LOCUS       NM_001369262            2504 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus myelin-associated glycoprotein (Mag), transcript
            variant 8, mRNA.
ACCESSION   NM_001369262 XM_011250438
VERSION     NM_001369262.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2504)
  AUTHORS   Torigoe,K.
  TITLE     Axonal regrowth under release of myelin-associated glycoprotein:
            chemotaxis by pioneer Schwann cells and Cajal's gigantic clubs
  JOURNAL   Microscopy (Oxf) 73 (3), 251-261 (2024)
   PUBMED   37757473
  REMARK    GeneRIF: Axonal regrowth under release of myelin-associated
            glycoprotein: chemotaxis by pioneer Schwann cells and Cajal's
            gigantic clubs.
REFERENCE   2  (bases 1 to 2504)
  AUTHORS   Zhang,Y., Song,Z., Wu,R., Kong,X., Zhang,H., Li,S., Gong,X.,
            Gong,S., Cheng,J., Yuan,F., Wu,H., Wang,S. and Yuan,Z.
  TITLE     PRRC2B modulates oligodendrocyte progenitor cell development and
            myelination by stabilizing Sox2 mRNA
  JOURNAL   Cell Rep 43 (3), 113930 (2024)
   PUBMED   38507412
REFERENCE   3  (bases 1 to 2504)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2504)
  AUTHORS   Waldhauser,V., Baroti,T., Frob,F. and Wegner,M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2504)
  AUTHORS   McKerracher,L. and Rosen,K.M.
  TITLE     MAG, myelin and overcoming growth inhibition in the CNS
  JOURNAL   Front Mol Neurosci 8, 51 (2015)
   PUBMED   26441514
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2504)
  AUTHORS   Kahn,R.A., Der,C.J. and Bokoch,G.M.
  TITLE     The ras superfamily of GTP-binding proteins: guidelines on
            nomenclature
  JOURNAL   FASEB J 6 (8), 2512-2513 (1992)
   PUBMED   1592203
REFERENCE   7  (bases 1 to 2504)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   8  (bases 1 to 2504)
  AUTHORS   Nakano,R., Fujita,N., Sato,S., Inuzuka,T., Sakimura,K.,
            Ishiguro,H., Mishina,M. and Miyatake,T.
  TITLE     Structure of mouse myelin-associated glycoprotein gene
  JOURNAL   Biochem Biophys Res Commun 178 (1), 282-290 (1991)
   PUBMED   1712586
REFERENCE   9  (bases 1 to 2504)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
REFERENCE   10 (bases 1 to 2504)
  AUTHORS   Fujita,N., Sato,S., Kurihara,T., Kuwano,R., Sakimura,K.,
            Inuzuka,T., Takahashi,Y. and Miyatake,T.
  TITLE     cDNA cloning of mouse myelin-associated glycoprotein: a novel
            alternative splicing pattern
  JOURNAL   Biochem Biophys Res Commun 165 (3), 1162-1169 (1989)
   PUBMED   2482022
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165340.3.
            
            On Mar 29, 2019 this sequence version replaced XM_011250438.2.
            
            Summary: This gene encodes a type I membrane protein and member of
            the immunoglobulin-like superfamily. It is expressed in myelinating
            glial cells, including oligodendrocytes of the central nervous
            system and Schwann cells of the peripheral nervous system. Mice
            lacking the encoded protein express abundant myelin, but suffer
            long-term axon degeneration, altered distribution of channels and
            adhesion molecules at nodes of Ranvier, and altered axon
            cytoskeletal structure. While not required for myelination, the
            encoded protein enhances axon-myelin stability, helps to structure
            nodes of Ranvier, and regulates the axon cytoskeleton. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            Transcript Variant: This variant (8) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 8, and 9 all encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.231540.1,
                                           ERR3363658.975315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC165340.3         238091-238218       c
            129-181             AC165340.3         237624-237676       c
            182-237             AC165340.3         236179-236234       c
            238-310             AC165340.3         235246-235318       c
            311-679             AC165340.3         234756-235124       c
            680-976             AC165340.3         232331-232627       c
            977-1234            AC165340.3         231720-231977       c
            1235-1495           AC165340.3         230261-230521       c
            1496-1783           AC165340.3         225004-225291       c
            1784-1880           AC165340.3         224418-224514       c
            1881-1980           AC165340.3         223993-224092       c
            1981-2504           AC165340.3         222530-223053       c
FEATURES             Location/Qualifiers
     source          1..2504
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.26 cM"
     gene            1..2504
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /note="myelin-associated glycoprotein"
                     /db_xref="GeneID:17136"
                     /db_xref="MGI:MGI:96912"
     exon            1..128
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            129..181
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            182..237
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            238..310
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2148
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 8"
                     /codon_start=1
                     /product="myelin-associated glycoprotein isoform 1
                     precursor"
                     /protein_id="NP_001356191.1"
                     /db_xref="CCDS:CCDS90207.1"
                     /db_xref="GeneID:17136"
                     /db_xref="MGI:MGI:96912"
                     /translation="MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRF
                     DFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTL
                     LLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCM
                     VPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQ
                     AAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRD
                     GMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGT
                     VVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWC
                     VAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRN
                     VTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHR
                     LMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISG
                     APDKYESEKQRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEI
                     RVK"
     exon            311..679
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            680..976
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1234
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1495
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1783
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1880
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1980
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2504
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2479..2484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /note="hexamer: AATAAA"
     polyA_site      2504
                     /gene="Mag"
                     /gene_synonym="Gma; siglec-4a"
                     /note="major polyA site"
ORIGIN      
        1 aagcccggcc agccgagcag aaggtgcaga agtcagatcg tccaagtgag tactgaggca
       61 gagagggcta gggtgaaaga cccccagggg gtcgggggcg ctggacatca gggcatgtgc
      121 aaggccagcc ttctgtgtta gcgttcctca gctcctcatt gcagttccct gaagagactt
      181 ggttgaaagg ccacttcaag tggaatcagg agacatcccc aactcaggga gactaagccc
      241 tagctcaatc acttgctaaa caagatgata ttcctcgcca ccctgccgct gttttggata
      301 atgatttcag cttctcgagg gggccactgg ggtgcctgga tgccctcgac catctcagcc
      361 ttcgagggca cgtgtgtctc cattccctgc cgtttcgact tccccgatga gctcagaccg
      421 gctgtggtac atggcgtctg gtatttcaat agtccctacc ccaagaacta cccaccggtg
      481 gtcttcaagt cccgcacaca agtggtccat gagagtttcc agggccgcag ccgcctattg
      541 ggagacctgg gcctacgaaa ctgtaccctg cttctcagca cactgagccc cgagctggga
      601 ggcaaatact atttccgagg cgacctgggt ggctacaacc agtacacctt ctcggagcac
      661 agcgtcctgg acatcgtcaa cacccccaac attgtggttc ccccggaagt ggtggcagga
      721 acggaagtgg aggtcagttg tatggtgccg gacaactgcc cagagctgcg gccagagctg
      781 agctggctgg gccacgaggg gctgggagag cccactgtgc tgggtcggct gcgtgaggat
      841 gaaggcacct gggtgcaggt gtcgctgcta cacttcgtgc ctactagaga ggccaacggc
      901 caccgtctgg gctgtcaggc tgccttcccc aacaccacct tgcagttcga gggttacgcc
      961 agtttggacg tcaagtaccc cccagtgatt gtggagatga attcctctgt ggaggccatt
     1021 gagggctccc atgtcagcct gctctgtggg gctgacagca acccgccgcc gctgctgact
     1081 tggatgcggg atgggatggt gttgagggag gcagttgcca agagcctgta cctggatctg
     1141 gaggaggtga ccccaggaga ggacggcgtc tatgcttgcc tagcagagaa cgcctatggc
     1201 caggacaacc gcacggtgga gctgagtgtc atgtatgcac cttggaagcc cacagtgaat
     1261 gggacggtgg tggccgtaga gggggagact gtctctatcc tgtgttccac acagagcaac
     1321 ccggacccca tccttaccat cttcaaggag aagcagatcc tagccacggt catctatgag
     1381 agtcagctgc agctggaact ccctgcagtg acccccgagg atgatgggga atactggtgt
     1441 gtggctgaga accagtatgg ccagagagcc actgccttca acctgtctgt ggagtttgcc
     1501 cccataatcc ttctggagtc acactgtgca gcggccagag acaccgtgca gtgtctatgt
     1561 gtggtaaaat ccaacccgga accctctgtg gcctttgagc tgccttcccg caacgtgact
     1621 gtgaatgaga cggagaggga gtttgtgtac tccgagcgca gtggcctcct gctcaccagc
     1681 atcctcacga tccggggtca ggcccaagcc ccaccccgcg tcatttgtac ctccaggaac
     1741 ctctatggca cccagagcct cgagctgcct ttccagggag cacaccgact gatgtgggcc
     1801 aaaatcggtc ctgtgggtgc tgtggtcgcc tttgccatcc tgattgccat tgtgtgctac
     1861 atcacccaga cgagaagaaa aaagaatgtc acggagagct ccagcttctc agggggagac
     1921 aaccctcatg tcctgtacag ccccgaattc agaatctctg gggcacctga taagtatgag
     1981 agtgagaagc agcgcctggg atctgagagg aggctgctgg gccttcgggg ggaatcccca
     2041 gaactggacc tcagttattc ccactcagac ctgggaaaac gacccaccaa ggacagctac
     2101 accctgacag aggagctggc tgagtatgca gaaatccgag tcaagtgagg acgctggggg
     2161 ctggccctgt ggctcacccc ccatcaagac cctcgctggc ccccactggc tgtgggctcc
     2221 ctttctcttg agagtagtag gggtgagggc gggaaggggc aggacaggaa acagtgaggt
     2281 cctgggggcc tggcctcccc tccttcccag ctgttcctcc ttgccaacat tccttgccta
     2341 cattagagct cccctctccc ttccttttaa cctcagctgt tgagaggggt gctctgtctg
     2401 tccatgttat ttattgctat ccctttcctg gtctcctgtc ccttacctgg ccccaggacc
     2461 tgtacaaaag ggacatgaaa taaatgtcct aatgacaaat gcca
//
