LOCUS       NM_175296               1546 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus maelstrom spermatogenic transposon silencer (Mael),
            mRNA.
ACCESSION   NM_175296
VERSION     NM_175296.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   De Luca,C., Gupta,A. and Bortvin,A.
  TITLE     Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient
            mouse spermatocytes: Ribonucleoproteins overcoming the integrated
            stress response
  JOURNAL   PLoS Genet 19 (6), e1010797 (2023)
   PUBMED   37307272
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Ito,T., Osada,A., Ohta,M., Yokota,K., Nishiyama,A., Niikura,Y.,
            Tamura,T., Sekita,Y. and Kimura,T.
  TITLE     SWI/SNF chromatin remodeling complex is required for initiation of
            sex-dependent differentiation in mouse germline
  JOURNAL   Sci Rep 11 (1), 24074 (2021)
   PUBMED   34912016
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Dahlet,T., Truss,M., Frede,U., Al Adhami,H., Bardet,A.F., Dumas,M.,
            Vallet,J., Chicher,J., Hammann,P., Kottnik,S., Hansen,P., Luz,U.,
            Alvarez,G., Auclair,G., Hecht,J., Robinson,P.N., Hagemeier,C. and
            Weber,M.
  TITLE     E2F6 initiates stable epigenetic silencing of germline genes during
            embryonic development
  JOURNAL   Nat Commun 12 (1), 3582 (2021)
   PUBMED   34117224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Nguyen,D.H., Soygur,B., Peng,S.P., Malki,S., Hu,G. and Laird,D.J.
  TITLE     Apoptosis in the fetal testis eliminates developmentally defective
            germ cell clones
  JOURNAL   Nat Cell Biol 22 (12), 1423-1435 (2020)
   PUBMED   33199844
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Ungewitter,E.K., Rotgers,E., Kang,H.S., Lichti-Kaiser,K., Li,L.,
            Grimm,S.A., Jetten,A.M. and Yao,H.H.
  TITLE     Loss of Glis3 causes dysregulation of retrotransposon silencing and
            germ cell demise in fetal mouse testis
  JOURNAL   Sci Rep 8 (1), 9662 (2018)
   PUBMED   29941866
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Vasileva,A., Tiedau,D., Firooznia,A., Muller-Reichert,T. and
            Jessberger,R.
  TITLE     Tdrd6 is required for spermiogenesis, chromatoid body architecture,
            and regulation of miRNA expression
  JOURNAL   Curr Biol 19 (8), 630-639 (2009)
   PUBMED   19345099
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Soper,S.F., van der Heijden,G.W., Hardiman,T.C., Goodheart,M.,
            Martin,S.L., de Boer,P. and Bortvin,A.
  TITLE     Mouse maelstrom, a component of nuage, is essential for
            spermatogenesis and transposon repression in meiosis
  JOURNAL   Dev Cell 15 (2), 285-297 (2008)
   PUBMED   18694567
  REMARK    GeneRIF: This study demonstrates that MAEL, a nuage component, is
            indispensable for the silencing of transposable elements (TEs) and
            identifies the initiation of meiosis as an important step in (TE)
            control in the male germline.
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Costa,Y., Speed,R.M., Gautier,P., Semple,C.A., Maratou,K.,
            Turner,J.M. and Cooke,H.J.
  TITLE     Mouse MAELSTROM: the link between meiotic silencing of unsynapsed
            chromatin and microRNA pathway?
  JOURNAL   Hum Mol Genet 15 (15), 2324-2334 (2006)
   PUBMED   16787967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034122.12.
            
            On Nov 17, 2006 this sequence version replaced NM_175296.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050800.1, AK077103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC034122.12        84469-84678         c
            211-303             AC034122.12        84197-84289         c
            304-403             AC034122.12        82807-82906         c
            404-559             AC034122.12        81335-81490         c
            560-601             AC034122.12        80099-80140         c
            602-726             AC034122.12        72500-72624         c
            727-781             AC034122.12        71771-71825         c
            782-923             AC034122.12        71524-71665         c
            924-986             AC034122.12        51787-51849         c
            987-1119            AC034122.12        50724-50856         c
            1120-1195           AC034122.12        48209-48284         c
            1196-1546           AC034122.12        47319-47669         c
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.56 cM"
     gene            1..1546
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /note="maelstrom spermatogenic transposon silencer"
                     /db_xref="GeneID:98558"
                     /db_xref="MGI:MGI:2138453"
     exon            1..210
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            211..303
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            304..403
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            404..559
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            560..601
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            602..726
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            727..781
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..923
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            924..986
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1119
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1195
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1546
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1546
                     /gene="Mael"
                     /gene_synonym="4933405K18Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttactaag ggcgggagcc cggcaagggc gccggctgct tgctgcgtct ctggagggcg
       61 tcgaggcccg acgacgccat gcccaaccgc agggccagcc gcaatgccta ctatttcttc
      121 gtacaggaga agattcccga actgcgccgg cgaggcctgc cggtggcccg cgtggcagac
      181 gccatcccct actgctcggc cgactgggcg ctcttgaggg aggatgagaa ggagaaatac
      241 tcagaaatgg ctcgagagtg gagagcagcc cagggaaagg attctgggcc ttcagagaag
      301 cagaaacttg tatctacacc actgaggagg ccaggcatgc ttgtaccaaa accaagtatt
      361 tctccccctg atatgtcaaa tttatctata aaaagtgatc aagctctcct tggaggcatt
      421 ttttattttc tgaacatttt tagccatggt gagctacctc ctcattgtga acagcgcttc
      481 ctcccttgtg aaattggctg tgttaaatac tccctccagg aaggtattat ggcagatttc
      541 cacagtttta tccatccagg tgaaattcca cgaggatttc gattccattg ccaggctgca
      601 agtgattcta gtcacaagat tcctatttca aactttgaat tcgggcatga ccaagcaact
      661 gtgttacaaa acctctataa atttatacat ccaaacccag ggaactggcc acctatttac
      721 tgcaagtctg atgatagagc cagagtcaac tggtgtttga agcgtatgga gcgggcatca
      781 gaaataaggc aagatctaga acttctcact gtagaggacc ttgtagttgg gatctaccag
      841 caaaaattcc tcaaggagcc ctctaagacc tgggtgcgaa gcctcctaga tgtggccatg
      901 tgggactatt ctagcaacac gaggtgcaaa tggcatgaag aaaatgatat tctcttctgt
      961 gctttagctg tttgcaagaa aatcgcgtac tgcatcagta attctctagc cactctgttt
     1021 ggaatccagc tcactggagc tcatgtacca ctacaagact atgaggccag caacagtgtg
     1081 acacccaaaa tggttgtatt ggatgcaggg cggtaccaga agctaagagt tgagagtcca
     1141 ggattctgtc atttcaactc ttacaatcag gaacaaagat caaatacatc tactggttat
     1201 tatccatctg gggtgaaaat ttcgggccct cacagcagtg ttcgcggaag aggaattacc
     1261 cgcttactag agagcatctc aaactcctcc aacaacatcc atagattctc cagctgtgag
     1321 acttcactct caccttacac gccccaaaaa gatgggtaca aacctttctc ctccttttct
     1381 taatgatggt actttgtgcg atttctggaa aaataacaag ccaacttcct ttctgactac
     1441 agtcatatta acaaacatca catcaatagt aaatgtcact cctaaaacct acttaatttg
     1501 taaggaaact atttcataga ttaaaagtaa ttgtggttgg agaaga
//
