LOCUS       NM_027985               1249 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus MAD2 mitotic arrest deficient-like 2 (Mad2l2),
            transcript variant 1, mRNA.
ACCESSION   NM_027985
VERSION     NM_027985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Shah,P., Hill,R., Dion,C., Clark,S.J., Abakir,A., Willems,J.,
            Arends,M.J., Garaycoechea,J.I., Leitch,H.G., Reik,W. and
            Crossan,G.P.
  TITLE     Primordial germ cell DNA demethylation and development require DNA
            translesion synthesis
  JOURNAL   Nat Commun 15 (1), 3734 (2024)
   PUBMED   38702312
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1249)
  AUTHORS   Vassel,F.M., Laverty,D.J., Bian,K., Piett,C.G., Hemann,M.T.,
            Walker,G.C. and Nagel,Z.D.
  TITLE     REV7 Monomer Is Unable to Participate in Double Strand Break Repair
            and Translesion Synthesis but Suppresses Mitotic Errors
  JOURNAL   Int J Mol Sci 24 (21), 15799 (2023)
   PUBMED   37958783
  REMARK    GeneRIF: REV7 Monomer Is Unable to Participate in Double Strand
            Break Repair and Translesion Synthesis but Suppresses Mitotic
            Errors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1249)
  AUTHORS   Wang,X.L., Miao,C., Su,Y., Zhang,C. and Meng,X.
  TITLE     MAD2B Blunts Chronic Unpredictable Stress and Corticosterone
            Stimulation-Induced Depression-Like Behaviors in Mice
  JOURNAL   Int J Neuropsychopharmacol 26 (2), 137-148 (2023)
   PUBMED   36573299
  REMARK    GeneRIF: MAD2B Blunts Chronic Unpredictable Stress and
            Corticosterone Stimulation-Induced Depression-Like Behaviors in
            Mice.
REFERENCE   6  (bases 1 to 1249)
  AUTHORS   Wojtaszek,J., Liu,J., D'Souza,S., Wang,S., Xue,Y., Walker,G.C. and
            Zhou,P.
  TITLE     Multifaceted recognition of vertebrate Rev1 by translesion
            polymerases zeta and kappa
  JOURNAL   J Biol Chem 287 (31), 26400-26408 (2012)
   PUBMED   22700975
  REMARK    GeneRIF: identification of the Rev7 binding surface of the Rev1
            C-terminal domain
REFERENCE   7  (bases 1 to 1249)
  AUTHORS   Le Masson,F., Razak,Z., Kaigo,M., Audouard,C., Charry,C., Cooke,H.,
            Westwood,J.T. and Christians,E.S.
  TITLE     Identification of heat shock factor 1 molecular and cellular
            targets during embryonic and adult female meiosis
  JOURNAL   Mol Cell Biol 31 (16), 3410-3423 (2011)
   PUBMED   21690297
REFERENCE   8  (bases 1 to 1249)
  AUTHORS   Tsai,C.Y., Chou,C.K., Yang,C.W., Lai,Y.C., Liang,C.C., Chen,C.M.
            and Tsai,T.F.
  TITLE     Hurp deficiency in mice leads to female infertility caused by an
            implantation defect
  JOURNAL   J Biol Chem 283 (39), 26302-26306 (2008)
   PUBMED   18676373
REFERENCE   9  (bases 1 to 1249)
  AUTHORS   Khalaj,M., Abbasi,A.R., Nishimura,R., Akiyama,K., Tsuji,T.,
            Noguchi,J., Okuda,K. and Kunieda,T.
  TITLE     Leydig cell hyperplasia in an ENU-induced mutant mouse with germ
            cell depletion
  JOURNAL   J Reprod Dev 54 (3), 225-228 (2008)
   PUBMED   18385543
REFERENCE   10 (bases 1 to 1249)
  AUTHORS   Guo,C., Fischhaber,P.L., Luk-Paszyc,M.J., Masuda,Y., Zhou,J.,
            Kamiya,K., Kisker,C. and Friedberg,E.C.
  TITLE     Mouse Rev1 protein interacts with multiple DNA polymerases involved
            in translesion DNA synthesis
  JOURNAL   EMBO J 22 (24), 6621-6630 (2003)
   PUBMED   14657033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009587.1, AK150216.1 and CO043741.1.
            
            On Mar 11, 2015 this sequence version replaced NM_027985.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009587.1, AK150216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-882               AK009587.1         2-883
            883-992             AK150216.1         877-986
            993-1224            AK009587.1         994-1225
            1225-1249           CO043741.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.67 cM"
     gene            1..1249
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /note="MAD2 mitotic arrest deficient-like 2"
                     /db_xref="GeneID:71890"
                     /db_xref="MGI:MGI:1919140"
     exon            1..345
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            346..464
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            465..536
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            537..637
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            638..732
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            733..806
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            807..899
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1232
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1185..1190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /note="hexamer: AATAAA"
     polyA_site      1227
                     /gene="Mad2l2"
                     /gene_synonym="2310033C13Rik; G1-453-4; MAD2B; repro22;
                     REV7"
                     /note="major polyA site"
ORIGIN      
        1 gtggcttatg gttgtgctgg gaccgcggga gcaccgcggt ggttactgag gccaggggat
       61 tctggagtag cgcgttaggg gtctcagacg gtggtttcta tagcccggtc gtagattgga
      121 acctgaggtc gaaaccggag ccggcgaatc ggggaggagc gtagagaggg cgggatttcc
      181 gccgagaggg atccggctgc tcagggggcg gggcttcccc cgaccgggct gcgtttcccg
      241 cgtgcggggt cggttgcctt gagtccctac agacaccctc cacgccctcc cccaggcggc
      301 caaggatgac caccctcacg cgccaagacc tcaactttgg ccaagtggtg gctgacgtgc
      361 tctccgagtt cctggaggtg gccgtgcacc tgattctcta tgtgcgcgag gtctacccgg
      421 tgggcatctt ccagaagcgc aagaagtaca acgtgccggt tcagatgtcc tgtcacccgg
      481 agctgaacca gtacatccag gacacactcc actgcgtcaa acctctcctg gagaagaacg
      541 atgtggagaa ggtggtggtg gtgattttgg ataaggaaca ccgcccagtg gagaagtttg
      601 tctttgagat cactcagcct cccttgctgt ccatcaattc agactccctc ctgtctcatg
      661 tggagcagct gcttcgagcc ttcatcctta agattagtgt gtgtgatgct gtcctggatc
      721 acaaccctcc aggctgcaca tttacagtcc tcgtgcacac aagagaagct gctactcgaa
      781 acatggagaa gatacaggtc atcaaggact tcccatggat cctggcagat gaacaggatg
      841 tccacatgca cgacccccgc ttgatacccc taaaaaccat gacgtcggac attttaaaga
      901 tgcagctcta cgttgaagag cgagcgcata agaacagctg agggcatgcc tgtcaccagc
      961 tacccagctg tcccactacg gggccccagc ccggggcccc agactccaag tgctcttatt
     1021 gccttgacat gtggctgccc ctctggtcag gctgcccagt cctgcttgcc ttcgtgaggc
     1081 agccttccca ggagctgggg aaggatgcga ggacacacgc catttctcag cagcctcctg
     1141 ggctcagctg gctaacattg tccactgtgc catgcgttat tgttaataaa gtggccccaa
     1201 gggctgacta ccttgtcatt aaccaaacag gaaaaaaaaa aaaaaaaaa
//
