LOCUS       NM_025382               3842 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus macoilin 1 (Maco1), transcript variant 1, mRNA.
ACCESSION   NM_025382 XM_976454
VERSION     NM_025382.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3842)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3842)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3842)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   4  (bases 1 to 3842)
  AUTHORS   Kuvbachieva,A., Bestel,A.M., Tissir,F., Maloum,I., Guimiot,F.,
            Ramoz,N., Bourgeois,F., Moalic,J.M., Goffinet,A.M. and Simonneau,M.
  TITLE     Identification of a novel brain-specific and Reelin-regulated gene
            that encodes a protein colocalized with synapsin
  JOURNAL   Eur J Neurosci 20 (3), 603-610 (2004)
   PUBMED   15255972
  REMARK    GeneRIF: From E14.5 to birth, C61 was highly expressed in all
            neuronal differentiation fields, with the highest signal in the
            telencephalic cortical plate and mitral cells in the olfactory
            bulb.
REFERENCE   5  (bases 1 to 3842)
  AUTHORS   Kumada,M., Iwamoto,S., Kamesaki,T., Okuda,H. and Kajii,E.
  TITLE     Entire sequence of a mouse chromosomal segment containing the gene
            Rhced and a comparative analysis of the homologous human sequence
  JOURNAL   Gene 299 (1-2), 165-172 (2002)
   PUBMED   12459264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY846873.1.
            
            On Jul 30, 2009 this sequence version replaced NM_025382.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY846873.1, AY364165.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3226              AY846873.1         2-3227
            3227-3842           AY846873.1         3229-3844
FEATURES             Location/Qualifiers
     source          1..3842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.11 cM"
     gene            1..3842
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /note="macoilin 1"
                     /db_xref="GeneID:66146"
                     /db_xref="MGI:MGI:1913396"
     exon            1..308
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2223
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     macoilin; brain-specific adaptor protein C61;
                     brain-specific adapter protein C61; transmembrane protein
                     57"
                     /codon_start=1
                     /product="macoilin isoform 1"
                     /protein_id="NP_079658.2"
                     /db_xref="CCDS:CCDS18777.1"
                     /db_xref="GeneID:66146"
                     /db_xref="MGI:MGI:1913396"
                     /translation="MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLA
                     DFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFF
                     AASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIG
                     YPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEA
                     AKGLPDMDSSILIHHNGGIPANKKLSTTLPEIEYREKGKEKDKDAKKHNLGINNNNIL
                     QPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSKNYKNASGVVNSSPR
                     SHSATNGSIPSSSSKNEKKQKCTSKGPSAHKDLMENCIPNNQLSKPDALVRLEQDIKK
                     LKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDK
                     QNISQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRS
                     RIRELEAEGKKLTMDMKVKEEQIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQ
                     HLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSI
                     TYSAATSPLSPVSPHYSSKFVETSPSGLDPNASVYQPLKK"
     exon            309..450
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            451..577
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            578..701
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            702..880
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1382
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1541
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1724
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1845
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2020
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..3826
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2451..2456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /note="hexamer: ATTAAA"
     polyA_site      2477
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /note="major polyA site"
     regulatory      3802..3807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /note="hexamer: AATAAA"
     polyA_site      3826
                     /gene="Maco1"
                     /gene_synonym="1110007C24Rik; 9230118A01Rik; C61; Tmem57"
                     /note="major polyA site"
ORIGIN      
        1 ggctggtgcg gggcgggcgg gccccggaat tgtcatttct ttgtttccga aggcggagga
       61 ggctcggcgc ccccctcctg gccccctccc ccccggtgct ggctccatgt ctgtgtgacc
      121 ggccgcaggg gtaggattca ggcccgacgc ggggcgggcg ggcgacggcg gctgaggtga
      181 gaggcggcgg cggcggcgcg gctcgggcac cggcccccca gcgggaggat gaagcggcgg
      241 aacgccgact gcagtaagct ccgccgcccc ctgaagcgga accggatcac cgagggtatc
      301 tacggcagta catttttata cctgaaattc ctggtagtgt gggcacttgt cctccttgcc
      361 gactttgtcc tggagttccg atttgaatac ctgtggccgt tctggctttt catcagaagc
      421 gtctatgatt ccttcagata ccaaggactg gccttctcag tattttttgt ttgtgtagca
      481 ttcacttcaa atatcatatg tctcctcttc attcccatac aatggctttt tttcgctgct
      541 agcacatatg tatgggtcca gtacgtatgg cacacagaaa ggggagtgtg tttgcctaca
      601 gtgtcactct ggatcctctt tgtttatatt gaagcagcaa ttagatttaa agatctgaaa
      661 aactttcatg tagacctttg tcgaccgttt gctgctcact gcattggata ccctgtggtg
      721 actttgggct ttggcttcaa aagttatgtg agctacaaaa tgcggttaag gaagcagaag
      781 gaagttcaga aggagaacga gttttacatg cagcttcttc agcaggccct ccctccagag
      841 cagcaaatgt tgcagaagca ggagaaggag gctgaggaag cagccaaggg attgccggac
      901 atggattcct cgatccttat acaccacaac ggaggcatcc cagccaacaa aaaactgtcc
      961 acaacgttgc cagagataga atatcgagaa aaagggaaag agaaggacaa ggatgccaag
     1021 aaacacaacc ttggaataaa taacaacaac attctacaac ctgtagactc taagatacaa
     1081 gagattgagt atatggaaaa ccatatcaat agtaaaagat taaacaatga tcttgtggga
     1141 agtacagaaa atctcttaaa agaggactca tgcactgctt cctcaaaaaa ttacaaaaat
     1201 gccagtggag ttgtgaactc ctcgcctcga agtcacagcg ctacaaatgg aagcattcct
     1261 tcctcgtcta gtaaaaacga gaagaagcag aagtgcacca gcaagggccc gagtgcacac
     1321 aaggacttaa tggagaactg tattcctaac aaccagctga gcaaaccaga cgcgctggta
     1381 aggctggaac aagacattaa aaagctaaag gctgacctgc aagccagccg gcaagtggag
     1441 caagagctgc gcagtcagat cagcgccctc tcaagcacag agcgaggcat ccgctcagaa
     1501 atgggccagc tccggcagga gaacgagctg ctgcagaaca agttacacaa tgccgtgcaa
     1561 atgaagcaaa aagacaagca gaatatcagc cagctagaga agaagctaaa ggctgagcag
     1621 gaagcccgaa gctttgtaga aaagcagcta atggaggaga aaaaaaggaa gaagttagaa
     1681 gaagccacag ctgcacgggc tgttgccttt gctgctgcat ctaggggaga gtgcacggaa
     1741 accttacgga gtcggatcag agagctagaa gctgagggca agaagctcac aatggacatg
     1801 aaagtgaagg aggagcagat cagggaactg gaactgaagg ttcaggagct tcggaagtac
     1861 aaagaaaacg agaaggacac cgaggtattg atgtcagccc tctccgccat gcaagacaaa
     1921 acgcaacacc tagagaacag tctcagcgca gagacgagga tcaagctgga cctcttctct
     1981 gcacttggtg atgcaaagcg gcagctggag attgcccagg ggcaaattct tcagaaagac
     2041 caggaaatca aggacctaaa acagaaaata gctgaagtca tggctgtcat gcccagcata
     2101 acatacagtg ctgccaccag tcccctgagc cccgtgtccc cccactactc ttccaagttt
     2161 gtggagacca gcccctctgg acttgaccct aatgcctctg tctaccagcc cttgaagaag
     2221 tgaaggccaa ctgtgtgctc gcccaacatt tgcaaccagg aggcttcgaa aagcagcgtc
     2281 tctggcagtc aagataaaaa agttgatatt gtgttttgtg ggactgtata tgttgtcatt
     2341 tttaaagggg ggaaataaca tccaagtctg attagaaccg cccatcagtt gttcttggaa
     2401 gtttttagaa gacctcacgg actttgcagt ttatttttct tggccaacac attaaaacca
     2461 ttcttggatt tcaagtagcc aattttgcct ttttatgtat ttttacatag tttcctcttc
     2521 aagaaaaaaa aagcagagtt tttttgcttt tcaactctat tttgttctta aataagcaag
     2581 aaaattgcac gttgtattca ctgacgacaa caaaagctta gtttctagca tgagaggcta
     2641 aacagcccca cacagctctg attccatagc tgcattaaag atgattattt atattacaga
     2701 gaaaagaggg atcggccctc caaggaccag acagattgag agagagtcac ttaagctgag
     2761 agagacttaa gggtgagact ggcgtgcagg cgtgtgacgg tgtgtttgga gtattgccat
     2821 tcccatcgct gttagctcta gagcacatcc agagcatacg tttacagagg aaacttgatc
     2881 atttccaacc atcttcccct accccaccct ctcgcccctg gcacctgtct tctatttgtc
     2941 gagttcactg ttgatcctgt tgtaggtggt tgggctgctg gtcaccatgc caccacttgg
     3001 gttttttcca tgggaagcag cctgctgggt gtgcaaggcc gagtgatggc tgatcaatca
     3061 aagccgtggt ctaggaccag ctcccacgtg ccatttactg ctttcttcac cctcctcatc
     3121 tggagtttga tggtttacag atgtctgaca gttcctcagc tcttgtgcca aggaggagtg
     3181 gttgttgttg ttttgttttg aagacttaaa ctctgcacaa agatcctggt tcagctgtgt
     3241 actataggtt ggtaggaagt gtcgtgtcag cacagacctg ggagagggtg ttaagaatca
     3301 gggagcggga gggcagggga gagagaggac gggcaaagca gagatctggt ttgaaagctg
     3361 gggaaattga gaagccagat cgatttgact ttgcttccat gctgtgtgtt ctgaaaggac
     3421 atggctctaa aatttcctgt tgattggcat gtgtatctca tttaaagcaa aattaggtag
     3481 aacaaaccag tcagtaagat tagaagtatt acagagaatc atccttttaa tcacagatct
     3541 tattttggag taaaacaaac ttctagcttt agccaggtgt gcatgttgtc gccatttgca
     3601 ttttgagtca tcttgtgtaa atgtcaccat gaaagtgtta ctcagaattg tcatagtttt
     3661 tttcccccca tctttgtgct aaaacatgga aaattgtcac tgtgttgatg aggtttcccc
     3721 cattctgctg cctttgggac actgttttcg ttaaacttgg tcttggctgc attctttttt
     3781 ttccctcgtg gggttcaaaa gaataaacat tttcttactg ataaaaaaaa aaaaaaaaaa
     3841 aa
//
