LOCUS       NM_001358568            2257 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus MAGE family member D2 (Maged2), transcript variant 5,
            mRNA.
ACCESSION   NM_001358568
VERSION     NM_001358568.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Valino-Rivas L, Cuarental L, Agustin M, Husi H, Cannata-Ortiz P,
            Sanz AB, Mischak H, Ortiz A and Sanchez-Nino MD.
  TITLE     MAGE genes in the kidney: identification of MAGED2 as upregulated
            during kidney injury and in stressed tubular cells
  JOURNAL   Nephrol Dial Transplant 34 (9), 1498-1507 (2019)
   PUBMED   30541139
  REMARK    GeneRIF: High MAGED2 expression is associated with tubular cell
            injury during kidney disease.
REFERENCE   2  (bases 1 to 2257)
  AUTHORS   Gordeeva O, Gordeev A and Khaydukov S.
  TITLE     Expression dynamics of Mage family genes during self-renewal and
            differentiation of mouse pluripotent stem and teratocarcinoma cells
  JOURNAL   Oncotarget 10 (35), 3248-3266 (2019)
   PUBMED   31143371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2257)
  AUTHORS   De Donato M, Peters SO, Hussain T, Rodulfo H, Thomas BN, Babar ME
            and Imumorin IG.
  TITLE     Molecular evolution of type II MAGE genes from ancestral MAGED2
            gene and their phylogenetic resolution of basal mammalian clades
  JOURNAL   Mamm Genome 28 (9-10), 443-454 (2017)
   PUBMED   28516231
REFERENCE   4  (bases 1 to 2257)
  AUTHORS   Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP
            and Kobayashi A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   5  (bases 1 to 2257)
  AUTHORS   Weber MJ.
  TITLE     Mammalian small nucleolar RNAs are mobile genetic elements
  JOURNAL   PLoS Genet 2 (12), e205 (2006)
   PUBMED   17154719
  REMARK    Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
REFERENCE   6  (bases 1 to 2257)
  AUTHORS   Bertrand M, Huijbers I, Chomez P and De Backer O.
  TITLE     Comparative expression analysis of the MAGED genes during
            embryogenesis and brain development
  JOURNAL   Dev Dyn 230 (2), 325-334 (2004)
   PUBMED   15162511
  REMARK    GeneRIF: Maged2 is mainly expressed in tissues of mesodermal origin
REFERENCE   7  (bases 1 to 2257)
  AUTHORS   Hedlund E, Karsten SL, Kudo L, Geschwind DH and Carpenter EM.
  TITLE     Identification of a Hoxd10-regulated transcriptional network and
            combinatorial interactions with Hoxa10 during spinal cord
            development
  JOURNAL   J Neurosci Res 75 (3), 307-319 (2004)
   PUBMED   14743444
REFERENCE   8  (bases 1 to 2257)
  AUTHORS   Fowles LF, Bennetts JS, Berkman JL, Williams E, Koopman P, Teasdale
            RD and Wicking C.
  TITLE     Genomic screen for genes involved in mammalian craniofacial
            development
  JOURNAL   Genesis 35 (2), 73-87 (2003)
   PUBMED   12533789
REFERENCE   9  (bases 1 to 2257)
  AUTHORS   Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T and Lucas S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   10 (bases 1 to 2257)
  AUTHORS   Langnaese K, Kloos DU, Wehnert M, Seidel B and Wieacker P.
  TITLE     Expression pattern and further characterization of human MAGED2 and
            identification of rodent orthologues
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 233-240 (2001)
   PUBMED   11856887
  REMARK    GeneRIF: Expression pattern and further characterization of human
            MAGED2 and identification of rodent orthologues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672282.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.68232.1,
                                           SRR11927932.2456625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AL672282.9         56332-56640         c
            310-801             AL672282.9         55484-55975         c
            802-1110            AL672282.9         54535-54843         c
            1111-1174           AL672282.9         54342-54405         c
            1175-1254           AL672282.9         54005-54084         c
            1255-1349           AL672282.9         53364-53458         c
            1350-1429           AL672282.9         52908-52987         c
            1430-1472           AL672282.9         52771-52813         c
            1473-1535           AL672282.9         52382-52444         c
            1536-1650           AL672282.9         51233-51347         c
            1651-2122           AL672282.9         50371-50842         c
            2123-2257           AL672282.9         50082-50216         c
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..2257
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /note="MAGE family member D2"
                     /db_xref="GeneID:80884"
                     /db_xref="MGI:MGI:1933391"
     exon            1..309
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2115
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /note="melanoma antigen, family D, 2"
                     /codon_start=1
                     /product="melanoma-associated antigen D2"
                     /protein_id="NP_001345497.1"
                     /db_xref="CCDS:CCDS30466.1"
                     /db_xref="GeneID:80884"
                     /db_xref="MGI:MGI:1933391"
                     /translation="MSDTSESGADPARSQGKASEKDSGSVMQDLLTVTQNLEVSETPK
                     AEKAPEVSEAAKAPKASGNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSP
                     AADTKTQKSDLQAMTMPTTPTKKVSCGTDPKVNTKAPETEAPASQAGTDEPEPEGTAV
                     QVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRAS
                     RGPIAFWARRASRTRLAAWARRALLSLRSPRARRGKARRRAAKLQSSQEPEAPPPRDV
                     ALLQGRANDLVKYLLAKDQTKIPIRRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGI
                     QLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIW
                     EVLRKLGLRPGIHHSLFGDVKKLITDEFVKQKYLDYARVPNSNPPEYEFFWGLRSYYE
                     TSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRAQMGIGLG
                     SENAAGPCNWDEADIGPWAKARIQAGAETKAKAQGSGGANASAGAGASTGTSVGASGS
                     ASAGASAGASGGFSNNSSLTASLTFGLFAGLSGAGASTNSSSGACGFSYK"
     exon            310..801
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1110
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1174
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1254
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1349
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1429
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1472
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1535
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1650
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2122
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2257
                     /gene="Maged2"
                     /gene_synonym="4833439A22Rik; Mage-d2; ORF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagggggcg gggtcctcag agctgccgcg ctggcacatc ttcctggagg aggggagggt
       61 gcggctgcag agaactgaga cctagagaca gaatttctgt atctgagcac ctactggttg
      121 gggctccggg aggggctggg ctttggggcc ctaaagaagg tgaggatcag cttctaggca
      181 gaacaaggga tacgacgttc agcgggctct ccacttgacc caggccttct ctttgaactc
      241 agctttgcta ggtgaacttg agacatgtct gacacaagcg agagtggtgc agatccagct
      301 cgctctcagg gcaaagcttc agaaaaggac agcggctccg tgatgcagga cctgttgacc
      361 gtgacccaga acttggaggt ctcagaaaca ccaaaggcag aaaaggcacc agaggtttca
      421 gaggctgcaa aggctccaaa agcctctggg aacccaaagg cgacagaggt ctcaaaggcc
      481 ccagaggcgt ctgaggcagc tgccacccag gcctcaccta ccacacagct gagtgagacc
      541 caagttctgg caactgaaaa caagagtcca gcagctgaca ccaagacgca gaagtctgac
      601 ctgcaggcta tgacaatgcc tacaaccccg accaaaaagg tcagctgtgg taccgatcca
      661 aaggtcaata caaaggctcc ggagactgag gctcctgcct ctcaggctgg gacagatgaa
      721 ccagagcctg agggtacagc tgtccaggtt caggagaacc aggatactcg gcccaaggtc
      781 aaagccaaga atacccaaaa ggggaaacac ccggatggag aagaggatgg caacagtgac
      841 cagagtcagg cttcagaagc cacaggtggt cgaagggtct caaaggccct aatggcctcc
      901 atggctcgca gagcttcaag gggacccata gccttttggg cccgcagggc atcaaggact
      961 cggttggctg cctgggctcg gagagctttg ctctccctga ggtcacctag agctcgcaga
     1021 ggcaaggccc gaagaagagc tgcgaagcta cagtcatccc aggaacctga ggcaccccca
     1081 cccagagatg tggccctttt acaaggaagg gcaaatgact tggtgaagta cctgttggct
     1141 aaagaccaga caaagattcc catcagacgc tcagatatgc tgaaggacat catcaaagaa
     1201 tatactgatg tataccctga aatcattgaa cgagcaggct attccttgga gaaggtattt
     1261 ggaatccaat tgaaagaaat tgacaagaat gaccacttgt atattcttct cagtacctta
     1321 gagccaactg atgcaggcat attgggaacg accaaggact cacctaagct gggcctcctc
     1381 atggtgcttc ttagcatcat cttcatgaat ggaaatcggt ccagtgaggc tgtcatctgg
     1441 gaggtgctgc gcaagttggg gctgcgccct gggattcatc actcactctt tggagatgtg
     1501 aagaaactca ttactgatga gtttgtgaag cagaagtacc tggactatgc cagagtaccc
     1561 aatagcaatc ctcctgagta cgagttcttc tggggcctac gctcttacta tgagaccagc
     1621 aagatgaaag ttctcaagtt tgcttgtaag gtgcaaaaga aggatcccaa ggaatgggca
     1681 gctcagtacc gagaggcaat ggaagcagat ttgaaggctg cagctgaggc tgctgccgaa
     1741 gccaaggcga gggctgagat tagagctcag atgggcattg ggcttggctc tgagaatgcc
     1801 gctgggccct gcaactggga cgaagctgat attggaccct gggcaaaggc ccggatccag
     1861 gcaggagctg aaactaaagc caaagcccaa ggaagtggtg gtgccaatgc cagtgctggt
     1921 gccggtgcca gtactggtac cagtgttggt gccagtggca gtgccagtgc tggtgccagt
     1981 gctggtgcca gtggtggctt cagtaacaac tccagcctga ctgccagtct cacatttggg
     2041 ctcttcgctg gccttagtgg agctggggcc agtaccaaca gcagctctgg tgcctgtggt
     2101 ttctcctaca agtgagatac agattgctaa taatcacagc gtcttcttct caagccaggg
     2161 tgcactctca gaaacgtact caatgcagca ctccaggcag ccactatcaa atcaactgaa
     2221 gtcgacactc tatattaaat ctatttgcca tttctga
//
