LOCUS       NM_010756               1720 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus v-maf musculoaponeurotic fibrosarcoma oncogene family,
            protein G (avian) (Mafg), mRNA.
ACCESSION   NM_010756 XM_917323 XM_924884 XM_924887 XM_924890
VERSION     NM_010756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Ye,Y., Liang,J., Xu,C., Liu,Y., Chen,J. and Zhu,Y.
  TITLE     Inhibition of HMOX1 by MAFG potentiates the development of
            depression-like behavior in mice associated with astrocyte-mediated
            neuroinflammation
  JOURNAL   Brain Res 1843, 149115 (2024)
   PUBMED   38977234
  REMARK    GeneRIF: Inhibition of HMOX1 by MAFG potentiates the development of
            depression-like behavior in mice associated with astrocyte-mediated
            neuroinflammation.
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Patel,S.D., Anand,D., Motohashi,H., Katsuoka,F., Yamamoto,M. and
            Lachke,S.A.
  TITLE     Deficiency of the bZIP transcription factors Mafg and Mafk causes
            misexpression of genes in distinct pathways and results in lens
            embryonic developmental defects
  JOURNAL   Front Cell Dev Biol 10, 981893 (2022)
   PUBMED   36092713
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Pradas-Juni,M., Hansmeier,N.R., Link,J.C., Schmidt,E., Larsen,B.D.,
            Klemm,P., Meola,N., Topel,H., Loureiro,R., Dhaouadi,I.,
            Kiefer,C.A., Schwarzer,R., Khani,S., Oliverio,M., Awazawa,M.,
            Frommolt,P., Heeren,J., Scheja,L., Heine,M., Dieterich,C.,
            Buning,H., Yang,L., Cao,H., Jesus,D.F., Kulkarni,R.N., Zevnik,B.,
            Troder,S.E., Knippschild,U., Edwards,P.A., Lee,R.G., Yamamoto,M.,
            Ulitsky,I., Fernandez-Rebollo,E., Vallim,T.Q.A. and Kornfeld,J.W.
  TITLE     A MAFG-lncRNA axis links systemic nutrient abundance to hepatic
            glucose metabolism
  JOURNAL   Nat Commun 11 (1), 644 (2020)
   PUBMED   32005828
  REMARK    GeneRIF: Silencing Mafg in mouse hepatocytes and obese mice elicits
            a fasting-like gene expression profile, improves glucose
            metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Katsuoka,F., Otsuki,A., Takahashi,M., Ito,S. and Yamamoto,M.
  TITLE     Direct and Specific Functional Evaluation of the Nrf2 and MafG
            Heterodimer by Introducing a Tethered Dimer into Small
            Maf-Deficient Cells
  JOURNAL   Mol Cell Biol 39 (20), e00273-19 (2019)
   PUBMED   31383749
  REMARK    GeneRIF: results provide direct evidence that the Nrf2-MafG
            heterodimer acts as a transcriptional activator of Nrf2-dependent
            genes
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Caggiano,R., Cattaneo,F., Moltedo,O., Esposito,G., Perrino,C.,
            Trimarco,B., Ammendola,R. and Faraonio,R.
  TITLE     miR-128 Is Implicated in Stress Responses by Targeting MAFG in
            Skeletal Muscle Cells
  JOURNAL   Oxid Med Cell Longev 2017, 9308310 (2017)
   PUBMED   29138682
  REMARK    GeneRIF: In condition of hypoxia, MAFG induction correlated with
            reduced levels of miR-128. This lead to increased mRNA levels of
            HMOX-1 and x-CT for blunting stress. Overall, these findings
            identify MAFG as novel direct target of miR-128.
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Shavit,J.A., Motohashi,H., Onodera,K., Akasaka,J., Yamamoto,M. and
            Engel,J.D.
  TITLE     Impaired megakaryopoiesis and behavioral defects in mafG-null
            mutant mice
  JOURNAL   Genes Dev 12 (14), 2164-2174 (1998)
   PUBMED   9679061
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Martin,F., van Deursen,J.M., Shivdasani,R.A., Jackson,C.W.,
            Troutman,A.G. and Ney,P.A.
  TITLE     Erythroid maturation and globin gene expression in mice with
            combined deficiency of NF-E2 and nrf-2
  JOURNAL   Blood 91 (9), 3459-3466 (1998)
   PUBMED   9558405
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Motohashi,H., Shavit,J.A., Igarashi,K., Yamamoto,M. and Engel,J.D.
  TITLE     The world according to Maf
  JOURNAL   Nucleic Acids Res 25 (15), 2953-2959 (1997)
   PUBMED   9224592
  REMARK    Review article
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Igarashi,K., Kataoka,K., Itoh,K., Hayashi,N., Nishizawa,M. and
            Yamamoto,M.
  TITLE     Regulation of transcription by dimerization of erythroid factor
            NF-E2 p45 with small Maf proteins
  JOURNAL   Nature 367 (6463), 568-572 (1994)
   PUBMED   8107826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052633.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_917323.1, XM_924884.1, XM_924887.1, XM_924890.1, NM_010756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052633.1, BC002092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.35 cM"
     gene            1..1720
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /note="v-maf musculoaponeurotic fibrosarcoma oncogene
                     family, protein G (avian)"
                     /db_xref="GeneID:17134"
                     /db_xref="MGI:MGI:96911"
     exon            1..186
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            187..250
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..703
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /note="V-maf musculoaponeurotic fibrosarcoma oncogene
                     homolog G; avian musculoaponeurotic fibrosarcoma virus
                     (v-maf) AS42 oncogene, protein G"
                     /codon_start=1
                     /product="transcription factor MafG"
                     /protein_id="NP_034886.1"
                     /db_xref="CCDS:CCDS25748.1"
                     /db_xref="GeneID:17134"
                     /db_xref="MGI:MGI:96911"
                     /translation="MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGL
                     SKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKL
                     ELDALRSKYEALQNFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDA
                     RS"
     exon            251..1639
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1402
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /note="major polyA site"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
                     /note="hexamer: AACAAA"
     polyA_site      1505
                     /gene="Mafg"
                     /gene_synonym="C630022N07Rik"
ORIGIN      
        1 gcggcggatt ctgagcccgg tccggcccgg ccttcccagc gcgcttggcc cggcccgcgc
       61 aggcggccag tcctcctaag cccccggccc ggacccttcg cgcccgcccc agccccgcgc
      121 agccccggag cgcgcgcgcg cggccccgcc ccagccccgc cttggcccgc ccgggcccgc
      181 agtgtgagtg cctgctcact gtgtcccccg ggttatgacg acccccaata aaggaaacaa
      241 ggccttaaag gtgaagcggg agccaggcga gaatggcacc agcttgaccg acgaggagct
      301 ggtaaccatg tcggtgcgag agttgaacca gcacctgcga ggcctctcca aggaagagat
      361 catccagctg aagcagcgga ggcgcacact gaagaaccgg ggctacgcgg ccagctgccg
      421 cgtcaagcgg gtgacacaga aggaggagct ggagaagcag aaggcggagc tccagcagga
      481 ggtggagaag ctggcctcgg agaatgccag catgaagctg gagctcgatg ccctgcgctc
      541 caagtacgag gccctgcaga actttgccag gaccgtggcc cgcagccctg tggccccagc
      601 tcggggtccc cttgctgctg gcctggggcc cctggttcct ggcaaggtgg ctgccaccag
      661 cgtcatcaca atagtaaagt ccaagacgga tgctcggtca tagggacacg tgcagttgcc
      721 aggcaggtct ttgaggggcc actaggtgcg tggcagagtt ggcagccccg tccctcttcc
      781 tttcatttcc cttcctttct cctctccctt ccctgtttcc ttccctgcaa agcacaacct
      841 gcacccaggg gcactgggct gagccccttg atcatcttcg ttgtcacgcc tgtgtttcgt
      901 acgttgggat cagccagttc aacagtgatg ttgggttgcc cttaacccct ttgtaccaag
      961 gccgtgcagg ctaggagtcc agagtgggcg ctgtgggagt ggacgagagt gcacgtgggc
     1021 aagtgtactg gtcttggggc tgcccttgtc tccctggtgg tctgcagtgg gatttgagcg
     1081 ctttcctttc agaagtccag tggggctctc agcttaatcc agaaggaaga gatgggctct
     1141 gccctgaaaa gtggttatgt cttgacgccc ctgggtgaat aggccaccag cctgggcact
     1201 ggggcaggaa ccatggtgct ggagcctggc acagtgcacc ggacaagacc gaatcgccgg
     1261 ttatgagtgt gggtggaagg tgtgtctgtg tgtccgatgg gtccggtgtc actgtttaca
     1321 tgacctattt gtgtggttat atagcccttt atttaaaaga gaagttcctt ttacggagtt
     1381 attaaattat atgtttaaga gctaaaacga aaaaaaaaag ctgcagagta tttataaaat
     1441 tgtcttaaaa aacaaaaaca aaaacaaaaa aaacatttga ccgtatacat ggaaaaggga
     1501 agaaagtata gtagaaactt tgctagttta aaaaaaaaat ccctttcttg taaacctggg
     1561 gacagcgctg tggctgttgg agtttagttt ttatacacag agttatcaga cattacttat
     1621 aaaacttagt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
