LOCUS       NM_001177720            5905 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MAP-kinase activating death domain (Madd), transcript
            variant 11, mRNA.
ACCESSION   NM_001177720
VERSION     NM_001177720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5905)
  AUTHORS   Lewis,M.A., Schulte,J., Matthews,L., Vaden,K.I. Jr., Steves,C.J.,
            Williams,F.M.K., Schulte,B.A., Dubno,J.R. and Steel,K.P.
  TITLE     Accurate phenotypic classification and exome sequencing allow
            identification of novel genes and variants associated with
            adult-onset hearing loss
  JOURNAL   PLoS Genet 19 (11), e1011058 (2023)
   PUBMED   38011198
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5905)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5905)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 5905)
  AUTHORS   Li,L.C., Wang,Y., Carr,R., Haddad,C.S., Li,Z., Qian,L.,
            Oberholzer,J., Maker,A.V., Wang,Q. and Prabhakar,B.S.
  TITLE     IG20/MADD plays a critical role in glucose-induced insulin
            secretion
  JOURNAL   Diabetes 63 (5), 1612-1623 (2014)
   PUBMED   24379354
  REMARK    GeneRIF: These findings indicated that IG20/MADD plays a critical
            role in glucose-induced insulin release from beta-cells and that
            its functional disruption can cause type 2 diabetes.
REFERENCE   5  (bases 1 to 5905)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   6  (bases 1 to 5905)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   7  (bases 1 to 5905)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 5905)
  AUTHORS   Yamaguchi,K., Tanaka,M., Mizoguchi,A., Hirata,Y., Ishizaki,H.,
            Kaneko,K., Miyoshi,J. and Takai,Y.
  TITLE     A GDP/GTP exchange protein for the Rab3 small G protein family
            up-regulates a postdocking step of synaptic exocytosis in central
            synapses
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14536-14541 (2002)
   PUBMED   12388783
  REMARK    GeneRIF: role of Rab3 GEP in regulating neurotransmitter release in
            autapses of mouse hippocampal neurons in culture
REFERENCE   9  (bases 1 to 5905)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   10 (bases 1 to 5905)
  AUTHORS   Tanaka,M., Miyoshi,J., Ishizaki,H., Togawa,A., Ohnishi,K., Endo,K.,
            Matsubara,K., Mizoguchi,A., Nagano,T., Sato,M., Sasaki,T. and
            Takai,Y.
  TITLE     Role of Rab3 GDP/GTP exchange protein in synaptic vesicle
            trafficking at the mouse neuromuscular junction
  JOURNAL   Mol Biol Cell 12 (5), 1421-1430 (2001)
   PUBMED   11359932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC063386.1 and BC042212.1.
            
            Transcript Variant: This variant (11) lacks one coding exon, has
            two additional coding exons, and uses an alternate splice site,
            compared to variant 10. The resulting isoform (11) is longer and
            differs at several internal portions and the C-terminus, compared
            to isoform 10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2010              BC063386.1         54-2063
            2011-5905           BC042212.1         1-3895
FEATURES             Location/Qualifiers
     source          1..5905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.46 cM"
     gene            1..5905
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /note="MAP-kinase activating death domain"
                     /db_xref="GeneID:228355"
                     /db_xref="MGI:MGI:2444672"
     exon            1..143
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..4968
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /note="isoform 11 is encoded by transcript variant 11;
                     Rab3 GDP/GTP exchange protein; MAP kinase-activating death
                     domain protein; insulinoma-glucagonoma protein 20; rab3
                     GDP/GTP exchange factor; Rab3 GEP"
                     /codon_start=1
                     /product="MAP kinase-activating death domain protein
                     isoform 11"
                     /protein_id="NP_001171191.1"
                     /db_xref="CCDS:CCDS50635.1"
                     /db_xref="GeneID:228355"
                     /db_xref="MGI:MGI:2444672"
                     /translation="MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPE
                     FPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQK
                     RMPKEKVEGGAGPRGKEGAHTSGASEEAAAGSSESGSTLQPPSADSTPDVNQSPRGKR
                     RAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQ
                     RDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQ
                     QALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMS
                     VMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDD
                     VWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEG
                     QEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMH
                     TRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIH
                     NNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSDPTEDSGSDS
                     QDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGE
                     EPGPDSENSQENPPLRSSSSTTASSSPSTVVHSAHSEAADSTEMGDKATAGISKPLPP
                     VPPSICKSTVDRRQTETGEGSVCQRTYDNPYFEPQYGFPPEEDEEEQGESYTPRFSQH
                     VSGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNH
                     STSFSLSNLTLPTKGAREKTTPFPSLKGNRRALVDQKSSVIKHSPTVKREPSSPQGRS
                     SNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDA
                     RQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSK
                     EPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTR
                     SLKEENFVASVELWNKHQEVKKQKALEKQRPEGIKPVFDLGETEEKKSQMSADSGVSL
                     TSASQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGG
                     EGSAHLASSRATLSDSEIETNSATSAIFGKAHSLKPKEKPAGSPIRSSEDVSQRVYLY
                     EGLLGRDKGSMWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQ
                     GPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMG
                     KSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFME
                     VCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRE
                     LYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQE
                     RKVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAA
                     VRSSEEDLRTPPRPVSS"
     exon            144..740
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1044
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1176
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1290
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1371
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1550
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1786
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1943
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2047
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2238
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2492
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2632
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2734
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2837
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3024
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3175
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3382
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3436
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3537
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3621
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3780
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3883
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..3946
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4067
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4173
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4174..4284
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4392
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4557
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4630
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4631..4737
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4746
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..4816
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4863
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..5905
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5886..5891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /note="hexamer: AATAAA"
     polyA_site      5905
                     /gene="Madd"
                     /gene_synonym="9630059K23Rik; IG20; Rab3GEP; RabGEF"
                     /note="major polyA site"
ORIGIN      
        1 attatatcag aattcctcct gggaatgctg gcttcttgct cagtgccctg aagtttctct
       61 gcaatgaact gacaaatcgg aaccatggtg caaaagaagt tctgccctcg gttacttgac
      121 tatctcgtga tcgtaggggc gaggcaccca agcagtgaca gtgtggctca gactcctgag
      181 ctgctgcgga ggtacccact agaggatcac ccagagttcc ccctgccccc agatgtggtg
      241 ttcttctgcc agccagaagg atgtctgagt gtgcggcagc ggcggatgag ccttcgggac
      301 gatacctctt ttgtcttcac cctaaccgat aaggacaccg gagtcacccg ctatggcatc
      361 tgtgtcaact tctaccgttc cttccaaaag cgaatgccaa aggaaaaggt ggaaggcgga
      421 gcaggacccc gtgggaagga aggcgctcac acctctggtg cctcagaaga ggctgccgct
      481 gggagctcag agagtggctc aaccttgcag ccgcctagtg ctgactccac tcctgacgta
      541 aaccagtctc ctcggggcaa acgtagggca aaagcgggca gccgctcccg caacagtacc
      601 ctgacatccc tgtgtgtgct tagccactac cctttcttct ctaccttcag agagtgtctg
      661 tatactctca aacgtttggt agactgctgt agtgaacggc tgctaggcaa gaaactgggc
      721 atccctcgag gtgtacaaag ggacaccatg tggcgaatct ttactggatc actgctagtg
      781 gaggagaagt ccagtgccct tctgcaagac cttcgagaga ttgaggcctg gatctatcgg
      841 ttgctacgtt ccccagtgcc tgtctctggg cagaagcgag tggacattga ggtcctgccc
      901 caggaactcc agcaggccct gacatttgct cttccagatc catctcgatt caccctagta
      961 gatttccctc ttcaccttcc cttggaactt ctgggtgtag atgcttgtct tcaggtgcta
     1021 acctgcatcc tgttggagca caaggtggtg ctgcagtctc gagactacaa tgcactctcc
     1081 atgtctgtga tggcgttcgt ggcaatgatc taccccctgg agtacatgtt cccggtcatc
     1141 ccgctgcttc ccacctgcat ggcctcggca gagcagctac tcttggctcc aaccccatac
     1201 atcattggag ttcctgccag cttcttcctc tacaagctag atttcaaaat gcccgatgac
     1261 gtgtggctag tggatctgga cagcaatagg gtgattgccc ccaccaatgc agaagtgcta
     1321 cccatcctgc cagaaccaga atcattagag ctgaaaaaac acttaaagca ggccttagcc
     1381 agcatgagtc tcaacaccca gcccattctt aacctggaga aattccacga gggccaggag
     1441 atcccgcttc tcttgggaag gccatctaat gaccttcagt ccacaccttc cactgaattc
     1501 aacccgctca tttatggcaa tgatgtagat tcagtcgacg ttgcaacgag agtggccatg
     1561 gtacgtttct tcaactctgc taacgtgctg cagggctttc agatgcacac acgtaccctg
     1621 cgactcttcc cccggcctgt ggtagctttc caagctggct cctttctggc ctcacgtccc
     1681 cggcagactc cctttgctga gaaactggcc aggacccaag ctgtggagta ttttggagaa
     1741 tggatcctga acccttctaa ctatgccttc cagcggattc acaacaatac gtttgatccg
     1801 gcccttattg gtgacaagcc aaagtggtac gctcaccagc tgcagcccat ccattatcga
     1861 gtctatgatg gcaactctca gctggccgag gccctgagtg tgcccccgga gcgcgattct
     1921 gactccgacc cgacggagga cagtggcagt gatagtcagg attatgatga ctcaagctct
     1981 tcttactcct cccttgggga ctttgtcagt gaaatgatga aatgtgacat caatggagac
     2041 actcccaatg tggatcctct gacccatgca gccctgggag atgccagtga agtggagatt
     2101 gacgagctgc agccccagaa ggagggagag gaacccggcc cagacagtga gaactctcag
     2161 gaaaaccctc cgctgcgctc cagctccagc accacggcca gcagcagccc cagcaccgtt
     2221 gtccacagtg cccactctga agctgctgac tctacagaga tgggagataa ggccacagca
     2281 ggcatctcca agcccctccc tcccgtgcct cccagcattt gcaaatctac tgtggacagg
     2341 agacagacag agactggaga ggggtcagtg tgccagcgaa cctatgacaa tccatacttc
     2401 gagccccagt atggctttcc ccccgaggaa gatgaggagg agcaggggga gagctacact
     2461 ccccggttca gccagcatgt cagtggcagt cgggctcaaa agctgctgcg gcccaacagc
     2521 ttgaagctgg caagtgactc agacgcagag tcagactcga gagcaagctc tcccaactcc
     2581 actgtctcta acaacagcac cgagggcttc gggggcatca tgtcttttgc tagcagcctg
     2641 tatcggaacc atagtacaag cttcagtctt tcaaacctca cactgcccac caaaggtgcc
     2701 cgcgagaaga cgacaccatt ccccagcctg aaaggaaata ggagggcctt agtggaccag
     2761 aagtcatctg tcattaaaca cagcccaacc gtgaaaagag aaccttcatc cccacagggc
     2821 cggtcgagca actctagcga gaaccagcag ttcctgaagg aagtagtcca tagtgtgctg
     2881 gacggccagg gagtgggctg gctcaatatg aagaaggtac gccggctcct ggagagtgag
     2941 cagcttagag tctttgtact gagcaagctg aatcgcgcag tgcagtcaga ggatgacgcc
     3001 cggcaggatg tcatccaaga cgtggagatc agccggaagg tgtacaaggg gatgctagac
     3061 ctcctcaagt gcacagtcct cagcctcgag cagtcctatg cccacgcagg tctgggtggt
     3121 atggccagca tctttgggct tttggagatt gcccagaccc actactatag taaagaacca
     3181 gacaaacgga agagaagtcc gacagagaat gtaaataccc cagttggcaa ggatcctggt
     3241 ctggctgggc ggggggaccc aaaggcaatg gcccagctaa gggtccctca actgggccct
     3301 cgggcaccaa gtgctacagg aaagggtcct aaagaactgg ataccagaag tttaaaggaa
     3361 gagaattttg tagcatctgt tgaattgtgg aacaagcacc aggaagtgaa aaagcaaaag
     3421 gctttggaaa aacagaggcc agagggcatc aagcctgtct ttgacctggg tgagacagag
     3481 gagaaaaagt cccagatgag cgcagacagt ggtgtgagcc tgacatctgc ctcccagagg
     3541 actgatcaag actctgtcat cggtgtgagt ccagctgtta tgatccgaag ctcaagtcag
     3601 gattctgaag ttagcaccgt ggtgagtaat agttccggag agacccttgg agctgacagt
     3661 gacctgagca gcaatgcagg tgacgggcca ggaggcgaag gcagcgccca cctggcaagt
     3721 tcccgggcca ctctgtccga cagtgaaatc gaaaccaatt ctgctacaag cgccatcttt
     3781 ggtaaagccc atagcttgaa gccaaaggag aagccggctg gtagtccgat tcgctcttcc
     3841 gaagacgtaa gccagcgagt ctatctctat gagggactgc taggaaggga caaaggatcc
     3901 atgtgggacc agctagagga tgccgctatg gagacctttt ctctgagcaa agaacgttct
     3961 accttatggg accaaatgca gttctgggaa gatgcattct tagatgctgt aatgttggaa
     4021 agagaaggaa tgggtatgga ccagggtcct caggaaatga tcgacaggta cctctcccta
     4081 ggggaacacg accggaagcg cctggaggat gatgaagacc gcttgctggc cacactttta
     4141 cacaacctca tatcctatat gctgctgatg aaggtgaaca agaatgacat caggaagaaa
     4201 gtacggcgcc taatgggaaa gtcccacatt gggctggtgt acagccagca agtcaatgag
     4261 gtgctcgatc agctgaacag cctgaatgga cgtgatctct ccatccggtc cagcggcagc
     4321 cggcacatga agaagcagac ttttgttgtg catgcaggga cggacacaaa tggagacatc
     4381 tttttcatgg aagtgtgtga tgactgcgtg gtgttgcgta gtaacattgg gacggtgtac
     4441 gagcgctggt ggtatgagaa gctcatcaat atgacctact gtcccaagac caaggtcctg
     4501 tgcttatggc ggagaaatgg ctctgagacc cagctcaaca agttctatac caagaagtgt
     4561 cgagagctgt actactgtgt gaaggacagc atggaacgtg ctgctgcccg acagcaaagc
     4621 atcaaacctg ggcctgagct aggcggtgag ttccctgtgc aggacatgaa gactggagag
     4681 ggtggcttgc ttcaagtcac cctggaaggg atcaatctca agttcatgca caaccaggag
     4741 cggaaggttt tcatagagct gaatcacatt aaaaagtgca atacagttcg aggcgtcttt
     4801 gtcctggaag aatttgttcc tgaaattaaa gaagtggtga gccacaagta caagacgcca
     4861 atggcccacg agatctgcta ctctgtgttg tgtctcttct cgtatgtggc cgcagttcgt
     4921 agcagtgaag aagaccttcg aaccccacct cggcctgtct ctagctgata gaagggttcc
     4981 acagctggcc aagcccaggg gtctcccctc acctcttgct gctcctaagc accgaagctg
     5041 ctggactgag atgggaatgt gtgtgtgttc tcagcaagtt ccttcccacg gtctagctgg
     5101 tcttctctta cgtctgagtg tctttgtgtt catctgtcac ggggctaagc tagcctcatt
     5161 actttctctt cctacaatag cagactagcc ttctgttccc tcagggctcc agagtgtgtg
     5221 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gtgtgtggtg tgtgtgtctg
     5281 tggggtcact gtgagcccac tattgcctgt ccttgagatg tttgcactgt ggtcccttgt
     5341 cctagtcctt atatcctcca gtttaggagt cttctctctg tcctctatga tctggcactg
     5401 tggggcacct gggacagttc cactctggga agtgaaagac acctggggac aaatcttcct
     5461 ggctgagggc ctgggaggag gaggggaggt tcaaaggaag ctcagtaagt ggtgggcgac
     5521 cttcctgctt cctcacagtt tctaaactgt gggtgcatgt catgctgctg cctgccccag
     5581 ctccatcgat gggtgtccct gagtggctgc catgtgccga gctgggattt gtgcagtggt
     5641 cttcctggcc tttggcatga gaggacggag gaatgaggtg atggtgtccc agacagcacc
     5701 agctgctctg cctaagggcc ggggataggt gggtcagggc tgagctgagc ccagagtgca
     5761 cgcctgtctg caggcagagt ctcctggctt cagtgccaga agaaagctat ggactggata
     5821 ggaggagaat gtaaatattt cagctccaca ttatttatag aaaaatgtac agctgtgtga
     5881 tgtgaaataa atgtcctgaa ctcca
//
