LOCUS       NM_010749               2515 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mannose-6-phosphate receptor, cation dependent (M6pr),
            mRNA.
ACCESSION   NM_010749
VERSION     NM_010749.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Elwell,C.A., Czudnochowski,N., von Dollen,J., Johnson,J.R.,
            Nakagawa,R., Mirrashidi,K., Krogan,N.J., Engel,J.N. and
            Rosenberg,O.S.
  TITLE     Chlamydia interfere with an interaction between the
            mannose-6-phosphate receptor and sorting nexins to counteract host
            restriction
  JOURNAL   Elife 6, e22709 (2017)
   PUBMED   28252385
  REMARK    GeneRIF: Finally, Chlamydia trachomatis infection interferes with
            the SNX5:cation-independent mannose-6-phosphate receptor
            interaction, suggesting that Chlamydia IncE and cation-independent
            mannose-6-phosphate receptor are dependent on the same binding
            surface on SNX5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Zhou,X., Sun,L., Bastos de Oliveira,F., Qi,X., Brown,W.J.,
            Smolka,M.B., Sun,Y. and Hu,F.
  TITLE     Prosaposin facilitates sortilin-independent lysosomal trafficking
            of progranulin
  JOURNAL   J Cell Biol 210 (6), 991-1002 (2015)
   PUBMED   26370502
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Dohgu,S., Ryerse,J.S., Robinson,S.M. and Banks,W.A.
  TITLE     Human immunodeficiency virus-1 uses the mannose-6-phosphate
            receptor to cross the blood-brain barrier
  JOURNAL   PLoS One 7 (6), e39565 (2012)
   PUBMED   22761827
  REMARK    GeneRIF: We conclude that M6PR is an important receptor used by
            HIV-1 to cross the blood-brain barrier.
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Chavele,K.M., Martinez-Pomares,L., Domin,J., Pemberton,S.,
            Haslam,S.M., Dell,A., Cook,H.T., Pusey,C.D., Gordon,S. and
            Salama,A.D.
  TITLE     Mannose receptor interacts with Fc receptors and is critical for
            the development of crescentic glomerulonephritis in mice
  JOURNAL   J Clin Invest 120 (5), 1469-1478 (2010)
   PUBMED   20407205
  REMARK    GeneRIF: Mannose receptor interacts with Fc receptors and is
            critical for the development of crescentic glomerulonephritis in
            mice
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Forejt,J. and Gregorova,S.
  TITLE     Genetic analysis of genomic imprinting: an Imprintor-1 gene
            controls inactivation of the paternal copy of the mouse Tme locus
  JOURNAL   Cell 70 (3), 443-450 (1992)
   PUBMED   1322799
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Ludwig,T., Ruther,U., Metzger,R., Copeland,N.G., Jenkins,N.A.,
            Lobel,P. and Hoflack,B.
  TITLE     Gene and pseudogene of the mouse cation-dependent mannose
            6-phosphate receptor. Genomic organization, expression, and
            chromosomal localization
  JOURNAL   J Biol Chem 267 (17), 12211-12219 (1992)
   PUBMED   1376319
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Matzner,U., von Figura,K. and Pohlmann,R.
  TITLE     Expression of the two mannose 6-phosphate receptors is spatially
            and temporally different during mouse embryogenesis
  JOURNAL   Development 114 (4), 965-972 (1992)
   PUBMED   1319896
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Ma,Z.M., Grubb,J.H. and Sly,W.S.
  TITLE     Cloning, sequencing, and functional characterization of the murine
            46-kDa mannose 6-phosphate receptor
  JOURNAL   J Biol Chem 266 (16), 10589-10595 (1991)
   PUBMED   1645352
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Koster,A., Nagel,G., von Figura,K. and Pohlmann,R.
  TITLE     Molecular cloning of the mouse 46-kDa mannose 6-phosphate receptor
            (MPR 46)
  JOURNAL   Biol Chem Hoppe Seyler 372 (4), 297-300 (1991)
   PUBMED   1647783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF730051.1, BC046956.1 and AK153302.1.
            
            On Jan 19, 2017 this sequence version replaced NM_010749.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153302.1, AK151607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               CF730051.1         1-290
            291-2512            BC046956.1         1-2222
            2513-2515           AK153302.1         2304-2306
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.52 cM"
     gene            1..2515
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /note="mannose-6-phosphate receptor, cation dependent"
                     /db_xref="GeneID:17113"
                     /db_xref="MGI:MGI:96904"
     exon            1..447
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     exon            448..627
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     exon            628..794
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     exon            795..904
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1035
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1162
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..2515
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /note="hexamer: ATTAAA"
     polyA_site      1625
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /note="major polyA site"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /note="hexamer: ATTAAA"
     polyA_site      2513
                     /gene="M6pr"
                     /gene_synonym="CD-MPR; Mpr46"
                     /note="major polyA site"
ORIGIN      
        1 acctggcgca tgaccccgcg tggatgagga gcgcccgccc agagtccctg gaggcggagc
       61 tcgaacctca ttggtagaaa ggcgacccga aaagaagaaa ctgatcttga caatctccga
      121 gtgattggag ttgatgggac cggggaacag cgaactaggc tgctgaccaa tcagcgtcca
      181 aaagagagac cagggaacca aggttctgcg gtcacacgcc gcggagtcta gtgggaggag
      241 cagttgctca gcaggctctc gctgcttcct gtttccggct tctggagcgg ggcgcattga
      301 ggcgcctagg gaagcgctgg cttcagagag gaatcgaggg actggggtct gcgcccccgc
      361 acccctgatc tccggacgcg tcttccaacc tcagagacac attcttgggg gcttctgagc
      421 cgcggttgct ctgttttccc gtgacacaat gttccccttc tctggctgct ggaggactga
      481 actgttattg ttgctactcc tggctgtggc tgtgagagaa tcctggcaga tagaagaaaa
      541 atcgtgtgac ctggtaggag agaaggataa ggagtcaaag aacgaggtgg ctctcctgga
      601 gaggttacgg ccactgttta acaaaagttt tgagagtact gtgggccagg gctcagacac
      661 atacagctac atattcagag tatgccggga agctagcaac cactcctctg gagcaggcct
      721 ggtccagatc aacaaaagca atgacaagga gacagtggtt gggagaatca acgagactca
      781 catcttcaat ggaagtaatt ggatcatgct gatatataaa gggggtgatg aatatgacaa
      841 ccactgtggc aaagagcagc gccgtgcagt ggtgatgatc tcctgcaatc ggcacacact
      901 agcggctaat tttaacccag tgtctgagga acgaggcaaa gtccaggatt gcttctacct
      961 ctttgagatg gatagcagcc tggcctgttc accagaggtc tcacacctca gtgtgggctc
     1021 gatcttactt gtcatatttg catcattggt tgctgtctat atcattgggg gtttcttata
     1081 ccagcgactg gtagtggggg ccaagggaat ggagcagttt cctcatctgg ccttctggca
     1141 ggatcttggc aacctagtag ctgatggttg tgactttgtg tgccgatcca aaccccgcaa
     1201 tgtgcctgca gcatatcgtg gagtgggaga tgaccagctg ggtgaagagt cggaagaaag
     1261 ggatgatcat ctgctaccaa tgtgattgca ctttaatgtc tagccacctc ttcagtcccc
     1321 aaaccaaagc atactcagcc agacttctca agccggtctc ccatctctca ccttgccctt
     1381 aatattcttg ctttccagtt ggcttttgat ttgaccctaa cctgcctctc tttgctcctt
     1441 cctattgttt ctcctctgca caagtagagt ggaaggcaga cagacatagg gcctgtgggg
     1501 cagactcctg caccccagga agagcaagga cagctaaata ggcagaaagc catgagccct
     1561 ggctgtaaac atttttataa gttgaaacac tggatactct aattaaaaag caaagattac
     1621 ttgtaccttt ggttgcctca agttgttctg cagtgcttac ctggctgtaa cccaaatact
     1681 cccatttgct ttgagcctgg aatcagtcac ctgattgtcc cttgtgtggg attaggacag
     1741 ggaaaaaaaa tgtgaaattc cccaactaca gaattctaag gtaccatcac gttgtgtata
     1801 ggtctttaag tggcttgata gtttgaattg gaccctgggc catggtttat aaatccatag
     1861 gtaacccaaa tgcctaatca agtagtcctt ttctaaagta aacagaccct gtgtgttgcc
     1921 ttgtggtagt tagtctcagt ggccagcctt ttcttcctca tctccctcta ctggtacttg
     1981 taaatctgag ttgcactttt ctcacagatc tgtagtttgg ctttttatac tttccccaat
     2041 cataaaggaa gggaatggaa gcggaagtgg acatggaggc tctgcaggtc tctgctttgg
     2101 gtggggacac tgctgcacct gtctctcctg ctggctcagg gaagtgtctg acccacttat
     2161 ctatgggaaa aggattttag ttctctcttt ctgtttaggc catctgccca gatgcaagct
     2221 gatctcgcta taatagtgaa cgcctaggcc actaagtaac aacacagtta atctgaacac
     2281 aggagatgtg ggaaaggcag ggccattcgt tactttagag aaaaatgaat gaagtcattc
     2341 ctacttctca atacccttgc aatggcagtg gaaattttgt ttctttctat acaagaaaaa
     2401 taatgttatt tttaaaaaag gcttctttgt tgtttgcatc ctaacccgtg ttttcaatga
     2461 aaaataatat accacttttg tacaaaaaca caataattaa aaaacaaaaa acacg
//
