LOCUS       NM_026859               1703 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus MAF1 homolog, negative regulator of RNA polymerase III
            (Maf1), transcript variant 2, mRNA.
ACCESSION   NM_026859
VERSION     NM_026859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Han,Y., Chen,K., Yu,H., Cui,C., Li,H., Hu,Y., Zhang,B. and Li,G.
  TITLE     Maf1 loss regulates spinogenesis and attenuates cognitive
            impairment in Alzheimer's disease
  JOURNAL   Brain 147 (6), 2128-2143 (2024)
   PUBMED   38226680
  REMARK    GeneRIF: Maf1 loss regulates spinogenesis and attenuates cognitive
            impairment in Alzheimer's disease.
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Willemin,G., Mange,F., Praz,V., Lorrain,S., Cousin,P., Roger,C.,
            Willis,I.M. and Hernandez,N.
  TITLE     Contrasting effects of whole-body and hepatocyte-specific deletion
            of the RNA polymerase III repressor Maf1 in the mouse
  JOURNAL   Front Mol Biosci 10, 1297800 (2023)
   PUBMED   38143800
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Tsang,C.K., Mi,Q., Su,G., Hwa Lee,G., Xie,X., D'Arcangelo,G.,
            Huang,L. and Steven Zheng,X.F.
  TITLE     Maf1 is an intrinsic suppressor against spontaneous neural repair
            and functional recovery after ischemic stroke
  JOURNAL   J Adv Res 51, 73-90 (2023)
   PUBMED   36402285
  REMARK    GeneRIF: Maf1 is an intrinsic suppressor against spontaneous neural
            repair and functional recovery after ischemic stroke.
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Phillips,E., Ahmad,N., Sun,L., Iben,J., Walkey,C.J., Rusin,A.,
            Yuen,T., Rosen,C.J., Willis,I.M., Zaidi,M. and Johnson,D.L.
  TITLE     MAF1, a repressor of RNA polymerase III-dependent transcription,
            regulates bone mass
  JOURNAL   Elife 11, e74740 (2022)
   PUBMED   35611941
  REMARK    GeneRIF: MAF1, a repressor of RNA polymerase III-dependent
            transcription, regulates bone mass.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1703)
  AUTHORS   Michels,A.A., Robitaille,A.M., Buczynski-Ruchonnet,D., Hodroj,W.,
            Reina,J.H., Hall,M.N. and Hernandez,N.
  TITLE     mTORC1 directly phosphorylates and regulates human MAF1
  JOURNAL   Mol Cell Biol 30 (15), 3749-3757 (2010)
   PUBMED   20516213
REFERENCE   7  (bases 1 to 1703)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   8  (bases 1 to 1703)
  AUTHORS   Goodfellow,S.J., Graham,E.L., Kantidakis,T., Marshall,L.,
            Coppins,B.A., Oficjalska-Pham,D., Gerard,M., Lefebvre,O. and
            White,R.J.
  TITLE     Regulation of RNA polymerase III transcription by Maf1 in mammalian
            cells
  JOURNAL   J Mol Biol 378 (3), 481-491 (2008)
   PUBMED   18377933
  REMARK    Erratum:[J Mol Biol. 2013 Mar 25;425(6):1099]
REFERENCE   9  (bases 1 to 1703)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1703)
  AUTHORS   Karlyshev,A.V., Linton,D., Gregson,N.A. and Wren,B.W.
  TITLE     A novel paralogous gene family involved in phase-variable
            flagella-mediated motility in Campylobacter jejuni
  JOURNAL   Microbiology (Reading) 148 (Pt 2), 473-480 (2002)
   PUBMED   11832511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY118992.1, AK042913.1, AK004406.1 and BB250147.2.
            
            On Sep 3, 2009 this sequence version replaced NM_026859.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3, encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016260.1, AK154047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY118992.1         2-60
            60-366              AK042913.1         1-307
            367-1697            AK004406.1         40-1370
            1698-1703           BB250147.2         656-661
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.75 cM"
     gene            1..1703
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /note="MAF1 homolog, negative regulator of RNA polymerase
                     III"
                     /db_xref="GeneID:68877"
                     /db_xref="MGI:MGI:1916127"
     exon            1..366
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..499
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..1193
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /codon_start=1
                     /product="repressor of RNA polymerase III transcription
                     MAF1 homolog"
                     /protein_id="NP_081135.3"
                     /db_xref="CCDS:CCDS27568.1"
                     /db_xref="GeneID:68877"
                     /db_xref="MGI:MGI:1916127"
                     /translation="MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMF
                     KQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEDESPLSDKCSRKTLFYLIATLNE
                     SFRPDYDFSTARSHEFSREPSLRWVVNAVNCSLFSAVREDFKALKPQLWNAVDEEICL
                     AECDIYSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGN
                     ALDLELGAEEADEESGGGGGEGRAEETSTMEEDRVPVICM"
     exon            500..628
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            629..794
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..916
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1036
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1171
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1703
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1678..1683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1698
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /note="major polyA site"
ORIGIN      
        1 attcagagga gtggggttgg gcccgtcgga cgcttgttgt tgtcgggtcg ggggaggcgg
       61 aggtcgctgt ttcgttctct ggctggtacg atctcggcgg tccgcggcag gttggtcgcg
      121 aaagcgggcg ttgcaggggg gcgaggctat gtcgcggctg cagcccgtat gggccggcag
      181 ggcctggagt aacgggacgt cgccgcgaag cttcttcccc cggatacagt gcggcccgag
      241 tggaggccgc ggcgccgccc tccagtcctg aggaacccgc gctgcgcaaa gcccgcgccg
      301 ccgtcacctc ggcaccgaca ctaaacaacc cgtctaccct ggcttgatct agcccaattc
      361 tggcaggtag tgctgcccta atcccactgg cacaagaatc tcccttccca aaggacatga
      421 agctattgga gaactccagc tttgaggcca tcaactcaca gttgacagtg gagactggag
      481 atgcccatat tattggcagg attgaaagct actcgtgtaa gatggcggga gatgataaac
      541 atatgttcaa gcagttctgc caggagggcc agccccatgt gttggaggca ctgtccccac
      601 cccaaacttc aggcctcagt cccagcagac tgagcaagag ccagggtggt gaggatgaga
      661 gtcctctgag cgacaagtgc agccgcaaga ccctcttcta tctgattgcc accctcaatg
      721 agtccttccg gccagactat gacttcagca cagccagaag tcatgaattc agccgagagc
      781 caagcctccg ctgggtggta aatgcagtca actgcagcct gttttcagct gttcgtgaag
      841 acttcaaggc cctgaagcca cagctgtgga atgcagtgga tgaggagatc tgcttagctg
      901 agtgtgacat ctacagctat aacccagatc tagactccga cccctttggg gaagatggaa
      961 gcctctggtc attcaactat ttcttttaca ataagagact gaagcgaatt gtcttcttta
     1021 gctgccgctc catcagtggc tccacgtaca caccctcaga ggcaggcaat gcactggact
     1081 tggaactggg ggcagaggag gctgatgaag agagtggagg tggaggcggt gagggcaggg
     1141 cagaggagac cagcaccatg gaggaagaca gggttccagt gatctgtatg tgatgagaag
     1201 aagcagaggt ctcagcgtca tccagctctg accaatccct ggacctgtct acctgaggag
     1261 ctccagagct tccccagatg ctggctatgc cttggcactg acaccgtcct ggcgctgccc
     1321 aaggctatac ctgtgtagcc ctttggattc agcctgtgga tgtccactca tccctgcagg
     1381 ctcctactgc ccatgctgtg gctggattaa acagcacggg gtctgataga aaacgggact
     1441 gctctgcacc aacagcctgt cacagacagg acagctggac cacagagttt atttttgtat
     1501 ttcttattgg gcctgtacac tccagctcta agggccagta gtttgaagcc ctataagtgg
     1561 tgcccagtgt tcatggggtc tggtctttga ccggcctctg gtgcccactt ttgtctccca
     1621 ctttaccagg tgggccacat gcactgagtg tcactttgct gcagctcatt tgtttccaat
     1681 aaaagtttct gtgacttaga tgg
//
