LOCUS       NM_133825               2738 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus macrophage immunometabolism regulator (Macir),
            transcript variant 1, mRNA.
ACCESSION   NM_133825
VERSION     NM_133825.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Muthana,M., Hawtree,S., Wilshaw,A., Linehan,E., Roberts,H.,
            Khetan,S., Adeleke,G., Wright,F., Akil,M., Fearon,U., Veale,D.,
            Ciani,B. and Wilson,A.G.
  TITLE     C5orf30 is a negative regulator of tissue damage in rheumatoid
            arthritis
  JOURNAL   Proc Natl Acad Sci U S A 112 (37), 11618-11623 (2015)
   PUBMED   26316022
  REMARK    GeneRIF: C5orf30 is a previously unidentified negative regulator of
            tissue damage in rheumatoid arthritis, and this protein may act by
            modulating the autoaggressive phenotype that is characteristic of
            synovial fibroblasts
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611324.1, AK152370.1, AK162223.1 and BY419889.1.
            
            On Aug 14, 2009 this sequence version replaced NM_133825.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023951.1, AK152370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               BB611324.1         1-181
            182-1469            AK152370.1         154-1441
            1470-1470           AK162223.1         1414-1414
            1471-2731           AK152370.1         1443-2703
            2732-2738           BY419889.1         385-391
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.76 cM"
     gene            1..2738
                     /gene="Macir"
                     /gene_synonym="D1Ertd622e"
                     /note="macrophage immunometabolism regulator"
                     /db_xref="GeneID:52392"
                     /db_xref="MGI:MGI:1277184"
     exon            1..188
                     /gene="Macir"
                     /gene_synonym="D1Ertd622e"
                     /inference="alignment:Splign:2.1.0"
     exon            189..278
                     /gene="Macir"
                     /gene_synonym="D1Ertd622e"
                     /inference="alignment:Splign:2.1.0"
     exon            279..2738
                     /gene="Macir"
                     /gene_synonym="D1Ertd622e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2715..2720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Macir"
                     /gene_synonym="D1Ertd622e"
                     /note="hexamer: AATAAA"
     polyA_site      2735
                     /gene="Macir"
                     /gene_synonym="D1Ertd622e"
                     /note="major polyA site"
ORIGIN      
        1 gggaggaggc gggactacgg cgggccgtag ctggcgccga gcgcggtggg agagcagcgg
       61 gtacccggct ggctccgctg gcggcctctg cccacacctc ggcgccgcag ccccgcgcct
      121 cgcccgccct tggcttcggg gtctgcggct gccggccata gaggaaccgg cggaaccctg
      181 gacgaccgta tctggactag aacagaaaac ttattatgcc tgtgctccct tgggacactt
      241 tggaacttgc acagtgacat catctgggat ttagtctggc gtgtgcagcc tggtgcctaa
      301 gatggaagta gatataaatg gggattccag aagtaccctg accaccctgc ccttgcctgt
      361 ggctgaggga agctctccag gaaaagcaga ggcagagaaa ccccgctgct ctagcacacc
      421 ctgctcgccc atgcgccgga ctgtgtctgg ttatcagatc ctccacatgg actctaacta
      481 cttggttggc ttcaccactg gtgaggaact cctgaagtta gcccagaagt gcacaggagg
      541 ggaagacagc aagggagaag ccatgcccgc cttgcgcgct aaacagctgg acacgggact
      601 cgcgcgttcc tctcgtctgt ataaaactag aagtaggtac tatcagccat atgagatccc
      661 agcggttaat ggcaggaggc gaaggcggat gcccagctca ggagacaagt gcaccaaacc
      721 cttaccttat gaaccttata aggccctcca tgggcccttg cctctatgtc ttcttaaagg
      781 taagagggct cactccaaat ctctggacta cctcaatcta gataaaatga acatcaagga
      841 gccagctgac acggaagtgc tacagtacca gcttcagcac ctgaccctcc gaggggaccg
      901 agtgtttgct agaaacaata catgagtggc gtgggcagag tttaaaccac tttaggtcag
      961 cctatgctcg gctagagaaa aatctactgt cgtactctgt acatgaccct tcacgttaga
     1021 gatggttata tcagctaagt gttcctggaa cataaaaatt gtttggatca agttttggat
     1081 acaggaatga aatcacaggt acttggggcg gggcgggggg atatcattct agagcacgca
     1141 attgcaaaga aaaccgaatg ttgactgtta gtttgcatag ctttttagct aggaaaaggc
     1201 tttggtgcag taatttcacc tttatgagtc tgacacccaa attgggaatg ttacctgctt
     1261 ggttgttgct aacttggtat gattcattag aaatttatac cgaagtaccc agtgcttctt
     1321 ggatctctgt attttactat aaaatgtatg taatgatttg tcttatgaaa tttaaagctt
     1381 gaacacggct gaactggacc actttttatt tttaaatatt gagtttaaat attttataac
     1441 tggttttgca ctgaaaacaa ttaacatttc agataattaa gagaataatc tttcttcact
     1501 tgcctcaata atgatattga gcaatggatt ttttttttta atttccgcat ggaaagttac
     1561 tgatctttat ggctgtaaaa tattcctttc tagcattatt aaagtgtgtc ttaataaaat
     1621 taaatttggg atacaaagta tttattttac gatgggtagc gggtggggcg cttttcagaa
     1681 tgtttccaat atgaagtttt cgtcagttgg aaacatttcc ttagtgctta ttatcaattt
     1741 aaattccaca tggaacttga agacagggag gattctcagc actgggttgt cagtatagtg
     1801 ctgcttgcat ctttacttct tgtaagtgac tgcagctcta gcagaggagc tcctgatttt
     1861 gactatcaaa ggcttaaact gagtatgaag tgataccgct cagcccaggg ttgggtcttt
     1921 ccaggctcag ttctctgcag cgaggcactc atcaaaactt tagttcggga ttagcgtagg
     1981 agcccaacat actcctacag ttttaatggg ctaatcctgg attacctaag agtttacgtc
     2041 catcacactg gtttgatttg ttgctaaaga aataattcct tgcctttagt aacagaagca
     2101 gctcaactat tcttgaccat aaatgtatgt aactttcctt ttgtaaacat ttctatttct
     2161 tttactcagt cttaaaggtg caatttatta ctgatttggc atttctggct atatagaact
     2221 acgtagttta tgttttcttt gggggcactg tgagtttcta aggggttagc agtcttgctt
     2281 ttaaaaataa gaacactttt taattggcgg atgggccatt cctggaacaa tcgtgatttt
     2341 tccctctgtc cagaatgaat ggcaagcttt attagagcag aataagtctt agaaacctca
     2401 gaaactcttc atagagagac aaccgtgttg gcaacatgta ggaaagagct ttggagatgc
     2461 tggcttccat cttactgaat cgattagagt tttcaatggc tggaaagttt ctgctgttgt
     2521 ctattttaaa gtaaactgca cctttgtaac atattgatga atgatcacta agattaacta
     2581 tatctataca gtcattagtt tgacaagtaa tagaatcctg tcagatgcca aagagttggg
     2641 atttttacat ttaatgatta aacaccgtta tttattgatg attttccctc tggaactgta
     2701 ttatttctaa ctgaaataaa agggtgatgt caacatcc
//
