LOCUS       NM_010750               2793 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus mab-21-like 1 (Mab21l1), mRNA.
ACCESSION   NM_010750
VERSION     NM_010750.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Promsut,W., Yamada,R., Takami,S., Miyazaki,N., Uemura,M.,
            Hiramatsu,R., Takahashi,N. and Kanai,Y.
  TITLE     External genitalia phenotypes of a Mab21l1-null mouse model for
            cerebellar, ocular, craniofacial, and genital (COFG) syndrome
  JOURNAL   Anat Rec (Hoboken) 307 (5), 1943-1959 (2024)
   PUBMED   37750449
  REMARK    GeneRIF: External genitalia phenotypes of a Mab21l1-null mouse
            model for cerebellar, ocular, craniofacial, and genital (COFG)
            syndrome.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Hall,H.N., Bengani,H., Hufnagel,R.B., Damante,G., Ansari,M.,
            Marsh,J.A., Grimes,G.R., Kriegsheim,A.V., Moore,D., McKie,L.,
            Rahmat,J., Mio,C., Blyth,M., Keng,W.T., Islam,L., McEntargart,M.,
            Mannens,M.M., Heyningen,V.V., Rainger,J., Brooks,B.P. and
            FitzPatrick,D.R.
  TITLE     Monoallelic variants resulting in substitutions of MAB21L1 Arg51
            Cause Aniridia and microphthalmia
  JOURNAL   PLoS One 17 (11), e0268149 (2022)
   PUBMED   36413568
  REMARK    GeneRIF: Monoallelic variants resulting in substitutions of MAB21L1
            Arg51 Cause Aniridia and microphthalmia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Yamada,R., Oguri,A., Fujiki,K., Shirahige,K., Hirate,Y.,
            Kanai-Azuma,M., Takezoe,H., Akimoto,Y., Takahashi,N. and Kanai,Y.
  TITLE     MAB21L1 modulates gene expression and DNA metabolic processes in
            the lens placode
  JOURNAL   Dis Model Mech 14 (12) (2021)
   PUBMED   34779479
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Yamada,R., Mizutani-Koseki,Y., Hasegawa,T., Osumi,N., Koseki,H. and
            Takahashi,N.
  TITLE     Cell-autonomous involvement of Mab21l1 is essential for lens
            placode development
  JOURNAL   Development 130 (9), 1759-1770 (2003)
   PUBMED   12642482
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Wong,R.L. and Chow,K.L.
  TITLE     Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests
            axial turning, and impairs notochord and neural tube
            differentiation
  JOURNAL   Teratology 65 (2), 70-77 (2002)
   PUBMED   11857508
  REMARK    GeneRIF: required in developing embryos for embryonic turning,
            formation of the notochord, neural tube, and other organ tissues
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Mariani,M., Baldessari,D., Francisconi,S., Viggiano,L., Rocchi,M.,
            Zappavigna,V., Malgaretti,N. and Consalez,G.G.
  TITLE     Two murine and human homologs of mab-21, a cell fate determination
            gene involved in Caenorhabditis elegans neural development
  JOURNAL   Hum Mol Genet 8 (13), 2397-2406 (1999)
   PUBMED   10556287
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Wong,R.L., Wong,H.T. and Chow,K.L.
  TITLE     Genomic cloning and chromosomal localization of the mouse Mab21l2
            locus
  JOURNAL   Cytogenet Cell Genet 86 (1), 21-24 (1999)
   PUBMED   10516425
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Mariani,M., Corradi,A., Baldessari,D., Malgaretti,N., Pozzoli,O.,
            Fesce,R., Martinez,S., Boncinelli,E. and Consalez,G.G.
  TITLE     Mab21, the mouse homolog of a C. elegans cell-fate specification
            gene, participates in cerebellar, midbrain and eye development
  JOURNAL   Mech Dev 79 (1-2), 131-135 (1998)
   PUBMED   10349626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB650529.1, AK032114.1, BC014750.1, AC112273.4 and BE950797.1.
            
            On Oct 31, 2007 this sequence version replaced NM_010750.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB650529.1         1-30
            31-2168             AK032114.1         2-2139
            2169-2368           BC014750.1         2118-2317
            2369-2695           AC112273.4         52753-53079         c
            2696-2793           BE950797.1         1-98                c
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 26.65 cM"
     gene            1..2793
                     /gene="Mab21l1"
                     /note="mab-21-like 1"
                     /db_xref="GeneID:17116"
                     /db_xref="MGI:MGI:1333773"
     exon            1..2778
                     /gene="Mab21l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..1564
                     /gene="Mab21l1"
                     /note="protein mab-21-like 1"
                     /codon_start=1
                     /product="putative nucleotidyltransferase MAB21L1"
                     /protein_id="NP_034880.1"
                     /db_xref="CCDS:CCDS17360.1"
                     /db_xref="GeneID:17116"
                     /db_xref="MGI:MGI:1333773"
                     /translation="MIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKE
                     VEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKL
                     SDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKL
                     RIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSL
                     AGKQSSAESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKT
                     LVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSA
                     LENAAKQTWRLAREILTNPKSLEKL"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mab21l1"
                     /note="hexamer: AATGAA"
     polyA_site      2368
                     /gene="Mab21l1"
                     /note="major polyA site"
     regulatory      2469..2474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mab21l1"
                     /note="hexamer: AATAAA"
     polyA_site      2489
                     /gene="Mab21l1"
ORIGIN      
        1 ttacacaaac caacagcagc ttcttctgac agacacacac tcacccccga cgcacactct
       61 gcacactttt cctctacctg attaacagtc ctgcacacac catgattacg ggaaaacgta
      121 aataaatacg gaaaggggtg attattttga ctactggaag agctttgctg ggtctcagca
      181 taacttttgt ttttattacc gagaaggtgc tctctccacg cgtctctctc tgacacggat
      241 tctttagcgg aggggagaaa aggggagagc tcagcctttc actttaagac ccgctagtct
      301 cgagcggggg aaaaaaggcc agcagggcag ggcggccccc tgctgcagct agtccgagag
      361 aggctcggtg ccttttgagc gtggtcccct ttctccaccg aagttggctc cagcgctagc
      421 agccgcattg gatcccacag cctattgcga gactccggtg tacaatccgg atctctgccc
      481 caacatgatc gcggcccagg ccaagctggt ctaccacctg aataagtact acaacgagaa
      541 atgccaggcc aggaaagctg ccatcgccaa aaccatccgg gaagtctgca aagtggtctc
      601 cgacgtcctg aaggaggttg aagtgcagga accgcgtttc atcagctccc tcaatgagat
      661 ggacaaccgc tacgagggcc tggaggttat ctctcccacc gagttcgagg tggtactcta
      721 tctgaaccag atgggggtgt ttaacttcgt ggacgacggc tccctgcctg gctgtgcggt
      781 gctgaaactg agcgatgggc gcaagaggag catgtccctc tgggtggaat tcatcaccgc
      841 ctctggctac ctctcggcac gcaaaatccg ttccaggttt cagacactgg tggctcaggc
      901 ggtggacaag tgtagctaca gagatgtagt aaagatggtg gctgacacga gcgaagtgaa
      961 actgagaatc cgagataggt atgtggtgca gatcaccccg gcctttaaat gcaccgggat
     1021 ttggccgcgg agtgctgccc actggccgct tccccacatc ccctggccag gacccaaccg
     1081 ggtggcagag gttaaggctg aagggttcaa tttgttgtcc aaggagtgcc actccctggc
     1141 cggcaagcag agttcggctg agagcgatgc ttgggtgctg cagtttgcag aggccgagaa
     1201 cagactgcag atggggggct gcaggaagaa atgcctctct atcctgaaaa ccctgcgtga
     1261 tcgccacctg gagttgccag gccagcccct gaacaactac cacatgaaga ctctggtgtc
     1321 ctacgagtgc gagaagcatc ctcgagagtc ggactgggac gaatcttgcc tgggcgatcg
     1381 gctgaacgga attcttctgc agctcatctc atgcctgcag tgccggcggt gtccccatta
     1441 cttcttaccg aacttagatc tgtttcaagg caaaccccac tcggccttgg aaaacgctgc
     1501 taaacaaacg tggcgactgg caagagagat cctgaccaac ccaaaaagtt tggaaaaact
     1561 ttagaggatg atctaatcca gggctgacaa gaatgagcat tcttctcaaa gtcccgacga
     1621 aatgaaaact tcctggttga ttcctatgta ctatttctcg agacagtgca aacaatctct
     1681 tcctttaaaa ggagtaacaa cacaacattt aaccatcatc tcacacaggg gaaaaaccac
     1741 accacaagca tctttatgga ggcatccccc agctcccccg aaaagtgcac aacaccccaa
     1801 aacagctggc tgcaatgcaa gaccatggcc aactccagca aaggattata gtaatcttga
     1861 gacttaggtg cggctgcctt ccagcaaaca gggcccggat gtaccatcgg aagcaaagtg
     1921 taatgtatat tttgatctgt aacaaaagtt gtgatctcat gttgtctttg aaagtgtgga
     1981 tattggtgtt ttgtgatttg gtgatcagaa ctgaaattac cattttggaa actttcagac
     2041 atttcccaca gaacagagat gcatttaaag gtagatttcc tcctggtact ttacctgtct
     2101 ttcaagtgtc tgaacttaaa acaaaagttt acattttgtt tcaaatatat tgcttgttct
     2161 aacattccgt aagtatactt gaaatgttat ttaaatatat tcaaaaattt gaattcagct
     2221 tatataataa cgcttgaata tctgaattat atatatattt gaaaatgcac ttgaaaatac
     2281 actggataat tacttttgtg atttagaatt taatttctgt tgctgatttt tatttaatta
     2341 gaagataata aatgaagtaa aataccaagt ttctgtttct ctttaaattg ttgttgttgt
     2401 tgttaaatga ggtaatgatg ctatttaaaa gtcaacttga gaattttaaa catttcgaca
     2461 aacaggttaa taaaatcact aaaattaaat gttaaaaggg ctctttttag aacagctata
     2521 gaaaatatcc acttccccag tttctaattt actcaatggt tcttttctac aatgaatata
     2581 tttatagcct acttctgaga ctttgattct ggttagtatt tctgtagtcg tttgacaata
     2641 taagggaaaa attaccatag caatagagaa gactgagttt aaaagcagca aaatctgaga
     2701 aaaattaact taaaccataa tgcaaaactc tgaagttttt atatgaaata taagcaataa
     2761 aatggagata tattttaaaa aaaaaaaaaa aaa
//
