LOCUS       NM_194350               2821 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus MAF bZIP transcription factor A (Mafa), mRNA.
ACCESSION   NM_194350 XM_910294
VERSION     NM_194350.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Lin,H.H., Yu,I.S., Cheng,M.S., Chang,T.J., Lin,H.Y., Chang,Y.C.,
            Ko,C.J., Chen,P.H., Lin,S.W., Huang,T.C., Huang,S.Y., Chen,T.Y.,
            Kan,K.W., Huang,H.P. and Lee,M.S.
  TITLE     Spint1 disruption in mouse pancreas leads to glucose intolerance
            and impaired insulin production involving HEPSIN/MAFA
  JOURNAL   Nat Commun 15 (1), 10537 (2024)
   PUBMED   39627229
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Kadhim,A.Z., Vanderkruk,B., Mar,S., Dan,M., Zosel,K., Xu,E.E.,
            Spencer,R.J., Sasaki,S., Cheng,X., Sproul,S.L.J., Speckmann,T.,
            Nian,C., Cullen,R., Shi,R., Luciani,D.S., Hoffman,B.G., Taubert,S.
            and Lynn,F.C.
  TITLE     Transcriptional coactivator MED15 is required for beta cell
            maturation
  JOURNAL   Nat Commun 15 (1), 8711 (2024)
   PUBMED   39379383
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Davidson,R.K., Wu,W., Kanojia,S., George,R.M., Huter,K.,
            Sandoval,K., Osmulski,M., Casey,N. and Spaeth,J.M.
  TITLE     The SWI/SNF chromatin remodelling complex regulates pancreatic
            endocrine cell expansion and differentiation in mice in vivo
  JOURNAL   Diabetologia 67 (10), 2275-2288 (2024)
   PUBMED   38958700
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2821)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2821)
  AUTHORS   Zhang,C., Moriguchi,T., Kajihara,M., Esaki,R., Harada,A.,
            Shimohata,H., Oishi,H., Hamada,M., Morito,N., Hasegawa,K., Kudo,T.,
            Engel,J.D., Yamamoto,M. and Takahashi,S.
  TITLE     MafA is a key regulator of glucose-stimulated insulin secretion
  JOURNAL   Mol Cell Biol 25 (12), 4969-4976 (2005)
   PUBMED   15923615
  REMARK    GeneRIF: These results show that MafA is a key regulator of
            glucose-stimulated insulin secretion in vivo.
REFERENCE   7  (bases 1 to 2821)
  AUTHORS   Kaneto,H., Matsuoka,T.A., Nakatani,Y., Miyatsuka,T., Matsuhisa,M.,
            Hori,M. and Yamasaki,Y.
  TITLE     A crucial role of MafA as a novel therapeutic target for diabetes
  JOURNAL   J Biol Chem 280 (15), 15047-15052 (2005)
   PUBMED   15664997
  REMARK    GeneRIF: mafA has a role in regulating insulin gene expression in
            the liver
REFERENCE   8  (bases 1 to 2821)
  AUTHORS   Kajihara,M., Sone,H., Amemiya,M., Katoh,Y., Isogai,M., Shimano,H.,
            Yamada,N. and Takahashi,S.
  TITLE     Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the
            specific transcriptional activity through the insulin promoter
  JOURNAL   Biochem Biophys Res Commun 312 (3), 831-842 (2003)
   PUBMED   14680841
REFERENCE   9  (bases 1 to 2821)
  AUTHORS   Matsuoka,T.A., Zhao,L., Artner,I., Jarrett,H.W., Friedman,D.,
            Means,A. and Stein,R.
  TITLE     Members of the large Maf transcription family regulate insulin gene
            transcription in islet beta cells
  JOURNAL   Mol Cell Biol 23 (17), 6049-6062 (2003)
   PUBMED   12917329
  REMARK    GeneRIF: These results strongly suggested that MafA was the
            beta-cell-enriched component of the RIPE3b1 activator
REFERENCE   10 (bases 1 to 2821)
  AUTHORS   Kataoka,K., Han,S.I., Shioda,S., Hirai,M., Nishizawa,M. and
            Handa,H.
  TITLE     MafA is a glucose-regulated and pancreatic beta-cell-specific
            transcriptional activator for the insulin gene
  JOURNAL   J Biol Chem 277 (51), 49903-49910 (2002)
   PUBMED   12368292
  REMARK    GeneRIF: MafA is a beta-cell-specific and glucose-regulated
            transcriptional activator for insulin gene expression and thus may
            be involved in the function and development of beta-cells as well
            as in the pathogenesis of diabetes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116393.10.
            
            On Feb 16, 2019 this sequence version replaced NM_194350.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2821              AC116393.10        125447-128267       c
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.82 cM"
     gene            1..2821
                     /gene="Mafa"
                     /gene_synonym="RIPE3b1"
                     /note="MAF bZIP transcription factor A"
                     /db_xref="GeneID:378435"
                     /db_xref="MGI:MGI:2673307"
     exon            1..2821
                     /gene="Mafa"
                     /gene_synonym="RIPE3b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1479
                     /gene="Mafa"
                     /gene_synonym="RIPE3b1"
                     /note="pancreatic beta-cell-specific transcriptional
                     activator; V-maf musculoaponeurotic fibrosarcoma oncogene
                     homolog A; Mafa homolog; v-maf musculoaponeurotic
                     fibrosarcoma oncogene family, protein A"
                     /codon_start=1
                     /product="transcription factor MafA"
                     /protein_id="NP_919331.1"
                     /db_xref="CCDS:CCDS27549.1"
                     /db_xref="GeneID:378435"
                     /db_xref="MGI:MGI:2673307"
                     /translation="MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHR
                     LPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGAGGGGSAAQAGGAPGPPSGGPGTV
                     GGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAA
                     YEAFRGQSFAGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGH
                     GGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQS
                     CRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGG
                     AGFPREPSPAQAGPGAAKGAPDFFL"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mafa"
                     /gene_synonym="RIPE3b1"
                     /note="hexamer: ATTAAA"
     polyA_site      2813
                     /gene="Mafa"
                     /gene_synonym="RIPE3b1"
ORIGIN      
        1 gagggaggcg gggccggccg gcagcgcggg tggggcgcgg ggcggggccg ggcgggagag
       61 cccggagcgc ggctgagccc ggggcgcggc ctctgcaccc tccaggccag gaccgcggag
      121 gaacagaagg aggaggaggg caggattggg ggccctgcgc ccgctcgtag cgggccgggg
      181 ggccacccga gaggcctggc cggcggcgtc ccctgagcac agcccagagt tgacagcagg
      241 aaacttttgc tgctgcgccc ttcggcggcg cgaccagagc ctgagcccac cgcggcccgg
      301 gggggagcta gggggagaga ggcccgcggc tccccccacg ctcccccgcc gcccgtcggg
      361 gcgcggccgg gcgcggcggc ggggctgggg ccccgggcga tggccgcgga gctggcgatg
      421 ggcgcagagc tgcccagcag cccactggcc atcgagtacg tcaacgactt cgacctgatg
      481 aagttcgagg tgaagaagga gccgcccgag gccgagcgct tctgccaccg cctgccgccc
      541 ggctcgctgt cctcgacgcc cctcagcacg ccctgctcct cggtgccctc ttcgcccagc
      601 ttctgcgcac ccagcccggg cacaggcggc ggcgcgggcg gcgggggcag cgcggctcag
      661 gccgggggcg ccccggggcc gccgagtgga ggccccggca ctgtcggggg cgcctcagga
      721 aaagcggtgc tggaggatct gtactggatg agcgggtacc agcaccacct gaaccccgag
      781 gcgctcaacc tgacgccgga ggacgcggtg gaggcgctca tcggcagcgg ccaccacggc
      841 gcgcaccacg gcgcgcatca cccggcggct gctgcggcct atgaggcctt ccggggtcag
      901 agcttcgcgg gcggcggcgg cgcggacgac atgggtgccg gccaccacca cggcgcacac
      961 cacactgccc accatcatca ctctgcccac catcaccatc accaccatca ccaccacgga
     1021 ggctctggcc accacggcgg aggcgcgggt cacggcggag gcggcgcagg ccaccacgtg
     1081 cgcttggagg agcgcttctc cgacgaccag ctggtatcca tgtccgtgcg ggagctgaac
     1141 cggcagctcc gcggcttcag caaggaggag gtcatccgac tgaaacagaa gcggcgcacg
     1201 ctcaagaacc gcggctacgc gcagtcgtgc cgcttcaagc gggtgcagca gcggcacatt
     1261 ctggagagcg agaagtgcca gctccagagc caggtggagc agctgaagct ggaggtgggg
     1321 cgtctggcca aggagcggga cctgtacaag gagaaatacg agaagttggc gggccggggc
     1381 ggccccgggg gcgcgggcgg ggccggcttc cctcgggagc cctcgccagc gcaggctggc
     1441 cccggggcgg ccaaaggcgc acccgacttc tttctgtgag tgccggaccc tgggcctcgc
     1501 cacggccggg gacaagtttg cgcaggccgc cccggtctcg gttcagactc tgaggcccgg
     1561 gacgcgcgct ccggcggtgc agccgcagct gccggggtcc tcctgtccgc cctgcgcacc
     1621 ccgccgccaa gccccagctc caggtaccta ccgcggtgcg cctctcccgc cgggccccgg
     1681 tccgagcgtc ttcggggtcg ccggctagac tttgccgggg tccctcggcg ccccgggaac
     1741 ggtgattgct tagggaagtc cgagccaggt ctgacttcct cggcagcgtc cacttgtaca
     1801 gacgtggagc gcagttctgc gtcccaacct ccgcccagcc gcagcggggc cgcgccgcca
     1861 ccagctcccg gtagcctccg ccggccccgc gctcctctgt cgtctttctt tctgcctccg
     1921 tttacttgct ctgtttttac tcctcctcct cctttttaaa gcagtcatat tttcgcaaca
     1981 ttaatattta ttttgcttgg taattagaaa acccggagga accccctggt ccccgtgcgc
     2041 cctcggaggt cggcgagtgc ccgcatgtgc cctcctcgct cattcgctct gaggggtccg
     2101 gccctgcctg ccttccagcc cgcttgtccc caccctgttc gctgctccct gtagaggaag
     2161 ccgaggaact tacctgcgtg ttggtcccac tgtcctgcta tactcgactg ggggaggggg
     2221 gtggggggtg gccgtgctca gccgggttgg ggctggcccg gactcccgcg ctgctatttc
     2281 tctatgcacc agatcgtatt tatgactctt ggggaaatat atcttatttt aaccttccag
     2341 agaagcgaaa gaatttaaaa agtaatgcac agttctagaa gaaaaaattt ttaaagagga
     2401 ggcttaggcc tgaacctcct ggcatgggcg ggtggaaaag tgtttttatt taatttaaat
     2461 tgtgtttcgt ttgtggaatc ttgtttaaag cttggtcgct tttttggact agccggaaga
     2521 gaggcccggt ggagggtgtt ataagctggg cgtatctgcg ccggctgaga tctggttttc
     2581 tgaggcttgg ccccggtgct ctgaggctcc gaggctcctt ccccttccgt cctctgctgc
     2641 tcccaggtgg ctctcactga gtcttctgaa caggacgcta gacaaatcgt tgggaaagaa
     2701 attttgtgtt gttggttttt gttgtgttct ctctctctct ctctcactca ctcactcatt
     2761 tgttacgaaa ctgaggaaag aaaaaacatt aaaaaaaaat aaatgtttag atccaaaagt
     2821 c
//
