LOCUS       NM_013779               4662 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus MAGE family member L2 (Magel2), mRNA.
ACCESSION   NM_013779 XM_622091
VERSION     NM_013779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4662)
  AUTHORS   Borie,A.M., Dromard,Y., Chakraborty,P., Fontanaud,P., Andre,E.M.,
            Francois,A., Colson,P., Muscatelli,F., Guillon,G., Desarmenien,M.G.
            and Jeanneteau,F.
  TITLE     Neuropeptide therapeutics to repress lateral septum neurons that
            disable sociability in an autism mouse model
  JOURNAL   Cell Rep Med 5 (11), 101781 (2024)
   PUBMED   39423809
REFERENCE   2  (bases 1 to 4662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4662)
  AUTHORS   Gigliucci,V., Busnelli,M., Santini,F., Paolini,C., Bertoni,A.,
            Schaller,F., Muscatelli,F. and Chini,B.
  TITLE     Oxytocin receptors in the Magel2 mouse model of autism: Specific
            region, age, sex and oxytocin treatment effects
  JOURNAL   Front Neurosci 17, 1026939 (2023)
   PUBMED   36998737
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4662)
  AUTHORS   Choi,Y., Min,H.Y., Hwang,J. and Jo,Y.H.
  TITLE     Magel2 knockdown in hypothalamic POMC neurons innervating the
            medial amygdala reduces susceptibility to diet-induced obesity
  JOURNAL   Life Sci Alliance 5 (11), e202201502 (2022)
   PUBMED   36007929
  REMARK    GeneRIF: Magel2 knockdown in hypothalamic POMC neurons innervating
            the medial amygdala reduces susceptibility to diet-induced obesity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4662)
  AUTHORS   Ben-Cnaan,E., Permyakova,A., Azar,S., Hirsch,S., Baraghithy,S.,
            Hinden,L. and Tam,J.
  TITLE     The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in
            Treating Diet- and Genetic-Induced Obesity
  JOURNAL   Int J Mol Sci 23 (10), 5610 (2022)
   PUBMED   35628417
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4662)
  AUTHORS   Chai,J.H., Locke,D.P., Ohta,T., Greally,J.M. and Nicholls,R.D.
  TITLE     Retrotransposed genes such as Frat3 in the mouse Chromosome 7C
            Prader-Willi syndrome region acquire the imprinted status of their
            insertion site
  JOURNAL   Mamm Genome 12 (11), 813-821 (2001)
   PUBMED   11845283
REFERENCE   7  (bases 1 to 4662)
  AUTHORS   Choi,J.D., Underkoffler,L.A., Collins,J.N., Marchegiani,S.M.,
            Terry,N.A., Beechey,C.V. and Oakey,R.J.
  TITLE     Microarray expression profiling of tissues from mice with
            uniparental duplications of chromosomes 7 and 11 to identify
            imprinted genes
  JOURNAL   Mamm Genome 12 (10), 758-764 (2001)
   PUBMED   11668390
REFERENCE   8  (bases 1 to 4662)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   9  (bases 1 to 4662)
  AUTHORS   Lee,S., Kozlov,S., Hernandez,L., Chamberlain,S.J., Brannan,C.I.,
            Stewart,C.L. and Wevrick,R.
  TITLE     Expression and imprinting of MAGEL2 suggest a role in Prader-willi
            syndrome and the homologous murine imprinting phenotype
  JOURNAL   Hum Mol Genet 9 (12), 1813-1819 (2000)
   PUBMED   10915770
  REMARK    GeneRIF: Magel2 gene is imprinted, with preferential expression
            from the paternal allele in mouse and human.
REFERENCE   10 (bases 1 to 4662)
  AUTHORS   Boccaccio,I., Glatt-Deeley,H., Watrin,F., Roeckel,N., Lalande,M.
            and Muscatelli,F.
  TITLE     The human MAGEL2 gene and its mouse homologue are paternally
            expressed and mapped to the Prader-Willi region
  JOURNAL   Hum Mol Genet 8 (13), 2497-2505 (1999)
   PUBMED   10556298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156555.8.
            
            On or before Sep 13, 2009 this sequence version replaced
            XM_622091.3, NM_013779.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK082944.1, AK086725.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 10915770
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4662              AC156555.8         194717-199378
FEATURES             Location/Qualifiers
     source          1..4662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.37 cM"
     gene            1..4662
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
                     /note="MAGE family member L2"
                     /db_xref="GeneID:27385"
                     /db_xref="MGI:MGI:1351648"
     exon            1..4662
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..4226
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
                     /note="melanoma antigen-like gene 2; melanoma antigen,
                     family L, 2; necdin-like 1; protein nS7"
                     /codon_start=1
                     /product="MAGE-like protein 2"
                     /protein_id="NP_038807.4"
                     /db_xref="CCDS:CCDS52264.1"
                     /db_xref="GeneID:27385"
                     /db_xref="MGI:MGI:1351648"
                     /translation="MSQLSTNLGDSSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWD
                     PPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQPPGLGAPMVQAPPLGGGMAKPP
                     TPGVLMVHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPP
                     PPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVHG
                     GPHGTPMPHVPITGTPIAQQPTPGVLMAQQLTPGVLMVQPPAPGAPMVQPPPQAALMT
                     QPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLPPGQPLATWAPQGQ
                     PLILQIQSQVIRAPPQVPSVPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQAT
                     QVTWQAPTIAWQATQPGRQGHSTIRTGHTPIRPGPAPLLRQIPPMIRQIQPVMRQAPP
                     LIRQVPIRPAPHGIASQPQLWQVLPPPPPLRQAPQARLLLPRVPGTGQVSTVPPVAQI
                     HLVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELP
                     VPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQE
                     LPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVPPHFWQPVSAQEAQEQA
                     TQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGPLPMLQA
                     QPGASATLANFPRGSTRSRMAPSGEPGPSSLEPRGPPRERRAPARDKKGPPKERMFIG
                     ATFCAPRGASASRAYVPTAWKNLPATSETFPATSRVFPSTSHFQPASSNAFRGPSAAS
                     ESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPAILMVAAAAPQASATAA
                     EASKSSEPPRRPGKATRKKKHLEPKEDNCGHRLSSRDWRGPRTWGNPSHSDWEIQRAM
                     QLLGDRESLYTPQGLNDWGCPNTSRMPRSLEGPSTSRDQEFCGDSGGSQTWMASEVPS
                     VSRGSSAAQEDPDRESQPLSPLDERANALVQFLLVKDQAKVPVQLSEMVNVVIREYKD
                     DSLDIINRANTKLECTFGCQLKEVDTKTHTYIIVNKMAYPQCNLLASYLERPKFSLLM
                     VVLSLIFMKGYCIRENLLFSFLFQLGLDVQETSGLFRITKKLITSVFVRHRYLEYRQI
                     PFTEPAEYELLWGPRAFLETNRVHILRFLAALYENQPQIWSCQYLDSLAELEYKDANA
                     AAEESHDSDDDAHDPTSSPHPH"
     regulatory      4641..4646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
                     /note="hexamer: TATAAA"
     regulatory      4645..4650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
                     /note="hexamer: AATATA"
     polyA_site      4659
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
     polyA_site      4662
                     /gene="Magel2"
                     /gene_synonym="Mage-l2; NDNL1; nM15; ns7"
                     /note="major polyA site"
ORIGIN      
        1 cttactgcgg agagctgcag agccagccga cactctgtgt gagctgcgct gcgagctgtg
       61 agctgagagc tgtgagctgc gtggcggagc aagccaggca gtagcacttg gctgaaagct
      121 gcggtgctag ccaggcagcg ctcgctgaga gttgcggtgc cagccaggta gtgcttgctg
      181 agagctgctg agagagccca gctgcgctcg ctgagagctg cggagagaac cgcggaacac
      241 gccagtctgc accggcttcc tattcagcct tcaagctgga gggggatcct ggacagccac
      301 gtcggcatgc tcagcactgg aagaaaaagc gcagcaaccg gagacgggcc accaccagtc
      361 aagcaaggga catgtcgcag ctaagtacga atctggggga ttccagccct ccggagtccc
      421 cagtgcctgc agtccatagc cgccctacgg ttctgatgcg ggctccgcct gcttcctccc
      481 gggctcctcc tgtcccctgg gatccacctc cagtggactt gcaggctccc atggctgctt
      541 ggcaggctcc tcaacctgcc tgggaggctc cggagggcca gctgcctgcc ccagtggctc
      601 agctggccca gcctcctggt ctaggggccc caatggtcca ggctccaccg ctcggagggg
      661 ggatggccaa gcctccaact cctggagtct tgatggtcca tcagccccct ccgggagccc
      721 ccatggccca gtcttcaact ccgggagtcc tgatgctaca tccttctgtc acgggggccc
      781 ctttggctca tcctcctccc ccaggaaccc cgatgacaca ccctcccggg acctcgatgg
      841 cgcaccctcc tcctcctcct cctccccctc ctcctcctcc tcctcctggg accccaatga
      901 cccacccacc tcctcctggg actccgatgg gtcaccatcc tcctcctggg aaccctatga
      961 cccatcctcc accggggaac ccgatggtgc atcctctcac tcatggagcc ccgatggtcc
     1021 atgggggacc acatggaact ccaatgccgc atgttcccat tacggggaca ccgatagccc
     1081 agcagccaac tccaggagtc ctgatggccc agcagctgac accgggagtc ctgatggtcc
     1141 agccgcctgc tccgggagct ccgatggtcc agccacctcc acaggctgcc ttgatgaccc
     1201 agcctgcacc ttcgattact ccgatggcca agcctccagg tcctggtgtc gtgatgatcc
     1261 atcctccagg tgccagaggt ccaatcattc agactccagt atcaggagca ccaatggctc
     1321 agacagtgct gccccctggg cagcctctgg ccacttgggc cccacagggt cagcctttga
     1381 tcctacaaat ccagtctcaa gtcataaggg ctcctccaca ggttccctct gtaccacaag
     1441 ccccccaggt acagctggcc acacccccag gctggcaagc caccacaccc aactggcagg
     1501 tgacccccca ggggtggcca gcaacgcctt tgacatggca ggctacacag gtgacctggc
     1561 aggcccccac aatagcctgg caggccactc aacctgggcg ccaagggcac tcaaccattc
     1621 gtactggtca cacacccatt cgacctggac cagctccatt gcttcgccag atacctccta
     1681 tgatccgtca gatccaacct gtgatgaggc aagccccacc actgatccga caggtcccta
     1741 tcagaccagc tccacatggc atagcaagcc agcctcagct gtggcaggtc ctgccacccc
     1801 cacctccact gcggcaggct ccacaggctc gtctactgct cccgagggta ccaggaacag
     1861 gccaggtgtc tacagtacca ccagttgctc agatacattt ggtgccacag tcaggcccac
     1921 aggtgcccca gacagtactg ccagcccaac tgtctatccc aattcctgta ccccaggctg
     1981 ctgctcagtc tgctccccgg actgtgcatt gcccacccat catctggcag gcccccaaag
     2041 gccaggcccc ggtgccacag gagctcccag tgccacagga gctcccggtg ccacaggagc
     2101 tcccggtgcc acaagaggtc ccggttccac aggagatccc ggtgccacag gagatcccgg
     2161 tgccacagga gctcccggtt ccacaggagc tcccggtgcc acaggagctc ccagtgccac
     2221 aagagctccc ggtgccacag gagctcccag tgccacagga gctcccggtg ccacaggagc
     2281 tcccggtgcc acaggagctc ccggtgccat tggagttcca ggaggtacag caggcccagg
     2341 cagtgggctg gcgggcaccc aaggtacctc ctcacttctg gcagcctgtg tctgcccagg
     2401 aggcccagga gcaggccact cagatcgccc atgtggagca gcagcagccc tttcagggag
     2461 ctccagcctc ctccaaggca ctgcaaactc agctgccgac ccaccaggcc caagcctctg
     2521 gcttgcaggc agaactgcct tcagtgcagc tgcagccttc ttggcaaggc ccactgccca
     2581 tgttgcaggc ccagcctgga gcctctgcca cactggcaaa ctttccccgg ggctccactc
     2641 gatcacgtat ggctccatca ggagaacctg gcccctcttc tctagaacct cggggccctc
     2701 ctagggaacg tagggcacct gcaagggaca aaaagggtcc tccaaaagag cgcatgttca
     2761 ttggtgccac tttctgtgct ccaagggggg catcagcatc cagggcatac gtgccaactg
     2821 cctggaaaaa cttgcctgcc acatcagaga cctttcctgc cacctcaagg gtctttccat
     2881 ctacctctca tttccagcct gcctcttcta atgcctttag aggtccatct gccgcctcag
     2941 agagcccaaa gtcactgcca tttgctctgc aggatcctta tgcctgcgta gaggccctgc
     3001 ctgcagttcc ctgggttccg tatccagatg gaaatgcctc atcagcatgt aagtcagtgc
     3061 ctgccatctt gatggtggca gcagctgccc cccaggcaag tgccactgct gcagaggcct
     3121 ctaagtcttc agagccgcca agacgccccg gcaaagccac caggaagaag aagcatctgg
     3181 aacccaaaga agacaactgt ggccacaggc tctcctcacg tgactggcgg gggccccgaa
     3241 cctggggcaa tcccagtcat tctgactggg agattcagag ggctatgcag ctcctggggg
     3301 accgggaatc cctctacact ccgcagggcc tgaatgactg ggggtgcccc aacacttcta
     3361 ggatgccaag gagcttggag ggccctagca cttcacggga ccaggaattc tgtggtgact
     3421 cgggtgggtc tcagacatgg atggcttctg aggtcccaag cgtctctcgg ggatccagtg
     3481 ctgctcagga ggaccctgat agggagagtc agcccttatc tcccttagat gagagagcaa
     3541 acgctttggt gcagtttctc ttggtcaaag accaagccaa ggtgcctgtc cagctctcgg
     3601 agatggtaaa tgttgtcatc cgagaataca aagacgacag cttagacatc atcaaccgtg
     3661 ccaacactaa gctggagtgc acctttggtt gtcaactgaa ggaagttgac accaaaaccc
     3721 acacttacat catcgtcaac aagatggcgt accctcagtg taatttgctg gcatcctatt
     3781 tagagaggcc aaagttcagc ctcctgatgg tggtcttgag cctcatcttt atgaaaggct
     3841 actgtatcag ggagaatctg ctctttagtt ttctgttcca gctagggctg gatgtccagg
     3901 agacaagtgg tctcttcaga attacaaaga agctcatcac cagtgtgttt gtgagacaca
     3961 ggtacctaga gtacaggcaa atcccgttca ctgagcctgc agaatacgag cttctctggg
     4021 ggccccgggc attcctcgaa accaacaggg tgcacatctt gagatttttg gccgcactct
     4081 acgagaacca gccccagatc tggtcatgcc agtaccttga ctcactggca gagttagaat
     4141 acaaggacgc aaatgccgcc gccgaagagt cccatgacag cgatgatgat gcccacgacc
     4201 ccaccagcag tccccatcct cactaataga cgttactaag atgattttta tacttgtggg
     4261 tccaaagcca aaggcaaaag acaatggggg gtgggggaca ttgtgctttc tggtgttttt
     4321 tggtattgtt ctctgtgtat aaattttaca gcctgttttt atatttgcca aagcttttgt
     4381 acagttttgt gaaatgttga tttaaactgg ctgctgtatt gttttgtatt ttggtgtctg
     4441 tattttttta aatgagatct gtgattccct gtttggtgta ctaattgtaa tgttacagta
     4501 tcagagttgt gctgccttgt gtgtgaaaag aaatgacagt ttatttgtct cgttttgttt
     4561 atgtaaaatc agaatgtttt tggatgttaa tatgactcat cggtaaaata ctgtctggag
     4621 aaaagtaaag atctatacta tataaatata cttttagcat aa
//
