LOCUS       NM_001163136            3818 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus metastasis associated in colon cancer 1 (Macc1), mRNA.
ACCESSION   NM_001163136 XM_138397 XM_906766
VERSION     NM_001163136.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3818)
  AUTHORS   Sun L, Duan J, Jiang Y, Wang L, Huang N, Lin L, Liao Y and Liao W.
  TITLE     Metastasis-associated in colon cancer-1 upregulates vascular
            endothelial growth factor-C/D to promote lymphangiogenesis in human
            gastric cancer
  JOURNAL   Cancer Lett 357 (1), 242-253 (2015)
   PUBMED   25444928
  REMARK    GeneRIF: Data suggest a critical role for MACC1 in lymphatic
            dissemination of GC, providing evidence that MACC1 upregulated
            VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met
            signaling.
REFERENCE   2  (bases 1 to 3818)
  AUTHORS   Chen XP, Ren XP, Lan JY, Chen YG and Shen ZJ.
  TITLE     Analysis of HGF, MACC1, C-met and apoptosis-related genes in
            cervical carcinoma mice
  JOURNAL   Mol Biol Rep 41 (3), 1247-1256 (2014)
   PUBMED   24469707
  REMARK    GeneRIF: HGF, MACC1 and C-met genes involve into malignant cervical
            tumors occurrence, development and prognosis, and might become
            potential molecular target therapy site of cervical cancer
REFERENCE   3  (bases 1 to 3818)
  AUTHORS   Pichorner A, Sack U, Kobelt D, Kelch I, Arlt F, Smith J, Walther W,
            Schlag PM and Stein U.
  TITLE     In vivo imaging of colorectal cancer growth and metastasis by
            targeting MACC1 with shRNA in xenografted mice
  JOURNAL   Clin Exp Metastasis 29 (6), 573-583 (2012)
   PUBMED   22484916
  REMARK    GeneRIF: MACC1 has a role in colorectal cancer and can be used for
            imaging in xenografts
REFERENCE   4  (bases 1 to 3818)
  AUTHORS   Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I,
            Birchmeier W and Schlag PM.
  TITLE     MACC1, a newly identified key regulator of HGF-MET signaling,
            predicts colon cancer metastasis
  JOURNAL   Nat Med 15 (1), 59-67 (2009)
   PUBMED   19098908
  REMARK    GeneRIF: MACC1 will be useful for the identification of poor
            prognosis subjects with colorectal cancer and is a promising new
            target for intervention in metastasis formation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138307.2 and AC132596.5.
            
            On or before Jul 10, 2009 this sequence version replaced
            XM_906766.2, XM_138397.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: The exon combination of this CCDS representation is
            inferred based on orthologous transcript alignments, e.g., human
            AJ313524.1, BC137090.1 or BC144470.1. Partial mouse transcript data
            also support this representation, e.g., mRNA accession AK028965.1,
            and RNA-Seq data from the ENCODE project.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC138307.2         155098-155212
            116-2154            AC138307.2         157302-159340
            2155-2343           AC138307.2         161933-162121
            2344-3818           AC132596.5         132697-134171       c
FEATURES             Location/Qualifiers
     source          1..3818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 63.48 cM"
     gene            1..3818
                     /gene="Macc1"
                     /gene_synonym="4732474O15Rik; Gm267"
                     /note="metastasis associated in colon cancer 1"
                     /db_xref="GeneID:238455"
                     /db_xref="MGI:MGI:2685113"
     CDS             1..2556
                     /gene="Macc1"
                     /gene_synonym="4732474O15Rik; Gm267"
                     /codon_start=1
                     /product="metastasis-associated in colon cancer protein 1"
                     /protein_id="NP_001156608.1"
                     /db_xref="CCDS:CCDS49199.1"
                     /db_xref="GeneID:238455"
                     /db_xref="MGI:MGI:2685113"
                     /translation="MLISERAYCWPREIGRSRSEGNLIDMEASKRSKNQNITARQGLG
                     LPHNWPDAPTLHRDSDAKATNPFWKELSASNPFLEDITQLRNNKKRDNMSILKEDPFL
                     FLRQIETENSFDSSGDELDMDQGFKSSSSRKSGRSKSVSELLDVLGDRTHTHQSIHSS
                     DQILIQDLEWLQNDREAYKMAWLSQRQLARSCLDLNTINQSPGWAQTQIAETIAVCKL
                     NHQGGSVQLPDSDITIHIPQGHIAVGEFQEVSLRAFLDPPPKLNHDLSCTVSPLLEIR
                     LSNLNTMEAILLEMKTGAEVKTDPLSQVMTKMVCLYSLDREGPFQALNTCYIYKDTIQ
                     AKLLDLSHVMYIVIAVQATIIHPPAATIWDYIHKTTSIGIYGPKYLHPSFTAVFTVCG
                     HNYVPGKFTVSDIRKGGKNTSPVVFHLWGKHSFSLDKPKDLIISAFSCDPDFEVKEEG
                     ERKVIAQRQLEAGVVVHQQVFFSSIDHREMHLFVFRVQVKTPNEKPVTQFFVTSPDPS
                     PNLKRFSYLPGFFQKREDKRVPLLSTGLVKYPTFQDKKLNFTNYGVALKTVLRQNKID
                     YLLEYLKGDTIALLGEGTVRAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMSM
                     SDGILTTKNLLEQIALPFKSLTYIYSVVLTLVSEKVHDWKVLANVLGYSHLAQEDFNR
                     IQADKEPERVSYVVKKLKEDCHEDRNTRKFLYELIVALLKMDCQELVAHLIQEAVILT
                     SAVKLGRSWRELAEKSAGLTKHQMQAYEIPHRGKSGDVSAEMMWKPAYDFLYAWSFHY
                     GNSYRDVLQDLQSALDRMKNPVTKRWRDLTGTLILINSLEILRVTAFSTSQEI"
     exon            1..115
                     /gene="Macc1"
                     /gene_synonym="4732474O15Rik; Gm267"
                     /inference="alignment:Splign:2.1.0"
     exon            116..2154
                     /gene="Macc1"
                     /gene_synonym="4732474O15Rik; Gm267"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2343
                     /gene="Macc1"
                     /gene_synonym="4732474O15Rik; Gm267"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..3818
                     /gene="Macc1"
                     /gene_synonym="4732474O15Rik; Gm267"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctaatca gtgaaagagc ctattgttgg ccacgagaaa ttggtcgaag tagatctgaa
       61 ggaaatttga ttgacatgga agcctcgaaa cgctcaaaaa atcaaaatat tacagcacgg
      121 caagggctag gcttgcctca caactggcca gatgctccta ccctccatcg tgatagtgat
      181 gccaaagcta caaatccatt ctggaaggaa ctgtctgcct caaacccatt tctggaggac
      241 atcacgcagc taagaaacaa caaaaagaga gataatatgt ctatcttgaa ggaagatcct
      301 tttctttttt taagacaaat agaaacagaa aattcttttg actcctctgg tgatgaactt
      361 gacatggatc aggggtttaa gtcatcttcc tctcggaagt caggaaggtc taagagtgtt
      421 tctgaactcc tggatgtttt aggtgatagg acacacactc atcaaagtat acatagctct
      481 gatcagatcc taatacaaga cttagaatgg ctacaaaatg accgagaagc atataaaatg
      541 gcttggctta gtcaacgtca gttggctcgc tcttgcctag atctgaatac aattaatcag
      601 agtcctgggt gggctcaaac acaaattgca gagaccattg cagtttgtaa attaaatcac
      661 caaggagggt cagtccaatt acccgactca gacatcacta ttcatatacc ccaaggacat
      721 atagctgtgg gagaattcca ggaggtatct ctgagagcat ttctggatcc tccaccaaag
      781 ctgaaccatg atctctcttg tactgtaagc cctctcttgg aaatcaggtt aagcaatctg
      841 aataccatgg aagctatttt gttggagatg aaaactggag cagaagtaaa aacagatcct
      901 ctgagccaag tcatgactaa aatggtgtgt ttgtacagcc tggacagaga aggccctttc
      961 caagcattaa acacctgcta tatctacaaa gataccatcc aagctaagct tcttgacctg
     1021 agccatgtaa tgtatatagt catagctgta caagctacga tcattcatcc accagctgct
     1081 actatttggg attatatcca caaaaccacc tctattggaa tttatggacc taaatatctc
     1141 catccaagct ttactgctgt tttcactgtt tgtggacaca actatgtgcc aggaaagttt
     1201 acagtctctg acattaggaa gggtggaaaa aacacatctc cagtcgtatt tcacctctgg
     1261 gggaagcatt cattttcact tgacaagcca aaagatttaa ttatttcagc tttttcgtgt
     1321 gatcctgatt ttgaagtaaa ggaagaggga gaaagaaaag taattgcaca aaggcaattg
     1381 gaagcaggtg tggtagttca tcaacaagtt ttcttttctt caattgatca cagagagatg
     1441 cacttgtttg ttttccgggt tcaggtaaag acccccaatg aaaaaccagt gacacagttc
     1501 tttgtcactt cacctgatcc atccccaaat ctaaaaaggt tctcatatct gccaggattt
     1561 ttccagaaga gagaagacaa gagagtgcct ttattgtcga caggacttgt taagtatccc
     1621 actttccaag ataaaaaatt gaactttacc aattatgggg ttgcactgaa gacagtactg
     1681 aggcaaaata agattgacta tttgcttgaa tatttaaaag gggacacaat tgcccttctt
     1741 ggagaaggta cagtaagagc cataggacag tccaaagtga aagaatggta cgtaggagtc
     1801 ctccgaggta agatcggact cgtgcattgt aaaaatgtca aagtgatttc taaagaacaa
     1861 gtgatgtcaa tgtctgatgg cattttgaca accaagaatc ttctggaaca aattgccttg
     1921 ccatttaaaa gtctgactta tatatactct gttgtattga ccttggtgtc agaaaaagtt
     1981 cacgactgga aagttttagc taatgtcctg ggttactcac atctggcaca ggaagatttt
     2041 aatagaattc aagcagacaa ggaaccagaa agggtttctt acgttgtcaa gaagttaaag
     2101 gaagattgcc atgaagatag aaataccagg aagttccttt atgaactgat tgtggctctg
     2161 ctaaaaatgg attgccaaga gttagtggca catcttatcc aagaggctgt tattctgact
     2221 tcagctgtga aacttggaag aagctggagg gaacttgctg agaaatctgc aggactcact
     2281 aagcatcaga tgcaggcata tgaaattcct caccgaggaa aatctggaga tgtttcagca
     2341 gagatgatgt ggaaacctgc ctatgatttt ctctatgcat ggagttttca ctatggaaat
     2401 agctacagag atgtgttaca agatcttcaa tcagctttgg acagaatgaa aaaccctgtc
     2461 actaaacggt ggagagattt aactggaact ttaatactta taaattcttt agagattctg
     2521 agagtgactg ctttctctac ttctcaggaa atatagaatg aaacaaattt agggaacaaa
     2581 gagaatggta agggggaaag gggtgtgtgt gagagggggg agggagaagg agagggagag
     2641 agaaataaag gaggatgaac tcaaagatgt cttacatttg gaaaattaag tgcagaaatc
     2701 aaaggtagaa gactacccat gaggctagtg taaagtcagt ttaatgcctt aaaaaaatcg
     2761 gtttttaatt tttgcaaaac cataccacat agcagagcag taaagaggac aaataataaa
     2821 aatgcatact gagaaacaaa acatgttcct ctcttaagta atttccagaa ggaaaatata
     2881 acaccatcag aaaaaatgtc ttcaaacatg cactaagaat tttttcagct accttctgca
     2941 tcttgagact atatctaatt ggaagttttc tcccatgatc agaatgcaaa ataatccttt
     3001 agccatcagg ctatttaata ctattattac aaacaattac tatcaccaaa acactcagtc
     3061 ctaagatact gacatatttg tgtatatgct cacatgaaga catgctctgt gtgtatgtgt
     3121 gaacatatct caaagtacat tacaaaactt gcggaaaaca aggctaatgt gagaccatga
     3181 atcagtatat ataaatgtta atgactggca gagttgacaa aaaaatggtc tctgttcaat
     3241 cattgcatgg ctgccaatgt ctttgtattt gagccttcct ttacttattg tagttctctt
     3301 aaaggatagt gaatctagtg ataggcatac agttacttga tataagatat tatgaggaag
     3361 aatgcatgat ttctggattc agtgctatta ataataagga tgggcaataa aaagataaca
     3421 ctgttatatg taaaaatggc atctacaatg acagctgcta tggagaagct gtgaggctgg
     3481 agtagaggat atcatatgaa tggggaagag agtggattca acagaattct gagaagcaaa
     3541 gcctgtagag gcttacgtat tgatgttggc agggtaggag ggatgggagc tagaaataat
     3601 tggatccttc agatagtgga cagacacctc agggttgaag ggaatagagg gacaggggta
     3661 agacaaaggt ataaaggtaa aaggacaaga ctggagttaa ttggaaagga ggctacagtc
     3721 aggtcactaa aacctttagc acttaggaag gaaagataca cctcaaaggt aacttggata
     3781 cggtgaataa agtattgttt gtgaatttct gaataaaa
//
