LOCUS       NM_001378919            1217 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mono-ADP ribosylhydrolase 1 (Macrod1), transcript
            variant 2, mRNA.
ACCESSION   NM_001378919 XM_006526562
VERSION     NM_001378919.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Crawford,K., Oliver,P.L., Agnew,T., Hunn,B.H.M. and Ahel,I.
  TITLE     Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice
  JOURNAL   Cells 10 (2), 368 (2021)
   PUBMED   33578760
  REMARK    GeneRIF: Behavioural Characterisation of Macrod1 and Macrod2
            Knockout Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Agnew,T., Munnur,D., Crawford,K., Palazzo,L., Mikoc,A. and Ahel,I.
  TITLE     MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to
            Mitochondria
  JOURNAL   Front Microbiol 9, 20 (2018)
   PUBMED   29410655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Ito,H., Morishita,R., Mizuno,M., Kawamura,N., Tabata,H. and
            Nagata,K.I.
  TITLE     Biochemical and Morphological Characterization of a
            Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase,
            MACRO Domain Containing 2
  JOURNAL   Dev Neurosci 40 (3), 278-287 (2018)
   PUBMED   30227424
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Zang,L., Xue,B., Lu,Z., Li,X., Yang,G., Guo,Q., Ba,J., Zou,X.,
            Dou,J., Lu,J., Pan,C. and Mu,Y.
  TITLE     Identification of LRP16 as a negative regulator of insulin action
            and adipogenesis in 3T3-L1 adipocytes
  JOURNAL   Horm Metab Res 45 (5), 349-358 (2013)
   PUBMED   23389992
  REMARK    GeneRIF: LRP16 acts as a negative regulator of insulin action and
            adipogenesis in 3T3-L1 adipocytes.
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Li,X.J., Guo,Q.H., Wang,X., Xue,B., Sun,L.Q., Meng,Q.T., Lu,J.M.
            and Mu,Y.M.
  TITLE     LRP16 gene protects mouse insulinoma MIN6 cells against fatty
            acid-induced apoptosis through Akt/FoxO1 signaling
  JOURNAL   Chin Med J (Engl) 125 (10), 1695-1702 (2012)
   PUBMED   22800886
  REMARK    GeneRIF: LRP16 played important roles not only in insulin content
            and GSIS but also in the antilipotoxic effect mediated by Akt/FoxO1
            signaling.
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Li,X., Xue,B., Wang,X., Sun,L., Zhang,T., Qu,L., Zou,X. and Mu,Y.
  TITLE     Reduced expression of the LRP16 gene in mouse insulinoma (MIN6)
            cells exerts multiple effects on insulin content, proliferation and
            apoptosis
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 32 (2), 190-198 (2012)
   PUBMED   22528219
  REMARK    GeneRIF: These results suggest that LRP16 plays a key role in
            maintaining pancreatic beta-cell functions and may help us to
            understand the protective effects of estrogen on the functions of
            pancreatic beta-cells.
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Zang,L., Mu,Y.M., Lu,Z.H., Xue,B., Ma,X.L., Yang,G.Q., Ba,J.M.,
            Dou,J.T. and Lu,J.M.
  TITLE     [LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting
            the IRS-1 signaling and the transcriptional activity of peroxisome
            proliferator actived receptor gamma]
  JOURNAL   Zhonghua Yi Xue Za Zhi 91 (20), 1408-1412 (2011)
   PUBMED   21756814
  REMARK    GeneRIF: LRP16 gene causes insulin resistance in C2-C12 cells by
            inhibiting the IRS-1 signaling and the transcriptional activity of
            PPARgamma.
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109619.11 and AC140307.3.
            
            On Mar 13, 2020 this sequence version replaced XM_006526562.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.949216.1,
                                           ERR3363658.5022689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AC109619.11        51805-52196
            393-494             AC109619.11        60479-60580
            495-611             AC109619.11        61101-61217
            612-641             AC140307.3         49006-49035
            642-758             AC140307.3         59844-59960
            759-880             AC140307.3         60219-60340
            881-911             AC140307.3         60435-60465
            912-985             AC140307.3         60581-60654
            986-1067            AC140307.3         60962-61043
            1068-1217           AC140307.3         61343-61492
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.17 cM"
     gene            1..1217
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /note="mono-ADP ribosylhydrolase 1"
                     /db_xref="GeneID:107227"
                     /db_xref="MGI:MGI:2147583"
     exon            1..392
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1105
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /EC_number="3.1.1.106"
                     /note="isoform 2 is encoded by transcript variant 2; MACRO
                     domain-containing protein 1; O-acetyl-ADP-ribose
                     deacetylase MACROD1; [Protein ADP-ribosylglutamate]
                     hydrolase; [Protein ADP-ribosylaspartate] hydrolase
                     MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1;
                     ADP-ribose glycohydrolase MACROD1; MACRO domain containing
                     1"
                     /codon_start=1
                     /product="ADP-ribose glycohydrolase MACROD1 isoform 2"
                     /protein_id="NP_001365848.1"
                     /db_xref="GeneID:107227"
                     /db_xref="MGI:MGI:2147583"
                     /translation="MSLQSQVSGRLAQLRAAGQLLVSLRPWPGRSAGGPRPRGSACGP
                     LVALGEHGYCAWLSAGVGAWGAAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKG
                     LSDKQREEHYFCKDFIKLKKIPTWKETAKGLAVKVEDPKYKKDKQLNEKISLYRGDIT
                     KLEVDAIVNAANSSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPA
                     KYVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEE
                     AAEVVLASLREWLEQHKDKVDRLIICVFLEKDEGIYRERLPHYFPVDPPGPVGIRSQL
                     "
     exon            393..494
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            495..611
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            612..641
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            642..758
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            759..880
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            881..911
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            912..985
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1067
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1217
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /note="hexamer: AATAAA"
     polyA_site      1217
                     /gene="Macrod1"
                     /gene_synonym="D930010J01Rik; Lrp16"
                     /note="major polyA site"
ORIGIN      
        1 gccactctcg tcccagagta aataagggac cgagcgcgac tctccggagc accgtaaata
       61 gagtccgagt gggcggggag ccgcccggca ccgcctgctc atgtcgctgc agagccaagt
      121 gtccggccgc ctggcacagc tgcgcgcggc ggggcagctg ctggtctccc tgcgcccctg
      181 gcccggccgc tcggcgggtg gcccgcggcc ccgtggcagt gcgtgcggtc ccctggtggc
      241 actgggcgag cacggctact gcgcgtggct ctcggcggga gttggggcgt ggggggcggc
      301 ggggcgtgga gcctgggtgc gcacctgggc ccccctggcc atggccgcga aggtggacct
      361 gagcacctcc accgactgga aggaggccaa atcctttctg aagggcctga gtgacaagca
      421 gagagaggaa cattacttct gcaaggattt cattaagctg aagaagatcc ccacgtggaa
      481 ggagacagca aaagggctgg ctgtgaaggt ggaggacccc aagtataaga aggacaagca
      541 actgaatgag aaaatctccc tgtaccgtgg ggacatcacc aagctggagg tggatgccat
      601 tgtcaacgct gccaacagct ccctgcttgg aggcggaggg gtggacggct gcattcatcg
      661 ggccgcggga tccctgctca cggacgaatg ccgcacccta cagaactgcg agaccggcaa
      721 agccaagatc acttgcggct atcggctgcc agccaagtat gtcatccaca cggtggggcc
      781 catcgccgtg ggccaaccca ctgccagcca ggcggccgag ctccgcagct gctacttgag
      841 cagcctggac ctgctgctgg agcaccggct gcgctcagtg gctttcccgt gcatctccac
      901 aggcgtgttt ggctacccca atgaggaggc tgcagaagta gtgctggctt cgctgcggga
      961 atggctggag cagcacaagg acaaggtgga tcggctcatc atctgtgtgt tcctggagaa
     1021 ggacgagggc atttaccggg agcgccttcc ccattatttc ccagtagacc cacccgggcc
     1081 tgtaggaatt cgttcccagc tttgagaggt ctcagaagcc tacagcttgt tccagcctgg
     1141 ccatcacagg gttctgtcct ttccttcagc cctgcctttc agaagcctcc taataaagct
     1201 gtctggctca gccctca
//
