LOCUS       NM_013591               1447 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus mucosal vascular addressin cell adhesion molecule 1
            (Madcam1), transcript variant 1, mRNA.
ACCESSION   NM_013591
VERSION     NM_013591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   He,C., Xiu,W., Chen,Q., Peng,K., Zhu,X., Wang,Z., Xu,X., Chen,Y.,
            Zhang,G., Fu,J., Dong,Q., Wu,X., Li,A., Liu,D., Gao,Y., Wang,J.,
            Wang,Z., Deng,B., Shuai,P., Gao,C., Chen,Y., Yu,L. and Lu,F.
  TITLE     Gut-licensed beta7+ CD4+ T cells contribute to progressive retinal
            ganglion cell damage in glaucoma
  JOURNAL   Sci Transl Med 15 (707), eadg1656 (2023)
   PUBMED   37531415
REFERENCE   2  (bases 1 to 1447)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   3  (bases 1 to 1447)
  AUTHORS   Fidelle,M., Rauber,C., Alves Costa Silva,C., Tian,A.L., Lahmar,I.,
            de La Varende,A.M., Zhao,L., Thelemaque,C., Lebhar,I.,
            Messaoudene,M., Pizzato,E., Birebent,R., Mbogning Fonkou,M.D.,
            Zoppi,S., Reni,A., Dalban,C., Leduc,M., Ferrere,G., Durand,S.,
            Ly,P., Silvin,A., Mulder,K., Dutertre,C.A., Ginhoux,F.,
            Yonekura,S., Roberti,M.P., Tidjani-Alou,M., Terrisse,S., Chen,J.,
            Kepp,O., Schippers,A., Wagner,N., Suarez-Gosalvez,J., Kobold,S.,
            Fahrner,J.E., Richard,C., Bosq,J., Lordello,L., Vitali,G.,
            Galleron,N., Quinquis,B., Le Chatelier,E., Blanchard,L.,
            Girard,J.P., Jarry,A., Gervois,N., Godefroy,E., Labarriere,N.,
            Koschny,R., Daillere,R., Besse,B., Truntzer,C., Ghiringhelli,F.,
            Coatnoan,N., Mhanna,V., Klatzmann,D., Drubay,D., Albiges,L.,
            Thomas,A.M., Segata,N., Danlos,F.X., Marabelle,A., Routy,B.,
            Derosa,L., Kroemer,G. and Zitvogel,L.
  TITLE     A microbiota-modulated checkpoint directs immunosuppressive
            intestinal T cells into cancers
  JOURNAL   Science 380 (6649), eabo2296 (2023)
   PUBMED   37289890
REFERENCE   4  (bases 1 to 1447)
  AUTHORS   Shintani,A., Fukai,S., Nobusawa,R., Taniguchi,K., Hatatani,T.,
            Nagai,H., Sakai,T., Yoshimura,T., Miyasaka,M. and Hayasaka,H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1447)
  AUTHORS   Lenti,E., Genovese,L., Bianchessi,S., Maurizio,A., Sain,S.B., di
            Lillo,A., Mattavelli,G., Harel,I., Bernassola,F., Hehlgans,T.,
            Pfeffer,K., Crosti,M., Abrignani,S., Evans,S.M., Sitia,G.,
            Guimaraes-Camboa,N., Russo,V., van de Pavert,S.A.,
            Garcia-Manteiga,J.M. and Brendolan,A.
  TITLE     Fate mapping and scRNA sequencing reveal origin and diversity of
            lymph node stromal precursors
  JOURNAL   Immunity 55 (4), 606-622 (2022)
   PUBMED   35358427
REFERENCE   6  (bases 1 to 1447)
  AUTHORS   Schiffer,S.G., Day,E., Latanision,S.M., Tizard,R. and Osborn,L.
  TITLE     An alternately spliced mRNA encoding functional domains of murine
            MAdCAM-1
  JOURNAL   Biochem Biophys Res Commun 216 (1), 170-176 (1995)
   PUBMED   7488084
REFERENCE   7  (bases 1 to 1447)
  AUTHORS   Sampaio,S.O., Li,X., Takeuchi,M., Mei,C., Francke,U., Butcher,E.C.
            and Briskin,M.J.
  TITLE     Organization, regulatory sequences, and alternatively spliced
            transcripts of the mucosal addressin cell adhesion molecule-1
            (MAdCAM-1) gene
  JOURNAL   J Immunol 155 (5), 2477-2486 (1995)
   PUBMED   7650378
REFERENCE   8  (bases 1 to 1447)
  AUTHORS   Berg,E.L., McEvoy,L.M., Berlin,C., Bargatze,R.F. and Butcher,E.C.
  TITLE     L-selectin-mediated lymphocyte rolling on MAdCAM-1
  JOURNAL   Nature 366 (6456), 695-698 (1993)
   PUBMED   7505053
REFERENCE   9  (bases 1 to 1447)
  AUTHORS   Berlin,C., Berg,E.L., Briskin,M.J., Andrew,D.P., Kilshaw,P.J.,
            Holzmann,B., Weissman,I.L., Hamann,A. and Butcher,E.C.
  TITLE     Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal
            vascular addressin MAdCAM-1
  JOURNAL   Cell 74 (1), 185-195 (1993)
   PUBMED   7687523
REFERENCE   10 (bases 1 to 1447)
  AUTHORS   Streeter,P.R., Berg,E.L., Rouse,B.T., Bargatze,R.F. and
            Butcher,E.C.
  TITLE     A tissue-specific endothelial cell molecule involved in lymphocyte
            homing
  JOURNAL   Nature 331 (6151), 41-46 (1988)
   PUBMED   3340147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066404.1, AK137028.1, BE632565.1 and BE691220.1.
            
            On Dec 9, 2017 this sequence version replaced NM_013591.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137028.1, L21203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ066404.1         2-16
            16-991              AK137028.1         2-977
            992-1012            BE632565.1         320-340
            1013-1435           AK137028.1         999-1421
            1436-1447           BE691220.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1447
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /note="mucosal vascular addressin cell adhesion molecule
                     1"
                     /db_xref="GeneID:17123"
                     /db_xref="MGI:MGI:103579"
     exon            1..109
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1266
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mucosal addressin cell adhesion molecule 1"
                     /codon_start=1
                     /product="mucosal addressin cell adhesion molecule 1
                     isoform 1 precursor"
                     /protein_id="NP_038619.2"
                     /db_xref="CCDS:CCDS23981.1"
                     /db_xref="GeneID:17123"
                     /db_xref="MGI:MGI:103579"
                     /translation="MESILALLLALALVPYQLSRGQSFQVNPPESEVAVAMGTSLQIT
                     CSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQH
                     SVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQ
                     ALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIP
                     VLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGP
                     CRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPM
                     VEGWFQCRQDPGGQVTNLYVPGQVTPNSSSTVVLWIGSLVLGLLALVFLAYRLWKCYR
                     PGPRPDTSSCTHL"
     exon            110..376
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..703
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1135
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1441
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1418..1423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /note="hexamer: AATAAA"
     polyA_site      1436
                     /gene="Madcam1"
                     /gene_synonym="MAdCAM-1"
                     /note="major polyA site"
ORIGIN      
        1 actcttattt aagccgcttc ccctggcggt cacaagacag aggcaggcat ggaatccatc
       61 ctggccctcc tgctggccct ggccctagta ccctaccagc tcagcagagg acagtccttc
      121 caggtgaacc cccctgagtc tgaggtagct gtggccatgg gcacatccct ccagatcacc
      181 tgcagcatgt cctgtgacga gggtgtagcc cgggtgcact ggcgtggtct ggacaccagc
      241 ttgggcagtg tacagaccct cccaggcagc agtatcctct ctgtacgggg catgctgtca
      301 gacacaggca ctcctgtgtg tgtgggctcc tgcgggagtc gaagcttcca gcactccgtg
      361 aagatccttg tgtatgcctt cccagaccag ctggtggtgt ccccggagtt ccttgtacct
      421 ggacaggacc aggtggtgtc ctgcacggcc cacaacatct ggcctgcaga cccgaacagt
      481 ctctcctttg ccctgctact gggagagcag agactggagg gtgcccaagc cctggaacca
      541 gagcaagaag aggagataca agaggctgag ggcacaccac tgttccgaat gacacaacgc
      601 tggcggttac cctccctggg gacccctgcc cctcctgccc ttcactgcca ggtcaccatg
      661 cagctgccca aactggtgct gacccataga aaggagattc cagtactaca gagccagacc
      721 tcacctaagc cccccaacac gacctctgct gagccctaca tcctgacctc atcaagtact
      781 gctgaggcag tctccactgg gctcaacatc accaccctac cttctgcccc tccatacccc
      841 aagcttagcc ctaggactct gagctctgag ggaccttgcc gcccgaaaat ccaccaggac
      901 ctggaggcag gctgggagct actctgtgaa gcatcctgtg ggcccggagt tactgtgcgc
      961 tggaccttgg ctcctggcga cctggcaacc taccacaaga gggaggctgg ggcccaggca
     1021 tggctaagcg tgctgccccc aggtcccatg gtagagggct ggttccagtg ccgccaggac
     1081 cctggcgggc aggtgaccaa tctgtatgtt cctggccagg tgaccccgaa ttcctcctcc
     1141 accgtcgtcc tatggattgg cagcttggtg ctggggctgc ttgcactggt cttccttgcc
     1201 taccgcctgt ggaaatgcta ccggccaggt cctcgcccag acactagctc atgtacacac
     1261 ctatgaagct ccattatgcc agactaaagg aggcagagag tgaccagctg caggatttgg
     1321 ggcatcaaga tgatagtgtg gcctctttcc ttggtggtca gcacatctat aagtttctcc
     1381 tgacttctgg gcttttctgc ctgctggccc agagctaaat aaaagccccg tatctagcca
     1441 caaaaaa
//
