LOCUS       NM_173783               2160 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus MAGE family member B18 (Mageb18), mRNA.
ACCESSION   NM_173783
VERSION     NM_173783.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Gordeeva,O., Gordeev,A. and Khaydukov,S.
  TITLE     Expression dynamics of Mage family genes during self-renewal and
            differentiation of mouse pluripotent stem and teratocarcinoma cells
  JOURNAL   Oncotarget 10 (35), 3248-3266 (2019)
   PUBMED   31143371
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Lin,Y., Wen,T., Meng,X., Wu,Z., Zhao,L., Wang,P., Hong,Z. and
            Yin,Z.
  TITLE     The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE
            protein and regulates cell proliferation and apoptosis in melanoma
            B16-F0 cells
  JOURNAL   Biochem J 443 (3), 779-788 (2012)
   PUBMED   22332604
  REMARK    GeneRIF: demonstrate that knockdown of MAGEB18 inhibits the growth
            of B16-F0 cells and induces apoptosis, which correlates with
            increased levels of TP53 (tumour protein 53), p21, Bax and caspase
            3
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046641.1.
            
            On Apr 6, 2007 this sequence version replaced NM_173783.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046641.1, BB645562.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849381 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2160              AK046641.1         3-2162
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 40.62 cM"
     gene            1..2160
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /note="MAGE family member B18"
                     /db_xref="GeneID:215641"
                     /db_xref="MGI:MGI:3045344"
     exon            1..124
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            125..170
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            171..257
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            258..350
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            351..2160
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1388
                     /gene="Mageb18"
                     /gene_synonym="B430216B18Rik"
                     /note="MAGE-B18 antigen; melanoma antigen family B, 18"
                     /codon_start=1
                     /product="melanoma-associated antigen B18"
                     /protein_id="NP_776144.1"
                     /db_xref="CCDS:CCDS30268.1"
                     /db_xref="GeneID:215641"
                     /db_xref="MGI:MGI:3045344"
                     /translation="MPRGQKSKLRAREKRRQARAKNAQEKEASPGPFYGCPHQASPVA
                     SMPTSPNMPMGEQSTFSHSYTSTSDQNLDEKSSDDSEDTEDWCKDPINHKVVLLVQFL
                     MEKYQKKEVITKADMLKYVIKTSKNHFNEILKRASEHMELAFGIDLKEVDPNRHCYAL
                     FNKLEHTFDGVMGEEKMPSSGLLMIVLGVIFMNDNCVSETEIWNVLSMMGVYANRKHF
                     IYGDPKKVITEDMVQLKYLEYQQVPNSNPPSFEFTWGPRACAEISKMKILEFWAKIHD
                     TTPDSFPTLYEAALKDEEERAQARAVARAHTAAMASPYSRATVCSSSHTNI"
ORIGIN      
        1 acataaagtt tgccttgatg gataagaaag agaatgccat gaaaattccc agctaaatta
       61 agatgaacaa atcttatttg agaagttgct ttgctactag aaccaggata ttttaagttc
      121 cttgggtctt ctttgaagat atttcagtga atttaagtct tatgcacaag gtgttgtgct
      181 gtttgctttt gctgtggcag tgaaaaagca tctgtggaag tgactggtcc agcagaagga
      241 agtaactgag acaacttcac aagtcattgc tcaaagcccc agactgctgg acacctgccc
      301 tacaagagga gagcttgcct tcagagagtg ctctgaccac tggaactcag ggtgacctct
      361 tcctcagcct gtttgcagta ctacttgtga tccccactac agtcatgccc cgtggccaga
      421 aaagcaaact ccgtgcccgt gagaagcgcc gccaggcccg tgctaaaaat gcacaggaga
      481 aagaagcctc tccaggtcct ttctatgggt gtccacatca ggctagtcct gttgccagta
      541 tgcctacatc tcccaacatg ccaatgggag agcagtctac cttttcacac tcatatacaa
      601 gtacaagtga ccaaaaccta gatgagaaaa gttcagatga ctctgaggac actgaggact
      661 ggtgtaaaga tcctattaac cacaaagtag ttttactggt gcagttcctg atggagaagt
      721 atcaaaagaa agaggttatt actaaggcag atatgctgaa gtatgttatc aaaacatcta
      781 aaaaccactt caatgagatc ctaaagagag cctcagagca catggaactg gcatttggta
      841 ttgatctgaa ggaagttgat ccaaacaggc actgctatgc cctttttaat aaactagaac
      901 atacttttga tggagtgatg ggtgaagaaa aaatgcccag tagtggcctc ctaatgattg
      961 tgctgggtgt gatattcatg aatgataact gtgtctctga aactgagatc tggaatgtgc
     1021 tgagtatgat gggtgtatat gctaatagaa aacacttcat ctatggagat cctaagaagg
     1081 tcatcactga agatatggtg cagctaaagt acttggagta ccaacaagtg cccaacagca
     1141 atcctccatc ctttgaattc acgtggggtc caagagcctg tgctgaaatc agcaagatga
     1201 aaatcttgga gttttgggcc aagatccatg atactacacc agattccttc ccaaccttgt
     1261 atgaagcagc tctgaaagat gaagaagaga gagcccaagc cagggctgta gccagggctc
     1321 acactgctgc aatggccagt ccatattcaa gagccacggt gtgcagctcc tcccatacta
     1381 atatctaagg ctatttcttc actatttgta aaggtctgta agctacctaa tagtggaagg
     1441 ttattaagtg cctataatat ttctgtttct cttttatatt agtaacttcc agttttcccc
     1501 ttttccctct tttaattcta ggttacacat caaaggttga cgtctgggaa agattttctg
     1561 tgtggaaatt agacaatgga caatttaaat ggtagatgac actctagaag gagcacactg
     1621 aatatcattg ttgcattctt ctgccatacc taagtttcaa atcagttttt tttttgtgtt
     1681 atatttcaga tgtttctttt aaaagtttcc agtactttta aaatgtaaaa tacataatgc
     1741 atttccttat acatttaatg cctggagctg ttggaagaga aagtcacttt tctttagggg
     1801 tgtgaccact ggtgtgttct ccatctacac ctgggcccat atggtagcac taactggact
     1861 taactttttt tttattatta ttattatttt tagagatgta ttagaagaaa gggtaagctc
     1921 tatatcagtt tgaatctacc agtttgttca atattagtgt cttgttggct cagtgagtaa
     1981 aatctgggtc aaaatatagt cgatgttaat taacattaag atagcataaa tggaaaaaga
     2041 aaaatgggag gatacctagt tcttagtttt ctttatttca cttcattgta tacaaataaa
     2101 atgtatgtac tttgatttgt tttactaaga aatttaggtg ataataaagt ttttaagctg
//
