LOCUS       NM_011839               2252 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus mab-21-like 2 (Mab21l2), mRNA.
ACCESSION   NM_011839
VERSION     NM_011839.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Ceroni,F., Cicekdal,M.B., Holt,R., Sorokina,E., Chassaing,N.,
            Clokie,S., Naert,T., Talbot,L.V., Muheisen,S., Bax,D.A., Kesim,Y.,
            Kivuva,E.C., Vincent-Delorme,C., Lienkamp,S.S., Plaisancie,J., De
            Baere,E., Calvas,P., Vleminckx,K., Semina,E.V. and Ragge,N.K.
  TITLE     Deletion upstream of MAB21L2 highlights the importance of
            evolutionarily conserved non-coding sequences for eye development
  JOURNAL   Nat Commun 15 (1), 9245 (2024)
   PUBMED   39455595
  REMARK    GeneRIF: Deletion upstream of MAB21L2 highlights the importance of
            evolutionarily conserved non-coding sequences for eye development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Yamada,R., Oguri,A., Fujiki,K., Shirahige,K., Hirate,Y.,
            Kanai-Azuma,M., Takezoe,H., Akimoto,Y., Takahashi,N. and Kanai,Y.
  TITLE     MAB21L1 modulates gene expression and DNA metabolic processes in
            the lens placode
  JOURNAL   Dis Model Mech 14 (12) (2021)
   PUBMED   34779479
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Yamada,R., Oguri,A., Fujiki,K., Shirahige,K., Takezoe,H.,
            Takahashi,N. and Kanai,Y.
  TITLE     Single-cell transcriptional analysis reveals developmental
            stage-dependent changes in retinal progenitors in the murine early
            optic vesicle
  JOURNAL   Biochem Biophys Res Commun 543, 80-86 (2021)
   PUBMED   33548738
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Tyser,R.C.V., Ibarra-Soria,X., McDole,K., Arcot Jayaram,S.,
            Godwin,J., van den Brand,T.A.H., Miranda,A.M.A., Scialdone,A.,
            Keller,P.J., Marioni,J.C. and Srinivas,S.
  TITLE     Characterization of a common progenitor pool of the epicardium and
            myocardium
  JOURNAL   Science 371 (6533) (2021)
   PUBMED   33414188
REFERENCE   6  (bases 1 to 2252)
  AUTHORS   Yamada,R., Mizutani-Koseki,Y., Hasegawa,T., Osumi,N., Koseki,H. and
            Takahashi,N.
  TITLE     Cell-autonomous involvement of Mab21l1 is essential for lens
            placode development
  JOURNAL   Development 130 (9), 1759-1770 (2003)
   PUBMED   12642482
REFERENCE   7  (bases 1 to 2252)
  AUTHORS   Wong,R.L. and Chow,K.L.
  TITLE     Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests
            axial turning, and impairs notochord and neural tube
            differentiation
  JOURNAL   Teratology 65 (2), 70-77 (2002)
   PUBMED   11857508
  REMARK    GeneRIF: required in developing embryos for embryonic turning,
            formation of the notochord, neural tube, and other organ tissues
REFERENCE   8  (bases 1 to 2252)
  AUTHORS   Mariani,M., Baldessari,D., Francisconi,S., Viggiano,L., Rocchi,M.,
            Zappavigna,V., Malgaretti,N. and Consalez,G.G.
  TITLE     Two murine and human homologs of mab-21, a cell fate determination
            gene involved in Caenorhabditis elegans neural development
  JOURNAL   Hum Mol Genet 8 (13), 2397-2406 (1999)
   PUBMED   10556287
REFERENCE   9  (bases 1 to 2252)
  AUTHORS   Wong,R.L., Chan,K.K. and Chow,K.L.
  TITLE     Developmental expression of Mab21l2 during mouse embryogenesis
  JOURNAL   Mech Dev 87 (1-2), 185-188 (1999)
   PUBMED   10495284
REFERENCE   10 (bases 1 to 2252)
  AUTHORS   Wong,R.L., Wong,H.T. and Chow,K.L.
  TITLE     Genomic cloning and chromosomal localization of the mouse Mab21l2
            locus
  JOURNAL   Cytogenet Cell Genet 86 (1), 21-24 (1999)
   PUBMED   10516425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053645.1 and BC058730.1.
            
            On Apr 12, 2018 this sequence version replaced NM_011839.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC058730.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1907              AK053645.1         2-1908
            1908-2252           BC058730.1         2014-2358
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.86 cM"
     gene            1..2252
                     /gene="Mab21l2"
                     /note="mab-21-like 2"
                     /db_xref="GeneID:23937"
                     /db_xref="MGI:MGI:1346022"
     exon            1..2234
                     /gene="Mab21l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             593..1672
                     /gene="Mab21l2"
                     /codon_start=1
                     /product="protein mab-21-like 2"
                     /protein_id="NP_035969.2"
                     /db_xref="CCDS:CCDS17447.1"
                     /db_xref="GeneID:23937"
                     /db_xref="MGI:MGI:1346022"
                     /translation="MIAAQAKLVYQLNKYYTERCQARKAAIAKTIREVCKVVSDVLKE
                     VEVQEPRFISSLSEIDARYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKL
                     SDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMIADTSEVKL
                     RIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSL
                     TGKQSSAESDAWVLQFGEAENRLLMGGCRNKCLSVLKTLRDRHLELPGQPLNNYHMKT
                     LLLYECEKHPRETDWDEACLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSA
                     LESAAKQTWRLAREILTNPKSLDKL"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mab21l2"
                     /note="hexamer: AATAAA"
     polyA_site      2234
                     /gene="Mab21l2"
                     /note="major polyA site"
ORIGIN      
        1 gcaaacctca gagtgcgctg cggcctgagc tgtacttcgc tgctctccgg gcattaatta
       61 catccttcac tttccttttg ggggagggta aggaaggcat cacctacgct gagcgaaggc
      121 gtccaaccat cgagggagaa gtttcagaat gaaccactga atgtttttgt cttattttta
      181 aatttacttt ggcacttata agacttcatt tccagatatc tgggcaatcg tggctgctgc
      241 ggacatctaa gcctagcctc ttggtaacct agttttttct ctctcacgat ttcatccatc
      301 tctcccgcac aaggagaggc tcgtctttat ttttgcaggt actttccccc ctaaataata
      361 ttatttctaa ttttctgcgg aagaaagaaa agaaaattcc aaagagggaa aagaaaaggc
      421 cagccggcta tatcatcagc cggtcagccc aggtggaaag caagagtgaa attggggctt
      481 cagggggaac gcaccgcctt tccacagccg cagggccacc accagtgcgt gagccttgga
      541 tccctcaacg tattgcgaga cgccggtgta cagcccggac ctgtgcccca acatgatcgc
      601 cgctcaggcc aagctggttt accagctcaa taaatactac accgagcgct gccaggcgcg
      661 caaggctgcg atcgccaaga ccatccgaga agtctgcaag gtagtgtcgg atgtgctaaa
      721 ggaagtggag gtgcaagagc cccgcttcat cagctctctg agtgagattg acgcccgcta
      781 cgaggggctg gaggtaatct cgcccaccga gttcgaggtg gtactctacc tcaaccagat
      841 gggagtcttc aacttcgtgg acgacggatc tctgcccggc tgtgccgtgc tcaaactaag
      901 cgatgggcgg aagcggagca tgtctctttg ggtcgagttc atcacagcgt ctggctacct
      961 ttctgcgcgc aagatccgct cgcgtttcca gacactagta gcccaggcgg tggacaagtg
     1021 cagctaccgg gacgtggtca agatgatcgc cgacactagt gaggtcaagt tgcgcatcag
     1081 ggagcgctac gtggtgcaaa tcaccccagc gttcaagtgc accgggatct ggcctcgcag
     1141 cgcggcacag tggcctatgc cccacatccc ctggcccggc cccaatcggg tggcggaggt
     1201 caaggccgaa gggttcaact tgctctccaa ggagtgctac tcgctgactg gcaagcagag
     1261 ctccgcagaa agcgacgcct gggtgctgca gttcggtgag gcggagaacc gcttgctgat
     1321 gggcggctgt agaaacaagt gcctctcggt gctgaagacg ctgcgggacc gccacctgga
     1381 gctgcctggc cagccgctca ataactacca catgaagacg ctgctgctgt acgagtgcga
     1441 gaaacacccg agggaaacgg actgggacga ggcttgcttg ggcgaccgtc tgaacggcat
     1501 cctgctacag ctcatctcct gcctgcagtg ccgccgctgc cctcactact ttttgcccaa
     1561 cctcgacctc ttccagggta agccccactc ggccctggag agcgctgcca agcagacctg
     1621 gagattggcc agggaaatcc tcaccaatcc caaaagcttg gacaaactat agagtgctgc
     1681 cgactgcgtg gaaagcaaca taaatgggca tgctctccca gaacacacaa caacagcaaa
     1741 aactcgaaac acaaactttt atgtaaatca cctgaaagaa cgggagtagg cagaagacat
     1801 cctaattaag aagcaaacaa aagagggcaa accaaccaac ccccccaccc caaaaataac
     1861 attcttgcac aaaaatgatc gtttccttcc aaacaatgtg aatttaaaga tcgcacaaaa
     1921 gaagcaatcc ggctttgcga acacaaaatg aaacccaagg tacatttttc aaatcaatgt
     1981 atagtagctt cccttctttt ccttctttac gcccgcccct ccttgttttg ggttgcttgc
     2041 gtgattgtca ccaagtgaaa ataattattt aactatatgt gaaatttctt ttacaaagtt
     2101 ttactgatgt gaaatgtgtc tcagtgccaa tgtcaatgtg cccctgcctc ctccttttgc
     2161 acccctaacc cccgccctaa aatgtcttgt tgaaaccagt aaaccagtaa taaaaatatt
     2221 actttacatt gtaaaaaaaa aaaaaaaaaa aa
//
