LOCUS       NM_001406384            4786 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus mono-ADP ribosylhydrolase 2 (Macrod2), transcript
            variant 3, mRNA.
ACCESSION   NM_001406384 XM_006500246
VERSION     NM_001406384.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4786)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4786)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4786)
  AUTHORS   Crawford,K., Oliver,P.L., Agnew,T., Hunn,B.H.M. and Ahel,I.
  TITLE     Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice
  JOURNAL   Cells 10 (2), 368 (2021)
   PUBMED   33578760
  REMARK    GeneRIF: Behavioural Characterisation of Macrod1 and Macrod2
            Knockout Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4786)
  AUTHORS   Lo Re,O., Mazza,T. and Vinciguerra,M.
  TITLE     Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine
            Responses to Metabolic and Genotoxic Insults
  JOURNAL   Front Genet 9, 654 (2018)
   PUBMED   30619475
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4786)
  AUTHORS   Sakthianandeswaren,A., Parsons,M.J., Mouradov,D., MacKinnon,R.N.,
            Catimel,B., Liu,S., Palmieri,M., Love,C., Jorissen,R.N., Li,S.,
            Whitehead,L., Putoczki,T.L., Preaudet,A., Tsui,C., Nowell,C.J.,
            Ward,R.L., Hawkins,N.J., Desai,J., Gibbs,P., Ernst,M., Street,I.,
            Buchert,M. and Sieber,O.M.
  TITLE     MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and
            Promotes Chromosome Instability and Growth of Intestinal Tumors
  JOURNAL   Cancer Discov 8 (8), 988-1005 (2018)
   PUBMED   29880585
  REMARK    Erratum:[Cancer Discov. 2024 Sep 4;14(9):1755. doi:
            10.1158/2159-8290.CD-24-0736.. PMID: 39228302]
REFERENCE   6  (bases 1 to 4786)
  AUTHORS   Ito,H., Morishita,R., Mizuno,M., Kawamura,N., Tabata,H. and
            Nagata,K.I.
  TITLE     Biochemical and Morphological Characterization of a
            Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase,
            MACRO Domain Containing 2
  JOURNAL   Dev Neurosci 40 (3), 278-287 (2018)
   PUBMED   30227424
  REMARK    GeneRIF: MacroD2 is expressed and may have a physiological role in
            the central nervous system during brain development
REFERENCE   7  (bases 1 to 4786)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 4786)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   9  (bases 1 to 4786)
  AUTHORS   Maas,N.M., Van de Putte,T., Melotte,C., Francis,A.,
            Schrander-Stumpel,C.T., Sanlaville,D., Genevieve,D., Lyonnet,S.,
            Dimitrov,B., Devriendt,K., Fryns,J.P. and Vermeesch,J.R.
  TITLE     The C20orf133 gene is disrupted in a patient with Kabuki syndrome
  JOURNAL   J Med Genet 44 (9), 562-569 (2007)
   PUBMED   17586838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731795.11, AL929027.10, AL844562.3, AL837516.14, AL844582.7,
            AL929443.4, AL845530.7 and AL928823.11.
            
            On May 13, 2022 this sequence version replaced XM_006500246.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4842316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AL731795.11        40364-40629         c
            267-383             AL731795.11        35107-35223         c
            384-491             AL929027.10        18495-18602
            492-521             AL844562.3         62326-62355
            522-638             AL837516.14        55241-55357
            639-760             AL844582.7         207277-207398       c
            761-791             AL929443.4         187763-187793       c
            792-865             AL929443.4         101754-101827       c
            866-947             AL845530.7         40883-40964
            948-992             AL845530.7         74389-74433
            993-1076            AL845530.7         81867-81950
            1077-1187           AL845530.7         120810-120920
            1188-1256           AL845530.7         125382-125450
            1257-1337           AL845530.7         160805-160885
            1338-1412           AL845530.7         182170-182244
            1413-1505           AL845530.7         182704-182796
            1506-1583           AL928823.11        50711-50788
            1584-1651           AL928823.11        60801-60868
            1652-4786           AL928823.11        66312-69446
FEATURES             Location/Qualifiers
     source          1..4786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 69.2 cM"
     gene            1..4786
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="mono-ADP ribosylhydrolase 2"
                     /db_xref="GeneID:72899"
                     /db_xref="MGI:MGI:1920149"
     exon            1..266
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1651
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="isoform 3 is encoded by transcript variant 3; MACRO
                     domain-containing protein 2; MACRO domain containing 2;
                     O-acetyl-ADP-ribose deacetylase MACROD2; [Protein
                     ADP-ribosylglutamate] hydrolase; [Protein
                     ADP-ribosylaspartate] hydrolase MACROD2; [Protein
                     ADP-ribosylglutamate] hydrolase MACROD2; ADP-ribose
                     glycohydrolase MACROD2"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase MACROD2 isoform 3"
                     /protein_id="NP_001393313.1"
                     /db_xref="GeneID:72899"
                     /db_xref="MGI:MGI:1920149"
                     /translation="MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWK
                     EEMKSKGQNDEENTQEAPQMKKSLSEKVSLYRGDITLLEVDAIVNAANASLLGGGGVD
                     GCIHRAAGPCLLAECRNLNGCETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKED
                     LANCYQSSLKLVKENNLRSVAFPCISTGIYGFPNEPAAVIALGTIKEWLAKNHQEVDR
                     IIFCVFLEVDFKIYKKKMNEFFPVDDNNEGTDADMKEDSEGPEPKGLSPPHKKSKAKK
                     PESSKDSSEDESGPEEKQTAEEMEGQSQEAGGLRFLLRNLLGLIHRDGVNTTPVPSPA
                     SEDKAEVHKDEADSAKDDNTVKDSDMTNHSVCDQELPNGQENDSAKSEGKTEAESPSS
                     SMETEDLSPNQEDAAIVEQPEVIPLIDDQEAQEGGEAQGKDAPAVFAESQGSSEAENT
                     SGPDVDMNSQVDGVNEPTESLQEDLQ"
     exon            267..383
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..491
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..521
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..638
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            639..760
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            761..791
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..865
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            866..947
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..992
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1076
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1187
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1256
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1337
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1412
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1505
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1583
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1651
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..4786
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4757..4762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4786
                     /gene="Macrod2"
                     /gene_synonym="1110033L15Rik; 2610107G07Rik;
                     2900006F19Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacaggctct gaggtgctgc tgtggcggcg gccgcctggc agagcgggcg ggtcgaggga
       61 ggagggcggc gacgggccag cggctagcgg cgcgggacgc agagcctttg cacttttccc
      121 tcccgagtgt cccctccatc caccccccac actccacaca ccctgtttgc ccgtgagcct
      181 ggggaacttg cagcttaaag ccagccaccc ccacggcagc atgtacccca gcaacaagaa
      241 gaaaaaggtg tggagagagg agaaagaacg tttgctgaag atgaccttag aggagagacg
      301 caaagaatac ataagggact atgtttctct gagcaccatt ctatcatgga aggaagagat
      361 gaagagcaaa ggccaaaatg atgaagaaaa tactcaggaa gcaccacaga tgaagaaaag
      421 cttgagtgaa aaggtttctc tctacagagg tgacatcact ctgctagagg tggatgcaat
      481 cgtcaatgcg gcaaatgcca gtcttctcgg aggaggaggt gtggatggct gtattcacag
      541 agctgctggc ccctgtttgt tagctgagtg tcggaacctg aacggctgtg agactggaca
      601 tgcaaaaatc acatgtggct acgacctccc tgcaaagtat gtcatccata ctgtagggcc
      661 aatagccaga ggccacatta atggttccca caaggaagac cttgcaaatt gctatcaatc
      721 atccttgaag ctggtgaaag aaaataacct ccgatcagtg gctttcccct gcatttcaac
      781 aggcatttat ggttttccga atgagcctgc ggcagtcatt gccctaggta cgattaagga
      841 atggctggcc aagaatcacc aggaggtgga tcgaatcatc ttctgtgtct tcctagaagt
      901 tgacttcaaa atctacaaaa agaaaatgaa cgagtttttc cctgttgatg ataacaatga
      961 aggaaccgat gctgacatga aagaagattc agaagggcca gagcctaaag gcctttctcc
     1021 accccacaag aagagcaaag caaagaaacc agaaagttct aaagactcca gtgaagatga
     1081 aagtggtcca gaggagaagc aaactgcgga agaaatggaa gggcagagcc aagaagcagg
     1141 tgggctcagg tttcttttga ggaatctcct tggtctcatc cacagagatg gtgtcaacac
     1201 cacccctgtg cccagcccag cttccgaaga caaagctgaa gtccacaaag atgaagcaga
     1261 ttctgcaaag gatgacaata ctgtaaaaga cagtgacatg accaatcatt ctgtgtgtga
     1321 ccaagaactt cccaatggac aagagaatga ctcagcaaag agtgagggga aaactgaggc
     1381 agaatcccca agctcctcta tggaaacaga agacctttca ccaaatcaag aagatgccgc
     1441 aattgtggaa caaccagaag tgatccccct gatagatgac caagaagcac aggaaggtgg
     1501 agaagctcaa ggcaaggatg cacctgctgt gtttgcagaa agccaaggtt ccagcgaggc
     1561 agaaaacact tcaggtcctg atgttgacat gaacagtcag gtggatggtg taaatgagcc
     1621 aacagagagt ctgcaagaag atctccaata aggccacaag atgaagcaaa ggaacaaaga
     1681 actgaagcta aatgacagcc ctcagcatgg caaggcctgg ccctggggga cttgggaaga
     1741 tgatagtatg tgctgtggaa gggggtgggg gaggggggaa gcaagttcat ggaagaaagg
     1801 gggtcctttg ctctaattct ccagctgcat ttcgtcgttt acctacagaa aagaaaaaga
     1861 tgaaaaaaac aaaacaaaaa gaaaagaaaa gacaagaaaa atgaaaaagc aagcaagctc
     1921 cctccatctg tgggaggccc catgcttagc atctttcagg cactcagtcc atatcatttc
     1981 tgtcttttat ccatgtctca ccctagggcc atggtgatag ggttaatact cacccagggc
     2041 tccttgcccc tctctgcttt cttgattctc tcacaaagct ggtcatagga cagtttgttc
     2101 catgaataag aaagaacatg atgacaagct aaactggcag gctaaatttc aagagctgcc
     2161 atgcccatca ctggtataat ccacaaagga ggaaggatag aaaatgggta caaacctcag
     2221 ataacacttg gaagaggtct gaataaggag ttcaaaatat tcaaatcagg cattaacgaa
     2281 gaaggtcaga cttggcagcc tctagattct ccactcttca cacccaggat gccctgtgtg
     2341 ttcatttttg gggctgattt caagcactgc ttccttggtt tatgaggtct tcactgtgtg
     2401 cttccttatg gagtccatcc ccaagatgtg tttttttttt ttgtacacaa ttggaatggg
     2461 tgttactatc attgagatca aagggagtgt cttgtttcat ttgggactct aatctattaa
     2521 taacaattgt agttttcaaa gttccacttg aagtctctac tcttcataaa agaatatcca
     2581 tggtgaccca agatgtgcta gcccacagag gttcacactt gaagttagga gcatttggag
     2641 ccattacttc tagccctgac ttcctggtct gctaatgcca aatccaaggg tgatttggca
     2701 gctcatccac tcatccaaaa cttatccaga actatacatg acttaagaag ccagtggaac
     2761 agtggtagct caaacaatga ggaccagagg aggctgggca tcctcccaac tatccatccc
     2821 agaataatcc taggtctccc actgcctctt ggggatctaa agacatggtc gtgtcttttg
     2881 catatcatct taacacccta ctgttttaga attgtaatgt tttatgttgc tattcctaac
     2941 aaaatgggga acatggagct gagagaggat atctaaagtt aacagtggga tgataccact
     3001 ttataagtat ctcatccaat ttgctagttt ggccctttcc tgtggaaaat catcttacct
     3061 tcctatgact agttttgcct gctctgcatt agtttctgtt tctaggtaat ttatttggta
     3121 taataaagta agtagcaaac cacacctctg catatgttac cttttaacag ctcttctttt
     3181 cattaacaca gttcatcaac ataacaacaa ggctatttca ggaatttcat aaagtttccc
     3241 catggctttt gctcattttt ttctctctct ctttctacag tttgacatga cagcatatac
     3301 ctctccatta cgtgttgttt tctagaacaa ttcctcctct aaataatcta aggataccac
     3361 ccagatagat agcttcaatg tttcctgcca tcttcatatt ttacaagcac ccatcacttt
     3421 tgtgaagtgc ctgacaaaag aaccatgctg gaaaggcatt tccccataac tccatgggga
     3481 agtataactc agcctccatt atagggtcac agtgggaagg cacacctgag ataagaggaa
     3541 tagccagaac tgagacaatt ccaggccacc tttctcatta ccaatggcag ccgttgtgtt
     3601 tggtcatctt gtgtggggat aggttaagaa acggggagag agaattctct ggaaactgta
     3661 ggaaaaggaa aacaatcttt atatttagga aacagaaaag gaggagttcc actcctgaat
     3721 ttgcttaaac ttccttttat gaattaaagt gcattttcat ctttgctttg cagtagattt
     3781 ttggttgcta tgtggctgaa tgattgtatg ctttaaaata aataatgcag ttaatttaca
     3841 cttcaataat gaaatataaa aatgttagct ctgggccaga ctgaaggcat ctcagataag
     3901 gagatgtgtt gttcactggc cctgtcactg cacaggctgt acaatgcagt acatgtggga
     3961 agtggactga tgctttctgc acatgaatgc tagatggcca tttccaaaca cacttcagac
     4021 aggcacatgt catgaagggc aataggggga tgggaggaaa ctagccctgt tattagtcac
     4081 gtttgcatac agaggactga agtagacctt caacataata gtcctaatta aaaaggtact
     4141 cactgcagac tagacaaagg ggcttttcct cttcctggta actattcaga tgatggacaa
     4201 gtcttctttg aaaaaagctt acaaagaaga catccgaagc actgtctatg atactgggtc
     4261 acatattaat cactgcagct aattgtaaat ctttctatga aacactgaaa agcctctttg
     4321 tgaattaata cagttctgct tgatgcactt ggtttgcaaa gacatttctc tgtatgtggt
     4381 gcatgtcagc tgtgctttga gaaacaacaa agttagcaga atatgttcaa tatattttct
     4441 cgggaaatag ggtttttatc atatgactca ttaaggattt gccttaccct gacatttgtg
     4501 atataaagga aaatcaggaa aaaagtaatt ttcttgaaca agatatgttt ttacttaatg
     4561 caaataagtg tagtctgttg cttgcaagga aaaaaatgtc ttctggtatt actagggtaa
     4621 catgtgcctc ttttgttaaa caagtcttga aatgctggac agcttctgaa tctgtttgtc
     4681 tcttttcatc tgtgccacac actatgacac ttaaatgact gttgccttcg aactatattt
     4741 gttagagcag agtgcaaata aacttctttg agaggataat gtggaa
//
