcagca ttcgtggagg aagggaatac
     3721 aagatggatc tgtatgtgtt gagattggca gaggatgggc cagccataag gaacggcagg
     3781 atgagggtag gagatcagat cattgaaata aatggggaaa gcacacgaga catgacccac
     3841 gccagagcaa tagaactcat caagtctgga ggaagaagag tgcggctgct gctgaagaga
     3901 ggcacggggc aggtcccgga gtatggaatg gtaccttcca gcctctccat gtgcatgaaa
     3961 agtgacaagc atgggtcccc atatttctac ttactgggcc accctaaaga cacgacgaac
     4021 cccacgcctg gagtgctgcc gctgccgccg ccccaggcct gccggaagta ggcgtctccc
     4081 tcgaagacat cctctctcca ttctctccat cacatccagc cccaccctcc gacccttccc
     4141 accagatagg cccagaccca acttgggata tccaaaggga acacgacgtt aggaaaccaa
     4201 aggagctttc ggccggcggc cagaagaagc agcgcctggg ggagcagagg gagcgctcgg
     4261 cgagcccgca gcgcagtgcg cggcccaggc tggaggaggt gcccggcggc caggggcggc
     4321 ccgaggccgg caggcccgcc tcggaggcgg ccgacgggaa ggaggcgctg cgcggccggc
     4381 gtgagggcct cggggccgcg ggcgcgcggg aggccgaggc caaggtgggt gtgcgctcgg
     4441 gggcccgacc cgcagcgcgg cccacggggg gcggcccagc gcgcaaggcg acgatggcgc
     4501 cggggccctg gaaggtgccg ggctccgaca agctgccggg cgccctgcag cctggcgcct
     4561 cggccgcggg cagatgagcc ccaaggcgag gggcccccgc ccgcctccac gcaggccgat
     4621 cttcctgggt tccgtctcac ggcgttttaa tttatttcca ctgtcacacg catagatcta
     4681 tacgaggcgc cgaagcccgg gagcgccggc gtgcgacgcg cgtaggcggc acggcacggt
     4741 gtgcgcgcag gcagacctaa actgatccta aagcccccgg ttccatggtg ggagctttgg
     4801 cagctacgga agaaccaaaa tcacgcaaac atcacagaga gacagtgcag tgtagcttta
     4861 gattcaaaaa gagaaaaaga aaaaagttcc ccccactgca tgaaggattt ggatgtcatc
     4921 caaactttat atcaagaaac tggacaagtt cagagcaatc acaaactgga atatcgcctt
     4981 aaaaaaaaat caaactgcac ggagcaagcg gaaactgaga caagattata tcttttaatt
     5041 gatctaaagt gttgtaaata aatcgttctt gacatatcta gacaggggat aaagggtttc
     5101 tttgaaacat ccagaactgt tctcccatgc tacgtttcca tggctccccc ttcagcatcc
     5161 accaacggta ttagcagcag cgtcccctgc ctactgcagg atgagttaga aacctagtga
     5221 attcattggt gtgatgcctt ttttactgcc atttctgtgg tcaagtcaca tttctgtaca
     5281 ttttcagtag tagggaaaaa aggttttaaa aattgtatcc tagggagcag tttgccgtaa
     5341 gtcagaattt tgcaggttag ctcgtagatc ctaattggtt gcctctaaaa taatgagttt
     5401 gataatcaaa agaccataat ctgtttaatc gagattgaca acgctgcagt tccttcctga
     5461 aaaggcttcc tgtcatccca ggcactcaga gatacgtagc tgctctgtta gcaatcttct
     5521 attttaccta tttgattgtc ttattttaaa gctcttcatt tgcactttga caaagtattt
     5581 gtcctatatt tctcaaatta gaatctctaa tattgaaagc attatgataa ctaatttatt
     5641 ttcattaaag aacataagtc ctttggcatt cctttctgct ttccttattt gatctccttt
     5701 ttgtttccac ctgtagcttt tcgcctccaa tttgctaatg ctttttgtta cactaacaat
     5761 ctatagatgc acctttatgt ccccgggtta ccatcgcagg tcagcgattg tccctgcagt
     5821 aaaaactgtc aaacgttaac attagtcagc tatccattgg tatttattgt agctgcacat
     5881 atttaaagac aaaatgtctg aaggcatttt gtcatgaata tgttttgtat aactgaggct
     5941 tcaactcttc agatattctg ctccttacac aagtacttgt tgagtaagag ggaagccggg
     6001 tccatcacgc caggtcacat gtaactgctg tctcaatgag tcttcccact ctctggacac
     6061 tacctagttt aatttccatc gtacataaag atagttgttc cacaagcaaa tatggtcaga
     6121 agcctcaagt gaagggtatt gcagcttgta aaagtaattt ccaaaatgaa acacattcat
     6181 cataaacaaa gcacaaacac gtgtagcggt ttatactttc ggtttaatct caatttgtct
     6241 ttttcccctg gactagaaat ccagtatagt ttgccattaa tttattgact ctgggtttgg
     6301 accatgctct gtagtgtagc tgcacgtacg tcctggtact gtgtcctctg acctttacgt
     6361 tccataggct tcagaaggac aaccgtggag atcacccttg cataaactct aatttgcaca
     6421 cttcacagct actacccgtg cagcaattgc tttatgcggc tgtaatccat aacccgtgaa
     6481 gacagcacat catctaaatc tcattccaaa taatatttct gtgtagtgtt agctgtgaat
     6541 ttaccctgta cagctgtatc tctataaata taattccatg tattaatagt cacagaaaga
     6601 ctgtaagtga gcaactattt ttatgaaacg caccactatg gataaattaa cttttacaga
     6661 aatcttgttt actgtatgat attctaaaac actgtcaaat aaaatatata tccaaaaatc
     6721 ttttcttttt ccagct
//
