LOCUS       NM_017372               1057 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus lysozyme 2 (Lyz2), mRNA.
ACCESSION   NM_017372
VERSION     NM_017372.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1057)
  AUTHORS   Zhu,X., Xu,B., Lian,A., Zhang,X., Wang,Y., Zhang,Y., Zhang,L.,
            Ma,J., Gao,S. and Jin,G.
  TITLE     Menin orchestrates macrophage reprogramming to maintain the
            pulmonary immune homeostasis
  JOURNAL   Cell Rep 44 (1), 115219 (2025)
   PUBMED   39817905
REFERENCE   2  (bases 1 to 1057)
  AUTHORS   Favret,J., Maulik,M., Masoom,R., Kushwaha,M., Thompson,D.,
            Browne,R. and Shin,D.
  TITLE     Ablation of lipocalin-2 reduces neuroinflammation in a mouse model
            of Krabbe disease
  JOURNAL   Sci Rep 14 (1), 31822 (2024)
   PUBMED   39738378
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1057)
  AUTHORS   Hajam,I.A., Tsai,C.M., Gonzalez,C., Caldera,J.R., Lazaro Diez,M.,
            Du,X., Aralar,A., Lin,B., Duong,W. and Liu,G.Y.
  TITLE     Pathobiont-induced suppressive immune imprints thwart T cell
            vaccine responses
  JOURNAL   Nat Commun 15 (1), 10335 (2024)
   PUBMED   39681568
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1057)
  AUTHORS   O'Siorain,J.R., Cox,S.L., Payet,C., Nally,F.K., He,Y.,
            Drewinksi,T.T., Kennedy,O.D., Dowling,J.K., Mellett,M., Early,J.O.
            and Curtis,A.M.
  TITLE     Time-of-day control of mitochondria regulates NLRP3 inflammasome
            activation in macrophages
  JOURNAL   FASEB J 38 (24), e70235 (2024)
   PUBMED   39686706
REFERENCE   5  (bases 1 to 1057)
  AUTHORS   Yoshida,Y., Nishikawa,N., Fukuoka,K., Tsuruta,A., Otsuki,K.,
            Fukuda,T., Terada,Y., Tanihara,T., Kumamoto,T., Tsukamoto,R.,
            Nishi,T., Oyama,K., Hamamura,K., Mayanagi,K., Koyanagi,S., Ohdo,S.
            and Matsunaga,N.
  TITLE     Monocyte/Macrophage-Specific Loss of ARNTL Suppresses Chronic
            Kidney Disease-Associated Cardiac Impairment
  JOURNAL   Int J Mol Sci 25 (23), 13009 (2024)
   PUBMED   39684718
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1057)
  AUTHORS   Yasuda,Y., Nishi,N., Takahashi,J.A., Konishi,H., Ohara,I.,
            Fujita,H., Ohta,M., Itoh,N., Hatanaka,M. and Tanimura,T.
  TITLE     Induction of avascular yolk sac due to reduction of basic
            fibroblast growth factor by retinoic acid in mice
  JOURNAL   Dev Biol 150 (2), 397-413 (1992)
   PUBMED   1372572
REFERENCE   7  (bases 1 to 1057)
  AUTHORS   Cross,M. and Renkawitz,R.
  TITLE     Repetitive sequence involvement in the duplication and divergence
            of mouse lysozyme genes
  JOURNAL   EMBO J 9 (4), 1283-1288 (1990)
   PUBMED   2323338
REFERENCE   8  (bases 1 to 1057)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
REFERENCE   9  (bases 1 to 1057)
  AUTHORS   Cross,M., Mangelsdorf,I., Wedel,A. and Renkawitz,R.
  TITLE     Mouse lysozyme M gene: isolation, characterization, and expression
            studies
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6232-6236 (1988)
   PUBMED   3413093
REFERENCE   10 (bases 1 to 1057)
  AUTHORS   Hammer,M.F. and Wilson,A.C.
  TITLE     Regulatory and structural genes for lysozymes of mice
  JOURNAL   Genetics 115 (3), 521-533 (1987)
   PUBMED   3569879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK153475.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017372.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148516.1, AK153475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1057              AK153475.1         2-1058
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.34 cM"
     gene            1..1057
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /note="lysozyme 2"
                     /db_xref="GeneID:17105"
                     /db_xref="MGI:MGI:96897"
     exon            1..166
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..477
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /EC_number="3.2.1.17"
                     /note="lysozyme C-2; lysozyme C type M;
                     1,4-beta-N-acetylmuramidase C; lysozyme f2"
                     /codon_start=1
                     /product="lysozyme C-2 precursor"
                     /protein_id="NP_059068.1"
                     /db_xref="CCDS:CCDS48694.1"
                     /db_xref="GeneID:17105"
                     /db_xref="MGI:MGI:96897"
                     /translation="MKTLLTLGLLLLSVTAQAKVYERCEFARTLKRNGMAGYYGVSLA
                     DWVCLAQHESNYNTRATNYNRGDQSTDYGIFQINSRYWCNDGKTPRAVNACGINCSAL
                     LQDDITAAIQCAKRVVRDPQGIRAWVAWRAHCQNRDLSQYIRNCGV"
     exon            167..331
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            332..410
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1057
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /note="hexamer: AATAAA"
     polyA_site      820
                     /gene="Lyz2"
                     /gene_synonym="Lys; Lysm; Lyzf2; Lyzs; Lzm; Lzm-s1; Lzp"
                     /note="major polyA site"
ORIGIN      
        1 agccagcagc tgacccagcc tccagtcacc atgaagactc tcctgactct gggactcctc
       61 ctgctttctg tcactgctca ggccaaggtc tatgaacgtt gtgagtttgc cagaactctg
      121 aaaaggaatg gaatggctgg ctactatgga gtcagcctgg ccgactgggt gtgtttagct
      181 cagcacgaga gcaattataa cacacgagct acaaactaca accgtggaga ccaaagcact
      241 gactatggga tatttcagat caatagccga tactggtgta atgatggcaa aaccccaaga
      301 gctgtgaatg cctgtgggat caattgcagt gctctgctgc aggatgacat cactgcagcc
      361 atacaatgtg caaagagggt ggtgagagat ccccaaggca ttcgagcatg ggtggcatgg
      421 cgagcacact gtcaaaaccg agatctgtcc cagtatattc ggaactgcgg agtctgaccg
      481 cggtgtgctt ctactgcagc tcattcggtc tctttctcac tgtaggagta gatatgagag
      541 aggtcacatt ccctcgattt cccctctaag tcacaggact tcagcagaaa cagggcaaaa
      601 cagagacttc ctcctcacaa gcttcagctg atgctgtgtt gtgcaaagtc tcccttgtca
      661 gtcagcacag ccctggacgc tggtgacagt cagccaacac aatgatcacc acacagacac
      721 ctctgtaggt cagttcttca gccaggaagt gattcacatt gagttccatt ggaattcatc
      781 ttaatcagac ctgtgtgaat aaaaatacaa gaactgctta taggagacca gttgatcttg
      841 ggaaacagca gtcgtgtgag ctgcagggct ttgtgcagtc ccagcaccca gttagaacag
      901 cctctgtggt gggccgggaa ggtttctgag ggcacaggag tctcagtgga tgagaactga
      961 gattgtctga actcagaaac ttatcaggga acccgtgacc tgtctttctt agagctgccc
     1021 ctttcatctt gcttaaaaaa taaattctca gctcatg
//
