LOCUS       NM_001130526            2773 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine zipper, putative tumor suppressor 2 (Lzts2),
            transcript variant 3, mRNA.
ACCESSION   NM_001130526
VERSION     NM_001130526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Yu,E.J., Hooker,E., Johnson,D.T., Kwak,M.K., Zou,K., Luong,R.,
            He,Y. and Sun,Z.
  TITLE     LZTS2 and PTEN collaboratively regulate ss-catenin in prostatic
            tumorigenesis
  JOURNAL   PLoS One 12 (3), e0174357 (2017)
   PUBMED   28323888
  REMARK    GeneRIF: The data demonstrate the significance of simultaneous Pten
            and Lzts2 deletion in oncogenic transformation in prostate cells
            and implicates a new mechanism for the dysregulation of
            Wnt/beta-catenin signaling in prostate tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Johnson,D.T., Luong,R., Lee,S.H., Peng,Y., Shaltouki,A., Lee,J.T.,
            Lin,D., Wang,Y. and Sun,Z.
  TITLE     Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases
            susceptibility to tumor development
  JOURNAL   J Biol Chem 288 (6), 3727-3738 (2013)
   PUBMED   23275340
  REMARK    GeneRIF: deletion of Lzts2 increases susceptibility to spontaneous
            and carcinogen-induced tumor development.
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Peng,Y., Clark,C., Luong,R., Tu,W.H., Lee,J., Johnson,D.T., Das,A.,
            Carroll,T.J. and Sun,Z.
  TITLE     The leucine zipper putative tumor suppressor 2 protein LZTS2
            regulates kidney development
  JOURNAL   J Biol Chem 286 (46), 40331-40342 (2011)
   PUBMED   21949185
  REMARK    GeneRIF: a critical role of LZTS2 in renal development and
            implicate LZTS2 as a critical regulator of beta-catenin-mediated
            nephrogenesis.
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY726859.1, CK021048.1, AK129446.1 and AA208269.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081367.1, AK129446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               BY726859.1         19-404
            387-557             CK021048.1         396-566
            558-2614            AK129446.1         475-2531
            2615-2773           AA208269.1         10-168
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.2 cM"
     gene            1..2773
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /note="leucine zipper, putative tumor suppressor 2"
                     /db_xref="GeneID:226154"
                     /db_xref="MGI:MGI:2385095"
     exon            1..96
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /inference="alignment:Splign:2.1.0"
     exon            97..546
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2154
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /note="putative tumor suppressor LAPSER1; protein LAPSER1"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 2"
                     /protein_id="NP_001123998.1"
                     /db_xref="CCDS:CCDS29855.1"
                     /db_xref="GeneID:226154"
                     /db_xref="MGI:MGI:2385095"
                     /translation="MAIVHTLPVPLEPARETATAPKTPAMGSVSSLISGRPCPGGPAP
                     QRHHGVPGPTFFRQQDGLLPGGYEAQEPLCPAVPPRKAVPGNSFTYVNEDFRTESPPS
                     PSSDVEDPREHQAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPS
                     LPGFLGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLALSGWASGCPSGTLS
                     DSGRNSLSSLPTYSTGGAEPTTNSPGGHLPSHGPGRGALPGPARGVPTGPSHSDSGRS
                     SSSKSTGSLGGRVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEALLHCVLEGKL
                     RDREAELQQLRDSMDESEATVCQAFGARQRRWPRERGEDCAAQAQQATQRVQRAQQLL
                     QLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQRELGPRLEETKWEVCQKSG
                     EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAREQEL
                     EACSQELQRYRQEAERLREKAGHLDAEASGLRDPPVPPATTDPFLLAESDEAKVQRAA
                     AGAGGSLRAQVERLRQELQREQRRGDEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYI
                     QMYRRNRQLEQELQQLSLELEARELADLGLAESAPCICLEEITATEI"
     exon            547..1209
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1470
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..2773
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /note="hexamer: AAGAAA"
     polyA_site      2773
                     /gene="Lzts2"
                     /gene_synonym="LAPSER1; mKIAA1813"
                     /note="major polyA site"
ORIGIN      
        1 gggcagctcc gagtggccgc gcgcgggctg gagcgggcgg cgcgcctgtg gagtgctggg
       61 gcggcccggg gctgagcatg gagcagcgcg gcggaggttg ccccggaggc ccctggccag
      121 acctgagcct ctgccaccat ggccattgtg cacactctgc cagtgcctct ggagcccgca
      181 cgtgagacag ccactgcccc caaaactcca gcaatgggca gcgtgagcag tcttatctca
      241 ggccggccct gccccggggg acctgctcct caacgacatc atggtgtccc tgggcccacc
      301 ttcttccgcc agcaggatgg gctgctaccg ggtggctacg aggcacagga accgctctgc
      361 ccggctgtgc caccgaggaa ggctgtccca ggcaatagct ttacctatgt caatgaggac
      421 ttccggacag agtctcctcc cagccccagc agtgatgttg aagatccccg ggaacatcag
      481 gcacacaatg cccacctccg tgggccccca ccaaagctca tccctgtctc tggaaagctg
      541 gagaagaata tggagaagat cctgatccgg ccaacagcct tcaagccagt gctacccaaa
      601 cctcgggggg cgccatccct acccggcttc cttggtcctc gagctgctgg gctatctggg
      661 agccagggca gcctgacaca gctgtttggg gggccagcct cttcctcctc ctcttcctct
      721 tcctcctctg ctgctgacaa acccttggca ctgagtggtt gggccagtgg ctgcccttca
      781 ggaacgctgt cagactctgg ccgaaattct ttatccagct tgcccaccta cagcactgga
      841 ggtgccgagc caaccaccaa ctccccaggt gggcacctgc cctcccacgg ccctggccga
      901 ggggcactgc ctggtccagc ccgaggggtc cctactgggc cctcccattc agacagtggc
      961 cggtcctcct ccagcaaaag cacgggctcc ttggggggtc gtgtagctgg ggggctcttg
     1021 ggcagtggtg cccgggcctc ccctggcagc agttctggtg gagaccgctc tccaccccct
     1081 ccaccacctc cacccccttc ggatgaggcc ttgctacact gtgtcctgga agggaagctc
     1141 agagaccgcg aggcagagct gcagcagctg cgggacagta tggatgagag tgaggccaca
     1201 gtgtgtcagg cattcggggc acggcagcgg cgctggccac gggagcgagg ggaggactgt
     1261 gcagcccagg cgcagcaggc cacgcagcgc gtccagcggg cccaacagct gctgcagctg
     1321 caggtgttcc agctgcagca agagaagcgc cagttgcagg atgactttgc ccagctgcta
     1381 caggagcggg aacagctgga gcgccgctgt gccacttttg aacgggagca gcgggaactc
     1441 gggccacggc tggaggagac caaatgggag gtgtgtcaga aatcaggtga gatctccctg
     1501 ctgaagcagc aactgaagga atctcaggca gagctggtcc agaagggcag tgagctggtg
     1561 gcgctgcggg tggccctccg tgaggcccgg gccaccttgc gggtcagtga gggccgtgcc
     1621 aggggcctgc aggaggcagc ccgagctcgg gagcaggagc tggaggcctg ctcgcaggag
     1681 cttcagcggt accgccagga ggctgagcgg ctccgggaga aggccgggca tttggatgcc
     1741 gaagcatcgg gactccggga tccccctgta ccccctgcca ccaccgaccc gttcctcctg
     1801 gcagagagtg atgaggccaa ggtgcagcgg gcagcggctg gggcaggggg tagcctgcgg
     1861 gctcaggtgg aacggctgcg ccaagaactg cagcgggagc agcggcgagg ggacgagcaa
     1921 cgggacagct ttgaggggga gcggctggcc tggcaggcag agaaggaaca ggtgatccgc
     1981 taccagaagc agctgcagca caactatatc cagatgtacc ggcgtaaccg gcagctggag
     2041 caggaactgc agcaactgag cctggagctg gaggcccgcg agcttgcgga tttgggcctg
     2101 gcggagtcgg ccccttgcat ctgtctggag gagatcactg ccactgagat ctagggctct
     2161 gcaaggggtc tgagccacag aggcccacct gcccggggat ccactgagca cgcgctccag
     2221 gtctcagagc caaagggcct cggccgagca ttcgggtggc tccgtaactt ggagaagcag
     2281 cagaatcaac cctctgtgtc accgtcaccc agaggctcct gcctactctg ccatttcact
     2341 ccctcactgt cgccactgcc agcccactcc agctgggaag ggaaagaggc tgcttccctg
     2401 tctccgcatc tacctgcctg aagccagaga gagcccgagg gcaaccagct gctccagatg
     2461 tgcctgccct caacatgtcc acgtggaggg gcagggccgg gcatggggct gatccccatg
     2521 ttgagctctg caagcctctt ctgggctgag ggggctgaag tcagaccaaa ggaagaaccc
     2581 agcaatgtct tgtttatttg tgtttgtgac caagccgtcc tccctagttc cagggttacg
     2641 gcctcatttc cacttgtata tttttcacac tgtaaatttc ttgtacaaac ccaaagggga
     2701 aaaaaattta aaaaaaaaaa aaagttttgt tttaaaaaaa aaaagtgcaa tggataaaga
     2761 aactgcaggg gaa
//
