LOCUS       NM_010752               2640 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus MAD1 mitotic arrest deficient 1-like 1 (Mad1l1),
            transcript variant 1, mRNA.
ACCESSION   NM_010752
VERSION     NM_010752.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2640)
  AUTHORS   Copeland,S.E., Snow,S.M., Wan,J., Matkowskyj,K.A., Halberg,R.B. and
            Weaver,B.A.
  TITLE     MAD1 upregulation sensitizes to inflammation-mediated tumor
            formation
  JOURNAL   PLoS Genet 20 (10), e1011437 (2024)
   PUBMED   39374311
  REMARK    GeneRIF: MAD1 upregulation sensitizes to inflammation-mediated
            tumor formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2640)
  AUTHORS   Goo,B.S., Mun,D.J., Kim,S., Nhung,T.T.M., Lee,S.B., Woo,Y.,
            Kim,S.J., Suh,B.K., Park,S.J., Lee,H.E., Park,K., Jang,H.,
            Rah,J.C., Yoon,K.J., Baek,S.T., Park,S.Y. and Park,S.K.
  TITLE     Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1)
            regulates the polarity of migrating neurons in the developing
            neocortex
  JOURNAL   Mol Psychiatry 28 (2), 856-870 (2023)
   PUBMED   36357673
  REMARK    GeneRIF: Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1)
            regulates the polarity of migrating neurons in the developing
            neocortex.
REFERENCE   3  (bases 1 to 2640)
  AUTHORS   Mora-Bermudez,F., Kanis,P., Macak,D., Peters,J., Naumann,R.,
            Xing,L., Sarov,M., Winkler,S., Oegema,C.E., Haffner,C.,
            Wimberger,P., Riesenberg,S., Maricic,T., Huttner,W.B. and Paabo,S.
  TITLE     Longer metaphase and fewer chromosome segregation errors in modern
            human than Neanderthal brain development
  JOURNAL   Sci Adv 8 (30), eabn7702 (2022)
   PUBMED   35905187
REFERENCE   4  (bases 1 to 2640)
  AUTHORS   Yue,W., Wang,Y., Meng,T.G., Zhang,H.Y., Zhang,X.R., Ouyang,Y.C.,
            Hou,Y., Schatten,H., Wang,Z.B. and Sun,Q.Y.
  TITLE     Kinetochore scaffold 1 regulates SAC function during mouse oocyte
            meiotic maturation
  JOURNAL   FASEB J 36 (3), e22210 (2022)
   PUBMED   35167144
REFERENCE   5  (bases 1 to 2640)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   6  (bases 1 to 2640)
  AUTHORS   Iritani,B.M., Delrow,J., Grandori,C., Gomez,I., Klacking,M.,
            Carlos,L.S. and Eisenman,R.N.
  TITLE     Modulation of T-lymphocyte development, growth and cell size by the
            Myc antagonist and transcriptional repressor Mad1
  JOURNAL   EMBO J 21 (18), 4820-4830 (2002)
   PUBMED   12234922
REFERENCE   7  (bases 1 to 2640)
  AUTHORS   Sironi,L., Mapelli,M., Knapp,S., De Antoni,A., Jeang,K.T. and
            Musacchio,A.
  TITLE     Crystal structure of the tetrameric Mad1-Mad2 core complex:
            implications of a 'safety belt' binding mechanism for the spindle
            checkpoint
  JOURNAL   EMBO J 21 (10), 2496-2506 (2002)
   PUBMED   12006501
REFERENCE   8  (bases 1 to 2640)
  AUTHORS   Sohl,G., Eiberger,J., Jung,Y.T., Kozak,C.A. and Willecke,K.
  TITLE     The mouse gap junction gene connexin29 is highly expressed in
            sciatic nerve and regulated during brain development
  JOURNAL   Biol Chem 382 (6), 973-978 (2001)
   PUBMED   11501764
REFERENCE   9  (bases 1 to 2640)
  AUTHORS   Rudolph,B., Hueber,A.O. and Evan,G.I.
  TITLE     Expression of Mad1 in T cells leads to reduced thymic cellularity
            and impaired mitogen-induced proliferation
  JOURNAL   Oncogene 20 (10), 1164-1175 (2001)
   PUBMED   11313860
REFERENCE   10 (bases 1 to 2640)
  AUTHORS   Jin,D.Y., Kozak,C.A., Pangilinan,F., Spencer,F., Green,E.D. and
            Jeang,K.T.
  TITLE     Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and
            mouse chromosome 5
  JOURNAL   Genomics 55 (3), 363-364 (1999)
   PUBMED   10049595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI735882.1 and AF083812.1.
            
            On Oct 7, 2006 this sequence version replaced NM_010752.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083812.1, AK136981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI735882.1         1-2
            3-2640              AF083812.1         10-2647
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.82 cM"
     gene            1..2640
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /note="MAD1 mitotic arrest deficient 1-like 1"
                     /db_xref="GeneID:17120"
                     /db_xref="MGI:MGI:1341857"
     exon            1..46
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            47..209
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2213
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /note="isoform a is encoded by transcript variant 1;
                     mitotic spindle assembly checkpoint protein MAD1;
                     MAD1-like protein 1; mitotic arrest deficient 1-like
                     protein 1; mitotic arrest deficient 1-like 1"
                     /codon_start=1
                     /product="mitotic spindle assembly checkpoint protein MAD1
                     isoform a"
                     /protein_id="NP_034882.2"
                     /db_xref="CCDS:CCDS19817.1"
                     /db_xref="GeneID:17120"
                     /db_xref="MGI:MGI:1341857"
                     /translation="MEDLGENTTVLSSLRSLNNFISQRMEGTSGLDVSTSASGSLQKQ
                     YEYHMQLEERAEQIRSKSYLIQVEREKMQMELSHKRARVELERAASTNARNYEREVDR
                     NQELLARIRQLQECEATAEEKMREQLERHRLCKQNLDAVSQQLREQEDSLASAREMIS
                     SLKGRVSELQLSAMDQKVQVKRLESEKQELKEQLELQQRKWQEANQKIQELQASQDER
                     AEHEQKIKDLEQKLCLQEQDAAVVKSMKSELMRMPRMERELKRLHEENTHLREMKETN
                     GLLTEELEGLQRKLSRQEKMQEALVDLELEKEKLLAKLQSWENLDQTMGLNLRTPEDL
                     SRFVVELQQRELTLKEKNNSITSSARGLEKVQQQLQDEVRQANAQLLEERKKRETHEA
                     LARRLQKRNALLTKERDGMRAILGSYDSELTQTEYSTQLTQRLWEAEDMVQKVHAHSS
                     EMEAQLSQALEELGVQKQRADTLEMELKMLKAQTSSAESSFSFCKEEVDALRLKVEEL
                     EGERSRLEQEKQVLEMQMEKLTLQGDYNQSRTKVLHMSLNPISMARQRQHEDHDRLQE
                     ECERLRGLVHALERGGPIPADLEAASSLPSSKEVAELRKQVESAELKNQRLKEVFQTK
                     IQEFRKVCYTLTGYQIDVTTESQYRLTSRYAEHQTDCLIFKATGPSGSKMQLLETEFS
                     RSVPELIELHLLQQDSIPAFLSALTIELFSRQTSI"
     exon            210..350
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..530
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..655
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..737
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..868
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..983
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1045
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1132
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1277
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1418
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1475
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1564
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1655
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1863
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2054
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2640
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2609..2614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /note="hexamer: AATAAA"
     polyA_site      2631
                     /gene="Mad1l1"
                     /gene_synonym="Mad1"
                     /note="major polyA site"
ORIGIN      
        1 gagggagatc tgagcggctg ctgcagcacc gggctcctca actgagaagg aggctgacca
       61 tggaagacct cggggagaac accacagtcc tctcctccct gagatctctg aacaacttca
      121 tttctcagcg aatggaggga acatcaggcc tggatgtgtc cacgtctgcc tcagggtccc
      181 tacagaagca gtatgagtat cacatgcagc tggaggaaag agcagagcag atccgctcaa
      241 agtcctacct catccaagtg gagcgggaga agatgcagat ggagctgagc cacaagagag
      301 cccgagtgga gctggagaga gcagccagca ccaatgccag gaactacgag cgcgaggtag
      361 atcgcaacca ggagctcctg gcacgcattc gacagctcca ggagtgtgag gccacagcag
      421 aagagaagat gcgggagcag ctggagcgcc acaggctgtg caagcaaaac ctggatgctg
      481 tcagtcagca gctgcgggaa caggaggaca gcctggcttc ggccagggag atgattagtt
      541 cattgaaggg gcgtgtctcg gagctgcagt tgagtgccat ggaccagaag gtacaggtca
      601 agcggctgga gtctgaaaag caggagctga aggagcagct ggagctgcag cagcggaaat
      661 ggcaagaggc aaatcagaag atccaggagc tgcaggccag tcaagatgag agagctgagc
      721 atgagcagaa gattaaggac ctggagcaga agctgtgtct acaagagcag gatgcagctg
      781 tggtgaagag catgaagtct gagctgatgc ggatgcccag gatggagcgt gagctgaaga
      841 ggctgcatga agagaacact catctaaggg agatgaagga gaccaatggg ctgctcacag
      901 aggagctgga aggtctgcag aggaaactga gccggcagga gaagatgcag gaggctctgg
      961 ttgacctgga gttggaaaag gagaagctac ttgcaaagct gcagagctgg gagaacctgg
     1021 accagaccat gggcttgaat ctcaggactc cagaggacct ttctaggttc gtggttgagc
     1081 tacagcagcg agagctcacc ctgaaggaga agaataacag catcaccagc agtgcccggg
     1141 gtctggagaa ggtccagcag cagctccagg atgaggtccg gcaggccaat gcacagctgc
     1201 tggaggagcg gaaaaagagg gagacacatg aggcacttgc ccgaaggctc cagaagcgca
     1261 atgcattgct gaccaaggag agagatggca tgcgtgccat cctgggatcc tacgacagtg
     1321 agctgaccca aactgagtac tcaacccagc tgacacagcg cctgtgggag gccgaggaca
     1381 tggttcagaa ggtacatgcc cacagctcgg agatggaggc tcagctgtct caggccctgg
     1441 aggagcttgg ggttcagaag cagagagctg acacgctgga gatggagttg aagatgctga
     1501 aggcccagac aagctcagct gaatctagct tctcattctg caaagaggag gtggatgcac
     1561 tcaggttgaa ggtggaggag ctggagggtg agcggagccg tctggaacag gaaaagcagg
     1621 tgctggagat gcagatggag aaactaaccc tacagggtga ctacaaccag agtcgaacca
     1681 aagtgctaca catgagcctt aacccaatca gcatggccag gcaacgccag catgaggacc
     1741 atgaccggct gcaggaggaa tgtgagcgct tacggggact tgtgcatgcc ctggagagag
     1801 ggggccccat ccctgctgac ctggaggctg cctccagtct gccctcatca aaggaggtgg
     1861 cagagctgcg gaagcaggtg gaaagtgctg agctgaagaa ccagcggctg aaggaggttt
     1921 tccagaccaa gatccaggag ttccgcaaag tttgctacac gctgaccggc taccagattg
     1981 acgtgaccac ggagagccaa taccgcctca cctcccgata cgctgagcac cagacggact
     2041 gcctcatctt caaggccaca ggaccctcgg gctccaagat gcagctgctg gagacagagt
     2101 tctcacggtc tgtgcctgag ctcattgaac tgcacttgct gcagcaggac agcatccctg
     2161 ccttcctcag tgcgctcacc atagagctgt tcagccgcca gacctctatc tagcctcttc
     2221 ccatgagcat cttcactaca gccgctggac ctcggcctag cctgtacctg cagcttctca
     2281 catgcagccc ccagaccttg agctagctct tggtctacag ttgcccacat catccccaga
     2341 tccctttgcc acccatagct gcatcatgtc acaaacacta gccgtggcct ctgctcaagc
     2401 agccactgtc tcttgtccct ggctaggagc aagctactgg ggatgaccaa gccagatcat
     2461 accccactac tctcctcccc accccacccc attctagagc cgctccacgt actgtcccaa
     2521 ggtgtacccc agcctccagt cccatgcgct ggttgcttag gcttcagtgg ccagactgta
     2581 gcctgtgtcc acagtctcag actaatgaaa taaagtgcta cctttatctt ccttcccgga
//
