LOCUS       NM_025808               3415 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus leucine-zipper-like transcriptional regulator, 1
            (Lztr1), transcript variant 1, mRNA.
ACCESSION   NM_025808
VERSION     NM_025808.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3415)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   2  (bases 1 to 3415)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3415)
  AUTHORS   Ko,A., Hasanain,M., Oh,Y.T., D'Angelo,F., Sommer,D., Frangaj,B.,
            Tran,S., Bielle,F., Pollo,B., Paterra,R., Mokhtari,K., Soni,R.K.,
            Peyre,M., Eoli,M., Papi,L., Kalamarides,M., Sanson,M., Iavarone,A.
            and Lasorella,A.
  TITLE     LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR
            and AXL
  JOURNAL   Cancer Discov 13 (3), 702-723 (2023)
   PUBMED   36445254
REFERENCE   4  (bases 1 to 3415)
  AUTHORS   Chen,S., Vedula,R.S., Cuevas-Navarro,A., Lu,B., Hogg,S.J., Wang,E.,
            Benbarche,S., Knorr,K., Kim,W.J., Stanley,R.F., Cho,H.,
            Erickson,C., Singer,M., Cui,D., Tittley,S., Durham,B.H.,
            Pavletich,T.S., Fiala,E., Walsh,M.F., Inoue,D., Monette,S.,
            Taylor,J., Rosen,N., McCormick,F., Lindsley,R.C., Castel,P. and
            Abdel-Wahab,O.
  TITLE     Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal
            Hematopoietic Transformation
  JOURNAL   Cancer Discov 12 (10), 2434-2453 (2022)
   PUBMED   35904492
REFERENCE   5  (bases 1 to 3415)
  AUTHORS   Cuevas-Navarro,A., Rodriguez-Munoz,L., Grego-Bessa,J., Cheng,A.,
            Rauen,K.A., Urisman,A., McCormick,F., Jimenez,G. and Castel,P.
  TITLE     Cross-species analysis of LZTR1 loss-of-function mutants
            demonstrates dependency to RIT1 orthologs
  JOURNAL   Elife 11, e76495 (2022)
   PUBMED   35467524
  REMARK    GeneRIF: Cross-species analysis of LZTR1 loss-of-function mutants
            demonstrates dependency to RIT1 orthologs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3415)
  AUTHORS   Castel,P., Cheng,A., Cuevas-Navarro,A., Everman,D.B.,
            Papageorge,A.G., Simanshu,D.K., Tankka,A., Galeas,J., Urisman,A.
            and McCormick,F.
  TITLE     RIT1 oncoproteins escape LZTR1-mediated proteolysis
  JOURNAL   Science 363 (6432), 1226-1230 (2019)
   PUBMED   30872527
REFERENCE   7  (bases 1 to 3415)
  AUTHORS   Steklov,M., Pandolfi,S., Baietti,M.F., Batiuk,A., Carai,P.,
            Najm,P., Zhang,M., Jang,H., Renzi,F., Cai,Y., Abbasi Asbagh,L.,
            Pastor,T., De Troyer,M., Simicek,M., Radaelli,E., Brems,H.,
            Legius,E., Tavernier,J., Gevaert,K., Impens,F., Messiaen,L.,
            Nussinov,R., Heymans,S., Eyckerman,S. and Sablina,A.A.
  TITLE     Mutations in LZTR1 drive human disease by dysregulating RAS
            ubiquitination
  JOURNAL   Science 362 (6419), 1177-1182 (2018)
   PUBMED   30442762
REFERENCE   8  (bases 1 to 3415)
  AUTHORS   Racedo,S.E., McDonald-McGinn,D.M., Chung,J.H., Goldmuntz,E.,
            Zackai,E., Emanuel,B.S., Zhou,B., Funke,B. and Morrow,B.E.
  TITLE     Mouse and human CRKL is dosage sensitive for cardiac outflow tract
            formation
  JOURNAL   Am J Hum Genet 96 (2), 235-244 (2015)
   PUBMED   25658046
REFERENCE   9  (bases 1 to 3415)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3415)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113006.9, AK004561.2 and
            BF457766.1.
            
            On Sep 14, 2016 this sequence version replaced NM_025808.3.
            
            Summary: This gene encodes a member of the BR-C, ttk and bab-kelch
            superfamily that, in humans, localizes to the Golgi network and is
            associated with the ras / mitogen-activated protein kinase pathway.
            Loss-of-function mutations in the human ortholog are associated
            with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and
            DiGeorge syndrome. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004561.2, AK083411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AC113006.9         157394-157681
            289-3396            AK004561.2         1-3108
            3397-3415           BF457766.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.85 cM"
     gene            1..3415
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /note="leucine-zipper-like transcriptional regulator, 1"
                     /db_xref="GeneID:66863"
                     /db_xref="MGI:MGI:1914113"
     exon            1..536
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2859
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LZTR-1"
                     /codon_start=1
                     /product="leucine-zipper-like transcriptional regulator 1
                     isoform 1"
                     /protein_id="NP_080084.2"
                     /db_xref="CCDS:CCDS37272.1"
                     /db_xref="GeneID:66863"
                     /db_xref="MGI:MGI:1914113"
                     /translation="MAGSGGPIGSGALTGGVRSKVAPSVDFDHSCSDSVEYLTLNFGP
                     FETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSW
                     CRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWT
                     EWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQS
                     GEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPP
                     PPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEM
                     PERASSSEDASTLTSEERSSFKKSRDVFGLDFGTTSAKQPVHLASELPSGRLFHAAAV
                     ISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKE
                     ECVQGHVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKEAPGPAVGRARPPLLRV
                     AIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQY
                     IEASVDLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVE
                     IVRRKQQPPPRTPSDQPVDIGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAIL
                     AARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLF
                     AAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFT
                     KVSKLPTLRLLSQQLLLDIIDSLASHISDKQCAELGADI"
     exon            537..599
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..656
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            657..736
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            737..845
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            846..929
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..987
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1127
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1329
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1485
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1596
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1689
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1785
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1951
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2121
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2278
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2405
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2555
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2661
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2742
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..3399
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3399
                     /gene="Lztr1"
                     /gene_synonym="1200003E21Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaggcatgcc gggagcgtgt agctcgccgc tgccttgaga atgtcagtgg tttactatgg
       61 tctgagtgcg tatcctgaaa gaggaaaccc aaatcgagac ttggccagaa atactttcca
      121 gaatgtgatg tgctcgatat acgataatgc gaggagccgg gctgccaggt tcctcgatag
      181 cgagccgcgt cgcgggaagc gcgaggtttg tcgggaggcc cgacaaaccg gccggaagtg
      241 ctacaccagc ggcgcagggc tctctgggaa gtgtagtcct ttggctctgc ccgggcggtg
      301 gccgtgagtc ctgcaacctg gcggcctatc cagcctgaac aagggatggc tggctccgga
      361 ggccccattg ggtccggggc cttgacagga ggggtacgct ccaaggtggc tccgagcgtg
      421 gactttgacc acagctgctc agacagtgtc gagtacctga cgctcaactt tggacccttc
      481 gaaacagtgc atcgctggcg gcgcctcccg ccctgtgacg aattcgtggg cgcccggcgc
      541 agcaagcaca cagtcgtggc atataaggat gccatctatg tgtttggtgg agacaacgga
      601 aagacgatgc tcaatgatct tctgcgtttc gatgtgaagg attgctcctg gtgcagagcc
      661 ttcaccaccg gcacccctcc agccccccgt taccaccact ctgctgtggt ctatgggagc
      721 agcatgttcg tctttggggg ctatactgga gatatttatt ccaattctaa cttgaagaat
      781 aaaaatgacc tctttgaata caaatttgca actggccagt ggacggagtg gaagattgaa
      841 gggaggttgc ctgttgccag gtcagcccat ggggctacag tgtacagtga taagctctgg
      901 atctttgctg gttatgatgg caatgccagg ttgaacgaca tgtggacaat tggcctccaa
      961 gaccgagagc tcacatgctg ggaggaggtg gcccagagtg gtgagatccc cccatcctgt
     1021 tgcaacttcc ctgtggctgt gtgccgggat aagatgttcg tgttctcagg acagagtgga
     1081 gccaagataa ctaacaacct cttccagttt gaattcaaag acaagacgtg gacacgcatc
     1141 cctactgagc acctgcttcg gggctcccca cccccgccac agcggcgcta cggacacacc
     1201 atggtggcct ttgaccgcca tctctatgtg tttgggggtg cagcggacaa tacactgccc
     1261 aatgagttgc actgctatga tgtggacttc cagacctggg aggttgtcca gcccagctct
     1321 gacagtgagg ttggtggggc cgagatgcct gagcgagctt cctcttctga ggatgcatct
     1381 actctaacct ctgaagagcg gagcagcttt aagaagtcca gagatgtgtt tggcttagac
     1441 ttcggcacca cttcagccaa gcagcctgtc catctggcat cagagctgcc cagcgggagg
     1501 ctcttccatg ctgccgctgt catctctgat gccatgtaca tctttggggg cactgtagac
     1561 aacaacattc gcagtgggga aatgtacagg ttccagttct cttgctaccc taagtgcaca
     1621 ctgcacgaag attatgggcg cctatgggag ggccgccagt tctgtgatgt ggagtttgtg
     1681 cttggtgaga aggaagagtg tgtgcaaggc catgttgcca tcgtcactgc aaggagccgg
     1741 tggcttcgta ggaagatcgt acaggctcaa gagtggctgg cccagaagct agaggaagat
     1801 ggggccctag ctcccaagga ggcccctggc ccagctgtgg gcagggcacg gccacccctg
     1861 ttacgtgtgg ccatccgtga ggctgaggcc cggccatttg aggtgctcat gcagtttctc
     1921 tacacagaca agatcaagta cccacggaaa ggccatgtag aagacgtgct gctcatcatg
     1981 gatgtgtata agttggcgct gagcttccag ctgtgtcgcc ttgagcagct gtgtcggcag
     2041 tacatcgagg cctctgtaga tctgcagaat gttctggttg tgtgtgagag tgctgccagg
     2101 ctacagctgg gccagctcaa ggagcattgc ctgaacttca tagtgaagga atcccacttc
     2161 aatcaggtga tcatgatgaa ggagtttgag cgcctctcat ccccactgat tgtagagata
     2221 gttcgtcgga agcagcagcc gccccctcgc acaccctccg atcagcctgt ggacattggc
     2281 acatctctga tccaagacat gaaggcttac ctggagggag caggctcgga gttctgtgac
     2341 atcacactac tgctagatgg ccagccacgg ccagcccaca aagccatcct agctgcccgt
     2401 tctagctact ttgaggccat gtttcggtcg ttcatgccag aggacgggca ggtgaacatc
     2461 tccattgggg agatggttcc cagcagacag gccttcgagt ccatgctacg ctacatctac
     2521 tatggcgagg tcaacatgcc ccctgaggac tcgctctacc tgtttgcagc cccgtactat
     2581 tacggcttct acaataaccg actgcaggct tactgcaagc aaaacctaga gatgaatgtc
     2641 acagtgcaga atgtgctgca gattctggag gcggctgaca agacgcaggc actggacatg
     2701 aagcggcact gtttgcacat cattgtacac caattcacca aggtctctaa gctgcccacg
     2761 ctgcggttgc tgagccagca gctgctgctg gacatcatag actccttggc ctcccacatc
     2821 tctgacaagc agtgtgcaga gctgggtgct gacatctgag gatctctgtt tggagagtga
     2881 agacacccaa ccaattggcc acatctccac ctgcagagtg atcacacctg tggggtcaag
     2941 ggttctcagc ttctacaggg ggctgaggtg tacagggacc ccccaaagcc tgcacttcat
     3001 tgaggacaca ggccccacag ggaatagcaa ataaagcaaa ctcctttcta gctggcacct
     3061 ctctgtcagg agccattttg cttgcttctg tgaaagccta tcaggccgag tcaagtcagg
     3121 ccagggtctg ctggcagatt ttctagcctg ctgactcatg aaacggtaag aggggataca
     3181 cttgaagctc aaggtgaggg gctgaatgtt cggttaatct tggagtaagg gacaaggagg
     3241 cctccagata ggtacagata tccaatgtat gtcagccatt gtctctgctg gcttgtgact
     3301 ttgtttcccg agatactgta aagaatataa agcctatgag agttattatt aaactcagag
     3361 ctgcagcggc actaactgaa cagccctctc aatttctaaa aaaaaaaaaa aaaaa
//
