LOCUS       NM_001370971            5002 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus leucine zipper, putative tumor suppressor 1 (Lzts1),
            transcript variant 2, mRNA.
ACCESSION   NM_001370971 XM_006509606
VERSION     NM_001370971.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5002)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 5002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5002)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5002)
  AUTHORS   Mu,T., Xu,L., Zhong,Y., Liu,X., Zhao,Z., Huang,C., Lan,X.,
            Lufei,C., Zhou,Y., Su,Y., Xu,L., Jiang,M., Zhou,H., Lin,X., Wu,L.,
            Peng,S., Liu,S., Brix,S., Dean,M., Dunn,N.R., Zaret,K.S., Fu,X.Y.
            and Hou,Y.
  TITLE     Embryonic liver developmental trajectory revealed by single-cell
            RNA sequencing in the Foxa2eGFP mouse
  JOURNAL   Commun Biol 3 (1), 642 (2020)
   PUBMED   33144666
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5002)
  AUTHORS   Mayanagi,T. and Sobue,K.
  TITLE     Social Stress-Induced Postsynaptic Hyporesponsiveness in
            Glutamatergic Synapses Is Mediated by PSD-Zip70-Rap2 Pathway and
            Relates to Anxiety-Like Behaviors
  JOURNAL   Front Cell Neurosci 13, 564 (2020)
   PUBMED   31969804
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5002)
  AUTHORS   Peng,Y., Clark,C., Luong,R., Tu,W.H., Lee,J., Johnson,D.T., Das,A.,
            Carroll,T.J. and Sun,Z.
  TITLE     The leucine zipper putative tumor suppressor 2 protein LZTS2
            regulates kidney development
  JOURNAL   J Biol Chem 286 (46), 40331-40342 (2011)
   PUBMED   21949185
REFERENCE   7  (bases 1 to 5002)
  AUTHORS   Baffa,R., Fassan,M., Sevignani,C., Vecchione,A., Ishii,H.,
            Giarnieri,E., Iozzo,R.V., Gomella,L.G. and Croce,C.M.
  TITLE     Fez1/Lzts1-deficient mice are more susceptible to
            N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis
  JOURNAL   Carcinogenesis 29 (4), 846-848 (2008)
   PUBMED   18192690
  REMARK    GeneRIF: Loss of one or both LZTS1 alleles hampers the normal
            defenses of urothelial cells against carcinogens, favoring bladder
            cancer development, which may make FEZ1 a target for gene therapy.
REFERENCE   8  (bases 1 to 5002)
  AUTHORS   Tsichlis,P.N., Hatziapostolou,M. and Hinds,P.W.
  TITLE     Timing is everything: regulation of Cdk1 and aneuploidy
  JOURNAL   Dev Cell 12 (4), 477-479 (2007)
   PUBMED   17419986
  REMARK    GeneRIF: Partial or complete loss of Lzts1 downregulates Cdc25C and
            inhibits Cdk1 activity during mitosis, leading to premature
            transition from metaphase to anaphase.
REFERENCE   9  (bases 1 to 5002)
  AUTHORS   Vecchione,A., Baldassarre,G., Ishii,H., Nicoloso,M.S., Belletti,B.,
            Petrocca,F., Zanesi,N., Fong,L.Y., Battista,S., Guarnieri,D.,
            Baffa,R., Alder,H., Farber,J.L., Donovan,P.J. and Croce,C.M.
  TITLE     Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis
            and predisposes mice to cancer development
  JOURNAL   Cancer Cell 11 (3), 275-289 (2007)
   PUBMED   17349584
  REMARK    GeneRIF: Lzts1 deficiency was associated with an increased
            incidence of both spontaneous and carcinogen-induced cancers in
            mice.
REFERENCE   10 (bases 1 to 5002)
  AUTHORS   Ishii,H., Baffa,R., Numata,S.I., Murakumo,Y., Rattan,S., Inoue,H.,
            Mori,M., Fidanza,V., Alder,H. and Croce,C.M.
  TITLE     The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein,
            and its expression is altered in multiple human tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3928-3933 (1999)
   PUBMED   10097140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114995.7.
            
            On Jun 18, 2019 this sequence version replaced XM_006509606.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.72176.1,
                                           SRR9219382.175836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC114995.7         34359-34583
            226-703             AC114995.7         77471-77948
            704-1501            AC114995.7         79408-80205
            1502-5002           AC114995.7         82398-85898
FEATURES             Location/Qualifiers
     source          1..5002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..5002
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /note="leucine zipper, putative tumor suppressor 1"
                     /db_xref="GeneID:211134"
                     /db_xref="MGI:MGI:2684762"
     exon            1..225
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /inference="alignment:Splign:2.1.0"
     exon            226..703
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1501
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..5002
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4968..4973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /note="hexamer: AATAAA"
     polyA_site      5002
                     /gene="Lzts1"
                     /gene_synonym="F37; FEZ1; PSD-Zip70"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcccg gacgagctgg cgggctctgg gaggctccga caagctcaca gtccgaaagt
       61 ttctctgtct ttctgctgct cctgggagtg tgacttgagc gacgcgggat ccgccggctc
      121 taggagccct ccagaaaaag agaaaggggc actgcacaaa atacaccgaa aaatcaaaat
      181 ctgcagccat ttgcagctat ccccaaggcg gaggaggaca gacaggtcca tggctttccc
      241 aggctctaag aagcttttgc tctgaccaca gtcccctggc tgagccagga ctacattttg
      301 ctgctccagt ctctccaagc ccctcttgta ccctgaaggc ccttggttcc gtgtcaccat
      361 gggcagtgtg agcagcctta tctcaggcca cagtttccac agcaagcact gccgtgcttc
      421 acagtacaag ctgcgcaagt cctcccacct caagaagctc aatcgatact cagatgggct
      481 gctgaggttt ggcttctccc aggactcagg ccgtggaaag tcaagttcca aaatgggaaa
      541 aagcgaagac ttcttctaca tcaaagtcag ccagaaggcc cgaggctccc atcgcccaga
      601 ctacacagcc ctgtccagtg gggacatagg gggtcagacc ggagtagatt ttgatccagc
      661 caccccacca aagctcatgc ccttctccaa tcaactggaa atgagttcag acaagggggc
      721 agtaaggccc actgccttca agcctgtgct gccacggtca ggagccatcc tccactcttc
      781 acctgagagt accagccacc aacttcatcc catgcctcca gataagccca aggagcagga
      841 gctgaagcca ggcctgtgct ccggggcact gtctgactca ggccggaact ccatgtctag
      901 cctgcccacg catagcacca ccagcagcta ccagctggat cctctggtca cccccgtggg
      961 gcctaccagc cgttttgggg gttcagctca caacatcaca caaggcatca tccttcagga
     1021 cagtaatatg atgagcctga aggctctgtc gttctctgat ggcggcagca agctggctca
     1081 cccaggcaag gcagataagg gcgcctcctg tgtgcgttcc ccactctcca cggatgagtg
     1141 caccatccag gagctggagc agaagctgct gcagagggag actgcactac agaagctaca
     1201 gcgcagtttc gatgagaagg agtttgcctc tggccaaacc tttgaggagc ggccacggcg
     1261 gactagagac gaactggagt gcctggagcc taagagcaag ctgaagccac cctcacagaa
     1321 gagccagcgc acacagcagg tgctccagct gcaggtgttg cagttgcagc aggagaaacg
     1381 gcagctaagg caggagctag agagcctaat gaaggagcag gacctgctgg agaccaagct
     1441 gaggtcctac gagcgggaga aaaccaactt cgcccctgca ctggaggaga cccaatggga
     1501 ggtgtgccag aagtcaggtg agatctctct tttgaagcaa cagctcaaag agtcccaatt
     1561 agaggtgaac actaaggcca gcgagatcct cagtctgaag gcacagctga aggatacccg
     1621 gggcaagctg gatggaatgg agctgaagac acaggacttg gagagtgccc tgcgcaccaa
     1681 agggctggag ctggaggtct gtgagaacga actgcagcgc aagaagaatg aggcagaact
     1741 gctgagagag aaggtgaacc ttctagaaca ggagttgatg gagctacggg cccaggctgc
     1801 tctgcatccg gcacccctgg ggcctccagg ggttgggctc actttctcag aggacatccc
     1861 tgctctgcag cgggagctgg atcggctgcg ggccgagctg aaggaggaga ggcaaggcca
     1921 tgaccagatg tcctcgggat tccagcatga gcggttggtg tggaaagaag agaaggagaa
     1981 agtgatccag taccaaaggc agctgcagca gagctacttg gccatgtacc agcgcaacca
     2041 gcgtctagag aaggccctgc agcagctggc ccgtggggat ggtccagggg aaccctttga
     2101 aattgacctg gagggagctg acatccccta cgaggacatc atagccactg agatctgagg
     2161 ggctgcctag gggtggaggg ctggggactg gacccagaaa gcagggaggg ctgagcctgt
     2221 tcaaagagac attttgagcc cctctgagag aagccacctc tggggccaga tggtgattag
     2281 gggtcaccac atagcctttc tcccctcctg cctttttcag cctaactaac cctgctgctt
     2341 ataacacctt gatctgctaa ccccaagctc tcctagagat gtgctcaggg agctggttga
     2401 ggtttctctc aactttggtc tcattcaaag tagtgagaaa aacactccat caggaaaggg
     2461 agcaactgcc atacaggcca actggccacc taaggacaga aacattttcc ctgtcacccc
     2521 tgagccccta cgatcccctg gtcatattgg ggtgcctttg ggaatagaaa gaagccatgt
     2581 gtaaccagaa gccttggacc ctgccttcac tacagcctgt tcttctgtct gtggaggtgg
     2641 aggagttgtg tcgccacata gttgagccag caagtcatgg gagcaagggg tagatggaca
     2701 gtccggcact acagaaccgt cataggtctc aagaggtctg ggtgggaggt gaagggagag
     2761 aaccaaagca gatagggaat cgagtctaaa atgagctgcg tagccccttt gacctcagtg
     2821 accactgttt ttaaagccat aggcattggg gtcctgggtg gggtacaggg aaatgacata
     2881 agacatagat tcccagctgt gccaggatat cctcctcagt agccaatgtg gagtggtttt
     2941 tttttttttt tttttttttt tttctgaaca ccaggttctt gcttggatcc agaatagccc
     3001 atccacttag atagtgtata tgggatctgg gcattagcct cccttgtctg tggcccaagt
     3061 cagcagtagc tcttcccctt atagaatctt cagagtccat agattgggaa gggtcactag
     3121 tgtgccaata ggctgcagtc caggtaggag agatatgcgg tgcatacaaa gagccttata
     3181 aatatcccaa gccacccact ctcctccctc catgtggcgg caccccatgt tgtaagaatt
     3241 tagtctagaa agcagcatgt gagcctgtgg gcgcctggcc ttgtcttttg aagatatcca
     3301 gatctagggg cagagggaag tgcagttgct tagttgaagg aattatcttc tctcaccttc
     3361 ccccttccat tctgtgtttt ccaaagcaag ccagatcaag caggcagcca agctgctcca
     3421 tattctattt ttggccctta ccacagctgt tgttggtagg gcacccagcc cttgctggat
     3481 tcctaagcca tgtgcttgcc tggtgggtgg ggcccaggat ataagagatg taagggaggg
     3541 tctacatgct tggtagtcca ggaaccaatc agtgttctac ctccctaatg ctggtcctta
     3601 agagtccctg ggtggatccc agccctagtg accttgtctt cccatgggct tttttccctt
     3661 cctagtgtct gcaggctagg tgcctcctcc ataggtggtc ctgctttctg ttcctggggt
     3721 tagggtggcc ctctcctgct actgactttc aatggcacac aatctctggt ctaccattgc
     3781 tcatagtcac atgctcattt aaacctggaa tctgcaggcc aaagatgact cccccaacat
     3841 gcagggccat acccttcact gggcacaggt cacagcccag tttaaaagcc caggcctcag
     3901 ttctttgttg tgtaccagtc tgtgccttgt ttgagtcctt cctattgaga ctgtccaaca
     3961 gaaggaaaga aaggtggggg ttagctgctt ctccctagat tgaaggactc cttcccctga
     4021 aagaacagcc agaagtccac ttctgtgcca tggagtcctt gcccaggaag aagcaggcct
     4081 gtgctctgta tctgcacagg gtgccttcta ctcaccgggg gttctgctca catcactgcc
     4141 cagtagccct gccctgatca tctttgagac ctctgcctgg gaattgttta acctttaaga
     4201 cggcagatac cttcccaagt ctgctatcag tctgagatcc caaggtagct ccaggatgca
     4261 actgtgctat aacctaacat ccttgcctgc cttcctgtgt gctttctttc cttttctgtc
     4321 ctaaagcatc ctcacagttt gtggtccatg cccatgatgg atggctagat ggaacagtga
     4381 ctcaggtgtg cgggttcagg gcagacgagt agcctgtctt gctttgtctc tcggacccat
     4441 actgcatccc agaggtgtct ggttccagag tgttgctgct ctctgaagga agaaagggcc
     4501 ttgtagtgtc cagactccca cagggcacct ccctgcttga ttttgtcctc tctaggtaca
     4561 cttgagcttt agcatgatga catttcaggg gtcttggcat cacttctctg agtgacactt
     4621 gctgatctgc tcgtccctgg ctccagcttg ggctgtgtct caggtaagag agatgtccac
     4681 gggaaagcca ggctggacca gagatttccc taggacctga gatctcctca gatgccacct
     4741 aaggccacag tgcccctcag tggagactgc tttctttccc ttttgagcac tggagccctc
     4801 agcaggctgc ttcggatgga ctggcgtttg gaagactacg tacacagttc tttttctctt
     4861 ccttgtttct ggtttgcttt gctcttgatg gcttcatttt gttttatttt tgaagttctt
     4921 tgtcggctct gtaaactatt tctgctaatt ttatgttttt atttatgaat aaagaatgcc
     4981 atttctcatg tcttcacggt ca
//
