LOCUS       NM_025649               1288 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MAD2L1 binding protein (Mad2l1bp), mRNA.
ACCESSION   NM_025649
VERSION     NM_025649.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1288)
  AUTHORS   Huang,L., Li,W., Dai,X., Zhao,S., Xu,B., Wang,F., Jin,R.T., Luo,L.,
            Wu,L., Jiang,X., Cheng,Y., Zou,J., Xu,C., Tong,X., Fan,H.Y.,
            Zhao,H. and Bao,J.
  TITLE     Biallelic variants in MAD2L1BP (p31comet) cause female infertility
            characterized by oocyte maturation arrest
  JOURNAL   Elife 12, e85649 (2023)
   PUBMED   37334967
  REMARK    GeneRIF: Biallelic variants in MAD2L1BP (p31[comet]) cause female
            infertility characterized by oocyte maturation arrest.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1288)
  AUTHORS   Choi,E., Zhang,X., Xing,C. and Yu,H.
  TITLE     Mitotic Checkpoint Regulators Control Insulin Signaling and
            Metabolic Homeostasis
  JOURNAL   Cell 166 (3), 567-581 (2016)
   PUBMED   27374329
REFERENCE   3  (bases 1 to 1288)
  AUTHORS   Shin,H.J., Park,E.R., Yun,S.H., Kim,S.H., Jung,W.H., Woo,S.R.,
            Joo,H.Y., Jang,S.H., Chung,H.Y., Hong,S.H., Cho,M.H., Park,J.J.,
            Yun,M. and Lee,K.H.
  TITLE     p31comet-Induced Cell Death Is Mediated by Binding and Inactivation
            of Mad2
  JOURNAL   PLoS One 10 (11), e0141523 (2015)
   PUBMED   26544187
  REMARK    GeneRIF: p31comet-induced cell death is mediated by interactions
            with Mad2
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1288)
  AUTHORS   Su,Y.Q., Denegre,J.M., Wigglesworth,K., Pendola,F.L., O'Brien,M.J.
            and Eppig,J.J.
  TITLE     Oocyte-dependent activation of mitogen-activated protein kinase
            (ERK1/2) in cumulus cells is required for the maturation of the
            mouse oocyte-cumulus cell complex
  JOURNAL   Dev Biol 263 (1), 126-138 (2003)
   PUBMED   14568551
REFERENCE   5  (bases 1 to 1288)
  AUTHORS   Habu,T., Kim,S.H., Weinstein,J. and Matsumoto,T.
  TITLE     Identification of a MAD2-binding protein, CMT2, and its role in
            mitosis
  JOURNAL   EMBO J 21 (23), 6419-6428 (2002)
   PUBMED   12456649
REFERENCE   6  (bases 1 to 1288)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110562.17, AK004224.1 and AI851249.1.
            
            On Jul 29, 2009 this sequence version replaced NM_025649.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156569.1, BC005768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC110562.17        164029-164075       c
            48-1268             AK004224.1         2-1222
            1269-1288           AI851249.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.88 cM"
     gene            1..1288
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /note="MAD2L1 binding protein"
                     /db_xref="GeneID:66591"
                     /db_xref="MGI:MGI:1913841"
     exon            1..109
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..885
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /codon_start=1
                     /product="MAD2L1-binding protein"
                     /protein_id="NP_079925.2"
                     /db_xref="CCDS:CCDS28821.1"
                     /db_xref="GeneID:66591"
                     /db_xref="MGI:MGI:1913841"
                     /translation="MAASGEEDMSELSPAAAPNLDWYEKPEETHAPEVDLETVIPPAQ
                     EPSNPAEPFCPRDLVPVVFPGPVSQEDCCQFTCELLKHILYQRHQLPLPYEQLKHFYR
                     KVPQAEDTARKKAWLATEARNRKCQQALAELESVLSHLRDFFARTLVPQVLILLGGNA
                     LSPKEFYELDLSRLAPFGVDQGLNTAACLRRLFRAIFLADPFSELQTPPLMGTIVMVQ
                     GHRDCGEDWFQPKLNYRVPSRGHKLTVTLSCGRPSVPAMASEDYIWFQAPVTLKGFHE
                     "
     exon            110..372
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1272
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1245..1250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /note="hexamer: AATAAA"
     polyA_site      1270
                     /gene="Mad2l1bp"
                     /gene_synonym="0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B;
                     Mad2lbp; mKIAA0110"
                     /note="major polyA site"
ORIGIN      
        1 gattctttgc ggggcgtcta ttttaaccgc aggacgacta ggctggcagt cgcgatggct
       61 gcgtccggtg aggaggatat gtccgaactg tcccctgctg ctgccccaaa tttggattgg
      121 tatgagaagc cggaagaaac tcatgctcct gaagtagatc ttgagactgt catcccgcca
      181 gcccaggaac cttccaatcc tgcggagccc ttttgcccaa gagacctggt gccggtggtg
      241 tttcccgggc ctgtgagcca ggaagactgc tgccagttta cttgtgaact tctcaagcat
      301 atcctgtacc agcgccatca gctccctctg ccctatgaac agctgaagca cttctaccgg
      361 aaagttcccc aggcagagga cacagcaagg aagaaagctt ggctcgccac ggaggcgagg
      421 aacaggaagt gtcagcaggc tttggcggag ctggagagcg tcctcagtca cctacgagac
      481 ttctttgccc ggacactcgt accacaagtg ttgatccttc ttggaggcaa tgccctcagc
      541 cctaaagaat tctatgaact tgacctgtcc aggctggctc cattcggtgt ggaccagggc
      601 ctgaacacag cggcttgctt gcgtcgtctc ttcagagcca tcttcttggc ggatccattt
      661 agcgaactgc agactccccc gctcatgggt accattgtca tggttcaggg ccaccgtgac
      721 tgtggagaag attggtttca accgaaactg aactaccggg tgcccagccg gggccacaaa
      781 ctcaccgtga cactgtcatg tggcagacct tccgtcccag ccatggcttc agaggattac
      841 atttggttcc aggcaccagt gacacttaaa ggtttccatg agtgaaggta taaggacaat
      901 ggctgaattc tctcccattc tcatgctagg gcacccatct tcccactgag ggaggaggaa
      961 ggctctgtcc tggccatgtg ccttctctcc ccagacttcc tgctgactga tggtgtgtgg
     1021 ctggggctgt gataattgtc atcaagcaaa gtcccccgaa tcagtgattg gctcccagag
     1081 gcccctgcgc caggaggatc tgtttgggag tagaaagcaa ggctgtgtca gtagatccct
     1141 ctaataatgg aggtggtcct tccctgcttc atgctatgga ttttcagaac tgttatcagg
     1201 atgataatgt gggtgttact catgatttta aatatgatga gatgaataaa gctgtatgaa
     1261 attttcctaa caaaaaaaaa aaaaaaaa
//
