LOCUS       NM_001409967            7844 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus membrane associated guanylate kinase, WW and PDZ
            domain containing 1 (Magi1), transcript variant 10, mRNA.
ACCESSION   NM_001409967 XM_030255176
VERSION     NM_001409967.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7844)
  AUTHORS   Wang,Y., Abe,J.I., Chau,K.M., Wang,Y., Vu,H.T., Reddy Velatooru,L.,
            Gulraiz,F., Imanishi,M., Samanthapudi,V.S.K., Nguyen,M.T.H.,
            Ko,K.A., Lee,L.L., Thomas,T.N., Olmsted-Davis,E.A., Kotla,S.,
            Fujiwara,K., Cooke,J.P., Zhao,D., Evans,S.E. and Le,N.T.
  TITLE     MAGI1 inhibits interferon signaling to promote influenza A
            infection
  JOURNAL   Front Cardiovasc Med 9, 791143 (2022)
   PUBMED   36082118
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7844)
  AUTHORS   Matsuzawa,K., Ohga,H., Shigetomi,K., Shiiya,T., Hirashima,M. and
            Ikenouchi,J.
  TITLE     MAGIs regulate aPKC to enable balanced distribution of
            intercellular tension for epithelial sheet homeostasis
  JOURNAL   Commun Biol 4 (1), 337 (2021)
   PUBMED   33712709
  REMARK    GeneRIF: MAGIs regulate aPKC to enable balanced distribution of
            intercellular tension for epithelial sheet homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7844)
  AUTHORS   Arimura,N., Okada,M., Taya,S., Dewa,K.I., Tsuzuki,A., Uetake,H.,
            Miyashita,S., Hashizume,K., Shimaoka,K., Egusa,S., Nishioka,T.,
            Yanagawa,Y., Yamakawa,K., Inoue,Y.U., Inoue,T., Kaibuchi,K. and
            Hoshino,M.
  TITLE     DSCAM regulates delamination of neurons in the developing midbrain
  JOURNAL   Sci Adv 6 (36) (2020)
   PUBMED   32917586
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7844)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7844)
  AUTHORS   Abe,J.I., Ko,K.A., Kotla,S., Wang,Y., Paez-Mayorga,J., Shin,I.J.,
            Imanishi,M., Vu,H.T., Tao,Y., Leiva-Juarez,M.M., Thomas,T.N.,
            Medina,J.L., Won,J.H., Fujii,Y., Giancursio,C.J., McBeath,E.,
            Shin,J.H., Guzman,L., Abe,R.J., Taunton,J., Mochizuki,N.,
            Faubion,W., Cooke,J.P., Fujiwara,K., Evans,S.E. and Le,N.T.
  TITLE     MAGI1 as a link between endothelial activation and ER stress drives
            atherosclerosis
  JOURNAL   JCI Insight 4 (7), 125570 (2019)
   PUBMED   30944250
  REMARK    GeneRIF: Study in mouse model of atherosclerosis suggests that
            MAGI1 simultaneously regulates endothelial cells activation and
            endoplasmic reticulum stress-induced apoptosis, which are critical
            molecular events for atherogenesis, via MAGI1-S741 phosphorylation
            by p90RSK and sentrin/SUMO-specific protease 2 T368
            phosphorylation-mediated MAGI1-K931 deSUMOylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7844)
  AUTHORS   Dobrosotskaya,I.Y.
  TITLE     Identification of mNET1 as a candidate ligand for the first PDZ
            domain of MAGI-1
  JOURNAL   Biochem Biophys Res Commun 283 (4), 969-975 (2001)
   PUBMED   11350080
REFERENCE   7  (bases 1 to 7844)
  AUTHORS   Patrie,K.M., Drescher,A.J., Goyal,M., Wiggins,R.C. and Margolis,B.
  TITLE     The membrane-associated guanylate kinase protein MAGI-1 binds
            megalin and is present in glomerular podocytes
  JOURNAL   J Am Soc Nephrol 12 (4), 667-677 (2001)
   PUBMED   11274227
REFERENCE   8  (bases 1 to 7844)
  AUTHORS   Glaunsinger,B.A., Lee,S.S., Thomas,M., Banks,L. and Javier,R.
  TITLE     Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and
            high-risk papillomavirus E6 oncoproteins
  JOURNAL   Oncogene 19 (46), 5270-5280 (2000)
   PUBMED   11077444
REFERENCE   9  (bases 1 to 7844)
  AUTHORS   Dobrosotskaya,I.Y. and James,G.L.
  TITLE     MAGI-1 interacts with beta-catenin and is associated with cell-cell
            adhesion structures
  JOURNAL   Biochem Biophys Res Commun 270 (3), 903-909 (2000)
   PUBMED   10772923
REFERENCE   10 (bases 1 to 7844)
  AUTHORS   Dobrosotskaya,I., Guy,R.K. and James,G.L.
  TITLE     MAGI-1, a membrane-associated guanylate kinase with a unique
            arrangement of protein-protein interaction domains
  JOURNAL   J Biol Chem 272 (50), 31589-31597 (1997)
   PUBMED   9395497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162382.8, AC138381.10 and AC153601.6.
            
            On Jul 26, 2022 this sequence version replaced XM_030255176.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.781940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-916               AC162382.8         161523-162438
            917-1033            AC138381.10        1197-1313
            1034-1153           AC138381.10        128692-128811
            1154-1360           AC153601.6         178951-179157       c
            1361-1562           AC153601.6         172049-172250       c
            1563-1645           AC153601.6         160211-160293       c
            1646-1681           AC153601.6         156112-156147       c
            1682-1739           AC153601.6         147312-147369       c
            1740-1849           AC153601.6         144259-144368       c
            1850-1942           AC153601.6         141618-141710       c
            1943-2125           AC153601.6         133796-133978       c
            2126-2746           AC153601.6         132038-132658       c
            2747-2778           AC153601.6         103844-103875       c
            2779-2992           AC153601.6         94608-94821         c
            2993-3076           AC153601.6         90881-90964         c
            3077-3168           AC153601.6         87894-87985         c
            3169-3361           AC153601.6         86220-86412         c
            3362-3655           AC153601.6         83798-84091         c
            3656-3856           AC153601.6         80612-80812         c
            3857-3950           AC153601.6         73386-73479         c
            3951-4011           AC153601.6         73181-73241         c
            4012-4155           AC153601.6         72158-72301         c
            4156-4294           AC153601.6         69556-69694         c
            4295-7844           AC153601.6         62057-65606         c
FEATURES             Location/Qualifiers
     source          1..7844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 42.7 cM"
     gene            1..7844
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /note="membrane associated guanylate kinase, WW and PDZ
                     domain containing 1"
                     /db_xref="GeneID:14924"
                     /db_xref="MGI:MGI:1203522"
     exon            1..916
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             604..5049
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /note="isoform i is encoded by transcript variant 10;
                     BAI1-associated protein 1; membrane-associated guanylate
                     kinase, WW and PDZ domain-containing protein 1;
                     membrane-associated guanylate kinase inverted 1"
                     /codon_start=1
                     /product="membrane-associated guanylate kinase, WW and PDZ
                     domain-containing protein 1 isoform i"
                     /protein_id="NP_001396896.1"
                     /db_xref="GeneID:14924"
                     /db_xref="MGI:MGI:1203522"
                     /translation="MSKVIQKKNHWTGRVHECTVKRGPQGELGVTVLGGAEHGEFPYV
                     GAVAAAEAAGLPGGGEGPKLAEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAV
                     RQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYS
                     FLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQST
                     PKRTKSYNDMQNAGIVHPENEEEEDVPEMNSSFTADSGDQDEHTLQEATLPPVNSSIL
                     AAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCL
                     NKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGVYYVDHINRKTQYENPVL
                     EAKRKKQLEQQQQQQQPQPPQPEEWTEDHASVVPPVAPSHPPSNPEPARETPLQGKPF
                     FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETG
                     DVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVA
                     ILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNSSHGYPNDTVSLA
                     SSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVN
                     KKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSPLERKDSQNSSQHSV
                     SSHRSLHTASPSHGIQVLPEYLPADAPAPDQTDSSGQKKPDPFKIWAQSRSMYENRPM
                     SPSPASGLSKGERDREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPI
                     YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR
                     KVVFAVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS
                     GGGGGSGVVSAVLQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGR
                     IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN
                     ATLLTNAEKIATITTTHAPSQQGTQETRTTTKPKQDSQFEFKGPQAAQEQDFYTVELE
                     RGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR
                     AIELIKNGGRRVRLFLRRGDGSVPEYDPSSDRNGPSTGAQGVPEVRPGPPDHRPHPAL
                     ESSYPPELHKSSQHAEKRAHAKDPKGNREHSKQPNEHHTWNGTSRKQDSGACRPKDRP
                     PDAWREAQPERTATNGSKRRSPEKRREGTRSADNTLERREKHEKRREISPERKRERSP
                     TRRKDSSPSRRRRSLERLLDQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDK
                     RNRDDKVGHREREEAGLKLEAGRSPRNPPEQRRRPYKECSTDLSI"
     exon            917..1033
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1153
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1360
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1562
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1645
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1681
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1739
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1849
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1942
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2125
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2746
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2778
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2992
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3076
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3168
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3361
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3655
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3856
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3950
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4011
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4155
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4294
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..7844
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5242..5247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /note="hexamer: AAGAAA"
     polyA_site      5262
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /note="major polyA site"
     regulatory      6926..6931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /note="hexamer: TATAAA"
     polyA_site      6949
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
     regulatory      7813..7818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
                     /note="hexamer: AATACA"
     polyA_site      7844
                     /gene="Magi1"
                     /gene_synonym="AIP3; Baiap1; BAP1; Gukmi1; Magi-1; MAGI1c;
                     mKIAA4129; TNRC19; WWP3"
ORIGIN      
        1 atgcgcgcgc gtctcctctc cagccggccg ctgcgctccg ccgcgcggag tagaatgaac
       61 tgtaacaaaa caagccgagc ctttgtatct gcttaaaggg gccgcggcca cttccctcgc
      121 gtcccctcac ccccgccccg cgccgtcgcg tctccagggc tcccggcaac tagcttggaa
      181 agggcttccc tcgcgctgag gagcggccgg ccggcgcgga gcaggcgcgg cgtgtgtgga
      241 gagagccgcg gagcggagag cgggcccggg cggcgccgga gtggactctg gtcccgggag
      301 cgcggtcggc gccggaacgc ggacccggag gcaccggaat gcaaacaaag ctcgcgggcg
      361 cccgtgcagg gctcttcacg gagcccggaa agtttgtttt atgatggctt gagagcgcga
      421 gagagtcggg cgaggaggct cgagtagctc gctcccgcgc tccgagagat gcttctcccg
      481 tgagcccgcc gctccggggg ctcgtgctgt gggggcacct gtctctcgtt ttagcagttt
      541 tcttttcttt ttcttttttt ctttaatttg aattttgttt tcgaggaggg gctgtaactc
      601 atcatgtcga aagtgatcca gaagaagaac cactggactg gccgcgttca cgagtgcacc
      661 gtgaagcggg gaccccaggg cgagctgggg gtgacggtcc tggggggcgc ggagcatggg
      721 gagtttccgt acgtgggggc ggtggcggcg gccgaggcgg cggggcttcc cggcggtggc
      781 gaggggccga agctggccga aggtgagctg ctgctggagg tgcagggggt ccgggtgtcc
      841 ggcttgcccc gctatgacgt gctgggagtc atcgacagct gcaaggaggc cgtcaccttc
      901 aaagccgtca gacaaggagg aaggctcaac aaggacctac gacatttcct caaccaacgg
      961 ttccagaagg ggtctccaga tcatgagctc cagcagacca taagggacaa cctctaccgc
     1021 catgctgtgc cttgcacaac ccggtctccc agagaaggag aagtgcctgg tgtggattac
     1081 agctttctga ctgtgaagga gttcttggac ctcgagcaga gcgggaccct gttggaagtc
     1141 ggcacctatg aaggaaacta ttatgggaca cccaaacctc ctagccagcc agtcagtggg
     1201 aaagtgatca cgacggatgc cttgcacagc ctgcagtctg gctccaagca gtcgacccct
     1261 aagcgaacaa agtcctacaa tgatatgcaa aatgctggca tagtccaccc ggagaatgag
     1321 gaggaggagg atgtccctga aatgaacagt agctttacag ccgactctgg agaccaggac
     1381 gagcacactc tccaagaagc aacgctcccg cctgtgaata gtagcatcct cgctgctccc
     1441 atcacggacc cttctcagaa gttccctcag tacctacctc tttctgcaga ggataattta
     1501 ggtcctctac ctgaaaactg ggagatggcc tatactgaaa atggagaagt ctatttcata
     1561 gaccacaaca cgaaaacaac atcatggtta gaccctcggt gcctgaacaa acagcagaag
     1621 cctctggaag aatgtgaaga tgatgaaggg gtacacaccg aggagctgga cagtgaacta
     1681 gagttgcctg ctggctggga aaagattgaa gaccctgtct acggtgtcta ctatgtagac
     1741 cacatcaaca ggaagacgca atatgaaaac ccagtcctag aagccaaacg gaagaaacag
     1801 cttgaacagc agcagcaaca gcagcagcct cagccaccgc agccagaaga gtggacagag
     1861 gatcatgcat ctgttgtgcc tcctgttgct ccttcccatc ccccgagcaa tccggagcca
     1921 gccagggaaa ctccacttca gggcaaacct ttttttacaa gaaacccctc tgagctgaaa
     1981 ggcaagttca ttcacacgaa gctacggaaa agcagccgag gctttggctt cacggtggtt
     2041 ggaggagacg agcctgatga gttcctgcag atcaagagcc tcgtcctcga tggtcctgcc
     2101 gcactggatg gcaagatgga gacaggggat gtaattgtga gtgtgaatga cacctgtgtt
     2161 ttgggacaca cacatgctca agttgtgaaa atcttccagt ccattcccat tggtgccagt
     2221 gtggaccttg aactctgcag aggttatcca ttgccttttg acccggatga ccctaataca
     2281 agtttagtga cctcggtggc cattttggac aaagaaccaa ttattgtaaa tggacaagag
     2341 acctacgatt caccagcgag ccacagtagt aaaacaggca aagtcagcag catgaaggat
     2401 gccaggccaa gcagccctgc tgatgtggct tccaacagct ctcatggtta tcccaacgac
     2461 acagtctcct tggcttcctc catagccacc cagccagagc taataactgt tcacatagtc
     2521 aaagggccaa tgggatttgg ctttacgatc gcagacagtc ccggtggggg tggccaaaga
     2581 gtgaaacaga ttgttgacag tccacgctgc agaggcctca aagaagggga tcttatcgtg
     2641 gaggtgaata agaagaacgt gcaggccctg acgcacaatc aagtcgtgga tatgctgatt
     2701 gaatgtccca agggaagtga ggtcacactg ttggtgcagc gaggagggct accagttccc
     2761 aagaagagcc caaagtcgcc actggagagg aaagacagcc agaatagctc ccagcacagc
     2821 gtctccagcc accggagcct gcacactgcg tccccgagcc acggcataca ggtgctccct
     2881 gagtacctac ctgcagacgc ccctgctcca gatcagaccg acagctctgg gcagaaaaag
     2941 ccagatcctt ttaaaatctg ggcccagtcc aggagcatgt atgaaaaccg acctatgtca
     3001 ccttcgcctg catcaggatt gagcaagggt gaaagagaca gagaaatcaa ttccacgaat
     3061 tttggagaat gtcagattcc agattaccag gaacaggaca tcttcctctg gagaaaagaa
     3121 accggatttg gatttaggat tctgggtgga aatgaaccag gggaacccat ttatatcggt
     3181 cacatcgtac cgctgggtgc tgctgacaca gacggccgcc tgaggtctgg agatgaatta
     3241 atctgtgtgg atgggacacc agtaattggg aaatcacacc agctcgtggt ccagcttatg
     3301 caacaagctg ccaagcaagg ccatgtcaat ctcacagtga ggcggaaagt ggtctttgcc
     3361 gtccccaaag cagagaatga ggtgccctca ccagcctcat cacaccacag tagcaaccag
     3421 cccgcgtccc tgacggagga gaaacgcaca ccgcaaggca gccagaactc tctgaacact
     3481 gtgagctctg gcagcggcag caccagtggc attggcagtg gtggcggcgg gggcagcggt
     3541 gtggtgagcg ctgtgctgca gccctatgat gtggagattc ggcgtgggga gaacgagggc
     3601 tttgggtttg tcatcgtgtc ctccgtgagc agacccgaag cgggcacaac cttcggcaat
     3661 gcatgtgtgg ctatgcctca caaaataggt cggattattg aggggagccc tgctgaccgc
     3721 tgtggcaagc tgaaagtagg agaccggatc ttggcagtaa atggatgttc catcaccaac
     3781 aaatcccatt ctgacattgt caacctaatc aaagaagcgg gcaacacagt gactctccgc
     3841 atcatccccg gggatgagtc ctcaaatgcc acgctgctga ctaatgctga gaagattgcc
     3901 accatcacca ccactcatgc cccctctcag caggggaccc aggaaacaag gaccaccacc
     3961 aaaccaaagc aggattctca gtttgagttc aaaggaccgc aggctgcaca ggagcaagat
     4021 ttctacactg tggaattgga aagaggggcc aagggatttg gctttagtct tcgagggggc
     4081 cgagaatata acatggatct ttatgttctg cgcttggcag aggatggtcc tgcagaaaga
     4141 tgtgggaaga tgaggattgg cgatgaaatt ctagagatca atggtgagac caccaaaaac
     4201 atgaaacact ctcgggccat agaactgatc aagaatggcg gccgcagggt ccgtctgttt
     4261 ctgcggcggg gagacggctc agtcccagaa tatgacccca gcagcgacag gaacggcccc
     4321 tccaccggtg cacaaggtgt tccggaagtg aggccggggc cgccagacca cagaccgcat
     4381 ccagccttgg agtccagtta cccacccgaa cttcacaaat catcacaaca tgccgaaaag
     4441 cgagcacacg cgaaggatcc aaaaggcaac agggagcaca gcaaacaacc caacgaacat
     4501 cacacctgga atggaacttc tagaaaacag gacagcgggg catgccggcc caaagaccgg
     4561 ccacccgacg catggagaga ggcgcagcca gagcggacag ccaccaatgg ttcaaagagg
     4621 aggtcaccgg agaagcgcag ggaaggcacc cgcagcgctg acaacacttt ggaaagaagg
     4681 gagaagcatg agaagagaag agagatatct cccgagagga agcgagagcg ttcacccacc
     4741 cggagaaaag atagctcccc gagccgccgg cggaggtccc tcgaaagact cctggatcaa
     4801 agacggtccc cagagcgcag aagagggggc tcccccgaga ggagagccaa atccaccgac
     4861 aggaggaggg ccaggtcccc tgagcgcagg cgagagcggt cactggacaa aaggaaccgg
     4921 gacgacaagg ttggccaccg agaaagagag gaggctggtc tgaagctgga agcggggaga
     4981 agcccccgaa atcccccaga gcagagaagg cggccttaca aagaatgtag caccgacctc
     5041 agcatctgag actcagcatt gcaaccttta ccgtgtcaaa ggttctaaga ggaaggtcgc
     5101 aaaacgaaat catttagttt cttacctgag gaagcatctg acacctgata gtcctaagaa
     5161 tagtaacgaa cattttatgc atctgaaatc ttataaggaa aaaatatata tgaaaagtct
     5221 tgtgcctggt gtaaaatatt aaagaaagta tttttaaatg catacttttt ttgaaaatta
     5281 tttgccaaaa tactggccca aagggatata cattttgttt cttcacaagc tatagagttg
     5341 ttccttattt ggggcaagct ctttctctcc tagataaaca gggctgttgg tcatgtccta
     5401 taagtaaatg caattaactt taactcaata gaaactgttc cgaagtgatg tagtgctgta
     5461 ctgtaaacct gttttcagaa aagcagaacg caaaaagaca aacttgtaca gactgaggat
     5521 cttttaggat ggattagaat ggccagtgag cctaaaattc agcaaactat gcgacaagag
     5581 tactactgcg aatgaagggt atttatgact acagtgtaca gcactaagag accttatggt
     5641 cttgagttat agttgctata gtcaaagaac agtctgtgct ctccctggcc caggaaggtg
     5701 cagaaacaag aaggttggct gccagtaacc aaacccagcc ttagctcaga gggtcagatt
     5761 catcaggccc cgccacagaa ccaatacatc tcacctgcag cagtgcccat tgcaaagcat
     5821 cagcctctgg atagaacaga caagctcctt ctgggttgtc tggtccagtc tgaagccgag
     5881 tagatccgaa tataggaccc catgcctctg ggatgaggga gatgtctgtt aatgtctcca
     5941 acgtgggaag agtcccctcc cccagtgttt agcataagcc cctgcttgcc ttctgcccag
     6001 tgggagcaga ggaatgaact gtggtggagg aaacctctgt cagcatattt taaaaggatt
     6061 gaggctccat attcccagaa tagttgatca tgcacttttt gaaaccataa tccaggtcct
     6121 aaggattgag tgaaacgtga tgacaccagt ggatcttgat ctgtctacag ggaaatgacc
     6181 ttgttccttg ggtttgggga cagcaaagga aagtgtaatg gtttttcttg ctaaagtaga
     6241 cccattttct gaaccctcag aaggtgtggt tgtgtcggct gtagccctga gaagtggttt
     6301 aagtggatta ctgcctagct gagccaaagt gtttgcttgt acctgtagga ccactacagc
     6361 aaaccctgct gacagagcat ttgtatttct gtagtaccgg gttttttgtt tttttgtttt
     6421 tttgcatttt cccttcagac acaaaacttt tccagtcaat cactgttgtt cctgtggtac
     6481 tgtaataagg gagagggcaa aaaaagagaa aacaaaaaca aaaaaataga aaagaaaacc
     6541 agccaatcat tgtatgtaga gtttaaaatt gtaattaata gagcctgttt gaaaaaaaac
     6601 aaaacaactg ttgccttttt ttttgtataa aagagaattt atgacagaag tctagctgtg
     6661 gagaatgtga catgtgtcta tatttctgaa tatgaacaga ttgattcttg gggatatact
     6721 ttattgtaaa ctaaatcagg tatgtaaagt tgttttaaaa ttatataagt aatcgctaca
     6781 gctttagttt gttggggcta ttgtttcccc acggagagac tgctcatgaa taatcaagca
     6841 ttcatttgca ttctcgtttc ttcatttatt tcttgcttaa cactctctct gggttgatga
     6901 aaagcaatgt gtgggccaac ctttttataa aacactatgc acatataaat attacattgt
     6961 tcatagcttt atttgactta gggtttatat ataacattac accgagtagt tatagttaat
     7021 atggacattt ctccaaattc tttctctgaa tcaaacacaa tatacatgtt atagctaaag
     7081 agggcaggga atctgtgatt gctacttcta ctattggagt tttccctaca aatcatacat
     7141 tggcaataga attaggctga ggaagactcc tactgagtgg tgatttttat tttatccaat
     7201 tacctgagag ccagcatgga ggttgctctt gaagttctaa agctaggatt tttctcacta
     7261 tttctagcac agcccatgat gttaactcat ggattcattc ccttgatcat ggactatggg
     7321 ttttaaacaa gtttaaaaaa aaaaatcaag gttgattttt tttttttttt ttttttttgg
     7381 aatgaacatc atgatatgtg tctcagttta agaaatggta tagggcattt aaagtcagtg
     7441 ctgagcccgg ctcggtatct gaggactttt gctgtgacaa tttcacctta aattccatac
     7501 atcagatttg agttgaaagt actgcactgt acgggaaact acatgtgcta aaccgaaacc
     7561 tagatgtctc ttcaatctac tgtagcctgt attggaaact gattcttgtg agcctacttc
     7621 cctaaccttt cacttcccat aagatgaggg atgaggggtg agtcttctgt atgattaaat
     7681 caaacacttt aagactcccc agcccccatg acacaacctg aaaggatgtt caggggttgg
     7741 gggagtcaat agcctacttg tattttttaa gtttcttttg tgaaagattt tttaatgcat
     7801 ttttactgta aaaatacatg gaagtgtatg cattccataa ccac
//
