LOCUS       NM_001355624            1613 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1),
            transcript variant 2, mRNA.
ACCESSION   NM_001355624 XM_006506406
VERSION     NM_001355624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Park,J., Hall,C., Hubbard,B., LaMoia,T., Gaspar,R., Nasiri,A.,
            Li,F., Zhang,H., Kim,J., Haeusler,R.A., Accili,D., Shulman,G.I.,
            Yu,H. and Choi,E.
  TITLE     MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic
            Homeostasis
  JOURNAL   Diabetes 72 (12), 1781-1794 (2023)
   PUBMED   37725942
  REMARK    GeneRIF: MAD2-Dependent Insulin Receptor Endocytosis Regulates
            Metabolic Homeostasis.
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Qiao,J.Y., Zhou,Q., Xu,K., Yue,W., Lei,W.L., Li,Y.Y., Gu,L.J.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Meng,T.G., Wang,Z.B. and Sun,Q.Y.
  TITLE     Mad2 is dispensable for accurate chromosome segregation but becomes
            essential when oocytes are subjected to environmental stress
  JOURNAL   Development 150 (14) (2023)
   PUBMED   37485540
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Wang,L., Wan,R., Chen,X., Guo,X., Li,Z., Zhao,W., Yan,P. and Yu,G.
  TITLE     Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment
            of Mitochondrial Function and Induction of Cell Senescence
  JOURNAL   Can Respir J 2022, 9663354 (2022)
   PUBMED   36247080
  REMARK    GeneRIF: Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through
            Impairment of Mitochondrial Function and Induction of Cell
            Senescence.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Farmer,M.A., Sundberg,J.P., Bristol,I.J., Churchill,G.A., Li,R.,
            Elson,C.O. and Leiter,E.H.
  TITLE     A major quantitative trait locus on chromosome 3 controls colitis
            severity in IL-10-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13820-13825 (2001)
   PUBMED   11707574
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   Michel,L.S., Liberal,V., Chatterjee,A., Kirchwegger,R., Pasche,B.,
            Gerald,W., Dobles,M., Sorger,P.K., Murty,V.V. and Benezra,R.
  TITLE     MAD2 haplo-insufficiency causes premature anaphase and chromosome
            instability in mammalian cells
  JOURNAL   Nature 409 (6818), 355-359 (2001)
   PUBMED   11201745
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Kallio,M., Eriksson,J.E. and Gorbsky,G.J.
  TITLE     Differences in spindle association of the mitotic checkpoint
            protein Mad2 in mammalian spermatogenesis and oogenesis
  JOURNAL   Dev Biol 225 (1), 112-123 (2000)
   PUBMED   10964468
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Dobles,M., Liberal,V., Scott,M.L., Benezra,R. and Sorger,P.K.
  TITLE     Chromosome missegregation and apoptosis in mice lacking the mitotic
            checkpoint protein Mad2
  JOURNAL   Cell 101 (6), 635-645 (2000)
   PUBMED   10892650
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122874.2.
            
            On Sep 21, 2017 this sequence version replaced XM_006506406.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160286.1, AK010401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               AC122874.2         84725-85103         c
            380-526             AC122874.2         84220-84366         c
            527-647             AC122874.2         82635-82755         c
            648-751             AC122874.2         81256-81359         c
            752-931             AC122874.2         80374-80553         c
            932-1613            AC122874.2         79217-79898         c
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.56 cM"
     gene            1..1613
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /note="MAD2 mitotic arrest deficient-like 1"
                     /db_xref="GeneID:56150"
                     /db_xref="MGI:MGI:1860374"
     exon            1..379
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..924
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /note="MAD2-like protein 1; mitotic arrest deficient
                     2-like protein 1; MAD2 (mitotic arrest deficient,
                     homolog)-like 1"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein
                     MAD2A"
                     /protein_id="NP_001342553.1"
                     /db_xref="CCDS:CCDS20210.1"
                     /db_xref="GeneID:56150"
                     /db_xref="MGI:MGI:1860374"
                     /translation="MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFT
                     RVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQF
                     DIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKD
                     LVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND"
     exon            380..526
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..647
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..751
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..931
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1613
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /note="hexamer: AATAAA"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /note="hexamer: TATAAA"
     polyA_site      1504
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
                     /note="major polyA site"
     polyA_site      1535
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
     polyA_site      1554
                     /gene="Mad2l1"
                     /gene_synonym="MAD2"
ORIGIN      
        1 gtggtgcaac tgggcatagg gcggaagagc cgatgtggag cggaatgttg aagagacccg
       61 gctctctaat gtgggagggg cttagggaac aaaacggaag cctgaggcgg ccttagggag
      121 ggattcggag ttacaaagcc agccggaaac tggcgacgta ggtggggctt agggctcatt
      181 acgcctgcgc accgagcaac cggcgggctg cgtagttatt tttgaaccgg gtggcgggga
      241 atagcttaga agccattagg gcgccgtctg cggtgaggtt ggtagtgttc tccgttcgat
      301 ctagtgatgg cacagcagct cgcccgagag caaggcatca ccctgcgtgg gagcgcagaa
      361 atcgtggccg agtttttctc atttggcatc aacagcattt tgtatcagcg tggcatttat
      421 ccgtcggaaa cctttactag agtgcagaaa tatggactca ccttgcttac aactactgac
      481 cccgagctca taaagtatct caataatgtg gtggaacagc taaaagagtg gctgtacaag
      541 tgctcagttc agaaactggt ggtggtcatc tcaaatattg aaagtggtga agtccttgaa
      601 agatggcagt ttgatattga gtgtgacaaa actgcaaaag aggaaggtgt tcgtagagaa
      661 aagtcccaga aagccataca ggatgaaatt cgctcagtga ttagacagat tacagctact
      721 gtgacatttc tgccactgtt ggaagtttct tgttcctttg atctgctgat ttacactgac
      781 aaagacttgg tggtacctga aaagtgggaa gaatcgggac cgcaatttat taccaattgt
      841 gaagaagtcc gtctacgctc atttacaacc acaatccata aagtgaatag tatggtggcc
      901 tacaaaaccc ctgtcaatga ctgacgagac ggttcgtttg gtctgctgat ttacactgac
      961 aaagatttgg tggtgcctga aacgagggaa gaatcaggac cccagtttat taccagttct
     1021 gaagaaatcc gtctacactg atttacaacc acaagccaca aagggaatag tattgtggcc
     1081 tacaaaaccc catcaatgaa gagacggtac acataccatc ccccatcaca ttataccttc
     1141 tgctgtattt atatttagat gcttctttat atcttggtca agattcttct gagcaaaatc
     1201 attagacaaa gtatttagct ttttaaaaga agtttttcta cctacagtga ccattgttaa
     1261 aggaatccat cccacagtga atctgttggc tcccttaata acgtgtagca ctcttgctga
     1321 ttctgtggta agttcaggaa gaacccacga aatgcagcag taagacacat ttctctttat
     1381 atagacccca tattgaaata catgctaatt atttgatttt gttgtatata tcttgagctc
     1441 acaaagcagt tgatgctgtt taatttctgt aataaagaac tcttatttta atgttttata
     1501 aaaatcaagc tttaaaagtc agtgatacaa aaaaattaag ccttgtgttt taaatttgtg
     1561 ttacagtatc tttgatattt agtttggtgc taatatagtc agatacttca gtg
//
