LOCUS       NM_207000               1910 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus macroH2A.2 histone (Macroh2a2), mRNA.
ACCESSION   NM_207000
VERSION     NM_207000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Filipescu,D., Carcamo,S., Agarwal,A., Tung,N., Humblin,E.,
            Goldberg,M.S., Vyas,N.S., Beaumont,K.G., Demircioglu,D.,
            Sridhar,S., Ghiraldini,F.G., Capparelli,C., Aplin,A.E., Salmon,H.,
            Sebra,R., Kamphorst,A.O., Merad,M., Hasson,D. and Bernstein,E.
  TITLE     MacroH2A restricts inflammatory gene expression in melanoma
            cancer-associated fibroblasts by coordinating chromatin looping
  JOURNAL   Nat Cell Biol 25 (9), 1332-1345 (2023)
   PUBMED   37605008
  REMARK    GeneRIF: MacroH2A restricts inflammatory gene expression in
            melanoma cancer-associated fibroblasts by coordinating chromatin
            looping.
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Ma,H., Su,L., Xia,W., Wang,W., Tan,G. and Jiao,J.
  TITLE     MacroH2A1.2 deficiency leads to neural stem cell differentiation
            defects and autism-like behaviors
  JOURNAL   EMBO Rep 22 (7), e52150 (2021)
   PUBMED   34046991
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Ni,K., Ren,J., Xu,X., He,Y., Finney,R., Braun,S.M.G.,
            Hathaway,N.A., Crabtree,G.R. and Muegge,K.
  TITLE     LSH mediates gene repression through macroH2A deposition
  JOURNAL   Nat Commun 11 (1), 5647 (2020)
   PUBMED   33159050
  REMARK    GeneRIF: LSH mediates gene repression through macroH2A deposition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Haque,N., Ouda,R., Chen,C., Ozato,K. and Hogg,J.R.
  TITLE     ZFR coordinates crosstalk between RNA decay and transcription in
            innate immunity
  JOURNAL   Nat Commun 9 (1), 1145 (2018)
   PUBMED   29559679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Gaspar-Maia,A., Qadeer,Z.A., Hasson,D., Ratnakumar,K., Leu,N.A.,
            Leroy,G., Liu,S., Costanzi,C., Valle-Garcia,D., Schaniel,C.,
            Lemischka,I., Garcia,B., Pehrson,J.R. and Bernstein,E.
  TITLE     MacroH2A histone variants act as a barrier upon reprogramming
            towards pluripotency
  JOURNAL   Nat Commun 4, 1565 (2013)
   PUBMED   23463008
  REMARK    GeneRIF: macroH2A1 and macroH2A2, together with histone 3 lysine 27
            methylated 3, co-occupy pluripotency genes in wild-type (wt)
            fibroblasts.
            Erratum:[Nat Commun. 2013;4:2090]
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Tanasijevic,B. and Rasmussen,T.P.
  TITLE     X chromosome inactivation and differentiation occur readily in ES
            cells doubly-deficient for macroH2A1 and macroH2A2
  JOURNAL   PLoS One 6 (6), e21512 (2011)
   PUBMED   21738686
REFERENCE   9  (bases 1 to 1910)
  AUTHORS   Costanzi,C. and Pehrson,J.R.
  TITLE     MACROH2A2, a new member of the MARCOH2A core histone family
  JOURNAL   J Biol Chem 276 (24), 21776-21784 (2001)
   PUBMED   11262398
REFERENCE   10 (bases 1 to 1910)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153136.3.
            
            On Mar 21, 2007 this sequence version replaced NM_207000.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. It replaces
            conventional H2A histones in a subset of nucleosomes where it
            represses transcription and may participate in stable X chromosome
            inactivation. [provided by RefSeq, Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF336305.1, BC046794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC153136.3         176979-177060       c
            83-313              AC153136.3         150920-151150       c
            314-420             AC153136.3         146658-146764       c
            421-618             AC153136.3         144873-145070       c
            619-729             AC153136.3         142472-142582       c
            730-829             AC153136.3         140868-140967       c
            830-919             AC153136.3         139829-139918       c
            920-1094            AC153136.3         134331-134505       c
            1095-1910           AC153136.3         131843-132658       c
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.27 cM"
     gene            1..1910
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /note="macroH2A.2 histone"
                     /db_xref="GeneID:404634"
                     /db_xref="MGI:MGI:3037658"
     exon            1..82
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..313
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1260
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /note="mH2A2; H2A histone family, member Y2; histone
                     macroH2A2"
                     /codon_start=1
                     /product="core histone macro-H2A.2"
                     /protein_id="NP_996883.1"
                     /db_xref="CCDS:CCDS23885.1"
                     /db_xref="GeneID:404634"
                     /db_xref="MGI:MGI:3037658"
                     /translation="MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVG
                     APVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIAS
                     GGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKAASGKKGGKKSKATKPRTSKKS
                     KAKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHP
                     TTAEIDLKEEIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHC
                     HIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAI
                     SAHFDDSSSSSLKNVYFLLFDSESIGIYVQEMAKLDTK"
     exon            314..420
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..618
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..729
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..829
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1094
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1910
                     /gene="Macroh2a2"
                     /gene_synonym="H2afy2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcacg cgggccgaac ctgcggccgg gattggcgcg cactaggcca ccgggcgccc
       61 ggagcccgcg gtgcagcacc agtattgtgt aggtgccaag agaccactct gtcagcaagc
      121 tgagaggaaa atcgaggcaa gatgtcaggc cggagcggga agaagaaaat gtccaagctg
      181 tcccggtcag ccagggccgg cgtcatcttt ccagtaggcc ggttgatgcg ctacttgaaa
      241 aagggaacct tcaagtacag gatcagcgta ggtgctcccg tctacatggc tgcggtcatt
      301 gagtacctag cagcggaaat cctggagttg gctgggaacg ctgcgaggga caacaagaag
      361 gcacggatag cccccagaca catcctgctg gccgttgcca acgacgagga actcaaccag
      421 ctactgaaag gagtgactat cgccagtggg ggtgtcctgc cgagaatcca ccccgaactg
      481 ctggccaaga agcgagggac caaaggcaag tcagagacga tcctctcccc acccccagag
      541 aaaagaggaa ggaaggccgc atcaggcaag aaggggggta agaaatccaa ggccaccaag
      601 ccacggacgt ccaagaagtc taaagcaaag gacagcgata aagaaggaac atcaaattcc
      661 acctcggagg atgggccggg agatggcttc accatcttgt cttcgaagag cctcgttctg
      721 gggcagaagc tatccctgac ccagagtgac atcagccata ttggctccat gagggtggag
      781 ggcatcgtcc acccaaccac agccgagatc gacctcaagg aagagatagg gaaagccttg
      841 gaaaaggctg ggggtaaaga gttcttggaa acagtgaagg agcttcgcaa gtcccaaggc
      901 cctttggaag tcgctgaagc tgccgtcagc caatccagtg gactcgcagc caaatttgtc
      961 atccactgtc acatccccca gtggggctcc gacaaatgtg aagaacagct ggaagagacc
     1021 atcaaaaact gcctgtctgc agcagaggac aagaagctta aatccgtcgc cttcccaccg
     1081 ttccccagtg gcagaaactg cttccccaaa cagacggccg cccaggtgac cctcaaggcc
     1141 atctcggctc acttcgacga ctcgagctcg tcctcgctga agaatgtgta cttcctgctc
     1201 ttcgacagcg agagcatcgg catctacgtg caggagatgg ccaaactgga caccaagtag
     1261 ctctctccag tggcggcgaa ggaggaggat cggcgtgacg tcacaagagc gggggtttta
     1321 ttttttacaa ggattgcaga agggtgacgg ggcatgggag cggagggtgg ctgagagggt
     1381 gaacggaggc agcgggaaca ggtcctgcct gcctggtgaa ggggtccggt gcattttata
     1441 ttctctttac aaagggcctc tcttccacag ttaaccaggt ctccaccagg gctttctttc
     1501 catgtgtttt tcttcttgtt gttttagaac tttttcaaaa acaaacaaga caaacaaaca
     1561 taaaaatagg ccttctttag atttatagca gtgactttta cacactctca cacacacaca
     1621 cacacacaaa atctgttcac agtttctgtg tctttgggtt cctccttttt ccaagagaaa
     1681 aggatgtgac tgcccatcct aggtatactg gctgtctccc tcagtggaga agatgagaag
     1741 aacatcttgg ggtgcttttc tgttataggg tcccctccct gacgcctaaa atatttgtaa
     1801 ctacacctaa aagggttttg cttcgggatt tttgtttgtt cggttttttt gtttttttaa
     1861 agaaaaagaa aaatgagaag aaaaaaataa aagctccagc gtctttctta
//
