LOCUS       NP_081135                258 aa            linear   ROD 18-JUN-2024
DEFINITION  repressor of RNA polymerase III transcription MAF1 homolog [Mus
            musculus].
ACCESSION   NP_081135
VERSION     NP_081135.3
DBSOURCE    REFSEQ: accession NM_026859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 258)
  AUTHORS   Han,Y., Chen,K., Yu,H., Cui,C., Li,H., Hu,Y., Zhang,B. and Li,G.
  TITLE     Maf1 loss regulates spinogenesis and attenuates cognitive
            impairment in Alzheimer's disease
  JOURNAL   Brain 147 (6), 2128-2143 (2024)
   PUBMED   38226680
  REMARK    GeneRIF: Maf1 loss regulates spinogenesis and attenuates cognitive
            impairment in Alzheimer's disease.
REFERENCE   2  (residues 1 to 258)
  AUTHORS   Willemin,G., Mange,F., Praz,V., Lorrain,S., Cousin,P., Roger,C.,
            Willis,I.M. and Hernandez,N.
  TITLE     Contrasting effects of whole-body and hepatocyte-specific deletion
            of the RNA polymerase III repressor Maf1 in the mouse
  JOURNAL   Front Mol Biosci 10, 1297800 (2023)
   PUBMED   38143800
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 258)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 258)
  AUTHORS   Tsang,C.K., Mi,Q., Su,G., Hwa Lee,G., Xie,X., D'Arcangelo,G.,
            Huang,L. and Steven Zheng,X.F.
  TITLE     Maf1 is an intrinsic suppressor against spontaneous neural repair
            and functional recovery after ischemic stroke
  JOURNAL   J Adv Res 51, 73-90 (2023)
   PUBMED   36402285
  REMARK    GeneRIF: Maf1 is an intrinsic suppressor against spontaneous neural
            repair and functional recovery after ischemic stroke.
REFERENCE   5  (residues 1 to 258)
  AUTHORS   Phillips,E., Ahmad,N., Sun,L., Iben,J., Walkey,C.J., Rusin,A.,
            Yuen,T., Rosen,C.J., Willis,I.M., Zaidi,M. and Johnson,D.L.
  TITLE     MAF1, a repressor of RNA polymerase III-dependent transcription,
            regulates bone mass
  JOURNAL   Elife 11, e74740 (2022)
   PUBMED   35611941
  REMARK    GeneRIF: MAF1, a repressor of RNA polymerase III-dependent
            transcription, regulates bone mass.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 258)
  AUTHORS   Michels,A.A., Robitaille,A.M., Buczynski-Ruchonnet,D., Hodroj,W.,
            Reina,J.H., Hall,M.N. and Hernandez,N.
  TITLE     mTORC1 directly phosphorylates and regulates human MAF1
  JOURNAL   Mol Cell Biol 30 (15), 3749-3757 (2010)
   PUBMED   20516213
REFERENCE   7  (residues 1 to 258)
  AUTHORS   Kantidakis,T., Ramsbottom,B.A., Birch,J.L., Dowding,S.N. and
            White,R.J.
  TITLE     mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes,
            and targets their repressor Maf1
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11823-11828 (2010)
   PUBMED   20543138
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11465]
REFERENCE   8  (residues 1 to 258)
  AUTHORS   Goodfellow,S.J., Graham,E.L., Kantidakis,T., Marshall,L.,
            Coppins,B.A., Oficjalska-Pham,D., Gerard,M., Lefebvre,O. and
            White,R.J.
  TITLE     Regulation of RNA polymerase III transcription by Maf1 in mammalian
            cells
  JOURNAL   J Mol Biol 378 (3), 481-491 (2008)
   PUBMED   18377933
  REMARK    Erratum:[J Mol Biol. 2013 Mar 25;425(6):1099]
REFERENCE   9  (residues 1 to 258)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (residues 1 to 258)
  AUTHORS   Karlyshev,A.V., Linton,D., Gregson,N.A. and Wren,B.W.
  TITLE     A novel paralogous gene family involved in phase-variable
            flagella-mediated motility in Campylobacter jejuni
  JOURNAL   Microbiology (Reading) 148 (Pt 2), 473-480 (2002)
   PUBMED   11832511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY118992.1, AK042913.1, AK004406.1 and BB250147.2.
            
            On Sep 3, 2009 this sequence version replaced NP_081135.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3, encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016260.1, AK154047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.75 cM"
     Protein         1..258
                     /product="repressor of RNA polymerase III transcription
                     MAF1 homolog"
                     /calculated_mol_wt=28649
     Region          25..202
                     /region_name="Maf1"
                     /note="Maf1 regulator; pfam09174"
                     /db_xref="CDD:462704"
     Region          58..85
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            60
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            68
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H063; propagated from
                     UniProtKB/Swiss-Prot (Q9D0U6.1)"
     Region          226..253
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D0U6.1)"
     CDS             1..258
                     /gene="Maf1"
                     /gene_synonym="1110068E11Rik"
                     /coded_by="NM_026859.3:417..1193"
                     /db_xref="CCDS:CCDS27568.1"
                     /db_xref="GeneID:68877"
                     /db_xref="MGI:MGI:1916127"
ORIGIN      
        1 mkllenssfe ainsqltvet gdahiigrie sysckmagdd khmfkqfcqe gqphvleals
       61 ppqtsglsps rlsksqgged esplsdkcsr ktlfyliatl nesfrpdydf starshefsr
      121 epslrwvvna vncslfsavr edfkalkpql wnavdeeicl aecdiysynp dldsdpfged
      181 gslwsfnyff ynkrlkrivf fscrsisgst ytpseagnal dlelgaeead eesgggggeg
      241 raeetstmee drvpvicm
//
