LOCUS       NM_053206               2338 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MAGE family member E2 (Magee2), mRNA.
ACCESSION   NM_053206 XM_195221
VERSION     NM_053206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Szpak,M., Collins,S.C., Li,Y., Liu,X., Ayub,Q., Fischer,M.C.,
            Vancollie,V.E., Lelliott,C.J., Xue,Y., Yalcin,B., Yang,H. and
            Tyler-Smith,C.
  TITLE     A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual
            Dimorphism in Human Brain Size and Shows Similar Phenotypes in
            Magee2 Null Mice
  JOURNAL   Mol Biol Evol 38 (12), 5655-5663 (2021)
   PUBMED   34464968
  REMARK    GeneRIF: A Positively Selected MAGEE2 LoF Allele Is Associated with
            Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes
            in Magee2 Null Mice.
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Gordeeva,O., Gordeev,A. and Khaydukov,S.
  TITLE     Expression dynamics of Mage family genes during self-renewal and
            differentiation of mouse pluripotent stem and teratocarcinoma cells
  JOURNAL   Oncotarget 10 (35), 3248-3266 (2019)
   PUBMED   31143371
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Tedeschi,A., Dupraz,S., Laskowski,C.J., Xue,J., Ulas,T., Beyer,M.,
            Schultze,J.L. and Bradke,F.
  TITLE     The Calcium Channel Subunit Alpha2delta2 Suppresses Axon
            Regeneration in the Adult CNS
  JOURNAL   Neuron 92 (2), 419-434 (2016)
   PUBMED   27720483
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036343.1 and BC094361.1.
            
            On May 25, 2007 this sequence version replaced NM_053206.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AK036343.1         2-112
            112-2338            BC094361.1         1-2227
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.77 cM"
     gene            1..2338
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /note="MAGE family member E2"
                     /db_xref="GeneID:272790"
                     /db_xref="MGI:MGI:2148316"
     exon            1..2316
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1796
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /note="melanoma antigen, family E, 2"
                     /codon_start=1
                     /product="melanoma-associated antigen E2"
                     /protein_id="NP_444436.1"
                     /db_xref="CCDS:CCDS30333.1"
                     /db_xref="GeneID:272790"
                     /db_xref="MGI:MGI:2148316"
                     /translation="MSLVSQNARQSSAETTADYSNSQGEMQATNASGPATSMLALEAP
                     QGPEIPNDPQGASASQAVRDPSDIEVLIDEQSRRLGALRVHDPLEERSVALVNFMRMK
                     SQNEGSIRQSEMLEFLKEYSDQFPEILRRASAHLDRVFGLNLRVLDPQMDTYNLISKP
                     GPQTTERLAETLDIPKAGLLALVLGHILLNGNRAREASIWDLLLKVDVIDGSQRINNQ
                     FGNTRNLLTIDFVHMRFLEYWPVYGTNPLEFEFLWGSRAHSEITKMEALKFVAEAHDE
                     EPWSWPEEYNKALEADKAKERSQAAGLEFWSEDTMNDKANELVQLAIGVTEELLPIHQ
                     DELFANTGKEFQDVFPNILSRATLILDLFYGFSLIEVDTSEHIYLLVPQPESEEEQVM
                     LESLGRPTQEYLMPILGLIFLMGNRVKEAKIWNLLQRFSVDVGRKHAITCKLMRQRYL
                     ECRPLSYSNPVEYELLWGPRAHHEITKMKALEYMARFYGKQPQDWPEQYREAVEDEEA
                     RARSEATAMFFFGSI"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /note="hexamer: AGTAAA"
     regulatory      2295..2300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /note="hexamer: AATAAA"
     polyA_site      2307
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /note="major polyA site"
     polyA_site      2316
                     /gene="Magee2"
                     /gene_synonym="9630059J11Rik; Mage-e2"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcct gcgtaggatg cggcaaagct aggtgctctt aggctttcct tcattgctgg
       61 ctactgcttt tgtaaaagga tcgcctgtct cgccagctct cactttcgaa ccgcacagct
      121 cctgagtatc aggcttcggc tctgagctga gctgccaaca cacctcagat cctccctgcg
      181 acggatcgct gacctccgcg ttcgcgttcc tgtctcctgg aaccatgtct ctggtaagcc
      241 agaatgcgcg ccaaagcagc gcagagacta ccgccgatta cagcaacagc cagggtgaaa
      301 tgcaggctac taatgcctcc gggcctgcca cctccatgct agccctcgaa gctccccagg
      361 gccctgagat tccaaacgat ccacagggag ccagcgcttc ccaggctgtg cgggacccga
      421 gtgacatcga ggttctcatc gacgagcagt cccgacgttt gggggcgctc agggtccacg
      481 accctcttga agagaggtcg gttgctttag tgaatttcat gcgcatgaaa agccaaaatg
      541 aggggtctat ccgacagtca gaaatgctgg agtttctcaa agaatactca gatcagttcc
      601 ctgagatact cagacgagcc tcagctcatc tggatcgggt ctttgggttg aatctgagag
      661 tccttgatcc tcagatggac acttacaacc taatcagcaa accaggtccc cagaccactg
      721 aacggctagc agagaccctg gacataccaa aagcgggtct cctggccttg gtcctaggcc
      781 atattctctt gaatggcaac cgggcaagag aggcctccat ttgggacctg ctgttaaagg
      841 tggatgtgat agatgggtct cagaggatca acaaccagtt tgggaacaca agaaacctcc
      901 ttactattga ctttgtccat atgcgatttt tggagtactg gccagtatat ggcactaatc
      961 cccttgaatt tgagttcctg tggggctcta gagctcacag tgaaatcaca aagatggaag
     1021 ccctgaagtt tgtagcagag gcccatgatg aagaaccctg gagctggcca gaagaatata
     1081 acaaagctct ggaagctgac aaagccaaag agagaagcca ggctgctggc ttagagttct
     1141 ggtcagagga cactatgaat gataaagcaa atgaattggt ccagttggcc attggtgtca
     1201 ctgaggagtt gctgcctatc catcaggatg agctatttgc taatactggc aaagaattcc
     1261 aggatgtgtt cccaaatatc ctcagcagag ccactctaat ccttgatctg ttttatgggt
     1321 tctctctgat tgaggttgat accagtgagc acatctacct ccttgtcccc caaccagaat
     1381 cagaagaaga acaagtaatg ctagagagcc tgggcagacc cacccaagaa tacttgatgc
     1441 caatcctggg tttgatcttc ctgatgggca accgtgtcaa agaggccaag atctggaact
     1501 tactccagag attcagtgtt gatgtaggga ggaaacatgc catcacctgt aagctaatga
     1561 ggcaacgcta cctagaatgc aggccgctct cctactcgaa tccagttgaa tacgagctgc
     1621 tctggggtcc tcgggctcac catgaaatca ccaaaatgaa agccttggaa tatatggcta
     1681 ggttctatgg aaaacagcca caggactggc cagagcaata cagggaggct gtggaagatg
     1741 aggaggccag ggccaggtct gaggcaacag ccatgttctt cttcggttcc atctgacgtt
     1801 ggacatttca ctttagttga gtgacatctg ttaaaagggc atttgggaaa tggacactag
     1861 ggtcctaaat caaaagttga gagggttgtg ggaaagagta caccttgtgt ttattgcatt
     1921 ccaattctaa tagcatttct tcccttctaa tatcctcttt aattgtcttc atgatcagtg
     1981 tttataagtg aaattgctca ttttcttttc ctgtcttgtt tcagtataag agttcagata
     2041 gctgtataaa atgtgttggt aatatttaca tatttgaaca accagtaaaa taagctaaat
     2101 aacagtaata atacacatgt gtgtgcgcgc gagcacacac acacacacac acacacacac
     2161 acacacacac acaccccaaa cacaaagtca tgtggttgct ctccttttga gtctattgtt
     2221 gtgttaacaa actaacaaaa attaaagact gttacttccc tgtatttaat ttgcggttgc
     2281 acagtgtagt aaaaaataaa agtataatga attagaaaaa aaaaaaaaaa aaaaaaaa
//
