LOCUS       NM_001406396             745 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus mono-ADP ribosylhydrolase 2 (Macrod2), transcript
            variant 15, mRNA.
ACCESSION   NM_001406396
VERSION     NM_001406396.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 745)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 745)
  AUTHORS   Crawford,K., Oliver,P.L., Agnew,T., Hunn,B.H.M. and Ahel,I.
  TITLE     Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice
  JOURNAL   Cells 10 (2), 368 (2021)
   PUBMED   33578760
  REMARK    GeneRIF: Behavioural Characterisation of Macrod1 and Macrod2
            Knockout Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 745)
  AUTHORS   Lo Re,O., Mazza,T. and Vinciguerra,M.
  TITLE     Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine
            Responses to Metabolic and Genotoxic Insults
  JOURNAL   Front Genet 9, 654 (2018)
   PUBMED   30619475
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 745)
  AUTHORS   Sakthianandeswaren,A., Parsons,M.J., Mouradov,D., MacKinnon,R.N.,
            Catimel,B., Liu,S., Palmieri,M., Love,C., Jorissen,R.N., Li,S.,
            Whitehead,L., Putoczki,T.L., Preaudet,A., Tsui,C., Nowell,C.J.,
            Ward,R.L., Hawkins,N.J., Desai,J., Gibbs,P., Ernst,M., Street,I.,
            Buchert,M. and Sieber,O.M.
  TITLE     MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and
            Promotes Chromosome Instability and Growth of Intestinal Tumors
  JOURNAL   Cancer Discov 8 (8), 988-1005 (2018)
   PUBMED   29880585
  REMARK    Erratum:[Cancer Discov. 2024 Sep 4;14(9):1755. doi:
            10.1158/2159-8290.CD-24-0736.. PMID: 39228302]
REFERENCE   6  (bases 1 to 745)
  AUTHORS   Ito,H., Morishita,R., Mizuno,M., Kawamura,N., Tabata,H. and
            Nagata,K.I.
  TITLE     Biochemical and Morphological Characterization of a
            Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase,
            MACRO Domain Containing 2
  JOURNAL   Dev Neurosci 40 (3), 278-287 (2018)
   PUBMED   30227424
  REMARK    GeneRIF: MacroD2 is expressed and may have a physiological role in
            the central nervous system during brain development
REFERENCE   7  (bases 1 to 745)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 745)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   9  (bases 1 to 745)
  AUTHORS   Maas,N.M., Van de Putte,T., Melotte,C., Francis,A.,
            Schrander-Stumpel,C.T., Sanlaville,D., Genevieve,D., Lyonnet,S.,
            Dimitrov,B., Devriendt,K., Fryns,J.P. and Vermeesch,J.R.
  TITLE     The C20orf133 gene is disrupted in a patient with Kabuki syndrome
  JOURNAL   J Med Genet 44 (9), 562-569 (2007)
   PUBMED   17586838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731795.11, AL929027.10 and AL928700.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO799748.1, SRR7345562.4354067.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AL731795.11        40364-40629         c
            267-383             AL731795.11        35107-35223         c
            384-491             AL929027.10        18495-18602
            492-745             AL928700.7         99840-100093
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 69.2 cM"
     gene            1..745
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="mono-ADP ribosylhydrolase 2"
                     /db_xref="GeneID:72899"
                     /db_xref="MGI:MGI:1920149"
     exon            1..266
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..598
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="isoform 15 is encoded by transcript variant 15;
                     MACRO domain-containing protein 2; MACRO domain containing
                     2; O-acetyl-ADP-ribose deacetylase MACROD2; [Protein
                     ADP-ribosylglutamate] hydrolase; [Protein
                     ADP-ribosylaspartate] hydrolase MACROD2; [Protein
                     ADP-ribosylglutamate] hydrolase MACROD2; ADP-ribose
                     glycohydrolase MACROD2"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase MACROD2 isoform 15"
                     /protein_id="NP_001393325.1"
                     /db_xref="GeneID:72899"
                     /db_xref="MGI:MGI:1920149"
                     /translation="MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWK
                     EEMKSKGQNDEENTQEAPQMKKSLSEKVSLYRGDITLLEVDAIVNAVLGPQSVQVLLL
                     EQHPPLQGACEKSAEHCSRLQTS"
     exon            267..383
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..491
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..745
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      745
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacaggctct gaggtgctgc tgtggcggcg gccgcctggc agagcgggcg ggtcgaggga
       61 ggagggcggc gacgggccag cggctagcgg cgcgggacgc agagcctttg cacttttccc
      121 tcccgagtgt cccctccatc caccccccac actccacaca ccctgtttgc ccgtgagcct
      181 ggggaacttg cagcttaaag ccagccaccc ccacggcagc atgtacccca gcaacaagaa
      241 gaaaaaggtg tggagagagg agaaagaacg tttgctgaag atgaccttag aggagagacg
      301 caaagaatac ataagggact atgtttctct gagcaccatt ctatcatgga aggaagagat
      361 gaagagcaaa ggccaaaatg atgaagaaaa tactcaggaa gcaccacaga tgaagaaaag
      421 cttgagtgaa aaggtttctc tctacagagg tgacatcact ctgctagagg tggatgcaat
      481 cgtcaatgcg gtgctcggac cccaaagtgt gcaagttctg ctactggagc agcatcctcc
      541 tctgcagggt gcgtgtgaga agtcagctga gcactgttcc agactccaga ctagctgaga
      601 tgccggagag aaggatggca ctctttaaaa ctgtgttctg gagccagact cttccctgtc
      661 agatctgcgt gatgtcgggc aaaatatgaa tctcctggag tcagcttcct tatttctaaa
      721 ataaaacaat tccgttgttt ccata
//
