LOCUS       NM_030700               2132 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus MAGE family member D2 (Maged2), transcript variant 1,
            mRNA.
ACCESSION   NM_030700 XM_907990 XM_920661 XM_920667 XM_920671 XM_920679
VERSION     NM_030700.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Valino-Rivas L, Cuarental L, Agustin M, Husi H, Cannata-Ortiz P,
            Sanz AB, Mischak H, Ortiz A and Sanchez-Nino MD.
  TITLE     MAGE genes in the kidney: identification of MAGED2 as upregulated
            during kidney injury and in stressed tubular cells
  JOURNAL   Nephrol Dial Transplant 34 (9), 1498-1507 (2019)
   PUBMED   30541139
  REMARK    GeneRIF: High MAGED2 expression is associated with tubular cell
            injury during kidney disease.
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Gordeeva O, Gordeev A and Khaydukov S.
  TITLE     Expression dynamics of Mage family genes during self-renewal and
            differentiation of mouse pluripotent stem and teratocarcinoma cells
  JOURNAL   Oncotarget 10 (35), 3248-3266 (2019)
   PUBMED   31143371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   De Donato M, Peters SO, Hussain T, Rodulfo H, Thomas BN, Babar ME
            and Imumorin IG.
  TITLE     Molecular evolution of type II MAGE genes from ancestral MAGED2
            gene and their phylogenetic resolution of basal mammalian clades
  JOURNAL   Mamm Genome 28 (9-10), 443-454 (2017)
   PUBMED   28516231
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP
            and Kobayashi A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   Weber MJ.
  TITLE     Mammalian small nucleolar RNAs are mobile genetic elements
  JOURNAL   PLoS Genet 2 (12), e205 (2006)
   PUBMED   17154719
  REMARK    Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Bertrand M, Huijbers I, Chomez P and De Backer O.
  TITLE     Comparative expression analysis of the MAGED genes during
            embryogenesis and brain development
  JOURNAL   Dev Dyn 230 (2), 325-334 (2004)
   PUBMED   15162511
  REMARK    GeneRIF: Maged2 is mainly expressed in tissues of mesodermal origin
REFERENCE   7  (bases 1 to 2132)
  AUTHORS   Hedlund E, Karsten SL, Kudo L, Geschwind DH and Carpenter EM.
  TITLE     Identification of a Hoxd10-regulated transcriptional network and
            combinatorial interactions with Hoxa10 during spinal cord
            development
  JOURNAL   J Neurosci Res 75 (3), 307-319 (2004)
   PUBMED   14743444
REFERENCE   8  (bases 1 to 2132)
  AUTHORS   Fowles LF, Bennetts JS, Berkman JL, Williams E, Koopman P, Teasdale
            RD and Wicking C.
  TITLE     Genomic screen for genes involved in mammalian craniofacial
            development
  JOURNAL   Genesis 35 (2), 73-87 (2003)
   PUBMED   12533789
REFERENCE   9  (bases 1 to 2132)
  AUTHORS   Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T and Lucas S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   10 (bases 1 to 2132)
  AUTHORS   Langnaese K, Kloos DU, Wehnert M, Seidel B and Wieacker P.
  TITLE     Expression pattern and further characterization of human MAGED2 and
            identification of rodent orthologues
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 233-240 (2001)
   PUBMED   11856887
  REMARK    GeneRIF: Expression pattern and further characterization of human
            MAGED2 and identification of rodent orthologues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA752082.1, BP757994.1 and AJ277114.1.
            
            On Dec 2, 2017 this sequence version replaced NM_030700.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ277114.1, AK169006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CA752082.1         1-6
            7-63                BP757994.1         1-57
            64-2132             AJ277114.1         1-2069
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..2132
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /note="MAGE family member D2"
                     /db_xref="GeneID:80884"
                     /db_xref="MGI:MGI:1933391"
     exon            1..117
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..184
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1990
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /note="melanoma antigen, family D, 2"
                     /codon_start=1
                     /product="melanoma-associated antigen D2"
                     /protein_id="NP_109625.1"
                     /db_xref="CCDS:CCDS30466.1"
                     /db_xref="GeneID:80884"
                     /db_xref="MGI:MGI:1933391"
                     /translation="MSDTSESGADPARSQGKASEKDSGSVMQDLLTVTQNLEVSETPK
                     AEKAPEVSEAAKAPKASGNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSP
                     AADTKTQKSDLQAMTMPTTPTKKVSCGTDPKVNTKAPETEAPASQAGTDEPEPEGTAV
                     QVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRAS
                     RGPIAFWARRASRTRLAAWARRALLSLRSPRARRGKARRRAAKLQSSQEPEAPPPRDV
                     ALLQGRANDLVKYLLAKDQTKIPIRRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGI
                     QLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIW
                     EVLRKLGLRPGIHHSLFGDVKKLITDEFVKQKYLDYARVPNSNPPEYEFFWGLRSYYE
                     TSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRAQMGIGLG
                     SENAAGPCNWDEADIGPWAKARIQAGAETKAKAQGSGGANASAGAGASTGTSVGASGS
                     ASAGASAGASGGFSNNSSLTASLTFGLFAGLSGAGASTNSSSGACGFSYK"
     exon            185..676
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..985
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1049
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1129
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1224
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1304
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1347
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1410
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1525
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1997
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2132
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcggaaa ggggctgggc tgggctgggc tgtctgcagc tctagtccag gaggctgaga
       61 cttcgagagg gactgagagg agcaggcaca cgcatcccag actcactgga ggacaagctt
      121 tgctaggtga acttgagaca tgtctgacac aagcgagagt ggtgcagatc cagctcgctc
      181 tcagggcaaa gcttcagaaa aggacagcgg ctccgtgatg caggacctgt tgaccgtgac
      241 ccagaacttg gaggtctcag aaacaccaaa ggcagaaaag gcaccagagg tttcagaggc
      301 tgcaaaggct ccaaaagcct ctgggaaccc aaaggcgaca gaggtctcaa aggccccaga
      361 ggcgtctgag gcagctgcca cccaggcctc acctaccaca cagctgagtg agacccaagt
      421 tctggcaact gaaaacaaga gtccagcagc tgacaccaag acgcagaagt ctgacctgca
      481 ggctatgaca atgcctacaa ccccgaccaa aaaggtcagc tgtggtaccg atccaaaggt
      541 caatacaaag gctccggaga ctgaggctcc tgcctctcag gctgggacag atgaaccaga
      601 gcctgagggt acagctgtcc aggttcagga gaaccaggat actcggccca aggtcaaagc
      661 caagaatacc caaaagggga aacacccgga tggagaagag gatggcaaca gtgaccagag
      721 tcaggcttca gaagccacag gtggtcgaag ggtctcaaag gccctaatgg cctccatggc
      781 tcgcagagct tcaaggggac ccatagcctt ttgggcccgc agggcatcaa ggactcggtt
      841 ggctgcctgg gctcggagag ctttgctctc cctgaggtca cctagagctc gcagaggcaa
      901 ggcccgaaga agagctgcga agctacagtc atcccaggaa cctgaggcac ccccacccag
      961 agatgtggcc cttttacaag gaagggcaaa tgacttggtg aagtacctgt tggctaaaga
     1021 ccagacaaag attcccatca gacgctcaga tatgctgaag gacatcatca aagaatatac
     1081 tgatgtatac cctgaaatca ttgaacgagc aggctattcc ttggagaagg tatttggaat
     1141 ccaattgaaa gaaattgaca agaatgacca cttgtatatt cttctcagta ccttagagcc
     1201 aactgatgca ggcatattgg gaacgaccaa ggactcacct aagctgggcc tcctcatggt
     1261 gcttcttagc atcatcttca tgaatggaaa tcggtccagt gaggctgtca tctgggaggt
     1321 gctgcgcaag ttggggctgc gccctgggat tcatcactca ctctttggag atgtgaagaa
     1381 actcattact gatgagtttg tgaagcagaa gtacctggac tatgccagag tacccaatag
     1441 caatcctcct gagtacgagt tcttctgggg cctacgctct tactatgaga ccagcaagat
     1501 gaaagttctc aagtttgctt gtaaggtgca aaagaaggat cccaaggaat gggcagctca
     1561 gtaccgagag gcaatggaag cagatttgaa ggctgcagct gaggctgctg ccgaagccaa
     1621 ggcgagggct gagattagag ctcagatggg cattgggctt ggctctgaga atgccgctgg
     1681 gccctgcaac tgggacgaag ctgatattgg accctgggca aaggcccgga tccaggcagg
     1741 agctgaaact aaagccaaag cccaaggaag tggtggtgcc aatgccagtg ctggtgccgg
     1801 tgccagtact ggtaccagtg ttggtgccag tggcagtgcc agtgctggtg ccagtgctgg
     1861 tgccagtggt ggcttcagta acaactccag cctgactgcc agtctcacat ttgggctctt
     1921 cgctggcctt agtggagctg gggccagtac caacagcagc tctggtgcct gtggtttctc
     1981 ctacaagtga gatacagatt gctaataatc acagcgtctt cttctcaagc cagggtgcac
     2041 tctcagaaac gtactcaatg cagcactcca ggcagccact atcaaatcaa ctgaagtcga
     2101 cactctatat taaatctatt tgccatttct ga
//
