LOCUS       NM_033079               2051 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus meiosis 1 associated protein (M1ap), mRNA.
ACCESSION   NM_033079
VERSION     NM_033079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Li,Y., Wu,Y., Khan,I., Zhou,J., Lu,Y., Ye,J., Liu,J., Xie,X.,
            Hu,C., Jiang,H., Fan,S., Zhang,H., Zhang,Y., Jiang,X., Xu,B., Ma,H.
            and Shi,Q.
  TITLE     M1AP interacts with the mammalian ZZS complex and promotes male
            meiotic recombination
  JOURNAL   EMBO Rep 24 (2), e55778 (2023)
   PUBMED   36440627
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Wyrwoll,M.J., Temel,S.G., Nagirnaja,L., Oud,M.S., Lopes,A.M., van
            der Heijden,G.W., Heald,J.S., Rotte,N., Wistuba,J., Woste,M.,
            Ledig,S., Krenz,H., Smits,R.M., Carvalho,F., Goncalves,J.,
            Fietz,D., Turkgenc,B., Ergoren,M.C., Cetinkaya,M., Basar,M.,
            Kahraman,S., McEleny,K., Xavier,M.J., Turner,H., Pilatz,A.,
            Ropke,A., Dugas,M., Kliesch,S., Neuhaus,N., Aston,K.I.,
            Conrad,D.F., Veltman,J.A., Friedrich,C. and Tuttelmann,F.
  CONSRTM   GEMINI Consortium
  TITLE     Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest
            and Severely Impaired Spermatogenesis Leading to Male Infertility
  JOURNAL   Am J Hum Genet 107 (2), 342-351 (2020)
   PUBMED   32673564
  REMARK    GeneRIF: Bi-allelic Mutations in M1AP Are a Frequent Cause of
            Meiotic Arrest and Severely Impaired Spermatogenesis Leading to
            Male Infertility.
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Arango,N.A., Li,L., Dabir,D., Nicolau,F., Pieretti-Vanmarcke,R.,
            Koehler,C., McCarrey,J.R., Lu,N. and Donahoe,P.K.
  TITLE     Meiosis I arrest abnormalities lead to severe oligozoospermia in
            meiosis 1 arresting protein (M1ap)-deficient mice
  JOURNAL   Biol Reprod 88 (3), 76 (2013)
   PUBMED   23269666
  REMARK    GeneRIF: Deficiency in M1ap results in a wide range of tubular
            defects, which led to severe oligozoospermia and infertility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Chen,H., Palmer,J.S., Thiagarajan,R.D., Dinger,M.E., Lesieur,E.,
            Chiu,H., Schulz,A., Spiller,C., Grimmond,S.M., Little,M.H.,
            Koopman,P. and Wilhelm,D.
  TITLE     Identification of novel markers of mouse fetal ovary development
  JOURNAL   PLoS One 7 (7), e41683 (2012)
   PUBMED   22844512
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Bird,A.D., Flecknoe,S.J., Tan,K.H., Olsson,P.F., Antony,N.,
            Mantamadiotis,T., Mollard,R., Hooper,S.B. and Cole,T.J.
  TITLE     cAMP response element binding protein is required for
            differentiation of respiratory epithelium during murine development
  JOURNAL   PLoS One 6 (3), e17843 (2011)
   PUBMED   21408140
  REMARK    Erratum:[PLoS One. 2012;7(1).
            doi:10.1371/annotation/ec04ad74-63cc-4fbe-9ad8-074a1d62fdf4.
            Mollard, Richard [added]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Arango,N.A., Huang,T.T., Fujino,A., Pieretti-Vanmarcke,R. and
            Donahoe,P.K.
  TITLE     Expression analysis and evolutionary conservation of the mouse germ
            cell-specific D6Mm5e gene
  JOURNAL   Dev Dyn 235 (9), 2613-2619 (2006)
   PUBMED   16881047
  REMARK    GeneRIF: D6Mm5e is expressed in the germ cells of the female embryo
            upon their initial entry into meiosis, and in male germ cells
            during the last stages of spermatogenesis.
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Jang,W., Hua,A., Spilson,S.V., Miller,W., Roe,B.A. and Meisler,M.H.
  TITLE     Comparative sequence of human and mouse BAC clones from the mnd2
            region of chromosome 2p13
  JOURNAL   Genome Res 9 (1), 53-61 (1999)
   PUBMED   9927484
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Weber,J.S., Jang,W., Simin,K., Lu,W., Yu,J. and Meisler,M.H.
  TITLE     High-resolution genetic, physical, and transcript map of the mnd2
            region of mouse chromosome 6
  JOURNAL   Genomics 54 (1), 107-115 (1998)
   PUBMED   9806835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131954.1 and BQ553015.1.
            
            On May 14, 2008 this sequence version replaced NM_033079.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1925              AK131954.1         1-1925
            1926-2051           BQ553015.1         1-126               c
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..2051
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /note="meiosis 1 associated protein"
                     /db_xref="GeneID:110958"
                     /db_xref="MGI:MGI:1315200"
     exon            1..31
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            32..329
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1679
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /note="meiosis 1-arresting protein;
                     spermatogenesis-associated protein 37"
                     /codon_start=1
                     /product="meiosis 1 arrest protein"
                     /protein_id="NP_149070.2"
                     /db_xref="CCDS:CCDS39525.1"
                     /db_xref="GeneID:110958"
                     /db_xref="MGI:MGI:1315200"
                     /translation="MNRRKTTSRGTSAAMKISHQPPRLLIVNIAVPSWVDICPNLCEA
                     LQNFFSIACSLMGPSRMSLFSLYTVQNQHECVLPFVQVRGNFIRLQACISELRMLQVE
                     GCHRPPHALLPLAIEDGLQQFKQYSSHMASSAAQPWTSLEITVLTSRPGKEVVKELEE
                     GLKDINLLSVRRLQVAEVTKGIQERSDSPSPTEEPSNDESSILEADIVLETLDNDVVS
                     MEVFFKAWLHNSETDQENIHLLLTPQSLPPPSRAKDHPICLKCDLQERFLSPSLLPGT
                     ADGVSRIDDPKGDISTLYQMASLASASPYKLQVVKALKSSGICESLTYGLPFILRPTS
                     CWQLDWDELETNQQHFHALCHCLLKRDWLLLARGEPLIHKHNQSLPACSFYVITPSHS
                     LTLLVKLVATRELMLPGFFPLLSEDPPEDSLKIIESTLDSLDLGLTYNPLHVGSHLYS
                     HLSSAHAKPQGRLYTSCASRGLRKGGQLQTNRVRAAVVPLPVAPAPRRALKMTAASKA
                     SSAAFLPSDSEEGEEERPSHT"
     exon            330..515
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            516..684
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            685..858
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1021
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1163
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1370
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1511
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..2051
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /note="hexamer: ATTAAA"
     polyA_site      1924
                     /gene="M1ap"
                     /gene_synonym="D6Mm5e"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggaagg cgtgcaggtg ctgagcttga ggctcataaa acattggtta ttcaagtggt
       61 ggccacagtt ccacactgct ttggctgcca tgaaccgaag gaaaactact agtagaggga
      121 cctccgctgc catgaaaatt agtcatcaac ctccgaggct tctcattgtg aatattgccg
      181 taccttcctg ggttgacatc tgccccaacc tctgtgaggc cttgcagaac ttcttctcga
      241 tagcctgcag tttgatgggc cccagccgga tgtctctgtt cagcttatac acagtacaga
      301 accagcatga gtgtgtcctc ccatttgtgc aagtgagagg gaacttcatt aggctgcagg
      361 cctgcatctc ggagcttcga atgttacagg tagaaggttg tcacagacca cctcacgcct
      421 tactacccct ggcaatagaa gatgggctcc agcagttcaa acagtacagc agtcacatgg
      481 cctcaagtgc tgctcagccc tggacttccc tggagattac tgtcctgact tctcggcctg
      541 gaaaagaagt ggtcaaagaa ctggaggaag ggttgaaaga tataaaccta cttagtgtca
      601 gaagactgca ggtggctgag gtcacaaaag gcatccagga gcgttcagac tcaccatctc
      661 ctactgaaga acccagcaat gatgagagtt ctatcctgga agctgacatt gtccttgaga
      721 cgctagacaa cgatgttgtc agcatggagg tcttcttcaa agcctggctg cataacagtg
      781 aaactgacca agaaaacatc caccttcttc ttactccaca gagtcttcct cctccttcca
      841 gagccaagga tcatccaata tgtctaaaat gtgatctcca agagcgattt ctcagcccat
      901 ccctgcttcc tggtacagct gatggcgtgt cgagaataga tgaccccaaa ggagacatca
      961 gcacactcta ccagatggca tccctggctt cagcctctcc gtataagctt caagtggtca
     1021 aggctctgaa atctagtggg atctgcgagt ccctgaccta tggactaccc ttcattctca
     1081 gacccacaag ctgttggcag ctggactggg atgagctgga aacaaatcaa caacattttc
     1141 atgccctgtg tcactgcttg ctgaagagag actggctgct gttggccaga ggggaacccc
     1201 tgatccacaa acacaaccag agtctccctg cctgcagctt ctatgtgatc acaccttctc
     1261 actctctcac actgctggtg aagctggtgg ccaccaggga gttgatgctg cctggcttct
     1321 tccccctgct ctctgaggac ccacctgaag acagcctaaa gatcatagag agcaccctag
     1381 acagcctgga cctggggctc acctacaacc ctctgcatgt tgggagccac ttgtactcac
     1441 atctgagcag cgcccatgcc aagcctcagg gacggctcta cacaagctgc gcaagccggg
     1501 gccttagaaa ggggggtcag ctgcagacca acagagttcg agccgcagtg gttcccctcc
     1561 cagtggctcc tgccccacgt agagctctga agatgacagc agccagcaaa gcatcctcag
     1621 cagccttcct gccttcggat tcggaggagg gagaggagga gcgtccttct cacacctaag
     1681 tccccggtgc cagcacacag ccatgcactc acccgatggc tgtctggggg cagatctgcc
     1741 tgctcccaac ctgtgcctgt aaatgagctc cggctaagaa acagctcttc ctcttctgac
     1801 gctgcccaat ggggaaggga gaccctgaaa gcaacacccc caggcctgtc ttttgagcag
     1861 cagggactct ctcttggatc atttgatagt gtttacacac ataattaaat gcccagtaag
     1921 cctccttcat tgttcagagc attcctgggc cagaatttct tcctgcagct ctgtgtaaga
     1981 aggtgggtga ggtcaagtca cccttgggaa actacaactc aagaataaag aggaggtttt
     2041 cacaaaacaa g
//
